ABSTRACT
Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition presenting as perioral inflammation in the absence of systemic disease. There is continued debate regarding whether OFG is a distinct clinical disorder or a manifestation of orofacial Crohn's disease. Our retrospective review identified 7 patients diagnosed with OFG between 2000 and 2018 at a tertiary pediatric hospital. Four of the 7 patients subsequently developed Crohn's disease with a median delay of 3.1 years (range 0.4-6.9 years). This indicates that gastroenterology evaluation with long-term monitoring for intestinal Crohn's disease is warranted.
Subject(s)
Crohn Disease , Granulomatosis, Orofacial , Child , Crohn Disease/complications , Crohn Disease/diagnosis , Granulomatosis, Orofacial/diagnosis , Granulomatosis, Orofacial/drug therapy , Granulomatosis, Orofacial/etiology , Humans , Inflammation , Retrospective Studies , Tertiary Care CentersABSTRACT
While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment (SOFA) scores have been associated with increased mortality in patients critically ill patients with COVID-19. It is important that clinicians managing critically ill COVID-19 patients be aware of the multisystem impact of the disease so that care can be focused on the prevention of end-organ injuries to potentially improve clinical outcomes. We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients.
Subject(s)
COVID-19/physiopathology , COVID-19/mortality , Cardiovascular Diseases/physiopathology , Critical Illness , Cytokines/biosynthesis , Endocrine System Diseases/physiopathology , Gastrointestinal Diseases/physiopathology , Hematologic Diseases/physiopathology , Humans , Kidney Diseases/physiopathology , Musculoskeletal Diseases/physiopathology , Nervous System Diseases/physiopathology , Obesity/physiopathology , Organ Dysfunction Scores , Respiratory Tract Diseases/physiopathology , Risk Factors , SARS-CoV-2 , Skin Diseases/physiopathology , Systemic Inflammatory Response Syndrome/physiopathologyABSTRACT
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin. The lesions initially were limited to the leg in which the hardware was placed, but the patient later developed painful palmoplantar and oropharyngeal blisters as well as edematous, erythematous plaques on the back and buttocks. A punch biopsy from a lesion on the left thigh revealed neutrophil-rich subepidermal bullae, and immunofluorescence revealed linear IgA and C3 deposition along the dermoepidermal junction, confirming a diagnosis of LABD. This report illustrates the importance of considering antibiotic-impregnated cement spacers, which frequently are used to manage prosthetic joint infections, as potential culprits in patients with cutaneous eruptions.