Does musculoskeletal pain interfere with motor learning in a gait adaptation task? A proof-of-concept study.

BACKGROUND: Experimental pain during gait has been shown to interfere with learning a new locomotor task. However, very few studies have investigated the impact of clinical pain on motor learning due to the challenges associated with clinical populations. OBJECTIVE: The first objective of this proof-of-concept study was to determine the feasibility to obtain two groups of participants with chronic ankle pathology with or without residual pain while walking. The second objective was to evaluate the impact of clinical musculoskeletal pain on motor learning during gait. METHODS: Participants with chronic isolated ankle pathology were recruited and their personal and clinical characteristics were collected (functional performance, dorsiflexion maximal strength, range of motion). To assess motor acquisition (Day 1) and retention (Day 2), participants performed an adaptation task on two consecutive days that consisted of walking while experiencing a perturbing force applied to the ankle. The level of pain during the task was measured, and participants who reported pain were attributed to the Pain group and participants without pain to the No Pain group. Learning performance was assessed by measuring ankle kinematics (Mean plantarflexion absolute error) and learning strategy was assessed by measuring the Relative timing of error and the tibialis anterior (TA) electromyographic activity. RESULTS: Twenty-five participants took part in the experiment. Eight (32%) were excluded because they could not be included in either the Pain or No Pain group due to the intermittent pain, leaving eight participants in the Pain group and nine in the No Pain group. Both groups were similar in terms of baseline characteristics. Musculoskeletal pain had no influence on learning performance, but the learning strategy were different between the two groups. The No Pain group showed a TA activity reduction before perturbation between the days, while the Pain group did not. CONCLUSION: Some barriers were identified in studying musculoskeletal pain including the high rates of participants' exclusion, leading to a small sample size. However, we showed that it is feasible to investigate clinical pain and motor learning. From the results of this study, musculoskeletal pain has no influence on motor learning performance but influences the learning strategy.

Power Spectrum of Acceleration and Angular Velocity Signals as Indicators of Muscle Fatigue during Upper Limb Low-Load Repetitive Tasks.

Muscle fatigue is a risk factor for developing musculoskeletal disorders during low-load repetitive tasks. The objective of this study was to assess the effect of muscle fatigue on power spectrum changes of upper limb and trunk acceleration and angular velocity during a repetitive pointing task (RPT) and a work task. Twenty-four participants equipped with 11 inertial measurement units, that include acceleration and gyroscope sensors, performed a tea bag filling work task before and immediately after a fatiguing RPT. During the RPT, the power spectrum of acceleration and angular velocity increased in the movement and in 6-12 Hz frequency bands for sensors positioned on the head, sternum, and pelvis. Alternatively, for the sensor positioned on the hand, the power spectrum of acceleration and angular velocity decreased in the movement frequency band. During the work task, following the performance of the fatiguing RPT, the power spectrum of acceleration and angular velocity increased in the movement frequency band for sensors positioned on the head, sternum, pelvis, and arm. Interestingly, for both the RPT and work task, Cohens' d effect sizes were systematically larger for results extracted from angular velocity than acceleration. Although fatigue-related changes were task-specific between the RPT and the work task, fatigue systematically increased the power spectrum in the movement frequency band for the head, sternum, pelvis, which highlights the relevance of this indicator for assessing fatigue. Angular velocity may be more efficient to assess fatigue than acceleration. The use of low cost, wearable, and uncalibrated sensors, such as acceleration and gyroscope, in industrial settings is promising to assess muscle fatigue in workers assigned to upper limb repetitive tasks.

Shoulder electromyography-based indicators to assess manifestation of muscle fatigue during laboratory-simulated manual handling task.

