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1.

A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.

Qi, Lijun; Iskols, Michael; Shi, David; Reddy, Pranav; Walker, Christopher; Lezgiyeva, Karina; Voisin, Tiphaine; Pawlak, Mathias; Kuchroo, Vijay K; Chiu, Isaac M; Ginty, David D; Sharma, Nikhil.

Cell ; 187(6): 1508-1526.e16, 2024 Mar 14.

Article in English | MEDLINE | ID: mdl-38442711

2.

Gut complement induced by the microbiota combats pathogens and spares commensals.

Wu, Meng; Zheng, Wen; Song, Xinyang; Bao, Bin; Wang, Yuanyou; Ramanan, Deepshika; Yang, Daping; Liu, Rui; Macbeth, John C; Do, Elyza A; Andrade, Warrison A; Yang, Tiandi; Cho, Hyoung-Soo; Gazzaniga, Francesca S; Ilves, Marit; Coronado, Daniela; Thompson, Charlotte; Hang, Saiyu; Chiu, Isaac M; Moffitt, Jeffrey R; Hsiao, Ansel; Mekalanos, John J; Benoist, Christophe; Kasper, Dennis L.

Cell ; 187(4): 897-913.e18, 2024 Feb 15.

Article in English | MEDLINE | ID: mdl-38280374

3.

Immunity to the microbiota promotes sensory neuron regeneration.

Enamorado, Michel; Kulalert, Warakorn; Han, Seong-Ji; Rao, Indira; Delaleu, Jérémie; Link, Verena M; Yong, Daniel; Smelkinson, Margery; Gil, Louis; Nakajima, Saeko; Linehan, Jonathan L; Bouladoux, Nicolas; Wlaschin, Josette; Kabat, Juraj; Kamenyeva, Olena; Deng, Liwen; Gribonika, Inta; Chesler, Alexander T; Chiu, Isaac M; Le Pichon, Claire E; Belkaid, Yasmine.

Cell ; 186(3): 607-620.e17, 2023 02 02.

Article in English | MEDLINE | ID: mdl-36640762

4.

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

Deng, Liwen; Costa, Flavia; Blake, Kimbria J; Choi, Samantha; Chandrabalan, Arundhasa; Yousuf, Muhammad Saad; Shiers, Stephanie; Dubreuil, Daniel; Vega-Mendoza, Daniela; Rolland, Corinne; Deraison, Celine; Voisin, Tiphaine; Bagood, Michelle D; Wesemann, Lucia; Frey, Abigail M; Palumbo, Joseph S; Wainger, Brian J; Gallo, Richard L; Leyva-Castillo, Juan-Manuel; Vergnolle, Nathalie; Price, Theodore J; Ramachandran, Rithwik; Horswill, Alexander R; Chiu, Isaac M.

Cell ; 186(24): 5375-5393.e25, 2023 11 22.

Article in English | MEDLINE | ID: mdl-37995657

5.

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.

Yang, Daping; Jacobson, Amanda; Meerschaert, Kimberly A; Sifakis, Joseph Joy; Wu, Meng; Chen, Xi; Yang, Tiandi; Zhou, Youlian; Anekal, Praju Vikas; Rucker, Rachel A; Sharma, Deepika; Sontheimer-Phelps, Alexandra; Wu, Glendon S; Deng, Liwen; Anderson, Michael D; Choi, Samantha; Neel, Dylan; Lee, Nicole; Kasper, Dennis L; Jabri, Bana; Huh, Jun R; Johansson, Malin; Thiagarajah, Jay R; Riesenfeld, Samantha J; Chiu, Isaac M.

Cell ; 185(22): 4190-4205.e25, 2022 10 27.

Article in English | MEDLINE | ID: mdl-36243004

6.

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.

Lai, Nicole Y; Musser, Melissa A; Pinho-Ribeiro, Felipe A; Baral, Pankaj; Jacobson, Amanda; Ma, Pingchuan; Potts, David E; Chen, Zuojia; Paik, Donggi; Soualhi, Salima; Yan, Yiqing; Misra, Aditya; Goldstein, Kaitlin; Lagomarsino, Valentina N; Nordstrom, Anja; Sivanathan, Kisha N; Wallrapp, Antonia; Kuchroo, Vijay K; Nowarski, Roni; Starnbach, Michael N; Shi, Hailian; Surana, Neeraj K; An, Dingding; Wu, Chuan; Huh, Jun R; Rao, Meenakshi; Chiu, Isaac M.

Cell ; 180(1): 33-49.e22, 2020 01 09.

Article in English | MEDLINE | ID: mdl-31813624

7.

Sensory neurons: An integrated component of innate immunity.

Deng, Liwen; Gillis, Jacob E; Chiu, Isaac M; Kaplan, Daniel H.

Immunity ; 57(4): 815-831, 2024 Apr 09.

Article in English | MEDLINE | ID: mdl-38599172

8.

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.

Pinho-Ribeiro, Felipe A; Baddal, Buket; Haarsma, Rianne; O'Seaghdha, Maghnus; Yang, Nicole J; Blake, Kimbria J; Portley, Makayla; Verri, Waldiceu A; Dale, James B; Wessels, Michael R; Chiu, Isaac M.

Cell ; 173(5): 1083-1097.e22, 2018 05 17.

