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1.

mRNA vaccine against malaria tailored for liver-resident memory T cells.

Ganley, Mitch; Holz, Lauren E; Minnell, Jordan J; de Menezes, Maria N; Burn, Olivia K; Poa, Kean Chan Yew; Draper, Sarah L; English, Kieran; Chan, Susanna T S; Anderson, Regan J; Compton, Benjamin J; Marshall, Andrew J; Cozijnsen, Anton; Chua, Yu Cheng; Ge, Zhengyu; Farrand, Kathryn J; Mamum, John C; Xu, Calvin; Cockburn, Ian A; Yui, Katsuyuki; Bertolino, Patrick; Gras, Stephanie; Le Nours, Jérôme; Rossjohn, Jamie; Fernandez-Ruiz, Daniel; McFadden, Geoffrey I; Ackerley, David F; Painter, Gavin F; Hermans, Ian F; Heath, William R.

Nat Immunol ; 24(9): 1487-1498, 2023 09.

Article in English | MEDLINE | ID: mdl-37474653

2.

Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation.

Sutton, Henry J; Gao, Xin; Kelly, Hannah G; Parker, Brian J; Lofgren, Mariah; Dacon, Cherrelle; Chatterjee, Deepyan; Seder, Robert A; Tan, Joshua; Idris, Azza H; Neeman, Teresa; Cockburn, Ian A.

Immunity ; 57(2): 245-255.e5, 2024 Feb 13.

Article in English | MEDLINE | ID: mdl-38228150

3.

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies.

Cockburn, Ian A; Seder, Robert A.

Nat Immunol ; 19(11): 1199-1211, 2018 11.

Article in English | MEDLINE | ID: mdl-30333613

4.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Wang, Lawrence T; Pereira, Lais S; Flores-Garcia, Yevel; O'Connor, James; Flynn, Barbara J; Schön, Arne; Hurlburt, Nicholas K; Dillon, Marlon; Yang, Annie S P; Fabra-García, Amanda; Idris, Azza H; Mayer, Bryan T; Gerber, Monica W; Gottardo, Raphael; Mason, Rosemarie D; Cavett, Nicole; Ballard, Reid B; Kisalu, Neville K; Molina-Cruz, Alvaro; Nelson, Jorgen; Vistein, Rachel; Barillas-Mury, Carolina; Amino, Rogerio; Baker, David; King, Neil P; Sauerwein, Robert W; Pancera, Marie; Cockburn, Ian A; Zavala, Fidel; Francica, Joseph R; Seder, Robert A.

Immunity ; 53(4): 733-744.e8, 2020 10 13.

Article in English | MEDLINE | ID: mdl-32946741

5.

Resident T cells seek the perfect place to work from home.

McNamara, Hayley A; Cockburn, Ian A.

Nat Immunol ; 22(9): 1076-1078, 2021 09.

Article in English | MEDLINE | ID: mdl-34426688

6.

HIV Immunogens: Affinity Is Key.

Prabhu, Savit; Cockburn, Ian A; Vinuesa, Carola G.

Immunity ; 48(1): 11-13, 2018 01 16.

Article in English | MEDLINE | ID: mdl-29343432

7.

Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz, Daniel; Ng, Wei Yi; Holz, Lauren E; Ma, Joel Z; Zaid, Ali; Wong, Yik Chun; Lau, Lei Shong; Mollard, Vanessa; Cozijnsen, Anton; Collins, Nicholas; Li, Jessica; Davey, Gayle M; Kato, Yu; Devi, Sapna; Skandari, Roghieh; Pauley, Michael; Manton, Jonathan H; Godfrey, Dale I; Braun, Asolina; Tay, Szun Szun; Tan, Peck Szee; Bowen, David G; Koch-Nolte, Friedrich; Rissiek, Björn; Carbone, Francis R; Crabb, Brendan S; Lahoud, Mireille; Cockburn, Ian A; Mueller, Scott N; Bertolino, Patrick; McFadden, Geoffrey I; Caminschi, Irina; Heath, William R.