Muscle fatigue is a risk factor for developing shoulder musculoskeletal disorders. The aim of this study was to identify shoulder electromyographic indicators that are most indicative of muscle fatigue during a laboratory simulated manual handling task. Thirty-two participants were equipped with electromyographic electrodes on 10 shoulder muscles and moved boxes for 45-minutes. The modified rate of perceived exertion (mRPE) was assessed every 5-minutes and multivariate linear regressions were performed between myoelectric manifestation of fatigue (MMF) and the mRPE scores. During a manual handling task representative of industry working conditions, spectral entropy, median frequency, and mobility were the electromyographic indicators that explained the largest percentage of the mRPE. Overall, the deltoids, biceps and upper trapezius were the muscles that most often showed significant changes over time in their electromyographic indicators. The combination of these three indicators may improve the accuracy for the assessment of MMF during manual handling. Practitioner Summary: To date, muscle fatigue has primarily been assessed during tasks done to exhaustion, which are not representative of typical working conditions. During a manual handling task representative of industry working conditions, EMG-derived spectral entropy, and median frequency, both extracted from time-frequency analysis, and mobility extracted from time domain, were the best indicators of the manifestation of muscle fatigue.

Sex differences in glenohumeral muscle activation and coactivation during a box lifting task.

Manual material handling is associated with shoulder musculoskeletal disorders, especially for women. Sex differences in glenohumeral muscle activity may contribute to women's higher injury risk by affecting shoulder load and stability. We assessed the effects of sex (25 women vs 26 men) and lifting load (6 kg vs 12 kg) on muscle activation during box lifting from hip to eye level. Surface and intramuscular electromyography were recorded from 10 glenohumeral muscles. Most muscles were more activated for the heavier box and for women. These effects were larger for 'prime movers' than for stabilisers and antagonists. Despite their apparently heterogeneous effects on muscle activity, sex and mass did not affect Muscle Focus, a metric of coactivation. This may be partly related to the limited sensitivity of the Muscle Focus. Nevertheless, sex differences in strength, more than in coactivation patterns, may contribute to the sex imbalance in the prevalence of musculoskeletal disorders. Practitioner summary: We studied sex differences in glenohumeral muscle activity in a lifting task to eye level. Women lifting a 6-kg box activated their muscles similarly to men lifting a 12-kg box, i.e. up to 48% of their maximum capacity. Interventions minimising shoulder load should be implemented, especially for women. Abbreviations: BB: biceps brachii; DeltA: anterior deltoid; DeltL: lateral deltoid; DeltP: posterior deltoid; DoF: degrees of freedom; ED: effect duration; EMG: electromyography; ES: effect size; Infra: infraspinatus; Lat: latissimus dorsi; MF: muscle focus; MMH: manual material handling; MVA: maximal voluntary activation; Pect: pectoralis major; Subscap: subscapularis; Supra: supraspinatus; TB: triceps brachii.

Sex differences in upper limb 3D joint contributions during a lifting task.

Sex-related differences in work technique may contribute to increasing the risk of musculoskeletal joint disorders among women. In lifting tasks, sex differences have been reported for the trunk and lower limb, although women present a higher prevalence of shoulder disorders. We investigated sex differences in the upper limb technique during a lifting task. Trunk and upper limb kinematics were recorded in 27 women and 27 men lifting a box (6 or 12 kg) from hip to eye level. Work technique was quantified through the three-dimensional contribution of each joint to overall box height. The glenohumeral joint showed a higher contribution in women with a 6 kg box and wrist and elbow joints did with a 12 kg box, compared to men at either 6 or 12 kg. Sex differences occurred systematically above shoulder level. Our results argue for careful consideration of sex during ergonomic intervention, particularly during the overhead task. Practitioner Summary: We investigated the sex-related differences in upper limb technique during lifting tasks. Results highlight a sex-specific kinematic strategy above the shoulder level on the glenohumeral joint and on the wrist and elbow joints. To help reduce women's shoulder disorders in overhead task, ergonomic interventions should account for those differences. Abbreviations: DoF: degree-of-freedom; WR/EL: wrist and elbow; GH: glenohumeral; SC/AC: sternoclavicular and acromioclavicular; TR/PE: pelvo-thoracic.

Effect of experimental muscle pain on the acquisition and retention of locomotor adaptation: different motor strategies for a similar performance.

