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1.

Deubiquitinases in cancer.

Dewson, Grant; Eichhorn, Pieter J A; Komander, David.

Nat Rev Cancer ; 23(12): 842-862, 2023 Dec.

Article in English | MEDLINE | ID: mdl-37935888

2.

Protein phosphatase 2A regulatory subunits and cancer.

Eichhorn, Pieter J A; Creyghton, Menno P; Bernards, René.

Biochim Biophys Acta ; 1795(1): 1-15, 2009 Jan.

Article in English | MEDLINE | ID: mdl-18588945

3.

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.

Eichhorn, Pieter J A; Creyghton, Menno P; Wilhelmsen, Kevin; van Dam, Hans; Bernards, René.

PLoS Genet ; 3(12): e218, 2007 Dec.

Article in English | MEDLINE | ID: mdl-18069897

4.

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.

Teyra, Joan; Singer, Alex U; Schmitges, Frank W; Jaynes, Patrick; Kit Leng Lui, Sarah; Polyak, Maria J; Fodil, Nassima; Krieger, Jonathan R; Tong, Jiefei; Schwerdtfeger, Carsten; Brasher, Bradley B; Ceccarelli, Derek F J; Moffat, Jason; Sicheri, Frank; Moran, Michael F; Gros, Philippe; Eichhorn, Pieter J A; Lenter, Martin; Boehmelt, Guido; Sidhu, Sachdev S.

Structure ; 27(4): 590-605.e5, 2019 04 02.

Article in English | MEDLINE | ID: mdl-30713027

5.

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma.

Kong, Li R; Tan, Tuan Z; Ong, Weijie R; Bi, Chonglei; Huynh, Hung; Lee, Soo C; Chng, Wee J; Eichhorn, Pieter J A; Goh, Boon C.

Mol Oncol ; 11(8): 965-980, 2017 08.

Article in English | MEDLINE | ID: mdl-28397399

6.

Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover.

Thanh Nguyen, Hung; Andrejeva, Diana; Gupta, Rajat; Choudhary, Chunaram; Hong, Xin; Eichhorn, Pieter J A; Loya, Anand C; Cohen, Stephen M.

Cell Discov ; 2: 16001, 2016.

Article in English | MEDLINE | ID: mdl-27462448

7.

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.

Serra, Violeta; Eichhorn, Pieter J A; García-García, Celina; Ibrahim, Yasir H; Prudkin, Ludmila; Sánchez, Gertrudis; Rodríguez, Olga; Antón, Pilar; Parra, Josep-Lluís; Marlow, Sara; Scaltriti, Maurizio; Pérez-Garcia, José; Prat, Aleix; Arribas, Joaquín; Hahn, William C; Kim, So Young; Baselga, José.

J Clin Invest ; 123(6): 2551-63, 2013 Jun.

Article in English | MEDLINE | ID: mdl-23635776

8.

USP15 stabilizes TGF-ß receptor I and promotes oncogenesis through the activation of TGF-ß signaling in glioblastoma.

Eichhorn, Pieter J A; Rodón, Laura; Gonzàlez-Juncà, Alba; Dirac, Annette; Gili, Magüi; Martínez-Sáez, Elena; Aura, Claudia; Barba, Ignasi; Peg, Vicente; Prat, Aleix; Cuartas, Isabel; Jimenez, Jose; García-Dorado, David; Sahuquillo, Juan; Bernards, Réné; Baselga, José; Seoane, Joan.

Nat Med ; 18(3): 429-35, 2012 Feb 19.

Article in English | MEDLINE | ID: mdl-22344298

9.

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

Eichhorn, Pieter J A; Gili, Magüi; Scaltriti, Maurizio; Serra, Violeta; Guzman, Marta; Nijkamp, Wouter; Beijersbergen, Roderick L; Valero, Vanesa; Seoane, Joan; Bernards, René; Baselga, José.

Cancer Res ; 68(22): 9221-30, 2008 Nov 15.

Article in English | MEDLINE | ID: mdl-19010894

10.

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

Serra, Violeta; Markman, Ben; Scaltriti, Maurizio; Eichhorn, Pieter J A; Valero, Vanesa; Guzman, Marta; Botero, Maria Luisa; Llonch, Elisabeth; Atzori, Francesco; Di Cosimo, Serena; Maira, Michel; Garcia-Echeverria, Carlos; Parra, Josep Lluis; Arribas, Joaquin; Baselga, José.

Cancer Res ; 68(19): 8022-30, 2008 Oct 01.

Article in English | MEDLINE | ID: mdl-18829560

11.

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle.

Creyghton, Menno P; Roël, Giulietta; Eichhorn, Pieter J A; Vredeveld, Liesbeth C; Destrée, Olivier; Bernards, René.

Proc Natl Acad Sci U S A ; 103(14): 5397-402, 2006 Apr 04.

Article in English | MEDLINE | ID: mdl-16567647

12.

HER2 signatures in breast cancer: ready to go to print?

Eichhorn, Pieter J A; Baselga, José.

J Clin Oncol ; 28(11): 1809-10, 2010 Apr 10.

Article in English | MEDLINE | ID: mdl-20231675

13.

PR72, a novel regulator of Wnt signaling required for Naked cuticle function.

Creyghton, Menno P; Roël, Giulietta; Eichhorn, Pieter J A; Hijmans, E Marielle; Maurer, Irma; Destrée, Olivier; Bernards, René.

Genes Dev ; 19(3): 376-86, 2005 Feb 01.

Article in English | MEDLINE | ID: mdl-15687260

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