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1.

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

Liang, Kaiwei; Volk, Andrew G; Haug, Jeffrey S; Marshall, Stacy A; Woodfin, Ashley R; Bartom, Elizabeth T; Gilmore, Joshua M; Florens, Laurence; Washburn, Michael P; Sullivan, Kelly D; Espinosa, Joaquin M; Cannova, Joseph; Zhang, Jiwang; Smith, Edwin R; Crispino, John D; Shilatifard, Ali.

Cell ; 168(1-2): 59-72.e13, 2017 Jan 12.

Article in English | MEDLINE | ID: mdl-28065413

2.

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

Wen, Qiang; Goldenson, Benjamin; Silver, Serena J; Schenone, Monica; Dancik, Vlado; Huang, Zan; Wang, Ling-Zhi; Lewis, Timothy A; An, W Frank; Li, Xiaoyu; Bray, Mark-Anthony; Thiollier, Clarisse; Diebold, Lauren; Gilles, Laure; Vokes, Martha S; Moore, Christopher B; Bliss-Moreau, Meghan; Verplank, Lynn; Tolliday, Nicola J; Mishra, Rama; Vemula, Sasidhar; Shi, Jianjian; Wei, Lei; Kapur, Reuben; Lopez, Cécile K; Gerby, Bastien; Ballerini, Paola; Pflumio, Francoise; Gilliland, D Gary; Goldberg, Liat; Birger, Yehudit; Izraeli, Shai; Gamis, Alan S; Smith, Franklin O; Woods, William G; Taub, Jeffrey; Scherer, Christina A; Bradner, James E; Goh, Boon-Cher; Mercher, Thomas; Carpenter, Anne E; Gould, Robert J; Clemons, Paul A; Carr, Steven A; Root, David E; Schreiber, Stuart L; Stern, Andrew M; Crispino, John D.

Cell ; 150(3): 575-89, 2012 Aug 03.

Article in English | MEDLINE | ID: mdl-22863010

3.

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia.

Zhao, Zibo; Wang, Lu; Volk, Andrew G; Birch, Noah W; Stoltz, Kristen L; Bartom, Elizabeth T; Marshall, Stacy A; Rendleman, Emily J; Nestler, Carson M; Shilati, Joseph; Schiltz, Gary E; Crispino, John D; Shilatifard, Ali.

Genes Dev ; 33(1-2): 61-74, 2019 01 01.

Article in English | MEDLINE | ID: mdl-30573454

4.

Malignant progression of pre-leukemic disorders.

Hall, Trent; Gurbuxani, Sandeep; Crispino, John D.

Blood ; 2024 Mar 18.

Article in English | MEDLINE | ID: mdl-38498034

5.

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification.

Hu, Deqing; Gao, Xin; Cao, Kaixiang; Morgan, Marc A; Mas, Gloria; Smith, Edwin R; Volk, Andrew G; Bartom, Elizabeth T; Crispino, John D; Di Croce, Luciano; Shilatifard, Ali.

Mol Cell ; 65(3): 460-475.e6, 2017 Feb 02.

Article in English | MEDLINE | ID: mdl-28157506

6.

IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.

Melo-Cardenas, Johanna; Bezavada, Lavanya; Crawford, Jeremy Chase; Gurbuxani, Sandeep; Cotton, Anitria; Kang, Guolian; Gossett, Jeffrey; Marinaccio, Christian; Weinberg, Rona; Hoffman, Ronald; Migliaccio, Anna Rita; Zheng, Yan; Derecka, Marta; Rinaldi, Ciro R; Crispino, John D.

Blood ; 140(26): 2805-2817, 2022 12 29.

Article in English | MEDLINE | ID: mdl-36283106

7.

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Carey-Smith, Shannon L; Simad, Maryam H; Panchal, Kunjal; Aya-Bonilla, Carlos; Smolders, Hannah; Lin, Sang; Armitage, Jesse D; Nguyen, Vivien T; Bentley, Kathryn; Ford, Jette; Singh, Sajla; Oommen, Joyce; Laurent, Anouchka P; Mercher, Thomas; Crispino, John D; Montgomery, Andrew P; Kassiou, Michael; Besson, Thierry; Deau, Emmanuel; Meijer, Laurent; Cheung, Laurence C; Kotecha, Rishi S; Malinge, Sébastien.

Haematologica ; 2024 Feb 29.

Article in English | MEDLINE | ID: mdl-38426275

8.

Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis.

