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1.
The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia.
Annu Rev Pharmacol Toxicol
; 57: 509-533, 2017 01 06.
Article
in English
| MEDLINE | ID: mdl-27860547
2.
Identification of potent inhibitors of the sortilin-progranulin interaction.
Bioorg Med Chem Lett
; 30(17): 127403, 2020 09 01.
Article
in English
| MEDLINE | ID: mdl-32738972
3.
The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
J Neurochem
; 142(2): 204-214, 2017 07.
Article
in English
| MEDLINE | ID: mdl-28444767
4.
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Bioorg Med Chem Lett
; 27(6): 1364-1370, 2017 03 15.
Article
in English
| MEDLINE | ID: mdl-28216403
5.
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.
Bioorg Med Chem Lett
; 27(10): 2087-2093, 2017 05 15.
Article
in English
| MEDLINE | ID: mdl-28389149
6.
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Bioorg Med Chem Lett
; 27(9): 2038-2046, 2017 05 01.
Article
in English
| MEDLINE | ID: mdl-28285916
7.
Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.
J Neurogenet
; 30(1): 32-41, 2016 03.
Article
in English
| MEDLINE | ID: mdl-27276194
8.
Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.
Bioorg Med Chem Lett
; 26(23): 5809-5814, 2016 12 01.
Article
in English
| MEDLINE | ID: mdl-27818110
9.
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 26(1): 126-32, 2016 Jan 01.
Article
in English
| MEDLINE | ID: mdl-26602277
10.
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 25(21): 4893-4898, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-26077491
11.
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Bioorg Med Chem Lett
; 25(12): 2488-92, 2015 Jun 15.
Article
in English
| MEDLINE | ID: mdl-25981685
12.
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett
; 25(3): 444-50, 2015 Feb 01.
Article
in English
| MEDLINE | ID: mdl-25577040
13.
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Bioorg Med Chem Lett
; 25(21): 4992-4999, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-25613676
14.
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology.
Pharmacol Rev
; 64(3): 389-420, 2012 Jul.
Article
in English
| MEDLINE | ID: mdl-22759794
15.
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
BMC Neurosci
; 15: 109, 2014 Sep 22.
Article
in English
| MEDLINE | ID: mdl-25242351
16.
Quantitative proteomics in laser capture microdissected sleep nuclei from rat brain.
J Neurogenet
; 28(1-2): 136-45, 2014.
Article
in English
| MEDLINE | ID: mdl-24579665
17.
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
Bioorg Med Chem Lett
; 24(9): 2079-85, 2014 May 01.
Article
in English
| MEDLINE | ID: mdl-24704030
18.
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
Bioorg Med Chem Lett
; 24(7): 1784-9, 2014 Apr 01.
Article
in English
| MEDLINE | ID: mdl-24630562
19.
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett
; 24(20): 4884-90, 2014 Oct 15.
Article
in English
| MEDLINE | ID: mdl-25248679
20.
Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs.
J Comput Aided Mol Des
; 28(1): 5-12, 2014 Jan.
Article
in English
| MEDLINE | ID: mdl-24488306