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1.

Relevance of Mu-Opioid Receptor Splice Variants and Plasticity of Their Signaling Sequelae to Opioid Analgesic Tolerance.

Chakrabarti, Sumita; Liu, Nai-Jiang; Gintzler, Alan R.

Cell Mol Neurobiol ; 41(5): 855-862, 2021 Jul.

Article in English | MEDLINE | ID: mdl-32804312

2.

Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine.

Chakrabarti, Sumita; Liu, Nai-Jiang; Gintzler, Alan R.

J Neurochem ; 152(4): 449-467, 2020 02.

Article in English | MEDLINE | ID: mdl-31479519

3.

Selective up-regulation of functional mu-opioid receptor splice variants by chronic opioids.

Chakrabarti, Sumita; Madia, Priyanka A; Gintzler, Alan R.

J Neurochem ; 136(6): 1119-1130, 2016 Mar.

Article in English | MEDLINE | ID: mdl-26718622

4.

Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory µ-opioid receptor adenylyl cyclase signaling.

Chakrabarti, Sumita; Chang, Andrew; Liu, Nai-Jiang; Gintzler, Alan R.

J Neurochem ; 139(5): 737-747, 2016 12.

Article in English | MEDLINE | ID: mdl-27726130

5.

Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.

Verzillo, Vittorio; Madia, Priyanka A; Liu, Nai-Jiang; Chakrabarti, Sumita; Gintzler, Alan R.

J Neurochem ; 130(6): 790-6, 2014 Sep.

Article in English | MEDLINE | ID: mdl-24848866

6.

Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia.

Chakrabarti, Sumita; Liu, Nai-Jiang; Gintzler, Alan R.

Proc Natl Acad Sci U S A ; 107(46): 20115-9, 2010 Nov 16.

Article in English | MEDLINE | ID: mdl-21041644

7.

Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and µ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.

Liu, Nai-Jiang; Chakrabarti, Sumita; Schnell, Stephen; Wessendorf, Martin; Gintzler, Alan R.

J Neurosci ; 31(33): 11836-45, 2011 Aug 17.

Article in English | MEDLINE | ID: mdl-21849544

8.

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

Chakrabarti, Sumita; Liu, Nai-Jiang; Zadina, James E; Sharma, Tarak; Gintzler, Alan R.

J Pharmacol Exp Ther ; 340(1): 56-63, 2012 Jan.

Article in English | MEDLINE | ID: mdl-21972236

9.

Subcellular localization of mu-opioid receptor G(s) signaling.

Chakrabarti, Sumita; Chang, Andrew; Gintzler, Alan R.

J Pharmacol Exp Ther ; 333(1): 193-200, 2010 Apr.

Article in English | MEDLINE | ID: mdl-20097777

10.

Plasticity of adenylyl cyclase-related signaling sequelae after long-term morphine treatment.

Shy, Michael; Chakrabarti, Sumita; Gintzler, Alan R.

Mol Pharmacol ; 73(3): 868-79, 2008 Mar.

Article in English | MEDLINE | ID: mdl-18045853

11.

The ambiguities of opioid tolerance mechanisms: barriers to pain therapeutics or new pain therapeutic possibilities.

Gintzler, Alan R; Chakrabarti, Sumita.

J Pharmacol Exp Ther ; 325(3): 709-13, 2008 Jun.

Article in English | MEDLINE | ID: mdl-18354057

12.

Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules.

Gintzler, Alan R; Chakrabarti, Sumita.

Life Sci ; 79(8): 717-22, 2006 Jul 17.

Article in English | MEDLINE | ID: mdl-16581089

13.

Chronic morphine acts via a protein kinase Cgamma-G(beta)-adenylyl cyclase complex to augment phosphorylation of G(beta) and G(betagamma) stimulatory adenylyl cyclase signaling.

Chakrabarti, Sumita; Regec, Annette; Gintzler, Alan R.

Brain Res Mol Brain Res ; 138(1): 94-103, 2005 Jul 29.

Article in English | MEDLINE | ID: mdl-15908039

14.

Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.

Chakrabarti, Sumita; Regec, Annette; Gintzler, Alan R.

Brain Res Mol Brain Res ; 135(1-2): 217-24, 2005 Apr 27.

Article in English | MEDLINE | ID: mdl-15857684

15.

Applying a new conceptual framework to evaluate tuberculosis surveillance and action performance and measure the costs, Hillsborough County, Florida, 2002.

McNabb, Scott J N; Surdo, Alison M; Redmond, Anne; Cobb, James; Wiley, Jennifer; Chakrabarti, Sumita; Duncan, Heather; Qualls, Noreen; Moore, Marisa.

Ann Epidemiol ; 14(9): 640-5, 2004 Oct.

Article in English | MEDLINE | ID: mdl-15380794

16.

Chronic morphine-induced plasticity among signalling molecules.

Gintzler, Alan R; Chakrabarti, Sumita.

Novartis Found Symp ; 261: 167-76; discussion 176-80, 191-3, 2004.

Article in English | MEDLINE | ID: mdl-15469050

17.

Phosphorylation of Gbeta is augmented by chronic morphine and enhances Gbetagamma stimulation of adenylyl cyclase activity.

Chakrabarti, Sumita; Gintzler, Alan R.

Brain Res Mol Brain Res ; 119(2): 144-51, 2003 Nov 26.

Article in English | MEDLINE | ID: mdl-14625081

18.

Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas.

Liu, Nai-Jiang; Chakrabarti, Sumita; Gintzler, Alan R.

Brain Res ; 1010(1-2): 1-9, 2004 Jun 04.

Article in English | MEDLINE | ID: mdl-15126111

19.

Phosphorylation of Galphas influences its association with the micro-opioid receptor and is modulated by long-term morphine exposure.

Chakrabarti, Sumita; Gintzler, Alan R.

Mol Pharmacol ; 72(3): 753-60, 2007 Sep.

Article in English | MEDLINE | ID: mdl-17576791

20.

Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

Chakrabarti, Sumita; Liu, Nai-Jiang; Gintzler, Alan R.

Proc Natl Acad Sci U S A ; 100(23): 13686-91, 2003 Nov 11.

Article in English | MEDLINE | ID: mdl-14597703

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Relevance of Mu-Opioid Receptor Splice Variants and Plasticity of Their Signaling Sequelae to Opioid Analgesic Tolerance.

Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine.

Selective up-regulation of functional mu-opioid receptor splice variants by chronic opioids.

Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory µ-opioid receptor adenylyl cyclase signaling.

Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.

Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia.

Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and µ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

Subcellular localization of mu-opioid receptor G(s) signaling.

Plasticity of adenylyl cyclase-related signaling sequelae after long-term morphine treatment.

The ambiguities of opioid tolerance mechanisms: barriers to pain therapeutics or new pain therapeutic possibilities.

Post-opioid receptor adaptations to chronic morphine; altered functionality and associations of signaling molecules.

Chronic morphine acts via a protein kinase Cgamma-G(beta)-adenylyl cyclase complex to augment phosphorylation of G(beta) and G(betagamma) stimulatory adenylyl cyclase signaling.

Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.

Applying a new conceptual framework to evaluate tuberculosis surveillance and action performance and measure the costs, Hillsborough County, Florida, 2002.

Chronic morphine-induced plasticity among signalling molecules.

Phosphorylation of Gbeta is augmented by chronic morphine and enhances Gbetagamma stimulation of adenylyl cyclase activity.

Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas.

Phosphorylation of Galphas influences its association with the micro-opioid receptor and is modulated by long-term morphine exposure.

Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.