As individuals with musculoskeletal disorders often experience motor impairments, contemporary rehabilitation relies heavily on the use of motor learning principles. However, motor impairments are often associated with pain. Although there is substantial evidence that muscle pain interferes with motor control, much less is known on its impact on motor learning. The objective of the present study was to assess the effects of muscle pain on locomotor learning. Two groups (Pain and Control) of healthy participants performed a locomotor adaptation task (robotized ankle-foot orthosis perturbing ankle movements during swing) on two consecutive days. On day 1 (acquisition), hypertonic saline was injected in the tibialis anterior (TA) muscle of the Pain group participants, while Control group participants were pain free. All participants were pain free on day 2 (retention). Changes in movement errors caused by the perturbation were assessed as an indicator of motor performance. Detailed analysis of kinematic and electromyographic data provided information about motor strategies. No between-group differences were observed on motor performance measured during the acquisition and retention phases. However, Pain group participants had a residual movement error later in the swing phase and smaller early TA activation than Control group participants, thereby suggesting a reduction in the use of anticipatory motor strategies to overcome the perturbation. Muscle pain did not interfere with global motor performance during locomotor adaptation. The different motor strategies used in the presence of muscle pain may reflect a diminished ability to anticipate the consequences of a perturbation. NEW & NOTEWORTHY This study shows that experimental muscle pain does not influence global motor performance during the acquisition or next-day retention phases of locomotor learning. This contrasts with previous results obtained with cutaneous pain, emphasizing the risk of directly extrapolating from one pain modality to another. Muscle pain affected motor strategies used when performing the task, however: it reduced the ability to use increased feedforward control to overcome the force field.

Psychometric properties of the Musculoskeletal Function Assessment and the Short Musculoskeletal Function Assessment: a systematic review.

OBJECTIVES: To investigate the psychometric properties of the Musculoskeletal Function Assessment (MFA) and Short Musculoskeletal Function Assessment (SMFA). DATA SOURCES: A systematic search of the following databases was undertaken concerning psychometric evidence of the MFA and SMFA: PubMed, Embase, Scopus and Cinahl. References of retrieved articles were inspected for additional data. REVIEW METHOD: Articles evaluating the validity, reliability or responsiveness of the MFA or SMFA in patients with musculoskeletal disorders were included in this systematic review. The methodological quality of included articles was critically appraised and the psychometric data were extracted using standardized forms. An established set of criteria were used to synthetize the evidence in order to highlight the strengths and weaknesses of included questionnaires and the gaps in the literature. RESULTS: Nine articles on MFA and 24 articles on SMFA met the inclusion criteria. The SMFA fulfilled 75% of the psychometric criteria analyzed, while the MFA fulfilled only 50%. MFA and SMFA have excellent content validity and relative reliability (weighted average intraclass correlation coefficient ⩾ 0.87), and are moderately to highly responsive (standardized response mean between 0.65 and 1.13). Absolute reliability and clinically important difference of both questionnaires need to be defined, while the construct validity of MFA still needs to be established. CONCLUSION: MFA and SMFA are reliable and responsive tools for monitoring the function of patients with various musculoskeletal disorders. Still, research is needed to justify their usage in a clinical setting.

Pain Induced during Both the Acquisition and Retention Phases of Locomotor Adaptation Does Not Interfere with Improvements in Motor Performance.

Cutaneous pain experienced during locomotor training was previously reported to interfere with retention assessed in pain-free conditions. To determine whether this interference reflects consolidation deficits or a difficulty to transfer motor skills acquired in the presence of pain to a pain-free context, this study evaluated the effect of pain induced during both the acquisition and retention phases of locomotor learning. Healthy participants performed a locomotor adaptation task (robotized orthosis perturbing ankle movements during swing) on two consecutive days. Capsaicin cream was applied around participants' ankle on both days for the Pain group, while the Control group was always pain-free. Changes in movement errors caused by the perturbation were measured to assess global motor performance; temporal distribution of errors and electromyographic activity were used to characterize motor strategies. Pain did not interfere with global performance during the acquisition or the retention phases but was associated with a shift in movement error center of gravity to later in the swing phase, suggesting a reduction in anticipatory strategy. Therefore, previously reported retention deficits could be explained by contextual changes between acquisition and retention tests. This difficulty in transferring skills from one context to another could be due to pain-related changes in motor strategy.

