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1.

Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers.

Dattani, Abhishek; Brady, Emer M; Kanagala, Prathap; Stoma, Svetlana; Parke, Kelly S; Marsh, Anna-Marie; Singh, Anvesha; Arnold, Jayanth R; Moss, Alastair J; Zhao, Lei; Cvijic, Mary Ellen; Fronheiser, Matthew; Du, Shuyan; Costet, Philippe; Schafer, Peter; Carayannopoulos, Leon; Chang, Ching-Pin; Gordon, David; Ramirez-Valle, Francisco; Jerosch-Herold, Michael; Nelson, Christopher P; Squire, Iain B; Ng, Leong L; Gulsin, Gaurav S; McCann, Gerry P.

BMC Cardiovasc Disord ; 24(1): 94, 2024 Feb 07.

Article in English | MEDLINE | ID: mdl-38326736

2.

Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1.

Le May, Cédric; Berger, Jean Mathieu; Lespine, Anne; Pillot, Bruno; Prieur, Xavier; Letessier, Eric; Hussain, M Mahmood; Collet, Xavier; Cariou, Bertrand; Costet, Philippe.

Arterioscler Thromb Vasc Biol ; 33(7): 1484-93, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23559630

3.

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Ducheix, Simon; Montagner, Alexandra; Polizzi, Arnaud; Lasserre, Frédéric; Marmugi, Alice; Bertrand-Michel, Justine; Podechard, Normand; Al Saati, Talal; Chétiveaux, Maud; Baron, Silvère; Boué, Jérôme; Dietrich, Gilles; Mselli-Lakhal, Laila; Costet, Philippe; Lobaccaro, Jean-Marc A; Pineau, Thierry; Theodorou, Vassilia; Postic, Catherine; Martin, Pascal G P; Guillou, Hervé.

J Hepatol ; 58(5): 984-92, 2013 May.

Article in English | MEDLINE | ID: mdl-23333450

4.

PCSK9 and LDL cholesterol: unravelling the target to design the bullet.

Costet, Philippe; Krempf, Michel; Cariou, Bertrand.

Trends Biochem Sci ; 33(9): 426-34, 2008 Sep.

Article in English | MEDLINE | ID: mdl-18672372

5.

Impact of diabetes on remodelling, microvascular function and exercise capacity in aortic stenosis.

Dattani, Abhishek; Brady, Emer M; Alfuhied, Aseel; Gulsin, Gaurav S; Steadman, Christopher D; Yeo, Jian L; Aslam, Saadia; Banovic, Marko; Jerosch-Herold, Michael; Xue, Hui; Kellman, Peter; Costet, Philippe; Cvijic, Mary Ellen; Zhao, Lei; Ebert, Christina; Liu, Laura; Gunawardhana, Kushan; Gordon, David; Chang, Ching-Pin; Arnold, J Ranjit; Yates, Thomas; Kelly, Damian; Hogrefe, Kai; Dawson, Dana; Greenwood, John; Ng, Leong L; Singh, Anvesha; McCann, Gerry P.

Open Heart ; 10(2)2023 08.

Article in English | MEDLINE | ID: mdl-37586847

6.

Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia.

Le May, Cédric; Kourimate, Sanae; Langhi, Cédric; Chétiveaux, Maud; Jarry, Anne; Comera, Christine; Collet, Xavier; Kuipers, Folkert; Krempf, Michel; Cariou, Bertrand; Costet, Philippe.

Arterioscler Thromb Vasc Biol ; 29(5): 684-90, 2009 May.

Article in English | MEDLINE | ID: mdl-19265033

7.

PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia.

Cariou, Bertrand; Ouguerram, Khadija; Zaïr, Yassine; Guerois, Raphael; Langhi, Cédric; Kourimate, Sanae; Benoit, Isabelle; Le May, Cédric; Gayet, Constance; Belabbas, Khaldia; Dufernez, Fabienne; Chétiveaux, Maud; Tarugi, Patrizia; Krempf, Michel; Benlian, Pascale; Costet, Philippe.

Arterioscler Thromb Vasc Biol ; 29(12): 2191-7, 2009 Dec.

Article in English | MEDLINE | ID: mdl-19762784

8.

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis.

Zhang, Ji; Muise, Eric S; Han, Seongah; Kutchukian, Peter S; Costet, Philippe; Zhu, Yonghua; Kan, Yanqing; Zhou, Haihong; Shah, Vinit; Huang, Yongcheng; Saigal, Ashmita; Akiyama, Taro E; Shen, Xiao-Lan; Cai, Tian-Quan; Shah, Kashmira; Carballo-Jane, Ester; Zycband, Emanuel; Yi, Lan; Tian, Ye; Chen, Ying; Imbriglio, Jason; Smith, Elizabeth; Devito, Kristine; Conway, James; Ma, Li-Jun; Hoek, Maarten; Sebhat, Iyassu K; Peier, Andrea M; Talukdar, Saswata; McLaren, David G; Previs, Stephen F; Jensen, Kristian K; Pinto, Shirly.

