Is there a benefit to drains with a Kocher-Langenbeck approach? A prospective randomized pilot study.

BACKGROUND: Closed suction drainage is a routine part of wound management for patients undergoing surgical treatment of acetabulum fractures. This pilot study seeks to determine if there is a difference in wound healing for a Kocher-Langenbeck approach with and without the use of drains. METHODS: We conducted a prospective, randomized study including 39 patients with acetabulum fractures treated through a Kocher-Langenbeck approach. During wound closure, patients were randomized into two groups: 20 patients (group I) received drains and 19 (group II) were closed without drains. All were followed up for drain output, quality and quantity of drainage, signs of infection, and duration of drainage. Patients were then evaluated at 2 weeks and 8 weeks for wound healing and any signs of infection. RESULTS: By the 8-week follow-up, all wounds healed without any signs of infection. There was no difference in the average number of days of drainage between groups: 7.45 days and 7.95 days for group I and group II, respectively (p = 0.37). There were two wound complications (5.13%), with one in each group. Both complications consisted of cellulitis without signs of deep infection and had complete resolution with intravenous antibiotics. A post hoc power analysis determined that a test population of 1,264 patients would be needed to show a reduction in wound drainage time by 1 day. CONCLUSION: With the numbers available in this pilot study, we showed no benefit to the use of drains for acetabular surgery performed through a Kocher-Langenbeck approach.

The surgical treatment of acetabular fractures.

The goals of treating an acetabular fracture are to restore the congruity and stability of the hip joint. Some fracture types may not require surgery for a satisfactory outcome, but a displaced fracture in the weight-bearing area of the acetabulum generally should be treated with open reduction and internal fixation. The surgery is complex and demanding, and the fracture reduction must be anatomic to obtain the best result. There is no doubt, however, that an experienced surgeon can achieve an excellent result. Usually a poor result is related to residual fracture displacement or a perioperative complication. The evaluation and treatment protocols initially developed by Letournel and Judet continue to be important; in addition, the surgeon should be aware of the progress made during the past decade.

Prostate Cancer Foundation-Department of Veterans Affairs Partnership: A Model of Public-Private Collaboration to Advance Treatment and Care of Invasive Cancers.

BACKGROUND: Prostate cancer is the most frequently diagnosed and treated cancer in the US Department of Veterans Affairs (VA). As the leading philanthropic source for prostate cancer research, the Prostate Cancer Foundation (PCF) entered into a unique public-private biomedical research partnership with the VA with the goal of addressing the urgent health challenges faced by veterans with prostate cancer. OBSERVATIONS: With a commitment of $50 million from PCF and the VA's vast medical center infrastructure, the PCF-VA partnership has established 12 precision oncology Centers of Excellence to date, forming a collaborative network called the Precision Oncology Program for Cancer of the Prostate (POPCaP) Network. A 4-year review reveals the importance of executive leadership, mission-driven advocacy, setting shared ambitious goals, maximizing existing infrastructure and human capital, recruiting talent and resources, and creating space for adaptation and iteration in the context of a learning health care system. CONCLUSIONS: The PCF-VA partnership seeks to continue translating clinical research into national standards of care for veterans and serves as an innovative model of public-private collaborations for future health initiatives.

Computed tomography reformation in evaluation of fracture healing with metallic fixation: correlation with clinical outcome.

BACKGROUND: The amount of callous needed for fracture stability is typically estimated by a combination of radiographic and physical examinations. Computed tomography (CT) with sagittal and coronal reformations was performed to determine the amount of callous needed for fracture stability based on a quartile analysis of bony bridging of the circumference of the fracture site. METHODS: All patients who received CT with sagittal and coronal reformations of a fractured tubular bone for the purpose of analyzing bony bridging over a 22-month period were retrospectively reviewed. The final analysis included 34 patients and a total of 47 examinations. Fractures were placed into one of four groups depending on the amount of cortical bridging of the circumference of the bone: group I, 0-24%, group II, 25-49%, group III, 50-74%, group IV, 75-100%. Clinical outcome was determined on the basis of fracture stability, with mean follow-up of approximately 62 weeks. RESULTS: A statistically significant increase in clinical failure was found in patients with <25% bridging. A cut-point analysis revealed that 37.5% (6 of 16) of failures occurred among patients with <25% bony bridging, and only 9.7% (3 of 31) of failures occurred among patients with >25% bridging, corresponding to a Fisher's exact test p value of 0.045. CONCLUSIONS: Patients with less than 25% bridging of the circumference of a tubular bone should be considered high risk for failure, indicating the need for continued protection of the site.

Effect of porosity on the fluid flow characteristics and mechanical properties of tantalum scaffolds.

