[Protein analytic studies in children with mastoiditis]. / Eiweissanalytische Untersuchungen bei Kindern mit Mastoiditis.

Protein analysing examinations were carried through in children--fit to be compared to their age--suffering from inflammable ear diseases (acute middle ear inflammation, mastoiditis) and those who were healthy as to their ears. The obtained values statistically analysed resulted in significant differences as to the acute phase and those of closely associated proteins in the sense that haptoglobin, C3c and C1-inactivators in patients with a mastoiditis and partially in those who suffered from an acute middle ear inflammation were increased but prealbumin and transferrin in the same group were decreased. Subsequently the correlative connections of the parameters with singled-out clinical findings in the mastoiditis-group were examined. A factor of the acute phase, a factor of the subacute phase and the immunoglobulin factor could have been marked off, whereby the two first-mentioned are significant for mastoiditis, a fact that will help to facilitate the decision on further therapeutical practice. Presently there are no specific proteins for diagnostics of 'mastoiditis', so that to clinical expertness and experience of the therapeutist will come up the most significant role for the ill child.

[Clinical pathology of chronic hyperplastic laryngitis. 2. Clinical, morphological and statistical studies with special reference to precancerous changes]. / Beitrag zur klinischen Pathologie der chronischen hyperplastischen Laryngitis. 2. Mitteilung: Klinische, morphologische und statistische Untersuchungen mit besonderer Berücksichtigung präkanzeröser Veränderungen.

Data on 13 different clinical, histological and environmental factors were obtained from 54 patients with hyperplastic laryngitis (HL). They were evaluated by multiple linear factor analysis. HL can be considered to be a complex clinico-morphological entity. Precancerous changes in the larynx were closely correlated with the grade of HL. Etiologically only a weak association with tobacco and alcohol use could be found. The development of the disease was independent of age, sex, nasal function and of other chemical, physical or mechanical factors.

[Immunologic and clinical findings in different liver diseases (statistical studies)]. / Immunologische und klinische Befunde bei unterschiedlichen Lebererkrankungen (statistische Untersuchungen).

In 140 out-patients of a liver dispensary department 18 clinical and immunological markers (autoantibodies) in 7 well defined diseases were found. We them underwent to a multiple linear factor analysis. 4 different and independent structural factors could be defined: 1. a so-called autoimmunity factor, 2. a parenchymatous factor, 3. an ethanol factor and, finally, a dysproteinemia factor. By individual factor analysis different hepatological diseases could be characterized.