The survival and flight capacity of commercial honeybees and endangered stingless bees are impaired by common agrochemicals.

The impact of agrochemicals on native Brazilian bees may be underestimated, since studies of non-target effects on bees have, by and large, concerned mostly the Apis mellifera L. Furthermore, bees may be exposed in the field to multiple agrochemicals through different routes, thus suggesting the necessity for more comprehensive toxicological experiments. Here, we assessed the lethal and sublethal toxicity of multiple agrochemicals (herbicide [glyphosate - Roundup®], fungicide [mancozeb], insecticide [thiamethoxam]) through distinct routes of exposure (contact or ingestion) to an endangered native Brazilian bee Melipona (Michmelia) capixaba Moure & Camargo, 1994 and to A. mellifera. Results indicate that none of the agrochemicals caused feeding repellency on the bees. Thiamethoxam caused high mortality of both species, regardless of the route of exposure or the dose used. In addition, thiametoxam altered the flight capacity of M. capixaba when exposed to the lowest dose via contact exposure. The field dose of glyphosate caused high mortality of both bee species after oral exposure as well as impaired the flight capacity of A. mellifera (ingestion exposure) and M. capixaba (contact exposure). The lower dose of glyphosate also impaired the flight of M. capixaba through either routes of exposure. Exposure of A. mellifera through contact and ingestion to both doses of mancozeb caused high mortality and significantly impaired flight capacity. Taken altogether, the results highlight the importance of testing the impact of multiple agrochemicals (i.e. not just insecticides) through different routes of exposure in order to understand more comprehensively the potential risks for Apis and non-Apis bees.

Honeybee survival and flight capacity are compromised by insecticides used for controlling melon pests in Brazil.

The extensive use of insecticides can cause adverse side effects on pollinators, which negatively impact crop productivity. The pollination carried out by the honeybee Apis mellifera L. (Hymenoptera: Apidae) is crucial in increasing the productivity of the melon (Cucumis melo L.). The main objective of this study was to assess if insecticides applied in the cultivation of cantaloupe melon exhibit significant levels of toxicity toward A. mellifera. We tested the toxicity of azadirachtin, pyriproxyfen, chlorantraniliprole, and imidacloprid, which are commonly sprayed to manage melon pests such as the whitefly Bemisia tabaci (Genn.) (Hemiptera: Aleyrodidae), the pickleworm Diaphania nitidalis (Stoll) and the melonworm Diaphania hyalinata (L.) (Lepidoptera: Pyralidae). Three treatments were carried out, 0.0×, 0.1x and 1.0x the concentration recommended by the manufacturer for the control of those pests. Repellency tests, analysis of mortality through contact and ingestion, and flight tests were performed. The insecticide imidacloprid caused mortality rates above 90% in all tested exposure pathways, displaying high residue persistence on plants. Although not causing significant mortality in the ingestion test, pyriproxyfen caused significant mortality after exposure through contact, and change in flight ability. Azadirachtin caused mortality in the ingestion test and impaired the flight ability of bees, while chlorantraniliprole only impaired the flight ability. Moreover, bees were not repelled by these insecticides, suggesting that they may collect contaminated food in the field while foraging. Altogether, ecofriendly, alternative pest control options should be developed, as well as the adoption of more selective insecticides, in order to reduce the non-target effects on honeybees and guarantee their pollination services.

Validation of two-channel sequencing-by-synthesis for noninvasive prenatal testing of fetal whole and partial chromosome aberrations.

OBJECTIVE: To validate Illumina's two-channel NextSeq 500 sequencing system for noninvasive prenatal testing (NIPT) of fetal whole chromosome and partial aberrations. METHODS: A total of 162 plasma samples, previously sequenced for NIPT on a SOLiD 5500xl platform, were sequenced on the NextSeq 500 using 75-bp single-end sequencing, followed by analysis using the WISECONDOR algorithm. RESULTS: For whole chromosome aneuploidy detection, all samples were classified correctly (in total 3× T13, 3× T18, 8× T21 and 145× euploid). Three partial aberrations (36-Mb terminal loss of 5p, 14-Mb gain on 18p and 33-Mb terminal loss of 13q) were also correctly identified. Fetal fractions in 34 male samples sequenced on both the SOLiD 5500xl and NextSeq 500 platform showed no significant difference. To test robustness, two sample sets, containing both euploid and aneuploid samples, were sequenced on different NextSeq 500 machines, revealing identical results. With unchanged laboratory flow, the NIPT turnaround time could be reduced from 15-16 calendar days to 7-8 calendar days, after switching from the SOLiD 5500xl to the NextSeq 500 platform. CONCLUSIONS: The NextSeq 500 platform can be used for NIPT to detect both whole and partial chromosome aberrations. It has fast turnaround times and is suitable for mid-sized laboratories.

Model of transpersonal caring in nursing home care according to Favero and Lacerda: case report. / Modelo de cuidado transpessoal de enfermagem domiciliar de Favero e Lacerda: relato de caso.

OBJECTIVE: The aim of this paper is to report the experiences of applying a model of transpersonal caring in nursing home care according to Favero and Lacerda to adult patients after hematopoietic stem cell transplantation. METHOD: This is a case report on the application of this model to an outpatient monitored by a bone marrow transplant service. In addition to the initial outpatient contact, the patient received home care visits in October 2014. Data were recorded in the field diary and analysed according to the Care Model and Clinical Caritas Process. RESULTS: The provided care served as support to meet basic human needs, and strengthen the belief system. It also promoted the necessary emotional care to cope with the treatment and professional maturity in the caring relationship. CONCLUSION: The experience description revealed that the model can support the application of the Theory of Human Caring in home care and the use of care models in practice, professional training, and research development.

[The network social support experience of people involved in home care]. / A vivência do apoio da rede social pelas pessoas envolvidas no cuidado domiciliário.

OBJECTIVE: To build a theoretical model to configure the network social support experience of people involved in home care. METHOD: A quantitative approach research, utilizing the Grounded Theory method. The simultaneous data collection and analysis allowed the interpretation of the phenomenon meaning The network social support of people involved in home care. RESULTS: The population passive posture in building their well-being was highlighted. The need of a shared responsibility between the involved parts, population and State is recognized. CONCLUSION: It is suggested for nurses to be stimulated to amplify home care to attend the demands of caregivers; and to elaborate new studies with different populations, to validate or complement the proposed theoretical model.

Monochorionic dizygous twins presenting with blood chimerism and discordant sex.

Monochorionic dizygous twins are probably more frequent than considered previously as many cases remain unrecognized, especially when the children have the same sex. Here we present a pair of dizygous, sex-discordant monochorionic twins who were conceived after artificial insemination. Histological examination of the placenta and extensive genetic studies of the healthy boy and girl clearly proved that they indeed were monochorionic dizygous twins with a fully joined blood circulation. We conclude that when counseling parents expecting monochorionic twins of discordant sex, not only a disorder of sexual differentiation in one of the twins should be addressed but also the possibility of dizygosity with a completely normal (sexual) development of both children.

Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait.

Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1ß, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.

Construction of a nursing care protocol for children in post-hematopoietic stem cell transplantation.

OBJECTIVE: To construct a nursing care protocol for children in post-hematopoietic stem cell transplantation. METHOD: Methodological research carried out from January to September 2019, in three steps: (a) integrative review (nursing care was identified); (b) theoretical structuring and organization of healthcare based on the Theory of Basic Human Needs and on the International Classification for Nursing Practice (supplementing the review data); and (c) development of a protocol in the three previously mentioned stages. Analysis of the understanding of the protocol's items/care was performed by three specialist nurses. RESULTS: The care protocol consists of 40 nursing problems and is organized in accordance with the psychobiological, psychosocial, and psycho-spiritual needs of children undergoing transplantation, integrating practical and guidance care. CONCLUSION: The care protocol is an important technology for nursing care to transplanted children, aimed to prevent and manage transplantation complications.

