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1.

ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.

Schuijs, Martijn J; Png, Shaun; Richard, Arianne C; Tsyben, Anastasia; Hamm, Gregory; Stockis, Julie; Garcia, Celine; Pinaud, Silvain; Nicholls, Ashley; Ros, Xavier Romero; Su, Jing; Eldridge, Matthew D; Riedel, Angela; Serrao, Eva M; Rodewald, Hans-Reimer; Mack, Matthias; Shields, Jacqueline D; Cohen, E Suzanne; McKenzie, Andrew N J; Goodwin, Richard J A; Brindle, Kevin M; Marioni, John C; Halim, Timotheus Y F.

Nat Immunol ; 21(9): 998-1009, 2020 09.

Article in English | MEDLINE | ID: mdl-32747815

2.

Gene reporters for magnetic resonance imaging.

Brindle, Kevin M.

Trends Genet ; 38(10): 996-998, 2022 10.

Article in English | MEDLINE | ID: mdl-35641343

3.

Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging.

Hesse, Friederike; Somai, Vencel; Kreis, Felix; Bulat, Flaviu; Wright, Alan J; Brindle, Kevin M.

Proc Natl Acad Sci U S A ; 118(12)2021 03 23.

Article in English | MEDLINE | ID: mdl-33727417

4.

Assessment of the sensitivity of ² H MR spectroscopy measurements of [2,3-² H₂ ]fumarate metabolism for detecting tumor cell death.

Hesse, Friederike; Wright, Alan; Bulat, Flaviu; Kreis, Felix; Brindle, Kevin M.

NMR Biomed ; 36(10): e4965, 2023 10.

Article in English | MEDLINE | ID: mdl-37148156

5.

Imaging breast cancer using hyperpolarized carbon-13 MRI.

Gallagher, Ferdia A; Woitek, Ramona; McLean, Mary A; Gill, Andrew B; Manzano Garcia, Raquel; Provenzano, Elena; Riemer, Frank; Kaggie, Joshua; Chhabra, Anita; Ursprung, Stephan; Grist, James T; Daniels, Charlie J; Zaccagna, Fulvio; Laurent, Marie-Christine; Locke, Matthew; Hilborne, Sarah; Frary, Amy; Torheim, Turid; Boursnell, Chris; Schiller, Amy; Patterson, Ilse; Slough, Rhys; Carmo, Bruno; Kane, Justine; Biggs, Heather; Harrison, Emma; Deen, Surrin S; Patterson, Andrew; Lanz, Titus; Kingsbury, Zoya; Ross, Mark; Basu, Bristi; Baird, Richard; Lomas, David J; Sala, Evis; Wason, James; Rueda, Oscar M; Chin, Suet-Feung; Wilkinson, Ian B; Graves, Martin J; Abraham, Jean E; Gilbert, Fiona J; Caldas, Carlos; Brindle, Kevin M.

Proc Natl Acad Sci U S A ; 117(4): 2092-2098, 2020 01 28.

Article in English | MEDLINE | ID: mdl-31964840

6.

Characterization of full-length p53 aggregates and their kinetics of formation.

Julian, Linda; Sang, Jason C; Wu, Yunzhao; Meisl, Georg; Brelstaff, Jack H; Miller, Alyssa; Cheetham, Matthew R; Vendruscolo, Michele; Knowles, Tuomas P J; Ruggeri, Francesco Simone; Bryant, Clare; Ros, Susana; Brindle, Kevin M; Klenerman, David.

Biophys J ; 121(22): 4280-4298, 2022 11 15.

Article in English | MEDLINE | ID: mdl-36230002

7.

Deuterium MRSI of tumor cell death in vivo following oral delivery of ² H-labeled fumarate.

Hesse, Friederike; Wright, Alan J; Bulat, Flaviu; Somai, Vencel; Kreis, Felix; Brindle, Kevin M.

Magn Reson Med ; 88(5): 2014-2020, 2022 11.

Article in English | MEDLINE | ID: mdl-35816502

8.

Genetic algorithm-based optimization of pulse sequences.

Somai, Vencel; Kreis, Felix; Gaunt, Adam; Tsyben, Anastasia; Chia, Ming Li; Hesse, Friederike; Wright, Alan J; Brindle, Kevin M.

Magn Reson Med ; 87(5): 2130-2144, 2022 05.

Article in English | MEDLINE | ID: mdl-34866238

9.

Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides.

Parle, Daniel R; Bulat, Flaviu; Fouad, Shahd; Zecchini, Heather; Brindle, Kevin M; Neves, André A; Leeper, Finian J.

Bioconjug Chem ; 33(8): 1467-1473, 2022 08 17.

Article in English | MEDLINE | ID: mdl-35876696

10.

Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized ¹³C MRI.

Rider, Oliver J; Apps, Andrew; Miller, Jack J J J; Lau, Justin Y C; Lewis, Andrew J M; Peterzan, Mark A; Dodd, Michael S; Lau, Angus Z; Trumper, Claire; Gallagher, Ferdia A; Grist, James T; Brindle, Kevin M; Neubauer, Stefan; Tyler, Damian J.

Circ Res ; 126(6): 725-736, 2020 03 13.

Article in English | MEDLINE | ID: mdl-32078413

11.

Labile Photo-Induced Free Radical in α-Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for InâVivo Hyperpolarized ¹³ C Magnetic Resonance.