Tonic pain experienced during locomotor training impairs retention despite normal performance during acquisition.

Many patients are in pain when they receive gait training during rehabilitation. Based on animal studies, it has been proposed that central sensitization associated to nociception (maladaptive plasticity) and plasticity related to the sensorimotor learning (adaptive plasticity) share similar neural mechanisms and compete with each other. The aim of this study was to evaluate whether experimental tonic pain influences motor learning (acquisition and next-day retention) of a new locomotor task. Thirty healthy human subjects performed a locomotor adaptation task (perturbing force field applied to the ankle during swing using a robotized orthosis) on 2 consecutive days. Learning was assessed using kinematic measures (peak and mean absolute plantarflexion errors) and electromyographic (EMG) activity. Half of the participants performed the locomotor adaptation task with pain on Day 1 (capsaicin cream around the ankle), while the task was performed pain-free for all subjects on Day 2 to assess retention. Pain had no significant effect on baseline gait parameters nor on performance during the locomotor adaptation task (for either kinematic or EMG measures) on Day 1. Despite this apparently normal motor acquisition, pain-free Day 2 performance was markedly and significantly impaired in the Pain group, indicating that pain during training had an impact on the retention of motor memories (interfering with consolidation and/or retrieval). These results suggest that the same motor rehabilitation intervention could be less effective if administered in the presence of pain.

Wheelchair-mounted robotic arms: a survey of occupational therapists' practices and perspectives.

PURPOSE: Despite the benefits of wheelchair-mounted robotic arms (WMRAs), occupational therapists are not yet widely involved in the recommendation or implementation of these assistive devices. The purpose of this study was to investigate and compare the current practices and perspectives of occupational therapists who had and had not recommended a WMRA on the recommendation, training, and implementation of WMRAs. METHODS: This was a descriptive cross-sectional study. An online survey was sent to Canadian, European, and American occupational therapists who had or had not worked with WMRAs. Respondents were asked close-ended questions about their experience, role, barriers, motivations, and future needs regarding WMRAs. We compared results between respondents who had and had not recommended WMRAs using descriptive statistics. RESULTS: Ninety-three North American and European occupational therapists completed the survey. Of those, 29 (31.2%) had recommended a WMRA, mostly the JACO robotic arm (n = 26, 89.7%) in rehabilitation centres (n = 18, 62.1%). Their perspectives on their role and barriers related to WMRAs were similar to those who had never recommended a WMRA. All respondents recognised the relevance of occupational therapists' contribution, and most reported interest in WMRAs (n = 76, 81.7%). However, many barriers emerged, mainly related to limited funding (n = 49, 76.6%), lack of training and knowledge (n = 38, 59.4%), and resource constraints (n = 37, 54.4%). Future needs identified matched these barriers. CONCLUSION: This survey provides novel insight into occupational therapists' perspectives on WMRAs. It highlights that health professionals need to have easier access to funding, formal training, and resources to support their involvement with WMRAs.Implications for rehabilitationMost occupational therapists are interested in working with WMRAs, considering the potential of these devices to support individuals with upper extremity impairments in their daily activities. They also recognise their unique contribution to the assessment, recommendation, and implementation process among multidisciplinary teams.WMRA recommendation is relevant in various clinical settings and with a wide range of client populations. Nevertheless, it appears that occupational therapists working with adults, in rehabilitation centres or specialised clinics, may have more opportunities to get involved in this process and to attend formal training on this technology, as compared to other settings.Many barriers remain, impeding occupational therapists' role in the recommendation and implementation of WMRAs. Addressing these barriers may increase the number of devices that are successfully adopted and utilised by individuals with upper extremity impairments. In particular, future research and health policies should focus on access to sufficient funding, formal training, and resources for occupational therapists relative to their role in recommending and implementing WMRAs.

Use of a dynamic arm support to drive a power wheelchair: a case report.

PURPOSE: Dynamic arm supports (DAS) can assist individuals with severe upper limb disabilities who use a wheelchair to accomplish their daily activities. The objective of this case series was to assess the potential of a DAS to improve power wheelchair (PWC) control in real-life contexts and to describe the integration process. A secondary objective was to explore factors that may influence the DAS integration process. METHODS: This case series includes four participants fitted with the Kinova DAS O110. A one-year follow-up was planned for each participant with qualitative and quantitative data collection to assess DAS outcomes. Assessment methods were selected to cover the three vantages of assistive technology outcomes assessment: effectiveness, subjective well-being, and social significance. RESULTS: Among the four participants, one used the DAS to help with his wheelchair control for at least 12 months (successful integration). For him, the DAS led to significantly improved wheelchair skills and an important positive psychosocial impact. He was, however, only able to use the DAS for PWC control (no effects on other daily activities), and could not use it in some contexts because the device increased his PWC width. As for the other participants, they stopped using the DAS for different reasons, including a DAS-related adverse event. CONCLUSION: This study demonstrated that a wheelchair-bound DAS has the potential to improve PWC use, but successful integration requires specific factors. The service delivery process and the environmental accessibility are crucial for the successful integration of such a device and to avoid safety issues.IMPLICATIONS FOR REHABILITATIONNo study deeply assessed the impacts of dynamic arm support on power wheelchair control, and the associated facilitators and obstacles.A wheelchair-bound dynamic arm support has the potential to improve power wheelchair control for individuals with upper limb disabilities and to lead to positive psychosocial impacts if some conditions conductive to successful integration are met.The service delivery process and the environmental accessibility appear as crucial aspects for the successful integration of a new device, such as dynamic arm support and avoiding safety issues.

Evaluation of the usability of an actively actuated arm support.

Dynamic arm supports can be used to increase the autonomy of people with upper limb disabilities, but their usability is often poorly documented. The objective of this study is to evaluate the usability of an actuated arm support (AAS), namely the Gowing power-assisted arm support. Nine participants with neurological disorders restricting their upper limb capacities (DASH = 63.51 ± 7.72) completed various tasks (Upper Extremity Performance Test for the Elderly (TEMPA)) with and without the AAS. Users' satisfaction (Quebec User Evaluation of Satisfaction with assistive Technology (QUEST)) and perceived benefits of the device (semi-structured interviews) were assessed. Large (effect size ≥ 1.15) and statistically significant (p < .05) improvements were found in the TEMPA functional rating, range of motion, strength, precision of gross movements and prehension patterns subscales while using the AAS. Two third of the participants were quite or very satisfied with the arm support (QUEST > 4/5) and interviews were positive about its usefulness in daily living activities. Our study demonstrated that the use of an AAS could result in significant improvements in the autonomy of people with upper limb disabilities.

The effect of experimental pain on the excitability of the corticospinal tract in humans: A systematic review and meta-analysis.

BACKGROUND AND OBJECTIVE: Pain influences motor control. Previous reviews observed that pain reduces the excitability of corticospinal projections to muscles tested with transcranial magnetic stimulation. However, the independent effect of the type of pain models (tonic, phasic), pain location and tissues targeted (e.g. muscle, skin) remains unexplored. The objective of this review was to determine the influence of experimental pain and of different methodological factors on the corticospinal excitability. DATABASES AND DATA TREATMENT: Three electronic databases were searched: Embase, Pubmed and Web of Science. Meta-analyses were conducted in three consecutive steps to reduce methodological variability: (a) all studies; (b) same pain location; (c) same tissues, pain location and muscle state. Strength of evidence was assessed for each analysis performed. RESULTS: Forty studies were included in the review and 26 in the meta-analysis as it focused only on studies using tonic pain. Overall, there was conflicting/moderate evidence of a diminution of corticospinal excitability during and after tonic pain. When considering only pain location, tonic hand and face pain induced a reduction in corticospinal excitability (limited evidence). Both muscle and cutaneous hand pain reduced corticospinal excitability (limited/conflicting evidence). Similar results were observed for phasic pain (limited evidence). CONCLUSIONS: Our results confirm the inhibitory effect of pain on corticospinal excitability for both tonic and phasic pain. This reduction was specific to hand and face pain. Also, both cutaneous and muscle hand pain reduced excitability. The strength of evidence remains limited/conflicting. More high-quality studies are needed to confirm our conclusions. SIGNIFICANCE: This study adds evidence on the effect of specific factors on the modulation of corticospinal excitability during/after experimental pain. The reduction in corticospinal excitability was driven by hand and face pain. We confirmed previous results that muscle pain reduces corticospinal excitability and provided evidence of a similar effect for cutaneous pain. Both models may inform on the influence of different types of pain on motor control. Future studies are needed to determine the origin of the effect of pain.