Cell Rep Med ; 1(4): 100056, 2020 07 21.

Article in English | MEDLINE | ID: mdl-33205063

9.

PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion.

Langhi, Cédric; Le May, Cédric; Gmyr, Valéry; Vandewalle, Brigitte; Kerr-Conte, Julie; Krempf, Michel; Pattou, François; Costet, Philippe; Cariou, Bertrand.

Biochem Biophys Res Commun ; 390(4): 1288-93, 2009 Dec 25.

Article in English | MEDLINE | ID: mdl-19878649

10.

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.

Langhi, Cédric; Le May, Cédric; Kourimate, Sanae; Caron, Sandrine; Staels, Bart; Krempf, Michel; Costet, Philippe; Cariou, Bertrand.

FEBS Lett ; 582(6): 949-55, 2008 Mar 19.

Article in English | MEDLINE | ID: mdl-18298956

11.

Galactosylated multimodular lipoplexes for specific gene transfer into primary hepatocytes.

Letrou-Bonneval, Emilie; Chèvre, Raphaël; Lambert, Olivier; Costet, Philippe; André, Corinne; Tellier, Charles; Pitard, Bruno.

J Gene Med ; 10(11): 1198-209, 2008 Nov.

Article in English | MEDLINE | ID: mdl-18816485

12.

Retinoic acid receptor-mediated induction of ABCA1 in macrophages.

Costet, Philippe; Lalanne, Florent; Gerbod-Giannone, Marie C; Molina, Jennifer R; Fu, Xuan; Lund, Erik G; Gudas, Lorraine J; Tall, Alan R.

Mol Cell Biol ; 23(21): 7756-66, 2003 Nov.

Article in English | MEDLINE | ID: mdl-14560020

13.

PCSK9: a promising therapeutic target for dyslipidemias?

Lambert, Gilles; Krempf, Michel; Costet, Philippe.

Trends Endocrinol Metab ; 17(3): 79-81, 2006 Apr.

Article in English | MEDLINE | ID: mdl-16487721

14.

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

Lambert, Gilles; Jarnoux, Anne-Laure; Pineau, Thierry; Pape, Olivier; Chetiveaux, Maud; Laboisse, Christian; Krempf, Michel; Costet, Philippe.

Endocrinology ; 147(10): 4985-95, 2006 Oct.

Article in English | MEDLINE | ID: mdl-16794006

15.

Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

Ouguerram, Khadija; Chetiveaux, Maud; Zair, Yassine; Costet, Philippe; Abifadel, Marianne; Varret, Mathilde; Boileau, Catherine; Magot, Thierry; Krempf, Michel.

Arterioscler Thromb Vasc Biol ; 24(8): 1448-53, 2004 Aug.

Article in English | MEDLINE | ID: mdl-15166014

16.

Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury.

Le Bras, Maëlle; Roquilly, Antoine; Deckert, Valérie; Langhi, Cédric; Feuillet, Fanny; Sébille, Véronique; Mahé, Pierre-Joachim; Bach, Kalyane; Masson, Damien; Lagrost, Laurent; Costet, Philippe; Asehnoune, Karim; Cariou, Bertrand.

J Clin Endocrinol Metab ; 98(4): E732-6, 2013 Apr.

Article in English | MEDLINE | ID: mdl-23450051

17.

Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets.

Cariou, Bertrand; Langhi, Cédric; Le Bras, Maëlle; Bortolotti, Murielle; Lê, Kim-Anne; Theytaz, Fanny; Le May, Cédric; Guyomarc'h-Delasalle, Béatrice; Zaïr, Yassine; Kreis, Roland; Boesch, Chris; Krempf, Michel; Tappy, Luc; Costet, Philippe.

Nutr Metab (Lond) ; 10(1): 4, 2013 Jan 08.

Article in English | MEDLINE | ID: mdl-23298392

18.

Regulation and mechanisms of macrophage cholesterol efflux.

Tall, Alan R; Costet, Philippe; Wang, Nan.

J Clin Invest ; 110(7): 899-904, 2002 Oct.

Article in English | MEDLINE | ID: mdl-12370265

19.

Clinical aspects of PCSK9.

Cariou, Bertrand; Le May, Cédric; Costet, Philippe.

Atherosclerosis ; 216(2): 258-65, 2011 Jun.

Article in English | MEDLINE | ID: mdl-21596380

20.

Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes.

Vergès, Bruno; Duvillard, Laurence; Brindisi, Marie Claude; Gautier, Emmanuel; Krempf, Michel; Costet, Philippe; Cariou, Bertrand.

Atherosclerosis ; 219(1): 342-8, 2011 Nov.

Article in English | MEDLINE | ID: mdl-21889145

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