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Introduction: Conservative management of primary obstructive megaureter (POM) appears as the best option in patients with adequate ureteral drainage. Nevertheless, surgical intervention is indicated in cases of recurrent urinary tract Infections (UTIs), deterioration of split renal function, and significant obstruction. The gold standard includes: Ureteral reimplantation with or without tapering by open approach. Our objective is to report our results in the treatment of POM by Laparoscopic-Assisted Extracorporeal Ureteral Tapering Repair (EUTR) and Laparoscopic Ureteral Extravesical Reimplantation (LUER) and to evaluate the efficacy and security of this procedure. Materials and Methods: From January 2011 to January 2018 a retrospective study was carried out by reviewing the clinical records of 26 patients diagnosed with POM. All patients underwent laparoscopic ureteral reimplantation following Lich Gregoir technique. In cases of ureteral tapering, an EUTR was performed with Hendren technique. Results: In all patients LUER and EUTR were performed without conversion. No ureteral tapering was necessary in six patients. There were no intraoperative complications. At 3 months in postoperative, 1 patient presented a febrile UTI, and subsequently, a vesicoureteral reflux (VUR) grade III was diagnosed by voiding cystourethrogram. In this case, a redo laparoscopic surgery was performed. After long-term follow-up, all patients were asymptomatic without recurrence of POM or VUR. Conclusion: Laparoscopic-assisted EUTR and LUER following Lich Gregoir technique for POM constitutes a safe and effective option, with a success rate similar to that of open procedure. Nevertheless, larger randomized prospective trials and long-term follow-up are required to validate this technique.
Subject(s)
Laparoscopy , Ureter , Vesico-Ureteral Reflux , Humans , Child , Retrospective Studies , Prospective Studies , Treatment Outcome , Urologic Surgical Procedures/methods , Ureter/surgery , Vesico-Ureteral Reflux/surgery , Vesico-Ureteral Reflux/etiology , Laparoscopy/methods , Replantation/methodsABSTRACT
Introduction: Urofacial, or Ochoa, syndrome (UFS) is an autosomal recessive disease featuring a dyssynergic bladder with detrusor smooth muscle contracting against an undilated outflow tract. It also features an abnormal grimace. Half of individuals with UFS carry biallelic variants in HPSE2, whereas other rare families carry variants in LRIG2.LRIG2 is immunodetected in pelvic ganglia sending autonomic axons into the bladder. Moreover, Lrig2 mutant mice have abnormal urination and abnormally patterned bladder nerves. We hypothesized that peripheral neurogenic defects underlie LRIG2-associated bladder dysfunction. Methods: We describe a new family with LRIG2-associated UFS and studied Lrig2 homozygous mutant mice with ex vivo physiological analyses. Results: The index case presented antenatally with urinary tract (UT) dilatation, and postnatally had urosepsis and functional bladder outlet obstruction. He had the grimace that, together with UT disease, characterizes UFS. Although HPSE2 sequencing was normal, he carried a homozygous, predicted pathogenic, LRIG2 stop variant (c.1939C>T; p.Arg647∗). Lrig2 mutant mice had enlarged bladders. Ex vivo physiology experiments showed neurogenic smooth muscle relaxation defects in the outflow tract, containing the urethra adjoining the bladder, and in detrusor contractility. Moreover, there were nuanced differences in physiological outflow tract defects between the sexes. Conclusion: Putting this family in the context of all reported UT disease-associated LRIG2 variants, the full UFS phenotype occurs with biallelic stop or frameshift variants, but missense variants lead to bladder-limited disease. Our murine observations support the hypothesis that UFS is a genetic autonomic neuropathy of the bladder affecting outflow tract and bladder body function.
