Search | VHL Search Portal

1.

Therapy-induced APOBEC3A drives evolution of persistent cancer cells.

Isozaki, Hideko; Sakhtemani, Ramin; Abbasi, Ammal; Nikpour, Naveed; Stanzione, Marcello; Oh, Sunwoo; Langenbucher, Adam; Monroe, Susanna; Su, Wenjia; Cabanos, Heidie Frisco; Siddiqui, Faria M; Phan, Nicole; Jalili, Pégah; Timonina, Daria; Bilton, Samantha; Gomez-Caraballo, Maria; Archibald, Hannah L; Nangia, Varuna; Dionne, Kristin; Riley, Amanda; Lawlor, Matthew; Banwait, Mandeep Kaur; Cobb, Rosemary G; Zou, Lee; Dyson, Nicholas J; Ott, Christopher J; Benes, Cyril; Getz, Gad; Chan, Chang S; Shaw, Alice T; Gainor, Justin F; Lin, Jessica J; Sequist, Lecia V; Piotrowska, Zofia; Yeap, Beow Y; Engelman, Jeffrey A; Lee, Jake June-Koo; Maruvka, Yosef E; Buisson, Rémi; Lawrence, Michael S; Hata, Aaron N.

Nature ; 620(7973): 393-401, 2023 Aug.

Article in English | MEDLINE | ID: mdl-37407818

2.

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan, Vasanthi S; Ryan, Matthew J; Dhruv, Harshil D; Gill, Shubhroz; Eichhoff, Ossia M; Seashore-Ludlow, Brinton; Kaffenberger, Samuel D; Eaton, John K; Shimada, Kenichi; Aguirre, Andrew J; Viswanathan, Srinivas R; Chattopadhyay, Shrikanta; Tamayo, Pablo; Yang, Wan Seok; Rees, Matthew G; Chen, Sixun; Boskovic, Zarko V; Javaid, Sarah; Huang, Cherrie; Wu, Xiaoyun; Tseng, Yuen-Yi; Roider, Elisabeth M; Gao, Dong; Cleary, James M; Wolpin, Brian M; Mesirov, Jill P; Haber, Daniel A; Engelman, Jeffrey A; Boehm, Jesse S; Kotz, Joanne D; Hon, Cindy S; Chen, Yu; Hahn, William C; Levesque, Mitchell P; Doench, John G; Berens, Michael E; Shamji, Alykhan F; Clemons, Paul A; Stockwell, Brent R; Schreiber, Stuart L.

Nature ; 547(7664): 453-457, 2017 07 27.

Article in English | MEDLINE | ID: mdl-28678785

3.

A combinatorial strategy for treating KRAS-mutant lung cancer.

Manchado, Eusebio; Weissmueller, Susann; Morris, John P; Chen, Chi-Chao; Wullenkord, Ramona; Lujambio, Amaia; de Stanchina, Elisa; Poirier, John T; Gainor, Justin F; Corcoran, Ryan B; Engelman, Jeffrey A; Rudin, Charles M; Rosen, Neal; Lowe, Scott W.

Nature ; 534(7609): 647-51, 2016 06 30.

Article in English | MEDLINE | ID: mdl-27338794

4.

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

Shaw, Alice T; Friboulet, Luc; Leshchiner, Ignaty; Gainor, Justin F; Bergqvist, Simon; Brooun, Alexei; Burke, Benjamin J; Deng, Ya-Li; Liu, Wei; Dardaei, Leila; Frias, Rosa L; Schultz, Kate R; Logan, Jennifer; James, Leonard P; Smeal, Tod; Timofeevski, Sergei; Katayama, Ryohei; Iafrate, A John; Le, Long; McTigue, Michele; Getz, Gad; Johnson, Ted W; Engelman, Jeffrey A.

N Engl J Med ; 374(1): 54-61, 2016 Jan 07.

Article in English | MEDLINE | ID: mdl-26698910

5.

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

Chen, Zhao; Cheng, Katherine; Walton, Zandra; Wang, Yuchuan; Ebi, Hiromichi; Shimamura, Takeshi; Liu, Yan; Tupper, Tanya; Ouyang, Jing; Li, Jie; Gao, Peng; Woo, Michele S; Xu, Chunxiao; Yanagita, Masahiko; Altabef, Abigail; Wang, Shumei; Lee, Charles; Nakada, Yuji; Peña, Christopher G; Sun, Yanping; Franchetti, Yoko; Yao, Catherine; Saur, Amy; Cameron, Michael D; Nishino, Mizuki; Hayes, D Neil; Wilkerson, Matthew D; Roberts, Patrick J; Lee, Carrie B; Bardeesy, Nabeel; Butaney, Mohit; Chirieac, Lucian R; Costa, Daniel B; Jackman, David; Sharpless, Norman E; Castrillon, Diego H; Demetri, George D; Jänne, Pasi A; Pandolfi, Pier Paolo; Cantley, Lewis C; Kung, Andrew L; Engelman, Jeffrey A; Wong, Kwok-Kin.