Article in English | MEDLINE | ID: mdl-29754819

9.

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Yissachar, Nissan; Zhou, Yan; Ung, Lloyd; Lai, Nicole Y; Mohan, James F; Ehrlicher, Allen; Weitz, David A; Kasper, Dennis L; Chiu, Isaac M; Mathis, Diane; Benoist, Christophe.

Cell ; 168(6): 1135-1148.e12, 2017 03 09.

Article in English | MEDLINE | ID: mdl-28262351

10.

Neuroimmune Interactions in Peripheral Organs.

Klein Wolterink, Roel G J; Wu, Glendon S; Chiu, Isaac M; Veiga-Fernandes, Henrique.

Annu Rev Neurosci ; 45: 339-360, 2022 07 08.

Article in English | MEDLINE | ID: mdl-35363534

11.

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Yan, Yiqing; Ramanan, Deepshika; Rozenberg, Milena; McGovern, Kelly; Rastelli, Daniella; Vijaykumar, Brinda; Yaghi, Omar; Voisin, Tiphaine; Mosaheb, Munir; Chiu, Isaac; Itzkovitz, Shalev; Rao, Meenakshi; Mathis, Diane; Benoist, Christophe.

Immunity ; 54(3): 499-513.e5, 2021 03 09.

Article in English | MEDLINE | ID: mdl-33691135

12.

Neuro-immune Interactions in the Tissues.

Chu, Coco; Artis, David; Chiu, Isaac M.

Immunity ; 52(3): 464-474, 2020 03 17.

Article in English | MEDLINE | ID: mdl-32187517

13.

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.

Perner, Caroline; Flayer, Cameron H; Zhu, Xueping; Aderhold, Pamela A; Dewan, Zaynah N A; Voisin, Tiphaine; Camire, Ryan B; Chow, Ohn A; Chiu, Isaac M; Sokol, Caroline L.

Immunity ; 53(5): 1063-1077.e7, 2020 11 17.

Article in English | MEDLINE | ID: mdl-33098765

14.

An airway-to-brain sensory pathway mediates influenza-induced sickness.

Bin, Na-Ryum; Prescott, Sara L; Horio, Nao; Wang, Yandan; Chiu, Isaac M; Liberles, Stephen D.

Nature ; 615(7953): 660-667, 2023 03.

Article in English | MEDLINE | ID: mdl-36890237

15.

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

Pinho-Ribeiro, Felipe A; Deng, Liwen; Neel, Dylan V; Erdogan, Ozge; Basu, Himanish; Yang, Daping; Choi, Samantha; Walker, Alec J; Carneiro-Nascimento, Simone; He, Kathleen; Wu, Glendon; Stevens, Beth; Doran, Kelly S; Levy, Dan; Chiu, Isaac M.

Nature ; 615(7952): 472-481, 2023 03.

Article in English | MEDLINE | ID: mdl-36859544

16.

Mast Cells Get on Your Nerves in Itch.

Voisin, Tiphaine; Chiu, Isaac M.

Immunity ; 50(5): 1117-1119, 2019 05 21.

Article in English | MEDLINE | ID: mdl-31117004

17.

Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.

Leyva-Castillo, Juan-Manuel; Galand, Claire; Kam, Christy; Burton, Oliver; Gurish, Michael; Musser, Melissa A; Goldsmith, Jeffrey D; Hait, Elizabeth; Nurko, Samuel; Brombacher, Frank; Dong, Chen; Finkelman, Fred D; Lee, Richard T; Ziegler, Steven; Chiu, Isaac; Austen, K Frank; Geha, Raif S.

Immunity ; 50(5): 1262-1275.e4, 2019 05 21.

Article in English | MEDLINE | ID: mdl-31027995

18.

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.

Wallrapp, Antonia; Burkett, Patrick R; Riesenfeld, Samantha J; Kim, Se-Jin; Christian, Elena; Abdulnour, Raja-Elie E; Thakore, Pratiksha I; Schnell, Alexandra; Lambden, Conner; Herbst, Rebecca H; Khan, Pavana; Tsujikawa, Kazutake; Xavier, Ramnik J; Chiu, Isaac M; Levy, Bruce D; Regev, Aviv; Kuchroo, Vijay K.

Immunity ; 51(4): 709-723.e6, 2019 10 15.

Article in English | MEDLINE | ID: mdl-31604686

19.

VLDLR and ApoER2 are receptors for multiple alphaviruses.

Clark, Lars E; Clark, Sarah A; Lin, ChieYu; Liu, Jianying; Coscia, Adrian; Nabel, Katherine G; Yang, Pan; Neel, Dylan V; Lee, Hyo; Brusic, Vesna; Stryapunina, Iryna; Plante, Kenneth S; Ahmed, Asim A; Catteruccia, Flaminia; Young-Pearse, Tracy L; Chiu, Isaac M; Llopis, Paula Montero; Weaver, Scott C; Abraham, Jonathan.

Nature ; 602(7897): 475-480, 2022 02.

Article in English | MEDLINE | ID: mdl-34929721

20.

Somatosensory and autonomic neuronal regulation of the immune response.

Udit, Swalpa; Blake, Kimbria; Chiu, Isaac M.

Nat Rev Neurosci ; 23(3): 157-171, 2022 03.

Article in English | MEDLINE | ID: mdl-34997214

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