Ling, Te; Birger, Yehudit; Stankiewicz, Monika J; Ben-Haim, Nissim; Kalisky, Tomer; Rein, Avigail; Kugler, Eitan; Chen, Wei; Fu, Chunling; Zhang, Kevin; Patel, Hiral; Sikora, Jacek W; Goo, Young Ah; Kelleher, Neil; Zou, Lihua; Izraeli, Shai; Crispino, John D.

Blood ; 134(19): 1619-1631, 2019 11 07.

Article in English | MEDLINE | ID: mdl-31409672

9.

GATA1 mutations in red cell disorders.

Ling, Te; Crispino, John D.

IUBMB Life ; 72(1): 106-118, 2020 01.

Article in English | MEDLINE | ID: mdl-31652397

10.

Introduction to a review series on hematopoietic stem cells.

Crispino, John D.

Blood ; 142(6): 497, 2023 08 10.

Article in English | MEDLINE | ID: mdl-37561539

11.

CALR goes rogue.

Melo-Cardenas, Johanna; Crispino, John D.

Blood ; 141(8): 818-820, 2023 02 23.

Article in English | MEDLINE | ID: mdl-36821187

12.

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.

Melo-Cardenas, Johanna; Xu, Yuanming; Wei, Juncheng; Tan, Can; Kong, Sinyi; Gao, Beixue; Montauti, Elena; Kirsammer, Gina; Licht, Jonathan D; Yu, Jindan; Ji, Peng; Crispino, John D; Fang, Deyu.

Blood ; 132(4): 423-434, 2018 07 26.

Article in English | MEDLINE | ID: mdl-29844011

13.

Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression.

Chlon, Timothy M; Doré, Louis C; Crispino, John D.

Mol Cell ; 47(4): 608-21, 2012 Aug 24.

Article in English | MEDLINE | ID: mdl-22771118

14.

Introduction to a review series on megakaryopoiesis and platelet production.

Crispino, John D.

Blood ; 139(22): 3227, 2022 06 02.

Article in English | MEDLINE | ID: mdl-35226720

15.

GATA factor mutations in hematologic disease.

Crispino, John D; Horwitz, Marshall S.

Blood ; 129(15): 2103-2110, 2017 04 13.

Article in English | MEDLINE | ID: mdl-28179280

16.

Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation.

Fu, Chunling; Shi, Xuanxuan; Gong, Yanqing; Wan, Yan; Sun, Zengtian; Shi, Hengliang; Wang, Zhenzhen; Marinaccio, Christian; Crispino, John D; Xu, Kailin.

Cell Physiol Biochem ; 50(6): 2314-2328, 2018.

Article in English | MEDLINE | ID: mdl-30423551

17.

Introduction to a review series on molecular mechanisms of hematologic malignancies.

Crispino, John D.

Blood ; 138(8): 587, 2021 08 26.

Article in English | MEDLINE | ID: mdl-34157077

18.

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.

Goldenson, Benjamin; Kirsammer, Gina; Stankiewicz, Monika J; Wen, Qiang Jeremy; Crispino, John D.

Blood ; 125(13): 2141-50, 2015 Mar 26.

Article in English | MEDLINE | ID: mdl-25670627

19.

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Shaham, Lital; Vendramini, Elena; Ge, Yubin; Goren, Yaron; Birger, Yehudit; Tijssen, Marloes R; McNulty, Maureen; Geron, Ifat; Schwartzman, Omer; Goldberg, Liat; Chou, Stella T; Pitman, Holly; Weiss, Mitchell J; Michaeli, Shulamit; Sredni, Benjamin; Göttgens, Berthold; Crispino, John D; Taub, Jeffrey W; Izraeli, Shai.

Blood ; 125(8): 1292-301, 2015 Feb 19.

Article in English | MEDLINE | ID: mdl-25533034

20.

The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease.

Volk, Andrew; Crispino, John D.

Biochim Biophys Acta ; 1849(8): 979-86, 2015 Aug.

Article in English | MEDLINE | ID: mdl-26066981

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia.

Malignant progression of pre-leukemic disorders.

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification.

IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis.

GATA1 mutations in red cell disorders.

Introduction to a review series on hematopoietic stem cells.

CALR goes rogue.

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.

Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression.

Introduction to a review series on megakaryopoiesis and platelet production.

GATA factor mutations in hematologic disease.

Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation.

Introduction to a review series on molecular mechanisms of hematologic malignancies.

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease.