ABSTRACT
Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study was performed including 1336 CRC cases and 2744 controls (MCC-Spain). Subjects were administered an epidemiological questionnaire and were genotyped with an array which included polymorphisms associated with blood lipids levels, selected to avoid pleiotropy. Four genetic lipid scores specific for triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), or total cholesterol (TC) were created as the count of risk alleles. The genetic lipid scores were not associated with CRC. The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72-1.16, p = 0.44), for HDL 1.14 (95%CI: 0.95-1.37, p = 0.16), for LDL 0.97 (95%CI: 0.81-1.16, p = 0.73), and for TC 0.98 (95%CI: 0.84-1.17, p = 0.88). The LDL and TC genetic risk scores were associated with statin use, but not the HDL or TG. Statin use, overall, was a non-significant protective factor for CRC (OR 0.84; 95%CI: 0.70-1.01, p = 0.060), but lipophilic statins were associated with a CRC risk reduction (OR 0.78; 95%CI 0.66-0.96, p = 0.018). Using the Mendelian randomization approach, our study does not support the hypothesis that lipid levels are associated with the risk of CRC. This study does not rule out, however, a possible protective effect of statins in CRC by a mechanism unrelated to lipid levels.
Subject(s)
Colorectal Neoplasms/epidemiology , Dyslipidemias/physiopathology , Lipids/analysis , Mendelian Randomization Analysis , Polymorphism, Single Nucleotide , Adult , Aged , Aged, 80 and over , Case-Control Studies , Colorectal Neoplasms/genetics , Colorectal Neoplasms/pathology , Female , Follow-Up Studies , Genetic Predisposition to Disease , Genome-Wide Association Study , Humans , Incidence , Male , Middle Aged , Prognosis , Risk Factors , Spain/epidemiology , Young AdultABSTRACT
INTRODUCTION: eating disorders (ED) are particularly common in young people. OBJECTIVE: To determine the prevalence of eating disorders in college students and its associated factors. METHODS: Study of prevalence in young Spanish university uniHcos project. Using unconditional logistic regression have determined the magnitude of the association between the risk factors associated with lifestyle and ED measured by questionnaire Sick, Control, One, Fat, Food (SCOFF). RESULTS: The prevalence of ED was 19.5%, being higher in women (ORa=1.59; p=0.006). In boys, have criteria of developing an eating disorder was associated with living in halls of residence, "binge drinking" and problematic Internet use. In women studying different courses at Health Sciences (ORa=1.50) and problematic Internet use (ORa=2.33). Those women at risk of ED more frequently had depression (ORa=2.02), menstrual pains (ORa=1.81) and perceived poor health (ORa=1.70). In men, those at risk for eating disorders more frequently had poor perceived health (ORa=2.42). CONCLUSIONS: The risk of a positive outcome in the scoff in our study is similar to that reported for other populations of students as well as their association with certain health problems and addictions. By gender differences that need attention in the design of prevention and control strategies were observed.
Introducción: Los trastornos de la conducta alimentaria (TCA) son especialmente frecuentes en los jóvenes. Objetivo: Determinar la prevalencia de TCA en jóvenes universitarios y sus factores asociados. Metodología: Estudio de prevalencia en jóvenes universitarios españoles del proyecto uniHcos. Mediante regresión logística no condicional se determinó la magnitud de la asociación entre los factores de riesgo asociados al estilo de vida y padecer un TCA medido mediante el cuestionario Sick, Control, One, Fat, Food (SCOFF). Resultados: La prevalencia de TCA fue del 19,5%, siendo mayor en mujeres (ORa=1,59; p=0,006). En los chicos, tener criterios de padecer TCA se asoció con vivir en colegios mayores, con realizar "binge drinking", y uso problemático de internet. En las mujeres el estudiar titulaciones diferentes a las ciencias de la salud (ORa=1,50) y el uso problemático de internet (ORa=2,33). Aquellas mujeres con riesgo de TCA presentaban con mayor frecuencia depresión (ORa=2,02), dolores menstruales (ORa=1,81) y mala salud percibida (ORa=1,70). En los hombres, aquellos con riesgo de TCA presentaban con mayor frecuencia una mala salud percibida (ORa=2,42). Conclusiones: El riesgo de obtener resultados positivos en el SCOFF en nuestro estudio es similar a lo publicado para otras poblaciones de estudiantes, así como su asociación con determinadas adicciones y problemas de salud. Se observaron diferencias en función del sexo que precisan atención en el diseño de estrategias de prevención y control.
