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Org Biomol Chem ; 17(35): 8079-8082, 2019 09 21.
Article in English | MEDLINE | ID: mdl-31454017

ABSTRACT

Site specific introduction of the polar hydrophobic trifluoromethyl-λ6-tetrafluorosulfanyl (CF3SF4) group can effectively control the secondary structure of a heptapeptide, the minimum repeat unit of an α-helix. The structural influence of CF3SF4-containing amino acid on the heptapeptide was established using NMR methods.


Subject(s)
Amino Acids/chemistry , Hydrocarbons, Fluorinated/chemistry , Oligopeptides/chemistry , Hydrophobic and Hydrophilic Interactions , Magnetic Resonance Spectroscopy , Molecular Conformation , Protein Structure, Secondary
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