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1.

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.

Takahashi, Nobuaki; Cho, Patricia; Selfors, Laura M; Kuiken, Hendrik J; Kaul, Roma; Fujiwara, Takuro; Harris, Isaac S; Zhang, Tian; Gygi, Steven P; Brugge, Joan S.

Mol Cell ; 80(5): 828-844.e6, 2020 12 03.

Article in English | MEDLINE | ID: mdl-33128871

2.

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

Shu, Shaokun; Wu, Hua-Jun; Ge, Jennifer Y; Zeid, Rhamy; Harris, Isaac S; Jovanovic, Bojana; Murphy, Katherine; Wang, Binbin; Qiu, Xintao; Endress, Jennifer E; Reyes, Jaime; Lim, Klothilda; Font-Tello, Alba; Syamala, Sudeepa; Xiao, Tengfei; Reddy Chilamakuri, Chandra Sekhar; Papachristou, Evangelia K; D'Santos, Clive; Anand, Jayati; Hinohara, Kunihiko; Li, Wei; McDonald, Thomas O; Luoma, Adrienne; Modiste, Rebecca J; Nguyen, Quang-De; Michel, Brittany; Cejas, Paloma; Kadoch, Cigall; Jaffe, Jacob D; Wucherpfennig, Kai W; Qi, Jun; Liu, X Shirley; Long, Henry; Brown, Myles; Carroll, Jason S; Brugge, Joan S; Bradner, James; Michor, Franziska; Polyak, Kornelia.

Mol Cell ; 78(6): 1096-1113.e8, 2020 06 18.

Article in English | MEDLINE | ID: mdl-32416067

3.

Cycling cancer persister cells arise from lineages with distinct programs.

Oren, Yaara; Tsabar, Michael; Cuoco, Michael S; Amir-Zilberstein, Liat; Cabanos, Heidie F; Hütter, Jan-Christian; Hu, Bomiao; Thakore, Pratiksha I; Tabaka, Marcin; Fulco, Charles P; Colgan, William; Cuevas, Brandon M; Hurvitz, Sara A; Slamon, Dennis J; Deik, Amy; Pierce, Kerry A; Clish, Clary; Hata, Aaron N; Zaganjor, Elma; Lahav, Galit; Politi, Katerina; Brugge, Joan S; Regev, Aviv.

Nature ; 596(7873): 576-582, 2021 08.

Article in English | MEDLINE | ID: mdl-34381210

4.

Uncovering a tumor suppressor for triple-negative breast cancers.

Albeck, John G; Brugge, Joan S.

Cell ; 144(5): 638-40, 2011 Mar 04.

Article in English | MEDLINE | ID: mdl-21376226

5.

Tumor self-seeding: bidirectional flow of tumor cells.

Leung, Cheuk T; Brugge, Joan S.

Cell ; 139(7): 1226-8, 2009 Dec 24.

Article in English | MEDLINE | ID: mdl-20064369

6.

Mutant p53 drives invasion by promoting integrin recycling.

Muller, Patricia A J; Caswell, Patrick T; Doyle, Brendan; Iwanicki, Marcin P; Tan, Ee H; Karim, Saadia; Lukashchuk, Natalia; Gillespie, David A; Ludwig, Robert L; Gosselin, Pauline; Cromer, Anne; Brugge, Joan S; Sansom, Owen J; Norman, Jim C; Vousden, Karen H.

Cell ; 139(7): 1327-41, 2009 Dec 24.

Article in English | MEDLINE | ID: mdl-20064378

7.

Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg, Helin; Kim, Minsu; Xia, Hong-Guang; Iwanicki, Marcin P; Ofengeim, Dimitry; Coloff, Jonathan L; Pan, Lifeng; Ince, Tan A; Kroemer, Guido; Brugge, Joan S; Yuan, Junying.

Genes Dev ; 30(7): 870, 2016 Apr 01.

Article in English | MEDLINE | ID: mdl-27036968

8.

Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.

Zervantonakis, Ioannis K; Poskus, Matthew D; Scott, Alexis L; Selfors, Laura M; Lin, Jia-Ren; Dillon, Deborah A; Pathania, Shailja; Sorger, Peter K; Mills, Gordon B; Brugge, Joan S.

Proc Natl Acad Sci U S A ; 117(28): 16500-16508, 2020 07 14.

Article in English | MEDLINE | ID: mdl-32601199

9.

Role for polo-like kinase 4 in mediation of cytokinesis.

Press, Michael F; Xie, Bin; Davenport, Simon; Zhou, Yu; Guzman, Roberta; Nolan, Garry P; O'Brien, Neil; Palazzolo, Michael; Mak, Tak W; Brugge, Joan S; Slamon, Dennis J.

Proc Natl Acad Sci U S A ; 116(23): 11309-11318, 2019 06 04.

Article in English | MEDLINE | ID: mdl-31097597

10.