Nursing care for patients in post-transplantation of hematopoietic stem cells: an integrative review.

OBJECTIVES: to analyze the available evidence on the nursing care provided to patients after hematopoietic stem cell transplantation. METHODS: integrative review with the search for primary studies in four databases and a virtual health library. A broad search strategy was used, including research published in English, Brazilian Portuguese, or Spanish, between 2008 and 2018, totaling a sample of 42 studies. RESULTS: the studies were grouped into three categories: multiple nursing care (n=19), first-line care (n=18), and self-management of care (n=5). CONCLUSIONS: nursing care is critical, comprising patients' physical, psychological and social aspects. It occurs in hospital and home contexts, mainly involving technical actions and health guidance. The evidence identified provide subsidies for decision-making; however, most studies are of the non-experimental type, indicating the need for conducting intervention research.

Juliano Moreira: the black Brazilian who greatly influenced the modern school of Neurology in Brazil.

Juliano Moreira was a black Brazilian physician, well recognized for his role in the foundation of scientific psychiatry in Brazil; however, little is known about his influences on modern Neurology. Our aim is to highlight Moreira's importance in the field of Neurology and his role in the development of scientific and medical societies in Brazil. We describe his contributions from his doctoral thesis in 1891 to his 27-year tenure as the director of the National Hospice for the Insane. We also review Moreira's role in the foundation of societies including the Brazilian Academy of Sciences and the first Brazilian journal dedicated to Neuropsychiatry, concluding that Moreira was one of the most important influential figures for the development of Neurology in Brazil. In addition to his influences on various medical fields, Moreira distinguished himself as an impactful citizen who fought against racist and xenophobic medical theories of his time.

Treatment of Chronic Spinal Cord Injury in Dogs Using Amniotic Membrane-Derived Stem Cells: Preliminary Results.

INTRODUCTION: Intervertebral disc diseases (IVDD) represent the majority of neurological attendance and responsible for the most cases of paralysis in dogs. Treatments currently used do not show satisfactory results in patients with more severe and chronic neurological manifestations. METHODS: To promote nerve and muscular recovery, as well as improve quality of life, we aimed to create a double-blind test method, associating spinal decompression surgery and allogeneic transplantation of amniotic membrane-derived stem cells (AMSCs) in dogs with chronic IVDD. Cells were characterized as fetal mesenchymal cells and safe for application. Eight animals completed the experiment: stem cell applications were made in four animals that had previously undergone an unsuccessful surgical procedure ("SC group", n = 4); two animals were submitted to surgery, followed by applications of stem cells ("Surgery + SC", n = 2); two other animals were submitted to surgery, followed by the application of saline solution ("Surgery + placebo", n = 2). During the surgical procedure, a topical application was performed on the lesion and after fifteen and forty-five days another two applications were made via epidural. Animals were monitored biweekly and reassessed three months after surgery, by functional tests and magnetic resonance exams. RESULTS: Some animals presented significant neurological improvement, such as the recovery of nociception and ability to remain on station. Despite the need further studies, until the present moment, cell therapy has been feasible and has no harmful effects on animals. CONCLUSION: The protocol of preclinical trial showed the association with decompressive surgery and cell transplantation in dogs with thoracolumbar IVDD proved feasible, and it was possible to observe neurological improvement after treatment. No tissue improvement through MRI was found. The double-blind test guaranteed reliability of the evaluations and results obtained that, even with a small sample size, generated satisfactory results for the animals and owners.

Care performed by family caregivers of children submitted to hematopoietic stem cell transplantation.

OBJECTIVE: to know the care provided by family caregivers of children submitted to hematopoietic stem cell transplantation. METHOD: the Grounded Theory was used as methodology. The study comprised four sample groups, comprising 36 caregivers. Data were collected by semi-structured interviews and analyzed according to the coding proposed by Strauss and Corbin in three phases: open, axial and selective. RESULTS: eight propositions were identified for the care provided to the child in the researched context, namely administering medications; attention to cleaning issues; care with water and food intake; care with the body; experiencing protective isolation; addressing the child's need for emotional support; addressing the child's self-care; and facing complications. CONCLUSION: the different aspects in which the caregiver acts in the care of the child were understood. Such care equips the health team to elaborate measures for guidance and preparation of home care that are effective and directed to the needs of the patient and their family. The understanding of the care that they accomplish enables the caregiver a greater understanding of their role, as well as of the decisions they will make by their being under treatment.

Canine fetus immune system at late development.

The immune system is mainly responsible for protecting the organism against agents that may interfere in its homeostasis. Thus, understand how this system develops and operates is very important, for create new therapies to assist this system in its operation, such as its failure. In domestic dogs, few studies show how actually occurs the development, maturation and functioning of the immune system. Therefore, this study demonstrates the development and possible activation of it on dog fetus from late gestational period by in situ and microscopic analyzes.

Enhancing the process of teaching and learning homecare.

OBJECTIVE: to identify possibilities for improvement in the process of teaching and learning homecare in nursing, pharmacy, medicine, nutrition, dentistry and occupational therapy courses. METHOD: qualitative research using the Grounded Theory approach. Sixty-three semi-structured interviews were conducted with students, teachers and graduates of the six mentioned courses at a public university in the south of Brazil. Data analysis was performed through open, axial and selective coding. RESULTS: the possibilities for improving the process of teaching and learning homecare included: scientific production in the area; use of different teaching techniques; development of extracurricular activities; extension projects; curricular reformulation; and laboratory simulation. FINAL CONSIDERATIONS: the strategies cited in this study enable undergraduate courses in health to envisage the possibility of enhance the process of teaching and learning homecare.

Qualidade de vida na hiperidrose: uma reflexão da literatura para o campo da Terapia ocupacional / Quality of life in hyperidrosis: a reflection of literature for the field of Occupational Therapy / Calidad de vida en hiperidrosis: reflexión de la literatura para el campo de la Terapia Ocupacional

ntrodução: A hiperidrose primária é uma condição caracterizada pela excessiva produção de suor. É considerada uma disfunção crônica que atinge aproximadamente 1% da população mundial. Não possui origem conhecida, mas está ligada à hiperatividade do sistema nervoso simpático. Objetivo: Compreender, através da literatura, quais os impactos gerados pela hiperidrose no que se refere à qualidade de vida dos sujeitos acometidos e relacionar os aspectos da qualidade de vida com as ocupações dos mesmos, tendo o terapeuta ocupacional como possível membro integrante da equipe multiprofissional na atenção aos sujeitos comprometidos com hiperidrose. Método: Levantamento bibliográfico de publicações periódicas nas bases de dados BVS, Scielo e Google Acadêmico, artigos completos em português e espanhol. Resultados: Foram encontrados um total de 50 artigos, destes, 19 artigos permaneceram após a leitura na íntegra. A maioria dos relatos sobre a qualidade de vida dos sujeitos com hiperidrose é referida ou está atrelada a algum procedimento médico, sendo escassos estudos de outras áreas profissionais. Quanto à atuação terapêutica ocupacional junto à sujeitos com hiperidrose, não encontramos citações. Conclusão: O estudo demonstrou que os impactos gerados podem ser atribuídos às dificuldades no desempenho de atividades cotidianas, além de afetar aspectos emocionais dos sujeitos, interferindo em suas relações pessoais, na participação social e nas atividades de autocuidado. Sugere-se o desenvolvimento de pesquisas no âmbito da Terapia Ocupacional, para o fomento de debates que promovam aprimoramento técnico da profissão na assistência a pacientes com hiperidrose.(AU) Palavras-chave: Hiperidrose. Qualidade de Vida. Terapia Ocupacional. Atividades Cotidianas. Ocupações.

Introduction: Primary hyperhidrosis is a condition characterized by excessive sweat production. It is considered a chronic dysfunction that affects approximately 1% of the world population. It has no known origin but is linked to hyperactivity of the sympathetic nervous system. Objective: To understand through the literature the impacts generated by hyperhidrosis about the quality of life of the affected and to relate the aspects of quality of life with their occupations, having the occupational therapist as a possible integral member of the multiprofessional team in dealing with problems committed to hyperhidrosis. Method: Bibliographic survey of periodical publications in the BVS, Scielo and Google Scholar databases, complete articles in Portuguese and Spanish. Results: A total of 50 articles were found, of these, 19 articles remained after reading them in full. Most reports on the quality of life of subjects with hyperhidrosis are referred to or linked to some medical procedure, with few studies from other professional areas. As for the occupational therapeutic performance with subjects with hyperhidrosis, we did not find any citations. Conclusion: The study demonstrated that the impacts generated can be attributed to difficulties in the performance of daily activities, in addition to affecting the emotional aspects of the subjects, interfering in their personal relationships, in social participation and in self-care activities. We suggest the development of research in the context of Occupational Therapy, to encourage debates that promote technical improvement of the profession in assisting patients with hyperhidrosis.(AU) Keywords: Hyperhidrosis. Quality of Life. Occupational Therapy. Activities of Daily Living. Occupations.

Introdución: La hiperhidrosis primaria es una condición caracterizada por una producción excesiva de sudor. Se considera una disfunción crónica que afecta aproximadamente al 1% de la población mundial. No tiene un origen conocido, pero está relacionado con la hiperactividad del sistema nervioso simpático. Objetivo: Comprender, a través de la literatura, los impactos que genera la hiperhidrosis en cuanto a la calidad de vida de los sujetos afectados y relacionar los aspectos de la calidad de vida con sus ocupaciones, con el terapeuta ocupacional como posible integrante de la multidisciplinariedad. equipo en la atención a sujetos comprometidos con hiperhidrosis. Método: Estudio bibliográfico de publicaciones periódicas en las bases de datos de la BVS, Scielo y Google Scholar, artículos completos en portugués y español. Resultados: Se encontraron un total de 50 artículos, de estos, quedaron 19 artículos después de leerlos íntegramente. La mayoría de los informes sobre la calidad de vida de los sujetos con hiperhidrosis están referidos os vinculados a algún procedimiento médico, con pocos estudios de otras áreas profesionales. En cuanto al desempeño terapéutico ocupacional con sujetos con hiperhidrosis, no encontramos citas. Conclusión: El estudio demostró que los impactos generados pueden atribuirse a dificultades en el desempeño de las actividades diarias, además de afectar los aspectos emocionales de los sujetos, interfiriendo en sus relaciones personales, participación social y actividades de autocuidado. Sugerimos el desarrollo de investigaciones en el contexto de la Terapia Ocupacional, para fomentar debates que promuevan la mejora técnica de la profesión en la asistencia a pacientes con hiperhidrosis.(AU) Palabras clave: Hiperhidrosis. Calidad de vida. Terapia ocupacional. Actividades diarias. Ocupaciones.

Construction of a nursing care protocol for children in post-hematopoietic stem cell transplantation / Construcción de protocolo de cuidados de enfermería para niños después del trasplante de células tronco hematopoyéticas / Construção de protocolo de cuidados de enfermagem à criança no pós-transplante de células-tronco hematopoiéticas

ABSTRACT Objective: To construct a nursing care protocol for children in post-hematopoietic stem cell transplantation. Method: Methodological research carried out from January to September 2019, in three steps: (a) integrative review (nursing care was identified); (b) theoretical structuring and organization of healthcare based on the Theory of Basic Human Needs and on the International Classification for Nursing Practice (supplementing the review data); and (c) development of a protocol in the three previously mentioned stages. Analysis of the understanding of the protocol's items/care was performed by three specialist nurses. Results: The care protocol consists of 40 nursing problems and is organized in accordance with the psychobiological, psychosocial, and psycho-spiritual needs of children undergoing transplantation, integrating practical and guidance care. Conclusion: The care protocol is an important technology for nursing care to transplanted children, aimed to prevent and manage transplantation complications.