Subject(s)
Feeding and Eating Disorders/epidemiology , Adolescent , Adult , Cross-Sectional Studies , Female , Humans , Male , Prevalence , Risk Factors , Surveys and Questionnaires , Universities , Young AdultABSTRACT
The University stage gives rise to social and personal changes as the independence of the nuclear family and the increased responsibilities that are related to the acquisition and/or consolidation of life styles and habits that may determine the future health status. Inadequate nutrition, a high level of inactivity, risky sexual behavior, abuse of new technologies or starting consumption of legal and illegal drugs, are among the most significant risk behaviors in this phase. In order to know how to set and / or consolidate the habits and lifestyles in the university stage and health effects in the future, to born the uniHcos project. It is a dynamic cohort of university students who join the project during the first academic year and will be followed during their stay at college and working life. The follow-up will be biennially and for the capture and the information collection will be used on-line technologies. This paper aims to show the uniHcos project to the scientific community as well as present preliminary results found so far in the two cohorts established since 2011.
Subject(s)
Life Style , Risk-Taking , Students , Adolescent , Adult , Cohort Studies , Female , Health Status , Humans , Internet/statistics & numerical data , Male , Middle Aged , Obesity/epidemiology , Risk , Sexual Behavior/statistics & numerical data , Spain/epidemiology , Substance-Related Disorders/epidemiology , Universities , Young AdultABSTRACT
No disponible
Subject(s)
Humans , Feeding and Eating Disorders/diagnosis , Reproducibility of Results , Observer VariationABSTRACT
Introducción: Los trastornos de la conducta alimentaria (TCA) son especialmente frecuentes en los jóvenes. Objetivo: Determinar la prevalencia de TCA en jóvenes universitarios y sus factores asociados. Metodología: Estudio de prevalencia en jóvenes universitarios españoles del proyecto uniHcos. Mediante regresión logística no condicional se determinó la magnitud de la asociación entre los factores de riesgo asociados al estilo de vida y padecer un TCA medido mediante el cuestionario Sick, Control, One, Fat, Food (SCOFF). Resultados: La prevalencia de TCA fue del 19,5%, siendo mayor en mujeres (ORa=1,59; p=0,006). En los chicos, tener criterios de padecer TCA se asoció con vivir en colegios mayores, con realizar "binge drinking", y uso problemático de internet. En las mujeres el estudiar titulaciones diferentes a las ciencias de la salud (ORa=1,50) y el uso problemático de internet (ORa=2,33). Aquellas mujeres con riesgo de TCA presentaban con mayor frecuencia depresión (ORa=2,02), dolores menstruales (ORa=1,81) y mala salud percibida (ORa=1,70). En los hombres, aquellos con riesgo de TCA presentaban con mayor frecuencia una mala salud percibida (ORa=2,42). Conclusiones: El riesgo de obtener resultados positivos en el SCOFF en nuestro estudio es similar a lo publicado para otras poblaciones de estudiantes, así como su asociación con determinadas adicciones y problemas de salud. Se observaron diferencias en función del sexo que precisan atención en el diseño de estrategias de prevención y control (AU)
Introduction: eating disorders (ED) are particularly common in young people. Objective: To determine the prevalence of eating disorders in college students and its associated factors. Methods: Study of prevalence in young Spanish university uniHcos project. Using unconditional logistic regression have determined the magnitude of the association between the risk factors associated with lifestyle and ED measured by questionnaire Sick, Control, One, Fat, Food (SCOFF). Results: The prevalence of ED was 19.5%, being higher in women (ORa=1.59; p=0.006). In boys, have criteria of developing an eating disorder was associated with living in halls of residence, "binge drinking" and problematic Internet use. In women studying different courses at Health Sciences (ORa=1.50) and problematic Internet use (ORa=2.33). Those women at risk of ED more frequently had depression (ORa=2.02), menstrual pains (ORa=1.81) and perceived poor health (ORa=1.70). In men, those at risk for eating disorders more frequently had poor perceived health (ORa=2.42). Conclusions: The risk of a positive outcome in the scoff in our study is similar to that reported for other populations of students as well as their association with certain health problems and addictions. By gender differences that need attention in the design of prevention and control strategies were observed (AU)
Subject(s)
Humans , Feeding and Eating Disorders/epidemiology , Psychometrics/instrumentation , Students/statistics & numerical data , Behavior, Addictive/epidemiology , Risk Factors , Age and Sex Distribution , ComorbidityABSTRACT