Gaunt, Adam P; Lewis, Jennifer S; Hesse, Friederike; Cheng, Tian; Marco-Rius, Irene; Brindle, Kevin M; Comment, Arnaud.

Angew Chem Int Ed Engl ; 61(2): e202112982, 2022 01 10.

Article in English | MEDLINE | ID: mdl-34679201

12.

Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent.

Szucs, Zoltan; Joseph, James; Larkin, Tim J; Xie, Bangwen; Bohndiek, Sarah E; Brindle, Kevin M; Neves, André A.

Breast Cancer Res ; 23(1): 25, 2021 02 17.

Article in English | MEDLINE | ID: mdl-33596961

13.

Comparison of ¹³ C MRI of hyperpolarized [1-¹³ C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model.

Fala, Maria; Somai, Vencel; Dannhorn, Andreas; Hamm, Gregory; Gibson, Katherine; Couturier, Dominique-Laurent; Hesketh, Richard; Wright, Alan J; Takats, Zoltan; Bunch, Josephine; Barry, Simon T; Goodwin, Richard J A; Brindle, Kevin M.

Magn Reson Med ; 85(6): 3027-3035, 2021 06.

Article in English | MEDLINE | ID: mdl-33421253

14.

Probing hepatic metabolism of [2-¹³C]dihydroxyacetone in vivo with ¹H-decoupled hyperpolarized ¹³C-MR.

Marco-Rius, Irene; Wright, Alan J; Hu, De-En; Savic, Dragana; Miller, Jack J; Timm, Kerstin N; Tyler, Damian; Brindle, Kevin M; Comment, Arnaud.

MAGMA ; 34(1): 49-56, 2021 Feb.

Article in English | MEDLINE | ID: mdl-32910316

15.

Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI.

Kreis, Felix; Wright, Alan J; Hesse, Friederike; Fala, Maria; Hu, De-En; Brindle, Kevin M.

Radiology ; 294(2): 289-296, 2020 02.

Article in English | MEDLINE | ID: mdl-31821119

16.

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized ¹³ C imaging.

Somai, Vencel; Wright, Alan J; Fala, Maria; Hesse, Friederike; Brindle, Kevin M.

Magn Reson Med ; 84(4): 1895-1908, 2020 10.

Article in English | MEDLINE | ID: mdl-32173908

17.

Increasing the sensitivity of hyperpolarized [¹⁵ N₂ ]urea detection by serial transfer of polarization to spin-coupled protons.

Kreis, Felix; Wright, Alan J; Somai, Vencel; Katz-Brull, Rachel; Brindle, Kevin M.

Magn Reson Med ; 84(4): 1844-1856, 2020 10.

Article in English | MEDLINE | ID: mdl-32153046

18.

Quantifying normal human brain metabolism using hyperpolarized [1-¹³C]pyruvate and magnetic resonance imaging.

Grist, James T; McLean, Mary A; Riemer, Frank; Schulte, Rolf F; Deen, Surrin S; Zaccagna, Fulvio; Woitek, Ramona; Daniels, Charlie J; Kaggie, Joshua D; Matys, Tomasz; Patterson, Ilse; Slough, Rhys; Gill, Andrew B; Chhabra, Anita; Eichenberger, Rose; Laurent, Marie-Christine; Comment, Arnaud; Gillard, Jonathan H; Coles, Alasdair J; Tyler, Damian J; Wilkinson, Ian; Basu, Bristi; Lomas, David J; Graves, Martin J; Brindle, Kevin M; Gallagher, Ferdia A.

Neuroimage ; 189: 171-179, 2019 04 01.

Article in English | MEDLINE | ID: mdl-30639333

19.

Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Wilson, Martin; Andronesi, Ovidiu; Barker, Peter B; Bartha, Robert; Bizzi, Alberto; Bolan, Patrick J; Brindle, Kevin M; Choi, In-Young; Cudalbu, Cristina; Dydak, Ulrike; Emir, Uzay E; Gonzalez, Ramon G; Gruber, Stephan; Gruetter, Rolf; Gupta, Rakesh K; Heerschap, Arend; Henning, Anke; Hetherington, Hoby P; Huppi, Petra S; Hurd, Ralph E; Kantarci, Kejal; Kauppinen, Risto A; Klomp, Dennis W J; Kreis, Roland; Kruiskamp, Marijn J; Leach, Martin O; Lin, Alexander P; Luijten, Peter R; Marjanska, Malgorzata; Maudsley, Andrew A; Meyerhoff, Dieter J; Mountford, Carolyn E; Mullins, Paul G; Murdoch, James B; Nelson, Sarah J; Noeske, Ralph; Öz, Gülin; Pan, Julie W; Peet, Andrew C; Poptani, Harish; Posse, Stefan; Ratai, Eva-Maria; Salibi, Nouha; Scheenen, Tom W J; Smith, Ian C P; Soher, Brian J; Tkác, Ivan; Vigneron, Daniel B; Howe, Franklyn A.

Magn Reson Med ; 82(2): 527-550, 2019 08.

Article in English | MEDLINE | ID: mdl-30919510

20.

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Timm, Kerstin N; Hu, De-En; Williams, Michael; Wright, Alan J; Kettunen, Mikko I; Kennedy, Brett W C; Larkin, Timothy J; Dzien, Piotr; Marco-Rius, Irene; Bohndiek, Sarah E; Brindle, Kevin M.

J Biol Chem ; 292(5): 1737-1748, 2017 02 03.

Article in English | MEDLINE | ID: mdl-27994059

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