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1.

Specialized replication mechanisms maintain genome stability at human centromeres.

Scelfo, Andrea; Angrisani, Annapaola; Grillo, Marco; Barnes, Bethany M; Muyas, Francesc; Sauer, Carolin M; Leung, Chin Wei Brian; Dumont, Marie; Grison, Marine; Mazaud, David; Garnier, Mickaël; Guintini, Laetitia; Nelson, Louisa; Esashi, Fumiko; Cortés-Ciriano, Isidro; Taylor, Stephen S; Déjardin, Jérôme; Wilhelm, Therese; Fachinetti, Daniele.

Mol Cell ; 84(6): 1003-1020.e10, 2024 Mar 21.

Article in English | MEDLINE | ID: mdl-38359824

2.

CENP-B-mediated DNA loops regulate activity and stability of human centromeres.

Chardon, Florian; Japaridze, Aleksandre; Witt, Hannes; Velikovsky, Leonid; Chakraborty, Camellia; Wilhelm, Therese; Dumont, Marie; Yang, Wayne; Kikuti, Carlos; Gangnard, Stephane; Mace, Anne-Sophie; Wuite, Gijs; Dekker, Cees; Fachinetti, Daniele.

Mol Cell ; 82(9): 1751-1767.e8, 2022 05 05.

Article in English | MEDLINE | ID: mdl-35320753

3.

Enrichment of centromeric DNA from human cells.

Gamba, Riccardo; Mazzucco, Giulia; Wilhelm, Therese; Velikovsky, Leonid; Salinas-Luypaert, Catalina; Chardon, Florian; Picotto, Julien; Bohec, Mylène; Baulande, Sylvain; Doksani, Ylli; Fachinetti, Daniele.

PLoS Genet ; 18(7): e1010306, 2022 07.

Article in English | MEDLINE | ID: mdl-35853083

4.

A genetic memory initiates the epigenetic loop necessary to preserve centromere position.

Hoffmann, Sebastian; Izquierdo, Helena M; Gamba, Riccardo; Chardon, Florian; Dumont, Marie; Keizer, Veer; Hervé, Solène; McNulty, Shannon M; Sullivan, Beth A; Manel, Nicolas; Fachinetti, Daniele.

EMBO J ; 39(20): e105505, 2020 10 15.

Article in English | MEDLINE | ID: mdl-32945564

5.

Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features.

Dumont, Marie; Gamba, Riccardo; Gestraud, Pierre; Klaasen, Sjoerd; Worrall, Joseph T; De Vries, Sippe G; Boudreau, Vincent; Salinas-Luypaert, Catalina; Maddox, Paul S; Lens, Susanne Ma; Kops, Geert Jpl; McClelland, Sarah E; Miga, Karen H; Fachinetti, Daniele.

EMBO J ; 39(2): e102924, 2020 01 15.

Article in English | MEDLINE | ID: mdl-31750958

6.

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

Bermejo, Rodrigo; Capra, Thelma; Gonzalez-Huici, Victor; Fachinetti, Daniele; Cocito, Andrea; Natoli, Gioacchino; Katou, Yuki; Mori, Hiroshi; Kurokawa, Ken; Shirahige, Katsuhiko; Foiani, Marco.

Cell ; 138(5): 870-84, 2009 Sep 04.

Article in English | MEDLINE | ID: mdl-19737516

7.

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy.

Giunta, Simona; Hervé, Solène; White, Ryan R; Wilhelm, Therese; Dumont, Marie; Scelfo, Andrea; Gamba, Riccardo; Wong, Cheng Kit; Rancati, Giulia; Smogorzewska, Agata; Funabiki, Hironori; Fachinetti, Daniele.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Article in English | MEDLINE | ID: mdl-33653953

8.

Plk1 protects kinetochore-centromere architecture against microtubule pulling forces.

Lera, Robert F; Norman, Roshan X; Dumont, Marie; Dennee, Alexandra; Martin-Koob, Joanne; Fachinetti, Daniele; Burkard, Mark E.

EMBO Rep ; 20(10): e48711, 2019 10 04.

Article in English | MEDLINE | ID: mdl-31468671

9.

From evolution to function: Two sides of the same CENP-B coin?

Gamba, Riccardo; Fachinetti, Daniele.

Exp Cell Res ; 390(2): 111959, 2020 05 15.

Article in English | MEDLINE | ID: mdl-32173469

10.

Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.

Han, Joo Seok; Holland, Andrew J; Fachinetti, Daniele; Kulukian, Anita; Cetin, Bulent; Cleveland, Don W.

Mol Cell ; 51(1): 92-104, 2013 Jul 11.

Article in English | MEDLINE | ID: mdl-23791783

11.

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.

Holland, Andrew J; Fachinetti, Daniele; Zhu, Quan; Bauer, Manuel; Verma, Inder M; Nigg, Erich A; Cleveland, Don W.

Genes Dev ; 26(24): 2684-9, 2012 Dec 15.

Article in English | MEDLINE | ID: mdl-23249732

12.

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.

Fachinetti, Daniele; Bermejo, Rodrigo; Cocito, Andrea; Minardi, Simone; Katou, Yuki; Kanoh, Yutaka; Shirahige, Katsuhiko; Azvolinsky, Anna; Zakian, Virginia A; Foiani, Marco.

Mol Cell ; 39(4): 595-605, 2010 Aug 27.

Article in English | MEDLINE | ID: mdl-20797631

13.

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.

Han, Joo Seok; Vitre, Benjamin; Fachinetti, Daniele; Cleveland, Don W.

Proc Natl Acad Sci U S A ; 111(40): E4185-93, 2014 Oct 07.

Article in English | MEDLINE | ID: mdl-25246557

14.

Artificial chromosomes.

Fachinetti, Daniele; Masumoto, Hiroshi; Kouprina, Natalay.

Exp Cell Res ; 396(1): 112302, 2020 11 01.

Article in English | MEDLINE | ID: mdl-32980292

15.

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells.

Holland, Andrew J; Fachinetti, Daniele; Han, Joo Seok; Cleveland, Don W.

Proc Natl Acad Sci U S A ; 109(49): E3350-7, 2012 Dec 04.

Article in English | MEDLINE | ID: mdl-23150568

16.

Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation.

Lin, Yu-Fen; Hu, Qing; Guyer, Alison; Fachinetti, Daniele; Ly, Peter.

Methods Cell Biol ; 182: 1-20, 2024.

Article in English | MEDLINE | ID: mdl-38359973

17.

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization.

Scelfo, Andrea; Barra, Viviana; Abdennur, Nezar; Spracklin, George; Busato, Florence; Salinas-Luypaert, Catalina; Bonaiti, Elena; Velasco, Guillaume; Bonhomme, Frédéric; Chipont, Anna; Tijhuis, Andréa E; Spierings, Diana C J; Guérin, Coralie; Arimondo, Paola; Francastel, Claire; Foijer, Floris; Tost, JÓ§rg; Mirny, Leonid; Fachinetti, Daniele.

J Cell Biol ; 223(4)2024 04 01.

Article in English | MEDLINE | ID: mdl-38376465

18.

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.

Yamaguchi, Kosuke; Chen, Xiaoying; Rodgers, Brianna; Miura, Fumihito; Bashtrykov, Pavel; Bonhomme, Frédéric; Salinas-Luypaert, Catalina; Haxholli, Deis; Gutekunst, Nicole; Aygenli, Bihter Özdemir; Ferry, Laure; Kirsh, Olivier; Laisné, Marthe; Scelfo, Andrea; Ugur, Enes; Arimondo, Paola B; Leonhardt, Heinrich; Kanemaki, Masato T; Bartke, Till; Fachinetti, Daniele; Jeltsch, Albert; Ito, Takashi; Defossez, Pierre-Antoine.

Nat Commun ; 15(1): 2960, 2024 Apr 05.

Article in English | MEDLINE | ID: mdl-38580649

19.

Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly.

Nechemia-Arbely, Yael; Fachinetti, Daniele; Cleveland, Don W.

Exp Cell Res ; 318(12): 1353-60, 2012 Jul 15.

Article in English | MEDLINE | ID: mdl-22561213

20.

The KaryoCreate technology generates specific aneuploid karyotypes on demand.

Angrisani, Annapaola; Fachinetti, Daniele.

Cell Rep Methods ; 3(6): 100514, 2023 06 26.

Article in English | MEDLINE | ID: mdl-37426746

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