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Bioorg Med Chem Lett
; 13(22): 4059-63, 2003 Nov 17.
Article
in English
| MEDLINE
| ID: mdl-14592508
ABSTRACT
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.