Developing creative and research skills through an open and interprofessional inquiry-based learning course.

BACKGROUND: Biomedicine needs innovative professionals. Inquiry-based learning (IBL) aims to develop higher order thinking skills, such as creativity and research. Stimulatory techniques and interprofessional education, which requires students from different fields to collaborate, also enhances creativity. In this study, the effectiveness of an interprofessional IBL course that introduces a creativity workshop based on stimulatory techniques to develop creative and research skills is examined. METHODS: 529 undergraduate human biology and medical students performed the interprofessional IBL course, 198 with the creativity workshop and 331 without. Students' perceptions of learning processes and outcomes were assessed in surveys and focus groups by the authors of this study. As well, the final learning results from both groups of students were analyzed by the teachers of the course and the researchers. RESULTS: The results show that the open IBL approach promoted the development of these skills, interprofessionality acted as a creativity enhancer and stimulatory techniques contributed to improve the learning outcomes. CONCLUSIONS: This study provides insight into how open interprofessional IBL fosters acquisition of complex skills and knowledge, pointing out the benefits and limitations of this approach in health sciences studies.

Teaching Responsible Research and Innovation: A Phronetic Perspective.

Across the European research area and beyond, efforts are being mobilized to align research and innovation processes and products with societal values and needs, and to create mechanisms for inclusive priority setting and knowledge production. A central concern is how to foster a culture of "Responsible Research and Innovation" (RRI) among scientists and engineers. This paper focuses on RRI teaching at higher education institutions. On the basis of interviews and reviews of academic and policy documents, it highlights the generic aspects of teaching aimed at invoking a sense of care and societal obligation, and provides a set of exemplary cases of RRI-related teaching. It argues that the Aristotelian concept of phronesis can capture core properties of the objectives of RRI-related teaching activities. Teaching should nurture the students' capacity in terms of practical wisdom, practical ethics, or administrative ability in order to enable them to act virtuously and responsibly in contexts which are often characterized by uncertainty, contention, and controversy.

Social participation in science: Perspectives of Spanish civil society organizations.

There is a general trend toward more active, broader, and more inclusive participation of different stakeholders in science. Civil society organizations' inclusion in the scientific process is being promoted. However, there are few attempts to understand the role of civil society organizations in research. This study is based on the analysis of 31 semi-structured interviews with Spanish civil society organization managers and representatives. Our main results regarding the current relationship between civil society organizations and the research system are (a) civil society organizations mainly participate in science within one single research moment and they are unaware of their potential. (b) We identify a lack of resources, mutual knowledge (among civil society organizations and academia), and capabilities as barriers for civil society organizations' participation.

Responsible research and innovation training programs: implementation and evaluation of the HEIRRI project.

Responsible research and innovation, or RRI, is a concept that aims to bring together society and science for a better future. There are six key elements of RRI: public engagement, gender equality, science education, open access, ethics and governance. Higher Education Institutions and Responsible Research and Innovation (HEIRRI) project aimed to bring the concept of RRI into the educational system. Using state-of-the-art review of good practices, HEIRRI team developed 10 training programs on RRI for different higher education institution educational levels, including a summer school and a massive open online course (MOOC). We conducted pilot of the trainings and evaluated participants' experiences. Satisfaction with HEIRRI training programs on responsible research and innovation was high, both for participants and for the trainers, and trainings raised awareness of RRI. Participants' feedback was used to identify areas that need improvement and provided for recommendations for final versions of the HEIRRI training programs. In order to equip researchers with skills to recognize and apply RRI values, RRI should be included in their education. HEIRRI training is suitable for a range of different disciplines, including forensic science, and is free to use and adjust for specific contexts (available from: https://rri-tools.eu/heirri-training-programmes). Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1970319 .

Scientists' opinions and attitudes towards citizens' understanding of science and their role in public engagement activities.

The increasing perception that public communication in science and technology is an important tool to create a knowledge society is encouraging numerous public engagement activities. However, too little is known about scientists' opinions of and attitudes towards the public with whom they interact during these activities, especially in southern European countries such as Spain. If we want to establish an effective dialogue between science and society, we need to be aware of the opinions and perceptions that both parties have of each other. In this study, we address this issue by focusing on 1022 responses to a survey conducted among scientists in Spain to discover their views of the public, and we then compare these responses with data from other national surveys on the public's understanding of science. The results show that approximately 75% of Spanish scientists think that the general public has a serious lack of knowledge and understanding of scientific reasoning, although scientists do recognize that science interests the public (73%). Scientists believe that the public values the scientific profession to a lesser extent than suggested by public surveys: on a scale of 1-5, survey respondents rate their valuation of the scientific profession at 4.22, whereas scientists rate the public's valuation of the profession at 3.12, on average. Significant differences were detected between scientists' perceptions of how citizens are informed about science and what citizens report in surveys. The challenge for the future is to narrow this gap in order to help scientists gain a better understanding of the public and their interests and to make public engagement activities more effective.

Amyloid-like properties of bacterial inclusion bodies.