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.

Albeck, John G; Mills, Gordon B; Brugge, Joan S.

Mol Cell ; 49(2): 249-61, 2013 Jan 24.

Article in English | MEDLINE | ID: mdl-23219535

11.

Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg, Helin; Kim, Minsu; Xia, Hong-Guang; Iwanicki, Marcin P; Ofengeim, Dimitry; Coloff, Jonathan L; Pan, Lifeng; Ince, Tan A; Kroemer, Guido; Brugge, Joan S; Yuan, Junying.

Genes Dev ; 27(15): 1718-30, 2013 Aug 01.

Article in English | MEDLINE | ID: mdl-23913924

12.

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.

Zoeller, Jason J; Vagodny, Aleksandr; Daniels, Veerle W; Taneja, Krishan; Tan, Benjamin Y; DeRose, Yoko S; Fujita, Maihi; Welm, Alana L; Letai, Anthony; Leverson, Joel D; Blot, Vincent; Bronson, Roderick T; Dillon, Deborah A; Brugge, Joan S.

Breast Cancer Res ; 22(1): 132, 2020 11 30.

Article in English | MEDLINE | ID: mdl-33256808

13.

The cell biology of cell-in-cell structures.

Overholtzer, Michael; Brugge, Joan S.

Nat Rev Mol Cell Biol ; 9(10): 796-809, 2008 Oct.

Article in English | MEDLINE | ID: mdl-18784728

14.

Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho, Susana A; Picone, Remigio; Burute, Mithila; Dagher, Regina; Su, Ying; Leung, Cheuk T; Polyak, Kornelia; Brugge, Joan S; Théry, Manuel; Pellman, David.

Nature ; 510(7503): 167-71, 2014 Jun 05.

Article in English | MEDLINE | ID: mdl-24739973

15.

Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors, Laura M; Stover, Daniel G; Harris, Isaac S; Brugge, Joan S; Coloff, Jonathan L.

Proc Natl Acad Sci U S A ; 114(52): E11276-E11284, 2017 12 26.

Article in English | MEDLINE | ID: mdl-29229826

16.

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.

Bast, Robert C; Matulonis, Ursula A; Sood, Anil K; Ahmed, Ahmed A; Amobi, Adaobi E; Balkwill, Frances R; Wielgos-Bonvallet, Monicka; Bowtell, David D L; Brenton, James D; Brugge, Joan S; Coleman, Robert L; Draetta, Giulio F; Doberstein, Kai; Drapkin, Ronny I; Eckert, Mark A; Edwards, Robert P; Elias, Kevin M; Ennis, Darren; Futreal, Andrew; Gershenson, David M; Greenberg, Roger A; Huntsman, David G; Ji, Jennifer Xiao Ye; Kohn, Elise C; Iavarone, Claudia; Lengyel, Ernst R; Levine, Douglas A; Lord, Christopher J; Lu, Zhen; Mills, Gordon B; Modugno, Francesmary; Nelson, Brad H; Odunsi, Kunle; Pilsworth, Jessica A; Rottapel, Robert K; Powell, Daniel J; Shen, Li; Shih, Ie-Ming; Spriggs, David R; Walton, Josephine; Zhang, Kaiyang; Zhang, Rugang; Zou, Lee.

Cancer ; 125(12): 1963-1972, 2019 06 15.

Article in English | MEDLINE | ID: mdl-30835824

17.

Biographical Feature: Marc S. Collett (23 May 1951-11 June 2022): the Battle against Viral Disease Has Lost a Valiant Warrior, and the World Has Lost a Splendid Human Being.

Glassman, Kimberly F; Brugge, Joan S; Purchio, Anthony F; Kakach, Laura T; Fuerst, Thomas R; Woods, Robert M; Stover, C Kendall; Chunduru, Srinivas K; Hincks, Jeffrey R; McKinlay, Mark A; Nash, Claude H; Pevear, Daniel C; Monath, Thomas P; Rice, Charles M; Peters, Pam.

J Virol ; 97(1): e0164322, 2023 01 31.

Article in English | MEDLINE | ID: mdl-36468860

18.

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Grassian, Alexandra R; Metallo, Christian M; Coloff, Jonathan L; Stephanopoulos, Gregory; Brugge, Joan S.

Genes Dev ; 25(16): 1716-33, 2011 Aug 15.

Article in English | MEDLINE | ID: mdl-21852536

19.

Psidin, a conserved protein that regulates protrusion dynamics and cell migration.

Kim, Ji Hoon; Cho, Aeri; Yin, Hongyan; Schafer, Dorothy A; Mouneimne, Ghassan; Simpson, Kaylene J; Nguyen, Kim-Vy; Brugge, Joan S; Montell, Denise J.

Genes Dev ; 25(7): 730-41, 2011 Apr 01.

Article in English | MEDLINE | ID: mdl-21406550

20.

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.