Similar effects of fatigue induced by a repetitive pointing task on local and remote light touch and pain perception in men and women.

BACKGROUND: Women involved in repetitive, fatiguing, jobs develop more neck and/or shoulder musculoskeletal disorders than men. Sex differences in the pain response to exercise could contribute to the higher prevalence of neck/shoulder musculoskeletal disorders in women. The objective of this study was to assess sex differences in pain sensitivity following a fatiguing upper limb task. Relationships between measures of fatigue and of the sensitivity to nociceptive and to non-nociceptive stimulations were also explored. METHODS: Thirty healthy adults (15 women) performed a fatiguing repetitive pointing task with their dominant arm. Upper limb electromyography was recorded from the dominant upper trapezius, anterior deltoid and bicep brachii and from the contralateral tibialis anterior. Before and immediately after the repetitive pointing task, pressure pain and light touch sensitivity thresholds were measured over the same muscles. RESULTS: Electromyographic signs of fatigue were observed only in the anterior deltoid and biceps brachii muscles. Pressure pain thresholds over both muscles increased slightly (effect size ≤ 0.34), but no changes occurred over the upper trapezius and the tibialis anterior. Light touch thresholds increased moderately to importantly after the repetitive pointing task over all four muscles (effect sizes = 0.58 to 0.87). No sex differences were observed in any sensory variable. Moreover, no or weak correlations (r = -0.27 to 0.39) were observed between electromyographical signs of fatigue, light touch threshold and pressure pain threshold variables. CONCLUSIONS: We observed sex-independent effects of a repetitive upper limb task on the sensitivity to painful and to nonpainful stimuli. Moreover, the hypoalgesia induced by the repetitive pointing task was weak and localized, and did not directly correlate with the induced muscle fatigue. Results suggest that fatigue-related changes in the sensitivity to noxious and innocuous stimuli could not explain women's greater prevalence of neck/shoulder musculoskeletal disorders.

Sex differences in kinematic adaptations to muscle fatigue induced by repetitive upper limb movements.

BACKGROUND: Muscle fatigue induced by repetitive movements contributes to the development of musculoskeletal disorders. Men and women respond differently to muscle fatigue during isometric single-joint efforts, but sex differences during dynamic multi-joint tasks have not been clearly identified. Moreover, most studies comparing men and women during fatigue development assessed endurance time. However, none evaluated sex differences in kinematic adaptations to fatigue during multi-joint dynamic tasks. The objective of the study was to compare how men and women adapt their upper body kinematics during a fatiguing repetitive pointing task. METHODS: Forty men and 41 women performed repetitive pointing movements (one per second) between two targets while maintaining their elbow elevated at shoulder height. The task ended when participants rated a perceived level of fatigue of 8/10. Trunk, humerothoracic, and elbow angles were compared between the first and last 30 s of the experiment and between men and women. Linear positions of the index finger (distance from the target) and the elbow (arm elevation) as well as movement timing were documented as task performance measures. RESULTS: Men (7.4 ± 3.2 min) and women (8.3 ± 4.5 min) performed the repetitive pointing task for a similar duration. For both sex groups, trunk range of motion increased with fatigue while shoulder's and elbow's decreased. Moreover, participants modified their trunk posture to compensate for the decreased humerothoracic elevation. Movements at all joints also became more variable with fatigue. However, of the 24 joint angle variables assessed, only two Sex × Fatigue interactions were observed. Although average humerothoracic elevation angle decreased in both subgroups, this decrease was greater in men (standardized response mean [SRM] - 1.63) than in women (SRM - 1.44). Moreover, the movement-to-movement variability of humerothoracic elevation angle increased only in women (SRM 0.42). CONCLUSION: Despite many similarities between men's and women's response to fatigue induced by repetitive pointing movements, some sex differences were observed. Those subtle differences may indicate that men's shoulder muscles were more fatigued than women's despite a similar level of perceived exertion. They may also indicate that men and women do not adapt the exact same way to a similar fatigue.

Changes in movement variability and task performance during a fatiguing repetitive pointing task.

Changes in neuromuscular strategies employed with fatigue during multi-joint movements are still poorly understood. Studies have shown that motor variability of individual joints increases when performing upper limb tasks to fatigue, while movement parameters related to the task goal remain constant. However, how the inter-limb coordination and its variability change during specific movement phases with fatigue is still unclear. The aim of this study was to assess the effects of neck-shoulder fatigue on shoulder and elbow kinematic variabilities, shoulder-elbow coordination and its variability, and endpoint characteristics during different phases of a forward pointing movement. Nineteen healthy young adults continuously performed a repetitive pointing task until fatigue (Borg rating of 8/10). Changes in elbow-shoulder coordination through the movement were assessed using the continuous relative phase and statistical nonparametric mapping methods. At the end of the task, muscle fatigue was evidenced by significant increases in anterior deltoid (+13%) and biceps brachii (+30%) activity. Shoulder horizontal abduction, elbow flexion variability and shoulder-elbow coordination variability were increased with fatigue at different moments of the movement cycle (shoulder: during the first 17% and most of the second half movement, elbow: from 73% to 91%, coordination: almost the whole movement). However, movement timing errors and endpoint spatial variability were mostly preserved, even with fatigue. We showed that increased variability with fatigue is not only observed in the fatigued joint (shoulder), but also in the elbow and shoulder-elbow coordination, and may have a goal of preserving global task performance.

Promoting Gait Recovery and Limiting Neuropathic Pain After Spinal Cord Injury.

Most persons living with a spinal cord injury experience neuropathic pain in the months following their lesion, at the moment where they receive intensive gait rehabilitation. Based on studies using animal models, it has been proposed that central sensitization in nociceptive pathways (maladaptive plasticity) and plasticity related to motor learning (adaptive plasticity) share common neural mechanisms and compete with each other. This article aims to address the discrepancy between the growing body of basic science literature supporting this hypothesis and the general belief in rehabilitation research that pain and gait rehabilitation represent two independent problems. First, the main findings from basic research showing interactions between nociception and learning in the spinal cord will be summarized, focusing both on evidence demonstrating the impact of nociception on motor learning and of motor learning on central sensitization. Then, the generalizability of these findings in animal models to humans will be discussed. Finally, the way potential interactions between nociception and motor learning are currently taken into account in clinical research in patients with spinal cord injury will be presented. To conclude, recommendations will be proposed to better integrate findings from basic research into future clinical research in persons with spinal cord injury.

Development and reliability of a measure evaluating dynamic proprioception during walking with a robotized ankle-foot orthosis, and its relation to dynamic postural control.

