1.
Bioorg Med Chem Lett
; 18(20): 5537-40, 2008 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-18819794
ABSTRACT
Previously, we reported a series of novel benzimidazole based Itk inhibitors that exhibited excellent enzymatic potency and selectivity but low microsomal stability. Employing a structure based approach a new series of inhibitors with comparable potency and selectivity to the original series and with a potential for improved microsome stability was identified.