RESUMEN Objetivo: Construir un protocolo de cuidados de enfermería para niños después del trasplante de células tronco hematopoyéticas. Método: Investigación metodológica realizada entre enero y septiembre de 2019 para construir un protocolo, en tres etapas: a) realización de revisión integradora (fueron identificados cuidados de enfermería); b) estructuración y organización teórica de cuidados a partir de la Teoría de las Necesidades Humanas Básicas y de la Clasificación Internacional para la Práctica de Enfermería, complementando los datos de la revisión; y, c) desarrollo del protocolo, cuya elaboración integró las etapas anteriores. El análisis de comprensión de ítems/cuidados del protocolo fue realizado por tres enfermeras especialistas. Resultados: El protocolo de cuidados está compuesto por 40 problemas de enfermería y está organizado de acuerdo con las necesidades psicobiológicas, psicosociales y psicoespirituales de niños sometidos a trasplante, integrando cuidados prácticos y de orientación. Conclusión: El protocolo de cuidados es una opción tecnológica para la asistencia de enfermería al niño trasplantado, con los objetivos de prevención y manejo de las complicaciones del trasplante.

RESUMO Objetivo: Construir protocolo de cuidados de enfermagem à criança no pós-transplante de células-tronco hematopoiéticas. Método: Pesquisa metodológica conduzida entre janeiro e setembro de 2019 e, em três etapas: a) realização de revisão integrativa (cuidados de enfermagem foram identificados); b) estruturação e organização teórica de cuidados a partir da Teoria das Necessidades Humanas Básicas e da Classificação Internacional para a Prática de Enfermagem, complementando os dados da revisão; c) desenvolvimento do protocolo, cuja elaboração integrou as etapas anteriores. A análise de compreensão de itens/cuidados do protocolo foi realizada por três enfermeiros especialistas. Resultados: O protocolo de cuidados é composto por 40 problemas de enfermagem e está organizado de acordo com as necessidades psicobiológicas, psicossociais e psicoespirituais de crianças submetidas ao transplante, integrando cuidados práticos e de orientação. Conclusão: O protocolo é opção tecnológica para a assistência de enfermagem à criança transplantada, com vistas à prevenção e manejo das complicações.

The experience of family care in transitional support houses. / A vivência do cuidado familiar em casas transitórias de apoio.

OBJECTIVE: to present the theoretical model that represents the experience of care in transitional homes of support to families of children in a period of post-transplantation of hematopoietic stem cells. METHOD: grounded theory, performed with 18 participants from three different samples. For analysis, we used the QSR Nvivo10 software. RESULTS: we elaborated four categories: living in the transitional support home; experiencing care of children in post-transplantation of hematopoietic stem cells; taking care of the family caregiver; and returning to a new life at home, which interrelate according to the theoretical code of the interactive family. CONCLUSION: this research contributes to understanding the experience of care in transitional support homes of families with children in post-transplantation of hematopoietic stem cells and subsidizes nursing and health actions provided to this population; it also contributes to the development of a hospital discharge guidance and care directed to this clientele.

Responses of woody Cerrado species to rising atmospheric CO2 concentration and water stress: gains and losses.