Nature ; 483(7391): 613-7, 2012 Mar 18.

Article in English | MEDLINE | ID: mdl-22425996

6.

Systematic identification of genomic markers of drug sensitivity in cancer cells.

Garnett, Mathew J; Edelman, Elena J; Heidorn, Sonja J; Greenman, Chris D; Dastur, Anahita; Lau, King Wai; Greninger, Patricia; Thompson, I Richard; Luo, Xi; Soares, Jorge; Liu, Qingsong; Iorio, Francesco; Surdez, Didier; Chen, Li; Milano, Randy J; Bignell, Graham R; Tam, Ah T; Davies, Helen; Stevenson, Jesse A; Barthorpe, Syd; Lutz, Stephen R; Kogera, Fiona; Lawrence, Karl; McLaren-Douglas, Anne; Mitropoulos, Xeni; Mironenko, Tatiana; Thi, Helen; Richardson, Laura; Zhou, Wenjun; Jewitt, Frances; Zhang, Tinghu; O'Brien, Patrick; Boisvert, Jessica L; Price, Stacey; Hur, Wooyoung; Yang, Wanjuan; Deng, Xianming; Butler, Adam; Choi, Hwan Geun; Chang, Jae Won; Baselga, Jose; Stamenkovic, Ivan; Engelman, Jeffrey A; Sharma, Sreenath V; Delattre, Olivier; Saez-Rodriguez, Julio; Gray, Nathanael S; Settleman, Jeffrey; Futreal, P Andrew; Haber, Daniel A.

Nature ; 483(7391): 570-5, 2012 Mar 28.

Article in English | MEDLINE | ID: mdl-22460902

7.

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.

Heist, Rebecca S; Duda, Dan G; Sahani, Dushyant V; Ancukiewicz, Marek; Fidias, Panos; Sequist, Lecia V; Temel, Jennifer S; Shaw, Alice T; Pennell, Nathan A; Neal, Joel W; Gandhi, Leena; Lynch, Thomas J; Engelman, Jeffrey A; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 112(5): 1547-52, 2015 Feb 03.

Article in English | MEDLINE | ID: mdl-25605928

8.

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

Faber, Anthony C; Farago, Anna F; Costa, Carlotta; Dastur, Anahita; Gomez-Caraballo, Maria; Robbins, Rebecca; Wagner, Bethany L; Rideout, William M; Jakubik, Charles T; Ham, Jungoh; Edelman, Elena J; Ebi, Hiromichi; Yeo, Alan T; Hata, Aaron N; Song, Youngchul; Patel, Neha U; March, Ryan J; Tam, Ah Ting; Milano, Randy J; Boisvert, Jessica L; Hicks, Mark A; Elmiligy, Sarah; Malstrom, Scott E; Rivera, Miguel N; Harada, Hisashi; Windle, Brad E; Ramaswamy, Sridhar; Benes, Cyril H; Jacks, Tyler; Engelman, Jeffrey A.

Proc Natl Acad Sci U S A ; 112(11): E1288-96, 2015 Mar 17.

Article in English | MEDLINE | ID: mdl-25737542

9.

Ceritinib in ALK-rearranged non-small-cell lung cancer.

Shaw, Alice T; Kim, Dong-Wan; Mehra, Ranee; Tan, Daniel S W; Felip, Enriqueta; Chow, Laura Q M; Camidge, D Ross; Vansteenkiste, Johan; Sharma, Sunil; De Pas, Tommaso; Riely, Gregory J; Solomon, Benjamin J; Wolf, Juergen; Thomas, Michael; Schuler, Martin; Liu, Geoffrey; Santoro, Armando; Lau, Yvonne Y; Goldwasser, Meredith; Boral, Anthony L; Engelman, Jeffrey A.

N Engl J Med ; 370(13): 1189-97, 2014 Mar 27.

Article in English | MEDLINE | ID: mdl-24670165

10.

MET Exon 14 Skipping in Non-Small Cell Lung Cancer.

Heist, Rebecca S; Shim, Hyo Sup; Gingipally, Shalini; Mino-Kenudson, Mari; Le, Long; Gainor, Justin F; Zheng, Zongli; Aryee, Martin; Xia, Junfeng; Jia, Peilin; Jin, Hailing; Zhao, Zhongming; Pao, William; Engelman, Jeffrey A; Iafrate, A John.

Oncologist ; 21(4): 481-6, 2016 Apr.

Article in English | MEDLINE | ID: mdl-27022036

11.

Acquired resistance to crizotinib from a mutation in CD74-ROS1.

Awad, Mark M; Katayama, Ryohei; McTigue, Michele; Liu, Wei; Deng, Ya-Li; Brooun, Alexei; Friboulet, Luc; Huang, Donghui; Falk, Matthew D; Timofeevski, Sergei; Wilner, Keith D; Lockerman, Elizabeth L; Khan, Tahsin M; Mahmood, Sidra; Gainor, Justin F; Digumarthy, Subba R; Stone, James R; Mino-Kenudson, Mari; Christensen, James G; Iafrate, A John; Engelman, Jeffrey A; Shaw, Alice T.

