ABSTRACT
We have presented a case of fetal intrauterine enterovirus (coxsackievirus A) infection at 36 weeks' gestation. Viral infection should be suspected when there is a history compatible with viral illness in the mother during pregnancy. Although an increased level of IgM antibodies in cord blood suggests a previous intrauterine infection, the diagnosis of fetal or neonatal viral infection ultimately depends upon the isolation of the viral agent.
Subject(s)
Coxsackievirus Infections/complications , Fetal Death/etiology , Pregnancy Complications, Infectious , Adult , Antibodies, Viral/analysis , Enterovirus/isolation & purification , Female , Fetal Blood/analysis , Humans , Immunoglobulin M/analysis , PregnancyABSTRACT
Currently, there exists no convenient, inexpensive screening test for the detection of postmenopausal women at risk for developing adenocarcinoma of the endometrium. After the administration of a progesterone challenge test (PCT) to asymptomatic postmenopausal women, the presence or absence of withdrawal bleeding may aid in detecting premalignant lesions of the endometrium. Of 30 such women who had endometrial sampling followed by a PCT, 25 had no withdrawal bleeding and all had nonpathologic histology. Five patients exhibited withdrawal bleeding. Of these five, three had unsuspected adenomatous hyperplasia (p less than 0.001). It is concluded that a PCT may be a reliable screening test for detecting those women at greater risk for developing endometrial hyperplasia or adenocarcinoma.