ABSTRACT
A 65-year-old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of toxic epidermal necrolysis (TEN), and considering the recent literature of successful use of etanercept in these cases, she was treated with a single dose of this antitumour necrosis factor (anti-TNF) agent. Subsequently, the exanthema progression stopped and resolution of the lesions happened in a few days. Later on, histopathology revealed a subepidermal blister with dense neutrophilic infiltrate and linear deposits of immunoglobulin A (IgA) on the dermoepidermal junction, allowing us to establish the diagnosis of drug-induced linear IgA dermatosis mimicking TEN. Linear IgA dermatosis can have severe clinical manifestations, even mimicking TEN, and can have high mortality, especially in drug-induced cases. We have not found any other report of linear IgA dermatosis treated with etanercept in the English literature. Anti-TNF medications could represent useful therapeutic alternatives in this dermatosis.
Subject(s)
Dermatologic Agents/therapeutic use , Etanercept/therapeutic use , Linear IgA Bullous Dermatosis/diagnosis , Stevens-Johnson Syndrome/diagnosis , Aged , Anti-Bacterial Agents/adverse effects , Diagnosis, Differential , Female , Humans , Linear IgA Bullous Dermatosis/drug therapy , Stevens-Johnson Syndrome/drug therapy , Treatment Outcome , Vancomycin/adverse effectsSubject(s)
Antiprotozoal Agents , Leishmaniasis, Cutaneous , Organometallic Compounds , Antiprotozoal Agents/therapeutic use , Electrocardiography , Humans , Injections, Intralesional , Leishmaniasis, Cutaneous/drug therapy , Meglumine/therapeutic use , Meglumine Antimoniate/therapeutic use , Organometallic Compounds/therapeutic useSubject(s)
Forecasting , Lupus Erythematosus, Systemic/immunology , Psoriasis/immunology , Th17 Cells/immunology , Adult , Biopsy , Female , Follow-Up Studies , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Male , Psoriasis/complications , Psoriasis/diagnosis , Retrospective Studies , Skin/pathologySubject(s)
Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Lichen Planus/diagnosis , Adult , Female , HumansSubject(s)
Communicable Diseases, Emerging/diagnosis , Viremia/diagnosis , Zika Virus Infection/diagnosis , Zika Virus/isolation & purification , Adult , Aedes/virology , Animals , Communicable Diseases, Emerging/epidemiology , Communicable Diseases, Emerging/virology , Dermatology , Disease Outbreaks , Dominican Republic/ethnology , Emergencies , Female , Humans , Insect Vectors/virology , Reverse Transcriptase Polymerase Chain Reaction , Spain , Travel , Zika Virus/physiology , Zika Virus Infection/epidemiology , Zika Virus Infection/transmission , Zika Virus Infection/virologySubject(s)
Melanocytes , Psoriasis/complications , Adult , Back , Humans , Male , Skin Diseases/etiology , Skin Diseases/pathologySubject(s)
Humans , Female , Aged, 80 and over , Antiprotozoal Agents/adverse effects , Meglumine Antimoniate/adverse effects , Long QT Syndrome/chemically induced , Antiprotozoal Agents/therapeutic use , Electrocardiography , Injections, Intralesional , Leishmaniasis, Cutaneous/drug therapy , Meglumine Antimoniate/therapeutic useSubject(s)
Humans , Female , Aged, 80 and over , Antiprotozoal Agents/adverse effects , Meglumine Antimoniate/adverse effects , Long QT Syndrome/chemically induced , Antiprotozoal Agents/therapeutic use , Electrocardiography , Injections, Intralesional , Leishmaniasis, Cutaneous/drug therapy , Meglumine Antimoniate/therapeutic useABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Aged, 80 and over , Sebaceous Gland Neoplasms/diagnostic imaging , Adenoma/diagnostic imaging , Microscopy, ConfocalABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Melanocytes/pathology , Back/pathology , Dermis/pathology , Psoriasis/diagnosis , Psoriasis/drug therapy , Methotrexate/administration & dosage , Betamethasone/administration & dosage , Administration, Topical , Immunohistochemistry , Diagnosis, DifferentialABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Lipomatosis/complications , Lipomatosis/diagnosis , Lipoma/complications , Lipoma/diagnosis , Kidney Transplantation/adverse effects , Diagnosis, Differential , Neurofibromatosis 1/complications , Neurofibromatosis 1/pathologyABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Lichen Planus/diagnosis , Keratoderma, Palmoplantar/diagnosis , Diagnosis, Differential , Pruritus/etiologyABSTRACT
No disponible