ABSTRACT
An evening symposium was held at the Museu de Historia de Catalunya (Barcelona, Spain) as a precursor to the European Bioanalysis Forum meeting, as part of the Waters Corporation Bioanalysis World Tour. The symposium was chaired by Robert Plumb and Jing Lin (Waters Corporation, MA, USA) with a focus on the future of the DMPK laboratory and its role in addressing large-molecule therapeutics and biomarkers. Lieve Dillen (Johnson and Johnson, Belgium) spoke on ultra-sensitive peptide quantification, Richard Kay (Quotient Bioresearch, UK) discussed quantifying proteins and peptides in plasma, Ian Wilson (AstraZeneca, UK) covered metabolic biomarkers and Robert Plumb concluded the evening with a presentation on the future of MS in DMPK studies. Following the presentations, all the speakers took questions from the audience and continued lively discussion over a cocktails and canapés reception.
Subject(s)
Biomarkers/analysis , Peptides/analysis , Pharmaceutical Preparations/analysis , Proteins/analysis , Amino Acid Sequence , Animals , Chromatography, High Pressure Liquid/methods , Equipment Design , Humans , Mass Spectrometry/instrumentation , Mass Spectrometry/methods , Mass Spectrometry/trends , Molecular Sequence Data , Pharmaceutical Preparations/metabolism , Spain , Urinalysis/methodsABSTRACT
Applied Pharmaceutical Analysis, Baltimore, MD, USA, 19 September 2010. As part of the Waters Corporation Bioanalysis World Tour [101] , an evening symposium was held at the Applied Pharmaceutical Analysis meeting in Baltimore (MD, USA) on 19 September 2010 [102,103] . The evening was chaired by Robert Plumb (Waters, MA, USA) and Christopher Evans (GlaxoSmithKline, PA, USA), and included three presentations from expert speakers. The talks covered diverse areas of bioanalysis unified by the theme of increasing sensitivity and data quality. Brian Hoffman (Advion, NY, USA) spoke about sample extraction plates for phospholipid depletion, Rand Jenkins (PPD Inc., VA, USA) discussed the use of 2D UPLC for enhancing the power and selectivity of UPLC-MS/MS bioanalysis, and Christopher Evans gave a presentation on increasing assay sensitivity for dried blood spot sample analysis, using a microfluidic chip-based column and a new mass spectrometer source. Following the presentations, all three speakers took to the stage again to respond to questions from the audience.