N Engl J Med ; 368(25): 2395-401, 2013 Jun 20.

Article in English | MEDLINE | ID: mdl-23724914

12.

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.

O'Brien, Timothy D; Jia, Peilin; Xia, Junfeng; Saxena, Uma; Jin, Hailing; Vuong, Huy; Kim, Pora; Wang, Qingguo; Aryee, Martin J; Mino-Kenudson, Mari; Engelman, Jeffrey A; Le, Long P; Iafrate, A John; Heist, Rebecca S; Pao, William; Zhao, Zhongming.

Methods ; 83: 118-27, 2015 Jul 15.

Article in English | MEDLINE | ID: mdl-25913717

13.

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

Ebi, Hiromichi; Costa, Carlotta; Faber, Anthony C; Nishtala, Madhuri; Kotani, Hiroshi; Juric, Dejan; Della Pelle, Patricia; Song, Youngchul; Yano, Seiji; Mino-Kenudson, Mari; Benes, Cyril H; Engelman, Jeffrey A.

Proc Natl Acad Sci U S A ; 110(52): 21124-9, 2013 Dec 24.

Article in English | MEDLINE | ID: mdl-24327733

14.

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.

Oser, Matthew G; Niederst, Matthew J; Sequist, Lecia V; Engelman, Jeffrey A.

Lancet Oncol ; 16(4): e165-72, 2015 Apr.

Article in English | MEDLINE | ID: mdl-25846096

15.

Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.

Li, Danan; Shimamura, Takeshi; Ji, Hongbin; Chen, Liang; Haringsma, Henry J; McNamara, Kate; Liang, Mei-Chih; Perera, Samanthi A; Zaghlul, Sara; Borgman, Christa L; Kubo, Shigeto; Takahashi, Masaya; Sun, Yanping; Chirieac, Lucian R; Padera, Robert F; Lindeman, Neal I; Jänne, Pasi A; Thomas, Roman K; Meyerson, Matthew L; Eck, Michael J; Engelman, Jeffrey A; Shapiro, Geoffrey I; Wong, Kwok-Kin.

Cancer Cell ; 12(1): 81-93, 2007 Jul.

Article in English | MEDLINE | ID: mdl-17613438

16.

Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.

Kodack, David P; Chung, Euiheon; Yamashita, Hiroshi; Incio, Joao; Duyverman, Annique M M J; Song, Youngchul; Farrar, Christian T; Huang, Yuhui; Ager, Eleanor; Kamoun, Walid; Goel, Shom; Snuderl, Matija; Lussiez, Alisha; Hiddingh, Lotte; Mahmood, Sidra; Tannous, Bakhos A; Eichler, April F; Fukumura, Dai; Engelman, Jeffrey A; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 109(45): E3119-27, 2012 Nov 06.

Article in English | MEDLINE | ID: mdl-23071298

17.

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

Ohashi, Kadoaki; Sequist, Lecia V; Arcila, Maria E; Moran, Teresa; Chmielecki, Juliann; Lin, Ya-Lun; Pan, Yumei; Wang, Lu; de Stanchina, Elisa; Shien, Kazuhiko; Aoe, Keisuke; Toyooka, Shinichi; Kiura, Katsuyuki; Fernandez-Cuesta, Lynnette; Fidias, Panos; Yang, James Chih-Hsin; Miller, Vincent A; Riely, Gregory J; Kris, Mark G; Engelman, Jeffrey A; Vnencak-Jones, Cindy L; Dias-Santagata, Dora; Ladanyi, Marc; Pao, William.

Proc Natl Acad Sci U S A ; 109(31): E2127-33, 2012 Jul 31.

Article in English | MEDLINE | ID: mdl-22773810

18.

Not just gRASping at flaws: finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers.

Ebi, Hiromichi; Faber, Anthony C; Engelman, Jeffrey A; Yano, Seiji.

Cancer Sci ; 105(5): 499-505, 2014 May.

Article in English | MEDLINE | ID: mdl-24612015

19.

Crizotinib Resensitization by Compound Mutation.

Shaw, Alice T; Engelman, Jeffrey A.

N Engl J Med ; 374(18): 1790-1, 2016 05 05.

Article in English | MEDLINE | ID: mdl-27144862

20.

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

Katayama, Ryohei; Khan, Tahsin M; Benes, Cyril; Lifshits, Eugene; Ebi, Hiromichi; Rivera, Victor M; Shakespeare, William C; Iafrate, A John; Engelman, Jeffrey A; Shaw, Alice T.

Proc Natl Acad Sci U S A ; 108(18): 7535-40, 2011 May 03.

Article in English | MEDLINE | ID: mdl-21502504

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: