Isolated left ventricular assist device implantation produces variable changes to patient body mass index.

BACKGROUND: Body mass index (BMI) is an important consideration for transplant-eligible left ventricular assist device (LVAD) recipients. LVAD therapy's impact on BMI is unclear. We evaluated BMI changes in patients who underwent LVAD implantation. The association between these patients' BMI and the transplant was studied. METHODS: This was a retrospective cohort study of patients who underwent LVAD implantation between January 1, 2012 and December 31, 2018 at our institution. Patients were stratified by preoperative BMI (kg/m2 ) into four groups: <30, 30-34.9, 34.9-39.9, and ≥40. BMI data were collected at 12 and 6 months prior to implantation, time of implantation, and 3- and 6- months postimplantation. RESULTS: A total of 107 patients underwent LVAD implantation at our institution. Data were available for 80 patients. Baseline characteristics included a mean age of 56.0 years, 69% male, and a mean implant BMI of 29.9 ± 6.8 kg/m2 . The mean BMI (kg/m2 ) for each of the BMI (kg/m2 ) groups <30, 30-34.9, 35-39.9, and ≥40 (n = 60, 25, 12, and 10, respectively) was 25.1, 32.5, 36.8, and 43.8, respectively. There was no consistent pattern with weight change across differing implant BMIs. No patient with a BMI of <30 gained sufficient weight to impact transplant candidacy. Twenty-three percent of patients with a BMI of 30-34.9 kg/m2 , 60% of patients with a BMI of 35-39.9 kg/m2 , and 87.5% of patients with a BMI of ≥40 kg/m2 had a 6-month BMI potentially affecting transplant. CONCLUSIONS: Associated weight changes during LVAD support may significantly impact transplant candidacy. Higher BMI groups may benefit from multimodal and multidisciplinary targeted weight-loss interventions.

Solid organ donor-recipient race-matching: analysis of the United Network for Organ Sharing database.

Donor ethnicity is a prognosticator in organ transplant. However, the impact of donor/recipient race-matching is unclear. We hypothesized that there would be increased survival in donor-recipient race-matched organ recipients because of genetic and physiologic similarities. The UNOS database from 1999 to 2018 was queried for all solid organ transplantations including heart, lung, liver, kidney, and pancreas transplants. Data were sorted by donor and recipient race into matched and unmatched categories for Caucasian, African American, and Hispanic transplant recipients. After controlling for potential confounders via inverse propensity of treatment weighting, post-transplant patient and graft survival were compared between race-matched and -unmatched donor groups for each organ. Race-matched Caucasian recipients experienced 1-3% improvement in mortality across most time points in lung, liver, and pancreas transplants, while Hispanics did not benefit. Matched African American recipients experienced 4-6% improvement in patient and graft survival in liver transplant but had 7-9% worse survival rates at 5 years in lung and pancreas transplants. Race-matching does not influence patient outcomes enough to factor into organ transplant offers. African American liver transplant recipients benefited the most. Matching was detrimental to African American lung and pancreas transplant recipients indicating there may be other factors influencing the outcomes of these transplants.

Celiac crisis presenting with status epilepticus and encephalopathy.

UNLABELLED: Celiac crisis is a life-threatening presentation of celiac disease which is described in the context of classic gastrointestinal (GI) symptoms of diarrhea, leading to dehydration and electrolyte imbalance. Neurologic manifestations are atypical symptoms of celiac crisis. To the best of our knowledge, there is no published report on seizure or encephalopathy as the presenting manifestation of celiac crisis. We describe a 2-year-old boy presenting with acute status epilepticus and lethargy. Prior to presentation, he had mild abdominal distention and intermittent diarrhea. Laboratory analysis revealed hyponatremia, anemia, hypocalcemia, transaminitis, and hyperglycemia. Electroencephalography revealed severe diffuse encephalopathy, and complete infectious work-up was negative. Initial brain magnetic resonance imaging was normal; however, repeat imaging showed osmotic demyelination syndrome. Given the history of GI symptoms and hyperglycemia, celiac serology was obtained revealing elevated tissue transglutaminase, and a diagnosis was confirmed by Marsh 3c lesions in the duodenum. He significantly improved with steroid therapy in addition to adequate nutrition, fluids, and initiation of a gluten-free diet. CONCLUSION: We report herein on the first case of celiac crisis presenting with status epilepticus and encephalopathy in the absence of profound GI symptoms. Our case suggests that celiac crisis should be considered in the differential of seizures and encephalopathy in children.