La etapa universitaria da lugar a cambios sociales y personales, que se relacionan con la adquisición y/o consolidación de estilos y hábitos de vida que pueden determinar el estado de salud futuro. Una inadecuada nutrición, un alto nivel de sedentarismo, conductas sexuales de riesgo, el abuso de las nuevas tecnologías o el inicio en el consumo de drogas tanto legales como ilegales, son algunas de las conductas más destacables de esta etapa. Con el objeto de conocer cómo se establecen y consolidan los hábitos y estilos de vida en la etapa universitaria y sus efectos sobre la salud futura nace el proyecto uniHcos. Se trata del estudio de una cohorte dinámica de estudiantes universitarios que se incorporan al proyecto durante el primer curso académico y serán seguidos durante su permanencia en la universidad y vida laboral. El seguimiento se realizará bienalmente y para la captación y recogida de información se utilizarán las nuevas tecnologías on-line. El objetivo del presente trabajo es dar a conocer el proyecto uniHcos a la comunidad científica así como presentar los resultados preliminares encontrados hasta el momento en las dos cohortes establecidas desde el 2011 (AU)
The University stage gives rise to social and personal changes as the independence of the nuclear family and the increased responsibilities that are related to the acquisition and / or consolidation of life styles and habits that may determine the future health status. Inadequate nutrition, a high level of inactivity, risky sexual behavior, abuse of new technologies or starting consumption of legal and illegal drugs, are among the most significant risk behaviors in this phase. In order to know how to set and / or consolidate the habits and lifestyles in the university stage and health effects in the future, to born the uniHcos project. It is a dynamic cohort of university students who join the project during the first academic year and will be followed during their stay at college and working life. The follow-up will be biennially and for the capture and the information collection will be used on-line technologies. This paper aims to show the uniHcos project to the scientific community aswell as present preliminary results found so far in the two cohorts established since 2011 (AU)
Subject(s)
Humans , Male , Female , Adult , Substance-Related Disorders/epidemiology , Substance-Related Disorders/prevention & control , Research and Development Projects , Preventive Medicine/methods , Public Health/methods , Cohort Studies , Students/psychology , Students/statistics & numerical data , Program Evaluation/methods , Program Evaluation/statistics & numerical data , Program Evaluation/standards , Health Surveys , 28599ABSTRACT
La etapa universitaria da lugar a cambios sociales y personales, que se relacionan con la adquisición y/o consolidación de estilos y hábitos de vida que pueden determinar el estado de salud futuro. Una inadecuada nutrición, un alto nivel de sedentarismo, conductas sexuales de riesgo, el abuso de las nuevas tecnologías o el inicio en el consumo de drogas tanto legales como ilegales, son algunas de las conductas más destacables de esta etapa. Con el objeto de conocer cómo se establecen y consolidan los hábitos y estilos de vida en la etapa universitaria y sus efectos sobre la salud futura nace el proyecto uniHcos. Se trata del estudio de una cohorte dinámica de estudiantes universitarios que se incorporan al proyecto durante el primer curso académico y serán seguidos durante su permanencia en la universidad y vida laboral. El seguimiento se realizará bienalmente y para la captación y recogida de información se utilizarán las nuevas tecnologías on-line. El objetivo del presente trabajo es dar a conocer el proyecto uniHcos a la comunidad científica así como presentar los resultados preliminares encontrados hasta el momento en las dos cohortes establecidas desde el 2011 (AU)
The University stage gives rise to social and personal changes as the independence of the nuclear family and the increased responsibilities that are related to the acquisition and/or consolidation of life styles and habits that may determine the future health status. Inadequate nutrition, a high level of inactivity, risky sexual behavior, abuse of new technologies or starting consumption of legal and illegal drugs, are among the most significant risk behaviors in this phase. In order to know how to set and / or consolidate the habits and lifestyles in the university stage and health effects in the future, to born the uniHcos project. It is a dynamic cohort of university students who join the project during the first academic year and will be followed during their stay at college and working life. The follow-up will be biennially and for the capture and the information collection will be used on-line technologies. This paper aims to show the uniHcos project to the scientific community as well as present preliminary results found so far in the two cohorts established since 2011 (AU)