Optimizing Battery Charging Using Neural Networks in the Presence of Unknown States and Parameters.

This work investigates the effectiveness of deep neural networks within the realm of battery charging. This is done by introducing an innovative control methodology that not only ensures safety and optimizes the charging current, but also substantially reduces the computational complexity with respect to traditional model-based approaches. In addition to their high computational costs, model-based approaches are also hindered by their need to accurately know the model parameters and the internal states of the battery, which are typically unmeasurable in a realistic scenario. In this regard, the deep learning-based methodology described in this work was been applied for the first time to the best of the authors' knowledge, to scenarios where the battery's internal states cannot be measured and an estimate of the battery's parameters is unavailable. The reported results from the statistical validation of such a methodology underline the efficacy of this approach in approximating the optimal charging policy.

Performance evaluation for the design of a hybrid cloud based distance synchronous and asynchronous learning architecture.

The COVID-19 emergency suddenly obliged schools and universities around the world to deliver on-line lectures and services. While the urgency of response resulted in a fast and massive adoption of standard, public on-line platforms, generally owned by big players in the digital services market, this does not sufficiently take into account privacy-related and security-related issues and potential legal problems about the legitimate exploitation of the intellectual rights about contents. However, the experience brought to attention a vast set of issues, which have been addressed by implementing these services by means of private platforms. This work presents a modeling and evaluation framework, defined on a set of high-level, management-oriented parameters and based on a Vectorial Auto Regressive Fractional (Integrated) Moving Average based approach, to support the design of distance learning architectures. The purpose of this framework is to help decision makers to evaluate the requirements and the costs of hybrid cloud technology solutions. Furthermore, it aims at providing a coarse grain reference organization integrating low-cost, long-term storage management services to implement a viable and accessible history feature for all materials. The proposed solution has been designed bearing in mind the ecosystem of Italian universities. A realistic case study has been shaped on the needs of an important, generalist, polycentric Italian university, where some of the authors of this paper work.

FGDB: a comprehensive graph database of ligand fragments from the Protein Data Bank.

This work presents Fragment Graph DataBase (FGDB), a graph database of ligand fragments extracted and generated from the protein entries available in the Protein Data Bank (PDB). FGDB is meant to support and elicit campaigns of fragment-based drug design, by enabling users to query it in order to construct ad hoc, target-specific libraries. In this regard, the database features more than 17 000 fragments, typically small, highly soluble and chemically stable molecules expressed via their canonical Simplified Molecular Input Line Entry System (SMILES) representation. For these fragments, the database provides information related to their contact frequencies with the amino acids, the ligands they are contained in and the proteins the latter bind to. The graph database can be queried via standard web forms and textual searches by a number of identifiers (SMILES, ligand and protein PDB ids) as well as via graphical queries that can be performed against the graph itself, providing users with an intuitive and effective view upon the underlying biological entities. Further search mechanisms via advanced conjunctive/disjunctive/negated textual queries are also possible, in order to allow scientists to look for specific relationships and export their results for further studies. This work also presents two sample use cases where maternal embryonic leucine zipper kinase and mesotrypsin are used as a target, being proteins of high biomedical relevance for the development of cancer therapies. Database URL: http://biochimica3.bio.uniroma3.it/fragments-web/.