Immunity ; 45(4): 889-902, 2016 10 18.

Article in English | MEDLINE | ID: mdl-27692609

8.

Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.

Rajakaruna, Harshana; O'Connor, James H; Cockburn, Ian A; Ganusov, Vitaly V.

J Immunol ; 208(5): 1292-1304, 2022 03 01.

Article in English | MEDLINE | ID: mdl-35131868

9.

Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8⁺ T Cell Localization in the Murine Liver.

O'Connor, James H; McNamara, Hayley A; Cai, Yeping; Coupland, Lucy A; Gardiner, Elizabeth E; Parish, Christopher R; McMorran, Brendan J; Ganusov, Vitaly V; Cockburn, Ian A.

J Immunol ; 208(12): 2738-2748, 2022 06 15.

Article in English | MEDLINE | ID: mdl-35649630

10.

Heterogeneity in killing efficacy of individual effector CD8⁺ T cells against Plasmodium liver stages.

Bera, Soumen; Amino, Rogerio; Cockburn, Ian A; Ganusov, Vitaly V.

Proc Biol Sci ; 290(2011): 20232280, 2023 Nov 29.

Article in English | MEDLINE | ID: mdl-38018100

11.

Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz, Daniel; Ng, Wei Yi; Holz, Lauren E; Ma, Joel Z; Zaid, Ali; Wong, Yik Chun; Lau, Lei Shong; Mollard, Vanessa; Cozijnsen, Anton; Collins, Nicholas; Li, Jessica; Davey, Gayle M; Kato, Yu; Devi, Sapna; Skandari, Roghieh; Pauley, Michael; Manton, Jonathan H; Godfrey, Dale I; Braun, Asolina; Tay, Szun Szun; Tan, Peck Szee; Bowen, David G; Koch-Nolte, Friedrich; Rissiek, Björn; Carbone, Francis R; Crabb, Brendan S; Lahoud, Mireille; Cockburn, Ian A; Mueller, Scott N; Bertolino, Patrick; McFadden, Geoffrey I; Caminschi, Irina; Heath, William R.

Immunity ; 51(4): 780, 2019 Oct 15.

Article in English | MEDLINE | ID: mdl-31618655

12.

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

Boast, Brigette; Miosge, Lisa A; Kuehn, Hye Sun; Cho, Vicky; Athanasopoulos, Vicki; McNamara, Hayley A; Sontani, Yovina; Mei, Yan; Howard, Debbie; Sutton, Henry J; Omari, Sofia A; Yu, Zhijia; Nasreen, Mariam; Andrews, T Daniel; Cockburn, Ian A; Goodnow, Christopher C; Rosenzweig, Sergio D; Enders, Anselm.

J Immunol ; 206(7): 1505-1514, 2021 04 01.

Article in English | MEDLINE | ID: mdl-33658297

13.

T_FH-derived dopamine accelerates productive synapses in germinal centres.

Papa, Ilenia; Saliba, David; Ponzoni, Maurilio; Bustamante, Sonia; Canete, Pablo F; Gonzalez-Figueroa, Paula; McNamara, Hayley A; Valvo, Salvatore; Grimbaldeston, Michele; Sweet, Rebecca A; Vohra, Harpreet; Cockburn, Ian A; Meyer-Hermann, Michael; Dustin, Michael L; Doglioni, Claudio; Vinuesa, Carola G.

Nature ; 547(7663): 318-323, 2017 07 20.

Article in English | MEDLINE | ID: mdl-28700579

14.

Development of Plasmodium-specific liver-resident memory CD8⁺ T cells after heat-killed sporozoite immunization in mice.

Ghilas, Sonia; Enders, Matthias H; May, Rose; Holz, Lauren E; Fernandez-Ruiz, Daniel; Cozijnsen, Anton; Mollard, Vanessa; Cockburn, Ian A; McFadden, Geoffrey I; Heath, William R; Beattie, Lynette.

