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1.

Targeted protein degradation: from mechanisms to clinic.

Tsai, Jonathan M; Nowak, Radoslaw P; Ebert, Benjamin L; Fischer, Eric S.

Nat Rev Mol Cell Biol ; 2024 Apr 29.

Article in English | MEDLINE | ID: mdl-38684868

2.

Doubling Down on Mutant RAS Can MEK or Break Leukemia.

Tothova, Zuzana; Ebert, Benjamin L.

Cell ; 168(5): 749-750, 2017 02 23.

Article in English | MEDLINE | ID: mdl-28235190

3.

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Puram, Rishi V; Kowalczyk, Monika S; de Boer, Carl G; Schneider, Rebekka K; Miller, Peter G; McConkey, Marie; Tothova, Zuzana; Tejero, Héctor; Heckl, Dirk; Järås, Marcus; Chen, Michelle C; Li, Hubo; Tamayo, Alfred; Cowley, Glenn S; Rozenblatt-Rosen, Orit; Al-Shahrour, Fatima; Regev, Aviv; Ebert, Benjamin L.

Cell ; 165(2): 303-16, 2016 Apr 07.

Article in English | MEDLINE | ID: mdl-27058663

4.

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

Tsai, Jonathan M; Aguirre, Jacob D; Li, Yen-Der; Brown, Jared; Focht, Vivian; Kater, Lukas; Kempf, Georg; Sandoval, Brittany; Schmitt, Stefan; Rutter, Justine C; Galli, Pius; Sandate, Colby R; Cutler, Jevon A; Zou, Charles; Donovan, Katherine A; Lumpkin, Ryan J; Cavadini, Simone; Park, Paul M C; Sievers, Quinlan; Hatton, Charlie; Ener, Elizabeth; Regalado, Brandon D; Sperling, Micah T; Slabicki, Mikolaj; Kim, Jeonghyeon; Zon, Rebecca; Zhang, Zinan; Miller, Peter G; Belizaire, Roger; Sperling, Adam S; Fischer, Eric S; Irizarry, Rafael; Armstrong, Scott A; Thomä, Nicolas H; Ebert, Benjamin L.

Mol Cell ; 83(15): 2753-2767.e10, 2023 08 03.

Article in English | MEDLINE | ID: mdl-37478846

5.

Clonal haematopoiesis and risk of chronic liver disease.

Wong, Waihay J; Emdin, Connor; Bick, Alexander G; Zekavat, Seyedeh M; Niroula, Abhishek; Pirruccello, James P; Dichtel, Laura; Griffin, Gabriel; Uddin, Md Mesbah; Gibson, Christopher J; Kovalcik, Veronica; Lin, Amy E; McConkey, Marie E; Vromman, Amelie; Sellar, Rob S; Kim, Peter G; Agrawal, Mridul; Weinstock, Joshua; Long, Michelle T; Yu, Bing; Banerjee, Rajarshi; Nicholls, Rowan C; Dennis, Andrea; Kelly, Matt; Loh, Po-Ru; McCarroll, Steve; Boerwinkle, Eric; Vasan, Ramachandran S; Jaiswal, Siddhartha; Johnson, Andrew D; Chung, Raymond T; Corey, Kathleen; Levy, Daniel; Ballantyne, Christie; Ebert, Benjamin L; Natarajan, Pradeep.

Nature ; 616(7958): 747-754, 2023 04.

Article in English | MEDLINE | ID: mdl-37046084

6.

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.

Bourgeois, Wallace; Cutler, Jevon A; Aubrey, Brandon J; Wenge, Daniela V; Perner, Florian; Martucci, Cynthia; Henrich, Jill A; Klega, Kelly; Nowak, Radoslaw P; Donovan, Katherine A; Boileau, Meaghan; Wen, Yanhe; Hatton, Charlie; Apazidis, Athina A; Olsen, Sarah Naomi; Kirmani, Nadia; Pikman, Yana; Pollard, Jessica A; Perry, Jennifer A; Sperling, Adam S; Ebert, Benjamin L; McGeehan, Gerard M; Crompton, Brian D; Fischer, Eric S; Armstrong, Scott A.

Blood ; 143(15): 1513-1527, 2024 Apr 11.

Article in English | MEDLINE | ID: mdl-38096371

7.

Design principles for cyclin K molecular glue degraders.

Kozicka, Zuzanna; Suchyta, Dakota J; Focht, Vivian; Kempf, Georg; Petzold, Georg; Jentzsch, Marius; Zou, Charles; Di Genua, Cristina; Donovan, Katherine A; Coomar, Seemon; Cigler, Marko; Mayor-Ruiz, Cristina; Schmid-Burgk, Jonathan L; Häussinger, Daniel; Winter, Georg E; Fischer, Eric S; Slabicki, Mikolaj; Gillingham, Dennis; Ebert, Benjamin L; Thomä, Nicolas H.

Nat Chem Biol ; 20(1): 93-102, 2024 Jan.

Article in English | MEDLINE | ID: mdl-37679459

8.

Densely interconnected transcriptional circuits control cell states in human hematopoiesis.

Novershtern, Noa; Subramanian, Aravind; Lawton, Lee N; Mak, Raymond H; Haining, W Nicholas; McConkey, Marie E; Habib, Naomi; Yosef, Nir; Chang, Cindy Y; Shay, Tal; Frampton, Garrett M; Drake, Adam C B; Leskov, Ilya; Nilsson, Bjorn; Preffer, Fred; Dombkowski, David; Evans, John W; Liefeld, Ted; Smutko, John S; Chen, Jianzhu; Friedman, Nir; Young, Richard A; Golub, Todd R; Regev, Aviv; Ebert, Benjamin L.

Cell ; 144(2): 296-309, 2011 Jan 21.

Article in English | MEDLINE | ID: mdl-21241896

9.

Small-molecule-induced polymerization triggers degradation of BCL6.

Slabicki, Mikolaj; Yoon, Hojong; Koeppel, Jonas; Nitsch, Lena; Roy Burman, Shourya S; Di Genua, Cristina; Donovan, Katherine A; Sperling, Adam S; Hunkeler, Moritz; Tsai, Jonathan M; Sharma, Rohan; Guirguis, Andrew; Zou, Charles; Chudasama, Priya; Gasser, Jessica A; Miller, Peter G; Scholl, Claudia; Fröhling, Stefan; Nowak, Radoslaw P; Fischer, Eric S; Ebert, Benjamin L.

Nature ; 588(7836): 164-168, 2020 12.

Article in English | MEDLINE | ID: mdl-33208943

10.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.

Slabicki, Mikolaj; Kozicka, Zuzanna; Petzold, Georg; Li, Yen-Der; Manojkumar, Manisha; Bunker, Richard D; Donovan, Katherine A; Sievers, Quinlan L; Koeppel, Jonas; Suchyta, Dakota; Sperling, Adam S; Fink, Emma C; Gasser, Jessica A; Wang, Li R; Corsello, Steven M; Sellar, Rob S; Jan, Max; Gillingham, Dennis; Scholl, Claudia; Fröhling, Stefan; Golub, Todd R; Fischer, Eric S; Thomä, Nicolas H; Ebert, Benjamin L.

Nature ; 585(7824): 293-297, 2020 09.

Article in English | MEDLINE | ID: mdl-32494016

11.

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.

Lin, Amy Erica; Bapat, Aneesh C; Xiao, Ling; Niroula, Abhishek; Ye, Jiangchuan; Wong, Waihay J; Agrawal, Mridul; Farady, Christopher J; Boettcher, Andreas; Hergott, Christopher B; McConkey, Marie; Flores-Bringas, Patricio; Shkolnik, Veronica; Bick, Alexander G; Milan, David; Natarajan, Pradeep; Libby, Peter; Ellinor, Patrick T; Ebert, Benjamin L.

Circulation ; 149(18): 1419-1434, 2024 Apr 30.

Article in English | MEDLINE | ID: mdl-38357791

12.

Causes and consequences of clonal hematopoiesis.

Weeks, Lachelle D; Ebert, Benjamin L.

Blood ; 142(26): 2235-2246, 2023 12 28.

Article in English | MEDLINE | ID: mdl-37931207

13.

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.

Miller, Peter G; Sperling, Adam S; Mayerhofer, Christina; McConkey, Marie E; Ellegast, Jana M; Da Silva, Carmen; Cohen, Drew N; Wang, Chuqi; Sharda, Azeem; Yan, Ni; Saha, Subha; Schluter, Cameron; Schechter, Ilexa; Slabicki, Mikolaj; Sandoval, Brittany; Kahn, Josephine; Boettcher, Steffen; Gibson, Christopher J; Scadden, David T; Stegmaier, Kimberly; Bhatt, Shruti; Lindsley, R Coleman; Ebert, Benjamin L.

Blood ; 142(24): 2079-2091, 2023 12 14.

Article in English | MEDLINE | ID: mdl-37595362

14.

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.

Vlasschaert, Caitlyn; Mack, Taralynn; Heimlich, J Brett; Niroula, Abhishek; Uddin, Md Mesbah; Weinstock, Joshua; Sharber, Brian; Silver, Alexander J; Xu, Yaomin; Savona, Michael; Gibson, Christopher; Lanktree, Matthew B; Rauh, Michael J; Ebert, Benjamin L; Natarajan, Pradeep; Jaiswal, Siddhartha; Bick, Alexander G.

Blood ; 141(18): 2214-2223, 2023 05 04.

Article in English | MEDLINE | ID: mdl-36652671

15.

Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.

Carter, Bing Z; Mak, Po Yee; Muftuoglu, Muharrem; Tao, Wenjing; Ke, Baozhen; Pei, Jingqi; Bedoy, Andrea D; Ostermann, Lauren B; Nishida, Yuki; Isgandarova, Sevinj; Sobieski, Mary; Nguyen, Nghi; Powell, Reid T; Martinez-Moczygemba, Margarita; Stephan, Clifford; Basyal, Mahesh; Pemmaraju, Naveen; Boettcher, Steffen; Ebert, Benjamin L; Shpall, Elizabeth J; Wallner, Barbara; Morgan, Robert A; Karras, Georgios I; Moll, Ute M; Andreeff, Michael.

Blood ; 142(12): 1056-1070, 2023 09 21.

Article in English | MEDLINE | ID: mdl-37339579

16.

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias.

Schuermans, Art; Vlasschaert, Caitlyn; Nauffal, Victor; Cho, So Mi Jemma; Uddin, Md Mesbah; Nakao, Tetsushi; Niroula, Abhishek; Klarqvist, Marcus D R; Weeks, Lachelle D; Lin, Amy E; Saadatagah, Seyedmohammad; Lannery, Kim; Wong, Megan; Hornsby, Whitney; Lubitz, Steven A; Ballantyne, Christie; Jaiswal, Siddhartha; Libby, Peter; Ebert, Benjamin L; Bick, Alexander G; Ellinor, Patrick T; Natarajan, Pradeep; Honigberg, Michael C.

Eur Heart J ; 45(10): 791-805, 2024 Mar 07.

Article in English | MEDLINE | ID: mdl-37952204

17.

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.

Döhner, Hartmut; Wei, Andrew H; Appelbaum, Frederick R; Craddock, Charles; DiNardo, Courtney D; Dombret, Hervé; Ebert, Benjamin L; Fenaux, Pierre; Godley, Lucy A; Hasserjian, Robert P; Larson, Richard A; Levine, Ross L; Miyazaki, Yasushi; Niederwieser, Dietger; Ossenkoppele, Gert; Röllig, Christoph; Sierra, Jorge; Stein, Eytan M; Tallman, Martin S; Tien, Hwei-Fang; Wang, Jianxiang; Wierzbowska, Agnieszka; Löwenberg, Bob.

Blood ; 140(12): 1345-1377, 2022 09 22.

Article in English | MEDLINE | ID: mdl-35797463

18.

An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis.

Zoref-Lorenz, Adi; Murakami, Jun; Hofstetter, Liron; Iyer, Swaminathan; Alotaibi, Ahmad S; Mohamed, Shehab Fareed; Miller, Peter G; Guber, Elad; Weinstein, Shiri; Yacobovich, Joanne; Nikiforow, Sarah; Ebert, Benjamin L; Lane, Adam; Pasvolsky, Oren; Raanani, Pia; Nagler, Arnon; Berliner, Nancy; Daver, Naval; Ellis, Martin; Jordan, Michael B.

Blood ; 139(7): 1098-1110, 2022 02 17.

Article in English | MEDLINE | ID: mdl-34780598

19.

Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms.

Sperling, Adam S; Guerra, Veronica A; Kennedy, James A; Yan, Yuanqing; Hsu, Joanne I; Wang, Feng; Nguyen, Andrew T; Miller, Peter G; McConkey, Marie E; Quevedo Barrios, Vanessa A; Furudate, Ken; Zhang, Linda; Kanagal-Shamanna, Rashmi; Zhang, Jianhua; Little, Latasha; Gumbs, Curtis; Daver, Naval; DiNardo, Courtney D; Kadia, Tapan; Ravandi, Farhad; Kantarjian, Hagop; Garcia-Manero, Guillermo; Futreal, P Andrew; Ebert, Benjamin L; Takahashi, Koichi.

Blood ; 140(16): 1753-1763, 2022 10 20.

Article in English | MEDLINE | ID: mdl-35512188

20.

TET2-mutant clonal hematopoiesis and risk of gout.

Agrawal, Mridul; Niroula, Abhishek; Cunin, Pierre; McConkey, Marie; Shkolnik, Veronica; Kim, Peter G; Wong, Waihay J; Weeks, Lachelle D; Lin, Amy E; Miller, Peter G; Gibson, Christopher J; Sekar, Aswin; Schaefer, Inga-Marie; Neuberg, Donna; Stone, Richard M; Bick, Alexander G; Uddin, Md Mesbah; Griffin, Gabriel K; Jaiswal, Siddhartha; Natarajan, Pradeep; Nigrovic, Peter A; Rao, Deepak A; Ebert, Benjamin L.

Blood ; 140(10): 1094-1103, 2022 09 08.

Article in English | MEDLINE | ID: mdl-35714308

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