1.
Angew Chem Int Ed Engl
; 58(15): 4948-4952, 2019 04 01.
Article
in English
| MEDLINE
| ID: mdl-30633837
ABSTRACT
In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin-NADP+ reductase and a second enzyme-the pairs being juxtaposed within the 5-100â nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.