Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla.

To increase granularity in human neuroimaging science, we designed and built a next-generation 7 Tesla magnetic resonance imaging scanner to reach ultra-high resolution by implementing several advances in hardware. To improve spatial encoding and increase the image signal-to-noise ratio, we developed a head-only asymmetric gradient coil (200 mT m-1, 900 T m-1s-1) with an additional third layer of windings. We integrated a 128-channel receiver system with 64- and 96-channel receiver coil arrays to boost signal in the cerebral cortex while reducing g-factor noise to enable higher accelerations. A 16-channel transmit system reduced power deposition and improved image uniformity. The scanner routinely performs functional imaging studies at 0.35-0.45 mm isotropic spatial resolution to reveal cortical layer functional activity, achieves high angular resolution in diffusion imaging and reduces acquisition time for both functional and structural imaging.

Electromagnetic and RF pulse design simulation based optimization of an eight-channel loop array for 11.7T brain imaging.

PURPOSE: Optimization of transmit array performance is crucial in ultra-high-field MRI scanners such as 11.7T because of the increased RF losses and RF nonuniformity. This work presents a new workflow to investigate and minimize RF coil losses, and to choose the optimum coil configuration for imaging. METHODS: An 8-channel transceiver loop-array was simulated to analyze its loss mechanism at 499.415 MHz. A folded-end RF shield was developed to limit radiation loss and improve the B 1 + $$ {B}_1^{+} $$ efficiency. The coil element length, and the shield diameter and length were further optimized using electromagnetic (EM) simulations. The generated EM fields were used to perform RF pulse design (RFPD) simulations under realistic constraints. The chosen coil design was constructed to demonstrate performance equivalence in bench and scanner measurements. RESULTS: The use of conventional RF shields at 11.7T resulted in significantly high radiation losses of 18.4%. Folding the ends of the RF shield combined with optimizing the shield diameter and length increased the absorbed power in biological tissue and reduced the radiation loss to 2.4%. The peak B 1 + $$ {B}_1^{+} $$ of the optimal array was 42% more than the reference array. Phantom measurements validated the numerical simulations with a close match of within 4% of the predicted B 1 + $$ {B}_1^{+} $$ . CONCLUSION: A workflow that combines EM and RFPD simulations to numerically optimize transmit arrays was developed. Results have been validated using phantom measurements. Our findings demonstrate the need for optimizing the RF shield in conjunction with array element design to achieve efficient excitation at 11.7T.

The effects of RF coils and SAR supervision strategies for clinically applicable nonselective parallel-transmit pulses at 7 T.

PURPOSE: To investigate the effects of using different parallel-transmit (pTx) head coils and specific absorption rate (SAR) supervision strategies on pTx pulse design for ultrahigh-field MRI using a 3D-MPRAGE sequence. METHODS: The PTx universal pulses (UPs) and fast online-customized (FOCUS) pulses were designed with pre-acquired data sets (B0 , B1 + maps, specific absorption rate [SAR] supervision data) from two different 8 transmit/32 receive head coils on two 7T whole-body MR systems. For one coil, the SAR supervision model consisted of per-channel RF power limits. In the other coil, SAR estimations were done with both per-channel RF power limits as well as virtual observation points (VOPs) derived from electromagnetic field (EMF) simulations using three virtual human body models at three different positions. All pulses were made for nonselective excitation and inversion and evaluated on 132 B0 , B1 + , and SAR supervision datasets obtained with one coil and 12 from the other. At both sites, 3 subjects were examined using MPRAGE sequences that used UP/FOCUS pulses generated for both coils. RESULTS: For some subjects, the UPs underperformed when simulated on a different coil from which they were derived, whereas FOCUS pulses still showed acceptable performance in that case. FOCUS inversion pulses outperformed adiabatic pulses when scaled to the same local SAR level. For the self-built coil, the use of VOPs showed reliable overestimation compared with the ground-truth EMF simulations, predicting about 52% lower local SAR for inversion pulses compared with per-channel power limits. CONCLUSION: FOCUS inversion pulses offer a low-SAR alternative to adiabatic pulses and benefit from using EMF-based VOPs for SAR estimation.

A self-decoupled 32-channel receive array for human-brain MRI at 10.5 T.

PURPOSE: Receive array layout, noise mitigation, and B0 field strength are crucial contributors to SNR and parallel-imaging performance. Here, we investigate SNR and parallel-imaging gains at 10.5 T compared with 7 T using 32-channel receive arrays at both fields. METHODS: A self-decoupled 32-channel receive array for human brain imaging at 10.5 T (10.5T-32Rx), consisting of 31 loops and one cloverleaf element, was co-designed and built in tandem with a 16-channel dual-row loop transmitter. Novel receive array design and self-decoupling techniques were implemented. Parallel imaging performance, in terms of SNR and noise amplification (g-factor), of the 10.5T-32Rx was compared with the performance of an industry-standard 32-channel receiver at 7 T (7T-32Rx) through experimental phantom measurements. RESULTS: Compared with the 7T-32Rx, the 10.5T-32Rx provided 1.46 times the central SNR and 2.08 times the peripheral SNR. Minimum inverse g-factor value of the 10.5T-32Rx (min[1/g] = 0.56) was 51% higher than that of the 7T-32Rx (min[1/g] = 0.37) with R = 4 × 4 2D acceleration, resulting in significantly enhanced parallel-imaging performance at 10.5 T compared with 7 T. The g-factor values of 10.5 T-32 Rx were on par with those of a 64-channel receiver at 7 T (eg, 1.8 vs 1.9, respectively, with R = 4 × 4 axial acceleration). CONCLUSION: Experimental measurements demonstrated effective self-decoupling of the receive array as well as substantial gains in SNR and parallel-imaging performance at 10.5 T compared with 7 T.

Ultra-high field MRI: parallel-transmit arrays and RF pulse design.

This paper reviews the field of multiple or parallel radiofrequency (RF) transmission for magnetic resonance imaging (MRI). Currently the use of ultra-high field (UHF) MRI at 7 tesla and above is gaining popularity, yet faces challenges with non-uniformity of the RF field and higher RF power deposition. Since its introduction in the early 2000s, parallel transmission (pTx) has been recognized as a powerful tool for accelerating spatially selective RF pulses and combating the challenges associated with RF inhomogeneity at UHF. We provide a survey of the types of dedicated RF coils used commonly for pTx and the important modeling of the coil behavior by electromagnetic (EM) field simulations. We also discuss the additional safety considerations involved with pTx such as the specific absorption rate (SAR) and how to manage them. We then describe the application of pTx with RF pulse design, including a practical guide to popular methods. Finally, we conclude with a description of the current and future prospects for pTx, particularly its potential for routine clinical use.