Eur J Immunol ; 51(5): 1153-1165, 2021 05.

Article in English | MEDLINE | ID: mdl-33486759

15.

A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.

Hicks, Sarah M; Pohl, Kai; Neeman, Teresa; McNamara, Hayley A; Parsons, Kate M; He, Jin-Shu; Ali, Sidra A; Nazir, Samina; Rowntree, Louise C; Nguyen, Thi H O; Kedzierska, Katherine; Doolan, Denise L; Vinuesa, Carola G; Cook, Matthew C; Coatsworth, Nicholas; Myles, Paul S; Kurth, Florian; Sander, Leif E; Mann, Graham J; Gruen, Russell L; George, Amee J; Gardiner, Elizabeth E; Cockburn, Ian A.

J Infect Dis ; 223(1): 10-14, 2021 01 04.

Article in English | MEDLINE | ID: mdl-33009908

16.

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype.

Aye, Racheal; Sutton, Henry J; Nduati, Eunice W; Kai, Oscar; Mwacharo, Jedida; Musyoki, Jennifer; Otieno, Edward; Wambua, Juliana; Bejon, Philip; Cockburn, Ian A; Ndungu, Francis M.

Eur J Immunol ; 50(8): 1187-1194, 2020 08.

Article in English | MEDLINE | ID: mdl-32222961

17.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

Fisher, Camilla R; Sutton, Henry J; Kaczmarski, Joe A; McNamara, Hayley A; Clifton, Ben; Mitchell, Joshua; Cai, Yeping; Dups, Johanna N; D'Arcy, Nicholas J; Singh, Mandeep; Chuah, Aaron; Peat, Thomas S; Jackson, Colin J; Cockburn, Ian A.

PLoS Pathog ; 13(7): e1006469, 2017 Jul.

Article in English | MEDLINE | ID: mdl-28759640

18.

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice.

Hortle, Elinor; Nijagal, Brunda; Bauer, Denis C; Jensen, Lora M; Ahn, Seong Beom; Cockburn, Ian A; Lampkin, Shelley; Tull, Dedreia; McConville, Malcolm J; McMorran, Brendan J; Foote, Simon J; Burgio, Gaetan.

Blood ; 128(9): 1290-301, 2016 09 01.

Article in English | MEDLINE | ID: mdl-27465915

19.

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.

Radtke, Andrea J; Kastenmüller, Wolfgang; Espinosa, Diego A; Gerner, Michael Y; Tse, Sze-Wah; Sinnis, Photini; Germain, Ronald N; Zavala, Fidel P; Cockburn, Ian A.

PLoS Pathog ; 11(2): e1004637, 2015 Feb.

Article in English | MEDLINE | ID: mdl-25658939

20.

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.

Cockburn, Ian A; Amino, Rogerio; Kelemen, Reka K; Kuo, Scot C; Tse, Sze-Wah; Radtke, Andrea; Mac-Daniel, Laura; Ganusov, Vitaly V; Zavala, Fidel; Ménard, Robert.

Proc Natl Acad Sci U S A ; 110(22): 9090-5, 2013 May 28.

Article in English | MEDLINE | ID: mdl-23674673

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mRNA vaccine against malaria tailored for liver-resident memory T cells.

Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation.

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Resident T cells seek the perfect place to work from home.

HIV Immunogens: Affinity Is Key.

Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.

Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8⁺ T Cell Localization in the Murine Liver.

Heterogeneity in killing efficacy of individual effector CD8⁺ T cells against Plasmodium liver stages.

Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

T_FH-derived dopamine accelerates productive synapses in germinal centres.

Development of Plasmodium-specific liver-resident memory CD8⁺ T cells after heat-killed sporozoite immunization in mice.

A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting.

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice.

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.