In many cases of traumatic bone injury, bone grafting is required. The primary source of graft material is either autograft or allograft. The use of both material sources are well established, however, both suffer limitations. In response, many grafting alternatives are being explored. This article specifically focuses on a porous tantalum metal grafting material (Trabecular Metaltrade mark) marketed by Zimmer. Twenty-one cylindrical scaffolds were manufactured (66% to 88% porous) and tested for porosity, intrinsic permeability, tangent elastic modulus, and for yield stress and strain behavior. Scaffold microstructural geometries were also measured. Tantalum scaffold intrinsic permeability ranged from 2.1 x 10(-10) to 4.8 x 10(-10) m(2) and tangent elastic modulus ranged from 373 MPa to 2.2 GPa. Both intrinsic permeability and tangent elastic modulus closely matched porosity-matched cancellous bone specimens from a variety of species and anatomic locations. Scaffold yield stress ranged from 4 to 12.7 MPa and was comparable to bovine and human cancellous bone. Yield strain was unaffected by scaffold porosity (average = 0.010 mm/mm). Understanding these structure-function relationships will help complete the basic physical characterization of this new material and will aid in the development of realistic mathematical models, ultimately enhancing future implant designs utilizing this material.

Magnetic resonance imaging of the knee after ipsilateral femur fracture.

OBJECTIVE: The purpose of this study is to identify and characterize the nature of internal knee derangement associated with ipsilateral femur fractures. DESIGN: A prospective consecutive investigation with the musculoskeletal radiologist being blinded to the clinical examination. SETTING: A certified Level I trauma center. PATIENTS: All adult (skeletally mature) patients with femur fractures resulting from blunt traumatic injury were included. Patients with penetrating, periprosthetic, pathologic, or previous femur fractures were excluded. In addition, all patients with previous knee injuries or previous knee surgery were excluded. Of the fifty-one patients with diaphyseal femur fractures originally enrolled in this investigation, fifteen were excluded by protocol and eleven were unable to obtain timely MRI studies. INTERVENTIONS: All patients were evaluated initially according to Advanced Trauma Life Support protocol. When appropriate, skeletal traction was used as provisional fracture stabilization. In most cases, however, operative fixation was performed immediately. In one case open reduction internal fixation was performed. In the remainder, fracture fixation with an anterograde ( = nineteen) or retrograde ( = seven) intramedullary nail was used. OUTCOME MEASURE: After surgical fixation, twenty-five patients with twenty-seven knees were examined clinically and with an MRI. RESULTS: Five anterior cruciate ligament and two posterior cruciate ligament injuries were discovered (19 percent and 7 percent, respectively). Four complete (Grade 3) medial meniscus tears (15 percent) and seven complete lateral meniscus tears (26 percent) were identified by postoperative MRI studies. The medial collateral ligament was injured in eleven knees (41 percent), with five (19 percent) identified as complete (Grade 3) injuries. The lateral collateral ligament was also injured in eight knees (30 percent); in half (15 percent) the injury was complete. Bone contusions (periarticular infractions of cortical and medullary trabecular bone) were noted in eight (30 percent) tibia (equally divided between medial and lateral compartments) and in 17 (63 percent) femurs (also equally divided between medial and lateral condyles). CONCLUSION: Given the large number of soft tissue injuries about the knee, it would be prudent to emphasize the importance of a thorough intraoperative examination once the femur fracture has been stabilized. Additionally, there should be a low threshold to obtain an MRI if the postoperative clinical examination suggests an associated knee injury. Bone bruises, which can only be identified by MRI studies, are increasingly being acknowledged as a source of persistent symptoms.

Nonunion of femoral neck fracture and trochanteric osteotomy after a pinned, slipped capital femoral epiphysis: a case report.

Femoral neck fracture as a complication of slipped capital femoral epiphysis (SCFE) is rare. Even rarer is a femoral neck nonunion as an additional complication. This is the first case reported in the literature of a failed valgus osteotomy for a femoral neck nonunion. A salvage operation involving a step-cut valgus/flexion/internal rotation osteotomy, open reduction and internal fixation, with a blade plate and cannulated screw, placement of an allograft femoral strut, and allograft bone grafting was successfully performed. Femoral neck fractures following SCFE fixation are more difficult to treat because of abnormal femoral neck configuration. Therefore a valgus, flexion, and internal rotation producing osteotomy may need to be initially performed to prevent a femoral neck nonunion.

Noninvasive measurement of compartment syndrome.

This study compared the effectiveness of a commercially available invasive intracompartmental pressure measuring device with an investigational noninvasive hardness measuring device in 75 patients undergoing examination for possible compartment syndrome. Legs, forearms, thighs, and arms were tested. Pressure values and hardness ratios were compared to one another as continuous variables and to the clinical diagnosis of compartment syndrome as discrete variables. The compartment with the highest pressure reading within a limb diagnosed with compartment syndrome was compared to limbs without compartment syndrome. Due to the low specificity of the noninvasive measurement of hardness compared to the invasive pressure measurement (0.82 versus 0.96), this study does not support the use of the hardness monitor in the diagnosis of compartment syndrome.