Supporting the right ventricle in postcardiotomy renal dysfunction: A case series.

Postcardiotomy RV dysfunction is an under-recognized cause of acute kidney injury (AKI). Insertion of a percutaneous right ventricular assist device (RVAD) reduces central venous hypertension and congestive nephropathy by augmenting cardiac output. In selected patients, percutaneous RVAD insertion may improve renal function and obviate the need for long-term dialysis.

End of Life Care Practices for Hindu Patients During COVID-19.

With coronavirus disease 2019, the risk of death has increased in the general population. In these unprecedented times and even otherwise, it is important for the health care professionals caring for Hindu patients to be aware of the end of life practices in Hinduism. There is limited information in the medical literature about traditions and practices followed in Hinduism which is observed by 15% of the world population. Hinduism is currently the third largest religion following Christianity and Islam. Based on Hindu beliefs about life, death, and reincarnation, we propose 10 end of life best practices for Hindu patients.

How Does Multiple Listing Affect Lung Transplantation? A Retrospective Analysis.

The impact of multiple listing (ML) strategies on lung transplantation is unknown. Retrospective review of United Network for Organ Sharing (UNOS) registry for lung transplantation between May 1, 2005 and March 31, 2017 was performed. Characteristics of single (SL) and ML candidates were compared, and incidence density matching was used to select up to 10 controls for each case. Overall survival was evaluated using Cox regression stratified by matched sets. Nelson-Aalen estimators were used to estimate the cumulative incidence (CI) of transplant, death on the waiting list, and removal from wait-list as competing risks; Gray's test was used to compare wait list outcomes between groups. 23,445 subjects listed for lung transplant, of which 467 (2%) subjects listed at 2+ centers; 206 matched sets. There was no difference in overall survival of matched cases and controls at 1 year (ML 83.7%, SL 90.2%), 3 years (ML 63.9%, SL 68%), and 5 years (ML 51.9%, SL 49.3%) (p=0.24). The CIs of receiving a lung transplant at 2 years for ML and SL were 83.6% and 71%, respectively. Multi-listing increased the probability of receiving a transplant (p<0.001) but was not associated with waitlist mortality (p=0.13). There was no difference in post-transplant survival between ML and SL candidates (HR=0.82, p=0.32). ML was associated with a substantial increase in probability of lung transplantation, but there was no difference in overall survival, post-transplant, or wait-list mortality. Our study permits more informed decision-making for patients considering the ML strategy.

Supporting Medical Student Mental Health during COVID-19: Strategies Implemented for an Accelerated Curriculum Medical Campus.

Medical student education has not been immune to life altering changes of the global Coronavirus disease 2019 (COVID-19) pandemic. Pre-pandemic anxiety and mental health concerns were already a significant problem in the world of medical student education. Educators are reformulating strategies to address the increased demand for mental health services and wellness during COVID-19. Adaptations include increased and varied internal and student focused communication, as well as new support structures built around student connection and coaching, mental illness, and general wellness. Additional alterations to student support include expanded mental health counseling and also incorporating novel wellness events in an effort to support thriving during COVID-19.

Medical Students and COVID-19: Challenges and Supportive Strategies.

As coronavirus disease 2019 (COVID-19) pandemic continues to spread across the world, it is also adversely affecting medical student education. In addition, COVID-19 poses several challenges to medical students' physical and mental health and their professional identity formation. Medical students are experiencing increasing anxiety due to the COVID-19 disruption. Medical students show higher rates of depression, suicidal ideation, and stigmatization around depression and are less likely to seek support. It is therefore important to safeguard their mental health and implement effective strategies to support their educational, physical, mental, and professional well-being.

