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Primary peritonitis due to Streptococcus pyogenes with reduced susceptibility to fluoroquinolones.
Doloy, Alexandra; Godin, Claire; Decousser, Jean-Winoc; Panel, Pierre; Greder-Belan, Alix; Doucet-Populaire, Florence.
Diagn Microbiol Infect Dis ; 62(4): 447-9, 2008 Dec.
Article in English | MEDLINE | ID: mdl-18842379

ABSTRACT

We report the 1st case of primary peritonitis caused by Streptococcus pyogenes with a reduced susceptibility to fluoroquinolones in a healthy woman, leading to a clinical and microbiological treatment failure. DNA sequencing of parC and gyrA revealed the association of the following 3 substitutions in ParC: Ser80Pro, Asp91Asn, and Ser140Pro.


Subject(s)
Anti-Bacterial Agents/pharmacology , Drug Resistance, Multiple, Bacterial , Fluoroquinolones/pharmacology , Peritonitis/microbiology , Streptococcal Infections/microbiology , Streptococcus pyogenes/drug effects , Adult , Female , Humans , Peritonitis/drug therapy , Streptococcal Infections/drug therapy
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