The rise in atmospheric CO2 concentration ([CO2]) has been accompanied by changes in other environmental factors of global climate change, such as drought. Tracking the early growth of plants under changing conditions can determine their ecophysiological adjustments and the consequences for ecosystem functions. This study investigated long-term ecophysiological responses in three woody Cerrado species: Hymenaea stigonocarpa Mart. ex Hayne, Solanum lycocarpum A. St.-Hil. and Tabebuia aurea (Silva Manso) Benth. and Hook. f. ex S. Moore, grown under ambient and elevated [CO2]. Plants were grown for 515 days at ambient (430mgdm-3) or elevated [CO2] (700mgdm-3). Some plants were also subjected to water stress to investigate the synergy between atmospheric [CO2] and soil water availability, and its effect on plant growth. All three species showed an increase in maximum net photosynthesis (PN) and chlorophyll index under high [CO2]. Transpiration decreased in some species under high [CO2] despite daily watering and a corresponding increase in water use efficiency was observed. Plants grown under elevated [CO2] and watered daily had greater leaf area and total biomass production than plants under water stress and ambient [CO2]. The high chlorophyll and PN in cerrado plants grown under elevated [CO2] are an investment in light use and capture and higher Rubisco carboxylation rate, respectively. The elevated [CO2] had a positive influence on biomass accumulation in the cerrado species we studied, as predicted for plants under high [CO2]. So, even with water stress, Cerrado species under elevated [CO2] had better growth.

Nursing care for patients in post-transplantation of hematopoietic stem cells: an integrative review / Atención de enfermería para pacientes en post-transplantación de células de madre hematopoyéticas: revisión integrativa / Cuidados de enfermagem aos pacientes em pós-transplante de células-tronco hematopoiéticas: revisão integrativa

ABSTRACT Objectives: to analyze the available evidence on the nursing care provided to patients after hematopoietic stem cell transplantation. Methods: integrative review with the search for primary studies in four databases and a virtual health library. A broad search strategy was used, including research published in English, Brazilian Portuguese, or Spanish, between 2008 and 2018, totaling a sample of 42 studies. Results: the studies were grouped into three categories: multiple nursing care (n=19), first-line care (n=18), and self-management of care (n=5). Conclusions: nursing care is critical, comprising patients' physical, psychological and social aspects. It occurs in hospital and home contexts, mainly involving technical actions and health guidance. The evidence identified provide subsidies for decision-making; however, most studies are of the non-experimental type, indicating the need for conducting intervention research.

RESUMEN Objetivos: analizar la evidencia disponible sobre los cuidados de enfermería brindados al paciente en el postrasplante de células madre hematopoyéticas. Métodos: revisión integradora con búsqueda de estudios primarios en cuatro bases de datos y biblioteca virtual en salud. Se utilizó una amplia estrategia de búsqueda, incluyendo investigaciones publicadas en inglés, portugués o español, entre 2008 y 2018, totalizando una muestra de 42 estudios. Resultados: los estudios se agruparon en tres categorías: cuidados múltiples de enfermería (n=19), cuidados de primera línea (n=18) y cuidados autogestionados (n=5). Conclusiones: el cuidado de enfermería es crítico, entendiendo los aspectos físicos, psicológicos y sociales del paciente. Ocurre en contextos hospitalarios y domiciliarios, involucrando principalmente acciones técnicas y de orientación sanitaria. Las evidencias identificadas brindan subsidios para la toma de decisiones, sin embargo, la mayoría de los estudios son del tipo no experimental, lo que indica la necesidad de realizar investigación de intervención.

RESUMO Objetivos: analisar as evidências disponíveis sobre os cuidados de enfermagem realizados ao paciente em pós-transplante de células-tronco hematopoiéticas. Métodos: revisão integrativa com a busca de estudos primários em quatro bases de dados e uma biblioteca virtual na área da saúde. Foi utilizada estratégia de busca ampla, incluindo-se pesquisas publicadas em inglês, português ou espanhol, entre 2008 e 2018, totalizando uma amostra de 42 estudos. Resultados: os estudos foram agrupados em três categorias: cuidados multíplices de enfermagem (n=19), cuidados de primeira linha (n=18) e autogerenciamento do cuidado (n=5). Conclusões: o cuidado de enfermagem é crítico, compreendendo os aspectos físico, psicológico e social do paciente. Ele ocorre em contextos hospitalares e domiciliares, principalmente envolvendo ações técnicas e de orientações em saúde. As evidências identificadas fornecem subsídios para a tomada de decisão, entretanto a maioria dos estudos é do tipo não experimental, indicando a necessidade de condução de pesquisas de intervenção.