Preparing for the interviewing process during Coronavirus disease-19 pandemic: Virtual interviewing experiences of applicants and interviewers, a systematic review.

PURPOSE: Coronavirus disease-19 (COVID-19) has forced upon all academic institutions to conduct virtual interviewing (VI) instead of face-to-face interviewing (FTFI) this interviewing cycle. The purpose of this systematic review was to understand the process of VI, its effectiveness as an alternative to FTFI, and the experiences of applicants and institutions with VI. We also share best practice strategies for applicants and institutions in VI preparation. METHOD: PubMed/MEDLINE, Cochrane Library of Systematic Reviews, Web of Science Core Collection, Scopus and CINAHL databases were searched through May 2020. Articles in English evaluating the effectiveness of VI were included, without applying any date limits. Two reviewers selected articles and extracted data. RESULTS: Of the 934 articles screened, 22 articles underwent full-text article analysis to include 15 studies. There were 4 studies that reported the use of VI as a screening tool. 11 studies completely replaced FTFI with VI. Most applicants could appropriately convey themselves through VI. Most applicants and interviewing programs expressed reservations about VI's use as an alternative to FTFI. CONCLUSION: There is dearth of evidence supporting the efficacy of VI. There is an opportunity for potential research at multi-institutional level to gain better understanding of the efficacy of VI. The knowledge obtained from this systematic review has the potential of helping applicants and institutions in preparing for VI process. Additionally, authors propose supportive strategies to help prepare applicants and institutions for VI.

A Novel Curriculum to Facilitate Career Choice in an Accelerated Medical Education Program.

INTRODUCTION: Various specialties face the challenge of resident attrition. Trainees may withdraw due to several factors, including lack of adequate exposure to the specialty prior to joining the program. Making career choices becomes more challenging and stressful for students in an accelerated curriculum. METHODS: The authors created and piloted a novel early clinical course: Specialty Longitudinal Integrated Clinical Experience (SPLICE), which provides an opportunity for clinical enrichment and early career exploration in an accelerated medical education program. RESULTS: Initial evaluation by student and faculty demonstrate the curriculum's feasibility and acceptability. DISCUSSION/CONCLUSION: Further implementation of the curriculum and long-term assessment is needed to determine its impact on career decisions and residency retention.

A Newborn with Genital Ambiguity, 45,X/46,XY Mosaicism, a Jumping Chromosome Y, and Congenital Adrenal Hyperplasia.

Disorders of sex development (DSD), formerly termed "intersex" conditions, arise from numerous causes. CAH secondary to 21-hydroxylase deficiency is the most common cause of DSD. Sex chromosome disorders, including sex chromosome mosaicism, are the second most common cause of DSD. We discuss a medically complex neonate with DSD presenting with ambiguous genitalia. Hormone levels suggested 21-hydroxylase deficiency. Molecular analysis revealed compound heterozygous mutations in the 21-hydroxylase gene (CYP21A2), confirming the diagnosis of CAH. Chromosome analysis revealed sex chromosome mosaicism with three cell lines: 45,X[8]/45,X,tas(Y;16)(p11.32;p13.3)[8]/45,X,t(Y;8)(p11.32;p23.3)[4] with the Y chromosome in telomere association with chromosomes 8p and 16p in different cell lines, a "jumping translocation." Histologically, the right gonad had irregular, distended seminiferous tubules with hyperplastic germ cells contiguous with ovarian stroma and primordial follicles. The left gonad had scant ovarian stroma and embryonic remnants. Chromosome analyses showed mosaicism in both gonads: 45,X[17]/45,X,tas(Y;8)(p11.32;p23.3)[3]. This is the first case of coexisting CAH and 45,X/46,XY mosaicism reported in the English literature and the third case of a constitutional chromosome Y "jumping translocation." Our report documents the medical and genetic complexity of children such as this one with ambiguous genitalia and discusses the need for a multidisciplinary team approach.