Open reduction internal fixation of displaced sacral fractures: technique and results.

Pelvic ring disruption with an associated sacral fracture is typically a result of high-energy injury. Due to significant local soft tissue trauma and the complex neurovascular anatomy in the region, exposure and reduction of sacral fractures has proven to be difficult, hazardous, and fraught with complications. We describe a modified reduction technique to address displacement in sacral fractures to show that it can be safe and effective through evaluation of radiographic, clinical, and functional outcomes. We retrospectively reviewed the radiographic and clinical results of consecutive patients treated at a single institution by the senior surgeon (K.F.D.) with open reduction for displaced sacral fractures. Radiographic follow-up was available on all patients. Complete clinical follow-up was available on 19 of 20 patients. The average duration of follow-up was 3.7 years. All fractures united with no additional surgery. There were no infections or additional neurologic deficits or vascular injuries. There was 1 asymptomatic hardware failure 2 years postoperatively with no further displacement. Average preoperative displacement on the anteroposterior (AP) radiograph was 14.72 mm with a long-term follow-up displacement of 3.25 mm. Iowa Pelvic Score questionnaires demonstrated an average score of 92.2. Eighty-nine percent of patients returned to full time work or their previous activity level. The technique of open reduction and fixation of displaced sacral fractures described in this review is safe and effective with a low complication rate and clinical results comparable to or exceeding that of previously published series.

Skeletal deformity after anterior external fixation of the pelvis.

OBJECTIVE: To study the deformity of acutely injured unstable pelves before and after emergent application of an anterior external fixator. DESIGN: Retrospective. SETTING: Large pelvic fracture referral practice. PATIENTS: Eleven of 151 patients referred to our institution after emergent application of an external fixator by the referring orthopaedist before transfer who were hemodynamically unstable and had a mechanically unstable pelvic injury with pre-external fixator radiographs and post-external fixator radiographs adequate to determine pelvic deformity. MAIN OUTCOME MEASUREMENTS: We reviewed all available radiographs both before and after placement of the external fixator (the anterior-posterior, inlet, outlet, and computed tomography), determining whether the external fixator improved or worsened the deformity. RESULTS: Although many deformities existed, we found that application of an anterior frame consistently worsened this deformity. Seven of the 11 patients (64%) had worsening of the posterior cephalad translation or posterior diastasis despite apparent improvement anteriorly on the anterior-posterior radiograph. "External fixator deformity," defined as increased flexion and/or internal rotation of the hemipelvis, also occurred in 8 of 11 patients (73%). After placement of the external fixator, all patients displayed greater than 1 cm of either posterior cephalad translation or posterior diastasis (average 3.4 cm, range 1.3-4.6 cm). CONCLUSIONS: Due to the forces placed on the pelvis during application of an anterior external fixator by the surgeon, an external fixator deformity may occur (flexed and internally rotated hemipelvis). Furthermore, most patients had an increase in posterior cephalad translation or posterior diastasis with placement of an external fixator. The surgeon should be aware of the potential of increasing the pelvic deformity when applying an emergent anterior external fixator.

The use of BoneSource hydroxyapatite cement for traumatic metaphyseal bone void filling.

OBJECTIVE: This prospective, randomized study was performed to determine whether a new, in situ setting hydroxyapatite cement is as safe or effective as autologous cancellous bone graft for the treatment of metaphyseal bone voids secondary to trauma. This was a multicenter study including Level I trauma centers and university hospitals. Thirty-eight patients who sustained an acute closed or open type I fracture of the humerus, radius, ulna, femur, tibia, or calcaneus and had a traumatic bone void requiring grafting of the metaphyseal or cancellous bone area were enrolled. Open reduction and internal fixation of the fracture was performed with use of either autologous cancellous bone or BoneSource hydroxyapatite cement to fill traumatic metaphyseal voids. Main outcome measures included maintenance of reduction, fracture healing, pain at defect site, pain at donor site, and clinical function of the limb. RESULTS: Patients treated with BoneSource had an 83% success rate in maintaining reduction, whereas patients treated with autograft had a 67% success rate. A successful clinical outcome, as measured by a healed fracture with minimal to no pain, moderate to maximum function, and no or minor donor site complications, was seen in 69% of patients treated with BoneSource and 57% of patients treated with autograft. In patients with at least 1 year of follow-up, the overall success rate was 79% in the BoneSource group and 70% in the autograft group. CONCLUSION: BoneSource is safe and effective when used to fill traumatic metaphyseal bone voids. It is at least as good as autograft for treatment of these defects.