Bacterial inclusion bodies are major bottlenecks in protein production, narrowing the spectrum of relevant polypeptides obtained by recombinant DNA. While regarded as amorphous deposits formed by passive and rather unspecific precipitation of unfolded chains, we prove here that they are instead organized aggregates sharing important structural and biological features with amyloids. By using an Escherichia coli beta-galactosidase variant, we show that aggregation does not necessarily require unfolded polypeptide chains but rather depends on specific interactions between solvent-exposed hydrophobic stretches in partially structured species. In addition, purified inclusion bodies are efficient and highly selective nucleation seeds, promoting deposition of soluble homologous but not heterologous polypeptides in a dose-dependent manner. Finally, inclusion bodies bind amyloid-diagnostic dyes, which, jointly with Fourier transform infra red spectroscopy data, indicates a high level of organized intermolecular beta-sheet structure. The evidences of amyloid-like structure of bacterial inclusion bodies, irrespective of potential applications in bioprocess engineering, prompts the use of bacterial models to explore the molecular determinants of protein aggregation by means of simple biological systems.

Benefits of using a hybrid problem-based learning curriculum to improve long-term learning acquisition in undergraduate biology education.

Although problem-based learning (PBL) has been used for over 40 years, with many studies comparing the benefits of PBL versus other educational approaches, little attention has been paid to the effectiveness of hybrid PBL (H-PBL) curricula. Here we aimed to compare the learning outcomes of two groups of undergraduate biology students working towards a bachelor's degree: one group used an H-PBL approach, while the second used a lecture-based learning (LBL) approach. Specifically, the H-PBL group used a PBL module with interdisciplinary problems, which represented 20% of the entire curriculum. The main outcomes of evaluation were the long-term acquisition of factual knowledge and the problem-solving skills at the end of the bachelor's degree. The sample included 85 students, 39 in the H-PBL group and 46 in the LBL group. We found that an H-PBL curriculum can improve the students' learning outcomes such as long-term knowledge acquisition, problem solving skills and generic competences.

Lon and ClpP proteases participate in the physiological disintegration of bacterial inclusion bodies.

Aggregated protein is solubilized by the combined activity of chaperones ClpB, DnaK and small heat-shock proteins, and this could account, at least partially, for the physiological disintegration of bacterial inclusion bodies. In vivo, the involvement of proteases in this process had been suspected but not investigated. By using an aggregation prone beta-galactosidase fusion protein produced in Escherichia coli, we show in this study that the main ATP-dependent proteases Lon and ClpP participate in the physiological disintegration of cytoplasmic inclusion bodies, their absence minimizing the protein removal up to 40%. However, the role of these proteases is clearly distinguishable especially regarding the fate of solubilized protein. While Lon appears as a minor contributor in the disintegration process, ClpP directs an important attack on the released or releasable protein even not being irreversibly misfolded. ClpP is then observed as a wide-spectrum, main processor of aggregation-prone proteins and also of polypeptides physiologically released from inclusion bodies, even when occurring as soluble versions with a conformation compatible with their enzymatic activity.

Percepciones de estudiantes y docentes sobre la implementación del aprendizaje basado en problemas como método docente / Perceptions of students and teachers about the implementation of problem-based learning as a teaching method

Introducción: La opinión de los participantes es un elemento clave en los procesos de innovación educativa. El presente artículo describe las percepciones de los estudiantes y de los docentes sobre la introducción del aprendizaje basado en problemas para la adquisición de competencias. Sujetos y métodos: El estudio se realizó para evaluar el proyecto de introducción parcial del aprendizaje basado en problemas como método docente en la licenciatura de Biología. Se recogió información durante seis promociones mediante una encuesta en la que se puntuaba de 1 a 10 sobre la percepción del desarrollo de competencias genéricas y científicas, el valor formativo de la metodología, la satisfacción con la experiencia y una pregunta abierta sobre sugerencias de mejora. Resultados: La percepción de adquisición de la competencia científica aumentó ligeramente a lo largo de los cursos, sin diferencias entre tutores y estudiantes, con valores medios cercanos a 7. En las competencias transversales, las puntuaciones fueron similares, pero las de los tutores resultaron generalmente superiores. Sobre la utilidad del método, los estudiantes puntuaron con valores medios de 5,5 a 6 según el curso y los tutores volvieron a dar puntuaciones superiores (rango: 7,3-8). En el caso de la satisfacción, los estudiantes dieron valores medios de 6 y los de los tutores fueron significativamente superiores. Conclusiones: La introducción del aprendizaje basado en problemas fue valorado positivamente por los estudiantes y especialmente por los tutores como método para adquirir competencia científica y diversas competencias transversales

Introduction: The opinions of participants are a key element in the processes of evaluating the effect of educative innovation. This paper describes the perceptions of students and teachers about the usefulness of problem-based learning for the acquisition of competencies. Subjects and methods: This survey was carried out in the Bachelor of Biology to assess the project of partial implementation of problem-based learning as a teaching method. Information was collected during six cohorts using a questionnaire with several questions about the perceptions on the acquisition of scientific competence and generic competences, the didactic usefulness of the method, and the satisfaction with the experience by means of a numerical scale from 0 to 10. An open question to suggest improvements was also included. Results: The perception on the acquisition of scientific competence slightly increased during the years of the Bachelor. No differences were observed between students and tutors, with mean values close to 7. In generic competences, the mean value was similar but tutors scored higher than students. Regarding the question of the usefulness of the method, mean values of students were in the range of 5.5-6 and tutors again scored higher (range: 7.3-8). When satisfaction was evaluated, students scored a mean value of 6 whereas tutors scores were significantly higher. Conclusions: The introduction of problem-based learning was considered positive by students, and especially by tutors, as a method to acquire scientific and generic competences