ABSTRACT
We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. Afterwards, he received total gastrectomy with extended D2 lymphadenectomy without spleno-pancreatectomy. A pathologic complete response was obtained with a combination of trastuzumab and oxaliplatin and capecitabine. He received 3 more cycles of trastuzumab containing regimen postoperatively.We conclude that resectable gastric carcinoma with overexpression of the c-erbB-2 protein should ideally be managed with perioperative combination of trastuzumab with chemotherapy. Further research to evaluate trastuzumab in combination with chemotherapy regimens in the perioperative and adjuvant setting is urgently needed.
Subject(s)
Adenocarcinoma/therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Gastrectomy , Neoadjuvant Therapy , Perioperative Care , Receptor, ErbB-2/metabolism , Stomach Neoplasms/therapy , Adenocarcinoma/metabolism , Adenocarcinoma/pathology , Adult , Antibodies, Monoclonal, Humanized/administration & dosage , Capecitabine , Chemotherapy, Adjuvant , Combined Modality Therapy , Deoxycytidine/administration & dosage , Deoxycytidine/analogs & derivatives , Fluorouracil/administration & dosage , Fluorouracil/analogs & derivatives , Humans , Male , Neoplasm Staging , Organoplatinum Compounds/administration & dosage , Oxaliplatin , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathology , Trastuzumab , Treatment OutcomeABSTRACT
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and remains a health problem, especially in developing countries. Abdominal location represents 5 to 10% of all locations. The clinical symptoms are not very specific, and the discovery of an abdominal mass in a context of deterioration of general state may wrongly lead to the diagnosis of a tumor. Radiological explorations remain sensitive in the detection of abdominal masses but they cannot prejudge their etiology. Surgical exploration is sometimes the only recourse either for diagnostic purposes or complications, and the diagnosis can only be confirmed by bacteriological and histological examinations of the surgical specimen. We report the case of abdominopelvic mass and lymph nodes revealing tuberculosis.
ABSTRACT
INTRODUCTION: The association of bowel tumor and inguinal hernia is rare. We report according to our research the first case of the migration of a small bowel schwannoma into an inguinal hernia. CASE PRESENTATION: We report the case of a 51-year-old Moroccan malen admitted for a non-reducible right inguinal hernia in which surgical exploration showed the presence of a small bowel tumor that had migrated into his hernia sac. A histopathological examination of the tumor was in favor of a small bowel schwannoma. CONCLUSION: Small bowel schwannoma is an exceptional clinical entity for which the diagnosis is difficult; its confirmation needs histological and immunohistochemical studies.
Subject(s)
Hernia, Inguinal/complications , Ileal Neoplasms/diagnosis , Neurilemmoma/diagnosis , Humans , Ileal Neoplasms/complications , Male , Middle Aged , Neurilemmoma/complicationsABSTRACT
Pancreatic-pleural fistula is a rare condition and few data related to its diagnosis and treatment are available. A fistulous connection linking the pancreas with the pleura via the diaphragm or mediastinum through the retroperitoneal area is formed. We report on a case with pancreatic-pleural fistula at its early stages in an alcoholic male patient aged 45 years with known chronic pancreatitis. The operation by Roux-en-Y jejuno-pseudocystostomy was followed by chest tube drainage.
Subject(s)
Cholangiopancreatography, Magnetic Resonance , Pancreatic Fistula/diagnosis , Pancreatitis, Alcoholic/complications , Pleural Diseases/diagnosis , Humans , Male , Middle Aged , Pancreatic Fistula/etiology , Pleural Diseases/etiologySubject(s)
Fibroma , Pelvic Neoplasms , Female , Fibroma/diagnosis , Fibroma/surgery , Humans , Pelvic Neoplasms/diagnosis , Pelvic Neoplasms/surgery , Young AdultABSTRACT
A true cyst of the pancreas is extremely rare, and few cases have been reported in adult patients. The authors report a new case of this rare pathological entity. A 35-year-old male patient was admitted to our unit with a cystic mass, about 6cm in diameter, located in the pancreatic head, in proximity to the duodenum, vena cava, biliary tree and right kidney. Clinical features and imagery were suggestive for a benign neoplasm, as did surgical findings. Cystoduodenostomy was done. Histological finding revealed a cyst lined by cuboidal epithelium without morphologic alterations. Analysis of the cyst fluid showed a high level of CA 19-9 (10,000Uml(-1)). After 1-year follow-up, the patient was found to be doing well without any abdominal symptoms. Ultrasound images revealed no cyst recurrence.