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INTRODUCTION: Laparoscopic appendicovesicostomy (LA) is a rather new technique and still a challenging procedure even for the most experienced surgeons because it requires advanced laparoscopic experience and surgical skill. The aim of this study is to analyze the short-term results and benefits of laparoscopic LA in children. MATERIALS AND METHODS: Prospective study of children undergoing LA at our institution between January 2018 and October 2021. The procedure was perfomed using a laparoscopic transperitoneal approach. The distal end of the appendix was spatulated and reimplanted in the bladder by a modified Shanfield technique. The proximal end was brought out as the cutaneous umbilical stoma. RESULTS: Over the study period 15 patients underwent LA (14 males,1 female). Mean age at intervention was 8.8 years (SD:3.1). Indication for surgery was pain during CIC in 13 (86.7%) and difficulty for CIC in 2 (13.3%). Eight patients (53.5%) presented end-stage renal disease (ESRD). Median operative time was 217.3 min (r:140-300). Two patients (13.3%) experienced early postoperative complications: ileus (1) and internal hernia over the mesoappendix with subsequent intestinal obstruction. Mean hospital stay was 6.8 days (SD:1.7). Four patients (26.7%) experienced late postoperative stoma related complications: stomal stenosis (1), granuloma (1) and inability to catheterize (2). With a mean follow-up of 21.46 months (SD: 13) all except the patent who lost the conduit are continent and on CIC every 3 h. CONCLUSIONS: We suggest that LA by this technique is effective, safe and reproducible, and is associated with good short-term results. The complication rate is similar to the open procedure being intestinal obstruction due to internal hernia probably the most serious.
Subject(s)
Intestinal Obstruction , Laparoscopy , Child , Cystostomy/methods , Female , Humans , Internal Hernia , Laparoscopy/methods , Male , Prospective Studies , Retrospective StudiesABSTRACT
INTRODUCTION: Despite survival rates after pediatric kidney transplantation (KT) are on the rise it is still likely that most pediatric recipients will require more than one retransplant in their lifetime. The earlier the age at the first KT the higher is the risk of repeat pediatric kidney transplantation (RPKT). OBJECTIVE: The current study aims to analyze the outcomes of repeat pediatric kidney transplantation (RPKT) among pediatric kidney transplant recipients focusing on surgical complications and compare the outcomes of second and subsequent grafts with those of the first kidney graft. MATERIALS AND METHODS: Retrospective study of RPKT (<18 years) undertaken between January 2000-2020. We analyzed primary etiology of renal disease, time to graft loss (GL), etiology of initial graft failure, history of acute rejection, previous delayed graft function, HLA-mismatches at the initial transplant, surgical complications and outcomes. Additionally, we compared the characteristics and outcomes of patients who underwent RPKT (group 1) with those who received a first kidney graft (group 2). RESULTS: Out of 229 kT, 59 patients underwent RPKT (26 females/33 males). At the time of RPKT median age was 11.37 years (SD:5.7). The most frequent primary renal disease was congenital nephrotic syndrome in 11 (18.6%). Fifty-four (91.5%) were on renal replacement therapy at the time of transplant. Fourty-one patients received their second KT (69.5%), 14 (23.7%) the third, 3 (5.1%) the fourth and 1 (1.7%) the fifth. Transplant graft nephrectomy (GN) was performed in 26 patients (44.1%) prior to retransplantation. Fifty-four (91.5%) received a cadaveric graft and 5 (8.5%) a living-related graft. An extraperitoneal approach was achieved in 53 patients (89.8%), whereas in the remaining 6 (10.2%) the graft was placed intraperitoneally. We observed 10 surgical complications (16.9%): 9 major which required reintervention and 1 minor (perirenal hematoma). No vascular complications were observed and none of the surgical complications were involved in graft loss. Graft survival at 1,3 and 5 years was 91%, 84% and 73% respectively. The most frequent cause of GL was chronic graft nephropathy in 15 (25.4%). After a mean follow-up of 9.40 years (SD: 4.7) only 2 patients died (3.4%), both with functioning grafts. DISCUSSION: Pediatric recipients of second and subsequent kidney grafts constitute a remarkable high-risk population but are becoming more frequent at reference pediatric transplant centers. CONCLUSIONS: RPKT is technically challenging but can yield good results. In our series overall the incidence of surgical complications and particularly vascular complications was low.