BACKGROUND: Proprioception is important for proper motor control. As the central nervous system modulates how sensory information is processed during movement (sensory gating), proprioceptive tests performed at rest do not correlate well with performance during dynamic tasks such as walking. Proprioception therefore needs to be assessed during movement execution. OBJECTIVES: 1) To develop a test evaluating the ability to detect movement errors during walking, and its test-retest reliability; 2) to quantify the relationship between proprioceptive threshold (obtained with this new test) and performance in a standardized dynamic balance task. METHOD: Thirty healthy subjects walked on a treadmill while wearing a robotized ankle-foot orthosis (rAFO) for 2 bouts of 6min on 2 evaluation sessions (test-retest reliability). Force perturbations resisting ankle dorsiflexion during swing were applied to the ankle via the rAFO (150ms duration, variable amplitude). Participants pushed a button when they detected the perturbations. The Star Excursion Balance Test (SEBT) was used to evaluate dynamic balance. ANALYSIS: Angular differences between perturbed and non-perturbed gait cycles were used to quantify movement error. Detection threshold was defined as the minimal movement error at which 50% of the perturbations were perceived. Intraclass correlation coefficients (ICCs) estimated test-retest reliability, and Pearson coefficients were used to determine the correlation between detection threshold and SEBT. RESULTS: Detection threshold was 5.31±2.12°. Good reliability (ICC=0.70) and a moderate to strong correlation to SEBT (r=-0.57 to -0.76) were found. CONCLUSION: Force perturbations produced by the robotized AFO provides a reliable way of evaluating proprioception during walking.

Effect of tonic pain on motor acquisition and retention while learning to reach in a force field.

Most patients receiving intensive rehabilitation to improve their upper limb function experience pain. Despite this, the impact of pain on the ability to learn a specific motor task is still unknown. The aim of this study was to determine whether the presence of experimental tonic pain interferes with the acquisition and retention stages of motor learning associated with training in a reaching task. Twenty-nine healthy subjects were randomized to either a Control or Pain Group (receiving topical capsaicin cream on the upper arm during training on Day 1). On two consecutive days, subjects made ballistic movements towards two targets (NEAR/FAR) using a robotized exoskeleton. On Day 1, the task was performed without (baseline) and with a force field (adaptation). The adaptation task was repeated on Day 2. Task performance was assessed using index distance from the target at the end of the reaching movement. Motor planning was assessed using initial angle of deviation of index trajectory from a straight line to the target. Results show that tonic pain did not affect baseline reaching. Both groups improved task performance across time (p<0.001), but the Pain group showed a larger final error (under-compensation) than the Control group for the FAR target (p = 0.030) during both acquisition and retention. Moreover, a Group x Time interaction (p = 0.028) was observed on initial angle of deviation, suggesting that subjects with Pain made larger adjustments in the feedforward component of the movement over time. Interestingly, behaviour of the Pain group was very stable from the end of Day 1 (with pain) to the beginning of Day 2 (pain-free), indicating that the differences observed could not solely be explained by the impact of pain on immediate performance. This suggests that if people learn to move differently in the presence of pain, they might maintain this altered strategy over time.

Effect of painful and non-painful sensorimotor manipulations on subjective body midline.

Patients with chronic pain often show disturbances in their body perception. Understanding the exact role played by pain is however complex, as confounding factors can contribute to the observed deficits in these clinical populations. To address this question, acute experimental pain was used to test the effect of lateralized pain on body perception in healthy subjects. Subjects were asked to indicate the position of their body midline (subjective body midline, SBM) by stopping a moving luminescent dot projected on a screen placed in front of them, in a completely dark environment. The effect of other non-painful sensorimotor manipulations was also tested to assess the potential unspecific attentional effects of stimulating one side of the body. SBM judgment was made in 17 volunteers under control and three experimental conditions: (1) painful (heat) stimulation; (2) non-painful vibrotactile stimulation; and (3) muscle contraction. The effects of the stimulated side and the type of trial (control vs. experimental condition), were tested separately for each condition with a 2 × 2 repeated measures ANOVA. The analyses revealed a significant interaction in both pain (p = 0.05) and vibration conditions (p = 0.04). Post hoc tests showed opposite effects of pain and vibration. Pain applied on the right arm deviated the SBM toward the right (stimulated) side (p = 0.03) while vibration applied on the left arm deviated the SBM toward the right (not stimulated) side (p = 0.01). These opposite patterns suggest that the shift in SBM is likely to be specifically linked to the stimulation modality. It is concluded that acute experimental pain can induce an SBM shift toward the stimulated side, which might be functionally beneficial to protect the painful area of the body. Interestingly, it appears to be easier to bias SBM toward the right side, regardless of the modality and of the stimulated side.