Subject(s)
Graft Survival , Kidney Diseases , Male , Female , Child , Humans , Reoperation , Retrospective Studies , Kidney , Treatment Outcome , Graft Rejection/epidemiologyABSTRACT
INTRODUCTION: In this video we aim to describe step-by-step a simplified surgical technique for the treatment of primary and secondary obstructed megaureters in children by laparoscopic extravesical ureteral reimplantation (LEUR). MATERIAL AND METHODS: A transperitoneal approach is used in all cases. The distal ureter is dissected and transected at the level of the stenosis. Detrusor fibers are divided to expose bladder mucosa and the distal ureter is introduced into the bladder to create a valve-like mechanism (modified-Shanfield technique). RESULTS: Between 2016 and 2020, 9 patients underwent LEUR (5 female, 4 male). Mean age at surgery was 31.6 months (SD:22.74) and indications were infection (2), obstruction (3), increase hydronephrosis (2) and decrease in renal differential function (2). The procedure was completed laparoscopically in all cases with a median operative time of 144 min (r: 120-160). The postoperative MAG-3 renogram revealed a non-obstructive pattern in 8/9 patients and MCUG demonstrated absence of VUR in all 8/9. With a mean follow-up of 2.4 years (SD:1.4) all are asymptomatic. CONCLUSIONS: LEUR by this new simplified technique is a feasible treatment of megaureters associated with good short and long-term results.
Subject(s)
Laparoscopy , Ureter , Ureteral Obstruction , Vesico-Ureteral Reflux , Child, Preschool , Female , Humans , Infant , Male , Replantation , Retrospective Studies , Treatment Outcome , Ureter/surgery , Ureteral Obstruction/surgery , Urologic Surgical Procedures , Vesico-Ureteral Reflux/surgeryABSTRACT
PURPOSE: To describe a simplified surgical technique for the treatment of primary and secondary obstructed megaureters in children by laparoscopic extravesical ureteral reimplantation (LEUR) and evaluate the short-term outcomes. METHODS: Prospective study of children with primary and secondary megaureters treated at our institution between 2016 and 2018 by LEUR. A transperitoneal approach was used in all cases. The distal ureter was transected at the level of the stenosis. Detrusor muscle fibers were divided to expose bladder mucosa. The distal ureter was introduced into the bladder to create a valve-like mechanism. The ureter was fixed to the bladder mucosa by four stitches. We analyzed indications for surgery, complications and outcomes. Definition of success was relieved of obstruction and absence of VUR. RESULTS: Six patients with a mean age of 28.83â¯months (SD: 21.4) underwent LEUR. Indications for surgery were: infection [2], obstruction [2], decrease in renal differential function [1] and increase in hydronephrosis [1]. There were no intraoperative complications. Resolution of hydronephrosis, obstruction and VUR was achieved in all cases. Mean follow-up was 13â¯months (SD: 6.67). CONCLUSION: LEUR for the correction of primary and secondary megaureters by this new technique is safe. The most important advantage is that this technique is simpler and more easily reproducible than conventional LEUR. However, long-term follow-up is required. TYPE OF STUDY: Prospective, observational. LEVEL OF EVIDENCE: Level III.
Subject(s)
Laparoscopy/methods , Replantation/methods , Ureter/surgery , Ureteral Obstruction/surgery , Urologic Surgical Procedures/methods , Child, Preschool , Humans , Hydronephrosis , Postoperative Complications , Prospective Studies , Treatment OutcomeABSTRACT
Introduction: Growth retardation is one of the main complications of chronic kidney disease (CKD) in children and induces a negative impact on quality of life. Materials and Methods: Retrospective analysis of all consecutive patients younger than 18 years old who received a first KT in our center between 2008 and 2018. Results: 95 first KT recipients, median age at KT of 7.83 years. At the time of KT, 65.52% of males and 54.05% females showed normal height. After transplantation, linear growth improved from -1.53 at transplant to -1.37 SDS height at the last visit. We detected a different linear growth pattern according to patient age at KT. Children younger than 3 years old exhibited the most significant growth retardation at baseline and the greatest linear growth over time (-2.29 vs. -1.82 SDS height), whereas catch-up was not observed in older patients. Multivariate analysis showed that use of corticosteroids was negatively related to SDS height at 1 year after transplantation and final SDS height only was positively associated with SDS height at KT. 44.2 and 22.1% patients received rhGH treatment before and after KT. 71.88% patients reached adulthood with normal final height. Conclusions: In our study, pediatric KT recipients exhibited a normal height in more than half of cases at KT and in more than two thirds at the final adult height. Only children younger than 6 years old presented a relevant growth catch-up after KT. Treatment with rhGH was used before and after KT with significant improvement in height.
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OBJECTIVE: Vascular thrombosis (VT) in pediatric kidney transplantation (KT) is a dreaded event that leads to graft loss in almost 100% of cases. In recent years, VT has become the most common cause of early graft loss. The aim of this study was to analyze our experience in diagnosis and treatment of VT and the impact of a new management protocol on patient outcome. METHODS: We conducted a retrospective study of 176 consecutive KT performed at our institution by the pediatric urology team between January 2000 and December 2015 and identified patients with VT. A protocol of prevention and early detection of VT was introduced in 2012. RESULTS: Out of 176 KT, nine cases of VT were identified (5.1%). The mean recipient age was 5.1 years (SD 4.9 years) and mean weight was 22.28 kg (SD 15.6 kg). Diagnosis was intraoperative in two cases and within the first 24 h after surgery in the remaining seven. Immediate surgical exploration was performed after diagnosis in all. Of the five episodes that occurred before 2012, all developed complete graft ischemia requiring transplantectomy. However, in the four cases diagnosed after 2012, graft perfusion could be restored in three, and abdominal wall closure with a mesh and delayed sequentially closure under ultrasound guidance was performed. With a follow-up of 30, 25, and 20 months, the three recovered grafts are still functioning normally. CONCLUSIONS: Increased awareness and the application of a protocol for prevention, detection and treatment of VT in pediatric KT can prevent graft loss. Immediate surgical intervention is mandatory after diagnosis. Avoiding compartment syndrome with delayed sequential closure may be useful to improve graft survival.
Subject(s)
Disease Management , Graft Survival , Kidney Transplantation/adverse effects , Postoperative Complications , Thrombosis , Child , Humans , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Postoperative Complications/therapy , Thrombosis/diagnosis , Thrombosis/etiology , Thrombosis/therapyABSTRACT
OBJECTIVE: Hemorrhagic cystitis (HC) is a serious event that can occur after hematopoietic stem cell transplantation (HSCT). Treatment goals are primarily to preserve life, and then the functionality of the bladder. There is no standard therapeutic approach for HC. Described treatment options provide low success rates and are related to potential life-threatening side effects. The aim of this study was to describe our experience in treatment of HC following HSCT. PATIENTS AND METHODS: This was a retrospective study of patients with HC treated at our institution between January 2010 and October 2016. We analyzed demographics, underlying diagnosis, and treatment modalities. RESULTS: We treated 39 patients with HC. Mean age was 9.4 years (SD 4.20) and 64% were males. Acute leukemia was the most common underlying diagnosis in 27 (69%). Mean time from HSCT to HC onset was 55.46 days (SD 112.35). HC grades were: I (3), II (21), III (8), and IV (7). BK-viuria was present in 34 patients (87.2%). Non-invasive treatment was performed in 28 patients (71.8%). The remaining 11 (28.2%) required urological intervention (all high-grade), consisting of bladder irrigation in all of these. Additional treatments consisted of: intravesical cidofovir (4), intravesical sodium hyaluronate (5), cystoscopy and clot evacuation (4), selective angioembolization (2), percutaneous nephrostomy (1), and open extraction of bladder clots and cutaneous cystotomy (1). Overall, eight patients (20.5%) died as a result of the malignancy (3 in the urological intervention group), and of these four had active HC at death. Mean follow-up was 36.2 months (SD 24.9). CONCLUSION: HC is associated with high morbidity and mortality. Treatment should be individualized and designed to prioritize survival. However, bladder function should be preserved for the future.
Subject(s)
Cystitis/therapy , Hematopoietic Stem Cell Transplantation , Hemorrhage/therapy , Postoperative Complications/therapy , Adolescent , Algorithms , Child , Child, Preschool , Female , Humans , Male , Pediatrics , Retrospective Studies , UrologyABSTRACT
BACKGROUND: Open surgery is a preferred treatment for primary obstructive megaureter (POM) in cases where the conservative treatment fails, with reported success rates of 90%-96%. OBJECTIVE: To describe our initial experience in the treatment of POM by laparoscopic-assisted extracorporeal ureteral tapering repair (EUTR) and laparoscopic ureteral extravesical reimplantation (LUER) by following Lich Gregoir technique as an alternative to open surgery. DESIGN, SETTING, AND PARTICIPANTS: A total of 7 patients with POM underwent laparoscopic-assisted extracorporeal ureteral tapering repair and ureteral extravesical reimplantation by following Lich Gregoir technique between 2011 and 2014. Postoperative follow-up included the following: Renal and bladder ultrasound, voiding cystourethrogram (VCUG), and mercaptoacetyltriglycine (MAG3) renogram were done at 6 months. Outcome Measurements and Statistical Analysis: Statistical analysis was performed by using the SPSS software package (version 15.0; SPSS, Chicago, IL), and P < .05 was considered statistically significant. Paired tests and Wilcoxon test were performed to compare pre- and post-measures. RESULTS: LUER and EUTR were completed successfully in all patients without conversion. A postoperative MAG3 renogram showed nonobstructive pattern in all patients. Statistical analysis revealed significant differences before and after surgery in the average time of elimination on the MAG3 renogram (T½ 59.10 minutes versus 13.57 minutes, P < .0001). After medium-term follow-up, the overall POM resolution was 100%. One case of vesicoureteral reflux (VUR) was found during VCUG control. A total of 7 patients were asymptomatic without recurrence of POM. CONCLUSION: Laparoscopic-assisted extracorporeal ureteral tapering repair and ureteral extravesical reimplantation by following Lich Gregoir technique for POM constitutes a safe and good option when the first line of treatment fails, with a success rate similar to the open procedure. Nevertheless, larger randomized prospective trials and long-term follow-up are required to validate this technique.
Subject(s)
Laparoscopy/methods , Ureter/surgery , Ureteral Obstruction/surgery , Urologic Surgical Procedures/methods , Child, Preschool , Female , Humans , Infant , Male , Replantation/methods , Retrospective Studies , Treatment Outcome , Vesico-Ureteral Reflux/surgeryABSTRACT
OBJECTIVE: To evaluate the correlation between different degrees of bowel intraluminal echogenicity showed by prenatal ultrasounds and the anatomic level of intestinal atresia. METHODS: We report three cases of intestinal atresia at different intestinal levels verified during the neonatal surgery with specific ultrasonographic prenatal features. Intensity of sonolucency was analyzed using the image-processing program ImageJ for quantitative measurements based on the gray-scale intensity values. RESULTS: A total of three cases are reported, a jejunal, an ileal and a colonic atresia. All cases showed intestinal dilatation. Both, jejunal and ileal atresia, showed two degrees of hypoechoic intestinal content, while colonic atresia showed hyperechogenic content dilated loop at prenatal ultrasound scan. CONCLUSIONS: We propose the use of prenatal ultrasounds echogenicity of intestinal dilated loop fluid content to help in determining the level of obstruction in bowel atresia. These are initial results, to be confirmed by a multicentric research with more cases.
Subject(s)
Colon/abnormalities , Intestinal Atresia/diagnostic imaging , Intestine, Small/abnormalities , Ultrasonography, Prenatal/methods , Adult , Colon/diagnostic imaging , Female , Humans , Infant, Newborn , Intestine, Small/diagnostic imaging , Male , Pregnancy , Retrospective Studies , Ultrasonography, DopplerABSTRACT
OBJECTIVE: Pediatric kidney transplantation (KT) in small children is assumed to be related to potential surgical complications that may cause severe morbidity and graft loss. The aim of our study was to analyze the outcome of KT recipients weighing ≤15 kg, focusing on surgical complications, associated morbidity and mortality, as well as allograft loss. METHODS: We reviewed our retrospective institutional database for recipients of KT between January 2000 and December 2014 with body weight ≤15 kg. RESULTS: Forty-four children weighing ≤15 kg, out of a total of 164 children (26.8%), received a deceased donor KT at our center during the study period. Mean weight was 10.10 ± 2.9 kg (3-15 kg), and weight was ≤10 kg in 23 patients (52.3%). The allograft was implanted intraperitoneally in two cases (4.5%) and extraperitoneally in the remaining 42 (95.5%). Two patients received a simultaneous double liver-kidney transplant. Postoperative complications appeared in 10 patients (22.7%) and eight required reintervention. Five allografts (11.4%) were lost secondary to surgical complications. No statistically significant differences in surgical complications were observed when compared with patients weighing >15 kg. Actuarial graft survival was 81% and 73% at 1 and 5 years, respectively. No significant differences in graft survival were observed compared with patients >15 kg. Mean follow-up was 84.95 ± 50 months (1-190 months). CONCLUSIONS: Our results demonstrate that KT in children weighing ≤15 kg is challenging but not associated with increased risk of surgical complications or early graft loss.
Subject(s)
Body Weight , Kidney Diseases/surgery , Kidney Transplantation/adverse effects , Postoperative Complications/epidemiology , Child , Child, Preschool , Female , Graft Survival , Humans , Infant , Kidney Diseases/diagnosis , Male , Retrospective Studies , Treatment OutcomeABSTRACT
OBJECTIVE: To review our single-center experience in managing posttransplant lymphoceles in pediatric kidney recipients. Lymphoceles are well-known complications after pediatric kidney transplantation (KT). However, there is no standard treatment for lymphoceles, and the literature lacks consensus on which is the most appropriate approach. MATERIALS AND METHODS: We reviewed our retrospective institutional database for recipients of pediatric KT performed between January 2000 and December 2015 who developed lymphoceles. RESULTS: Out of the 176 patients who underwent KT, lymphoceles occurred in 9 (5.1%) patients. The mean age of recipients in this group was 12.8 years (standard deviation [SD] 4.8) (r: 1-17) and the mean body weight was 43.1 kg (SD 18.8) (r: 9.5-69). Mean lymphocele onset was 32.2 days (SD 23.4) (r: 11-85) post transplantation. Six patients presented with increased serum creatinine from the baseline, whereas 3 patients remained asymptomatic. Ultrasound was the primary diagnostic procedure in all patients. Lymphoceles resolved spontaneously in asymptomatic patients (n = 3), and thus these patients were not further treated. All symptomatic patients (n = 6) were treated: 2 underwent percutaneous catheter drainage and 4 underwent transcatheter sclerotherapy (TS). The main sclerosing agent used was povidone-iodine. In 3 patients, TS with povidone-iodine failed, and they underwent additional procedures: 2 underwent TS with polidocanol and 1 underwent open drainage. There was no graft loss in any of the patients, and no recurrence was documented during a follow-up period of mean 30.3 months (SD 15.6) (r: 7-57). CONCLUSION: There is no gold-standard treatment for lymphoceles in children, and reports in the literature on the topic are scarce. Percutaneous catheter drainage with or without TS is safe and effective, although it can lengthen hospitalization and increase morbidity.
Subject(s)
Catheterization/methods , Drainage/methods , Kidney Transplantation/adverse effects , Lymphocele , Postoperative Complications , Povidone-Iodine/administration & dosage , Sclerotherapy/methods , Adolescent , Child , Creatinine/blood , Female , Humans , Kidney Transplantation/methods , Lymphocele/diagnostic imaging , Lymphocele/etiology , Lymphocele/physiopathology , Lymphocele/therapy , Male , Outcome and Process Assessment, Health Care , Postoperative Complications/diagnostic imaging , Postoperative Complications/physiopathology , Postoperative Complications/therapy , Sclerosing Solutions/administration & dosage , Ultrasonography/methodsABSTRACT
OBJECTIVE: To assess the results of the initial therapeutic approach to ureteroceles at our institution and the need for further interventions. PATIENTS AND METHODS: This is a retrospective study of all pediatric cases of ureterocele diagnosed at our center between January 2000 and December 2011. RESULTS: Forty-three patients were analyzed. Initial diagnoses were ureterohydronephrosis in 34 (33 prenatal), febrile urinary tract infection in 5, and prolapsed ureterocele in 3. Expectant management was decided upon in 6 patients (14%). Of these, 1 required surgery. The remaining 37 (86%) initially underwent surgery: transurethral puncture (18), heminephrectomy (14), nephrectomy (3), and reimplantation (2). Twelve (66.6%) of the 18 patients who underwent primary puncture progressed well and required no further intervention. New-onset vesicoureteral reflux to the upper pole appeared after puncture in 3 patients, but none required treatment. Only 6 patients (33.3%) underwent a second procedure. Mean follow-up was 8.5 years (standard deviation: 3.08). CONCLUSION: Early endoscopic puncture is useful for decompression and often the definitive treatment. Although new-onset vesicoureteral reflux into the punctured system is the most common complication, it often resolves spontaneously. Early heminephrectomy in patients with nonfunctioning upper moieties yields excellent results but may not be necessary. Some patients may not need transurethral puncture or any surgical intervention at all.
Subject(s)
Ureterocele/therapy , Clinical Protocols , Female , Humans , Infant , Male , Retrospective Studies , Treatment OutcomeABSTRACT
OBJECTIVE: In this study we aim to demonstrate that robot-assisted laparoscopic (RAL) reoperative repair is safe and effective and even less technically demanding than open repair for recurrent ureteropelvic-junction obstruction (UPJO). STUDY DESIGN: A retrospective study was conducted of all cases of failed open pyeloplasties who underwent RAL reoperative repair at our institution between January 2010 and December 2013. The general surgical procedure was the same we previously described for robot-assisted laparoscopic pyeloplasty. Success was defined as: improvement in the degree of hydronephrosis at ultrasound, improvement of diuretic washout time at postoperative diuretic renogram (<15 min), improvement or at least stable differential renal function and absence of symptoms. These radiographic and symptomatic criteria of success were considered the primary outcomes. Secondary outcomes included complications and length of hospital stay. RESULTS: Between 2000 and 2013 a total of 153 patients underwent open Anderson-Hynes dismembered pyeloplasty. Of these 9 (6%) had recurrent UPJO. Four patients underwent open redo pyeloplasty. As a result, our study population comprised 5 children who underwent reoperative RALP repair. Patient characteristics and outcomes are summarized in the table below. Our success rate was 100%. DISCUSSION: Due to the low failure rate of open dismembered pyeloplasty there is no consensus on the best surgical approach for recurrent obstruction. While endoscopic approaches have been favored in adults, children have shown better success rates with repeat pyeloplasty. Laparoscopic salvage pyeloplasty for failed open procedures has become more popular and has been shown to result in excellent outcomes while providing the advantages of minimally invasive surgery. To date, the literature regarding the use of RALP for failed open procedures in the pediatric population is scarce. Only 2 pediatric series of robotic reoperative pyeloplasty have been reported by Helmal et al. (9 patients) and Lindgren et al. (16 patients) with a success rate of 100 and 88%, respectively. Although this is one of the first published studies about robot-assisted laparoscopic reoperative repair for failed open pyeloplasty in pediatric patients, we acknowledge the limitations of our study due to the small number of patients, its retrospective nature and limited follow-up time. CONCLUSIONS: The incidence of failed open pyeloplasty is as low as 5% and management remains controversial. As reported by other authors, we believe that crossing vessels play a particularly important role in secondary obstruction and adversely impact the outcome. Redo pyeloplasty, open or minimally invasive, is associated with high success rates (80-100%) and therefore considered the treatment of choice by the majority of authors nowadays. Additionally, RALP for secondary procedures has demonstrated to be safe and even less technically demanding when compared to the open approach, providing the advantages of minimally invasive surgery.
Subject(s)
Kidney Pelvis/surgery , Robotic Surgical Procedures/methods , Ureteral Obstruction/surgery , Urologic Surgical Procedures/adverse effects , Adolescent , Child , Cohort Studies , Constriction, Pathologic/surgery , Feasibility Studies , Female , Follow-Up Studies , Humans , Kidney Pelvis/pathology , Male , Minimally Invasive Surgical Procedures/methods , Postoperative Complications/diagnosis , Postoperative Complications/surgery , Reoperation/methods , Retrospective Studies , Risk Assessment , Robotic Surgical Procedures/adverse effects , Time Factors , Treatment Outcome , Ureteral Obstruction/diagnosis , Urologic Surgical Procedures/methodsABSTRACT
Fonament: El traumatisme cranioencefàlic (TCE) és una entitat freqüent en l'edat pediàtrica. El risc de l'ús d'exploracions que sotmeten el pacient a radiació durant la seva valoració inicial fa necessari determinar quins pacients obtindran un benefici diagnòstic amb aquestes exploracions. Objectiu: Revisar el maneig dels infants amb TCE atesos a urgències valorant la utilització d'exploracions complementàries i l'eficàcia en detectar fractures cranials o lesions intracranials. Mètode: Estudi retrospectiu dels pacients diagnosticats de TCE a urgències d'un hospital terciari entre maig i setembre de 2013. Es va fer un estudi descriptiu de dades epidemiològiques, clíniques i exploracions complementàries i un de comparatiu valorant les diferències teòriques resultants d'aplicar tres protocols: protocol de l'hospital mateix (A), protocol de la Societat Espanyola d'Urgències Pediàtriques (SEUP) (B) i maneig del pacient amb TCE lleu proposat per l'American Academy of Pediatrics i el grup de Schutzman et al. (C). Resultats: De 377 pacients estudiats, es van fer radiografies de crani (RxC) a 208 ( 55%) i tomografies cranials (TC)a 49 (13%). Si s'hagués aplicat el protocol B, s'hauria reduït el nombre d'RxC (104; 28%) i augmentat el de TC (61; 16%). Utilitzant el protocol C s'haurien fet menys RxC (3; 1%) i menys TC (31; 8%). El 4,2% dels pacients van presentar fractura cranial i l'1,5% hematoma intracranial (0,5% ambdues). Aplicant estrictament cada protocol per separat s'hauria observat la mateixa taxa d'error diagnòstic. Conclusions: No hi ha diferències entre els protocols pel que fa a l'eficàcia diagnòstica, malgrat les diferències en les exploracions d'imatge fetes, i això fa concloure que cal promoure protocols que redueixin l'exposició a la radiació
Fundamento: El traumatismo craneoencefálico (TCE) es una entidad frecuente en la edad pediátrica. El riesgo del uso de exploraciones que someten al paciente a radiación durante su valoración inicial hace necesario determinar qué pacientes obtendrán un beneficio diagnóstico con estas exploraciones. Objetivo: Revisar el manejo de los niños con TCE atendidos en urgencias valorando la utilización de exploraciones complementarias y la eficacia en detectar fracturas craneales o lesiones intracraneales. Método: Estudio retrospectivo de los pacientes diagnosticados de TCE en urgencias de un hospital terciario entre mayo y septiembre de 2013. Se realizó un estudio descriptivo de datos pidemiológicos, clínicos y exploraciones complementarias y uno de comparativo valorando las diferencias teóricas resultantes de aplicar tres protocolos: protocolo del propio hospital (A), protocolo de la Sociedad Española de Urgencias Pediátricas (SEUP) (B) y manejo del paciente con TCE leve propuesto por la American Academy of Pediatrics y el grupo de Schutzman et al. (C). Resultados: De 377 pacientes estudiados, se realizaron radiografías de cráneo (RxC) en 208 (55%) y tomografías craneales (TC) en 49 (13%). De haberse aplicado el protocolo B, se hubiera reducido el número de RxC (104; 28%) con aumento de TC (61; 16%). Utilizando el protocolo C se hubieran realizado menos RxC (3; 1%) y menos TC (31; 8%). El 4,2% de los pacientes presentaron fractura craneal y el 1,5% hematoma intracraneal (0,5% ambas). Aplicando estrictamente cada protocolo por separado se hubiera observado la misma tasa de fallo diagnóstico. Conclusiones: No existen diferencias entre los protocolos en cuanto a su eficacia diagnóstica a pesar de las diferencias en las xploraciones de imagen realizadas. Este hecho nos hace concluir que es necesario promocionar protocolos que reduzcan la exposición a radiación
Background: Traumatic brain injury (TBI) is a common entity in the pediatric age. The risk associated with radiation exposure makes it necessary to determine which patients will benefit from brain imaging. Objective: To review the management of children with TBI in the emergency department of a tertiary hospital. Method: Retrospective study of patients seen between May and September 2013. Two studies were performed. The first was a descriptive study of the epidemiological, clinical, and diagnostic data. In the second study, we compared the potential differences resulting from applying three separate diagnostic algorithms: the hospital's own protocol (A), the protocol of the Spanish Society of Paediatric Emergency Medicine (SEUP)(B), and the guidelines proposed by the American Academy of Pediatrics and Schutzman et al. for the management of mild TBI (C). Results: Of 377 patients studied, skull radiographs were performed in 208 (55%) and head CT scans in 49 (13%). Had the B protocol been applied, the number of skull radiographs would have been reduced (104; 28%), with an increase in the number of head CT scans (61; 16%). Using protocol C, less skull radiographs (3; 1%) and head CT scans (31; 8%) would have been performed. 4.2% of patients were diagnosed with a skull fracture, 1.5% were found to have an intracranial hematoma, and 0.5% had both. The strict application of each protocol separately would have resulted in the same diagnostic failure rate. Conclusions: No differences in diagnostic rates were found between the three protocols despite the different recommendations for diagnostic imaging studies. Thus, the application of protocols that reduce radiation exposure should be recommended