ABSTRACT
Coronavirus disease 2019 (COVID-19) has been widely reported to be associated with increased risk of Venous Thromboembolism, both deep vein thrombosis (DVT) and pulmonary embolism. A rare and extreme manifestation of DVT is Phlegmasia cerulea dolens, characterized by poor tissue perfusion due to marked limb swelling which can progress to limb and life-threatening venous gangrene. We report the case of a 53-year-old man with severe SARS-CoV2 pneumonia who developed acute iliofemoral DVT leading to acute limb ischemia due to Phlegmasia cerulea dolens. The patient underwent successful emergent fasciotomy and mechanical thrombectomy with removal of extensive thrombus burden and restoration of normal venous circulation. Our case highlights the importance of clinical vigilance and early implementation of therapeutic interventions to avoid adverse outcomes in patients who develop SARS-CoV2 induced Venous Thromboembolism complications.
Subject(s)
COVID-19/therapy , Fasciotomy , Thrombectomy , Thrombophlebitis/surgery , Venous Thromboembolism/surgery , Anticoagulants/therapeutic use , COVID-19/complications , COVID-19/diagnosis , Humans , Male , Middle Aged , Severity of Illness Index , Thrombophlebitis/diagnosis , Thrombophlebitis/etiology , Treatment Outcome , Venous Thromboembolism/diagnosis , Venous Thromboembolism/etiologyABSTRACT
IgA nephropathy (IgAN), a frequent cause of chronic kidney disease worldwide, is characterized by mesangial deposition of galactose-deficient IgA1-containing immune complexes. Complement involvement in IgAN pathogenesis is suggested by the glomerular deposition of complement components and the strong protection from IgAN development conferred by the deletion of the CFHR3 and CFHR1 genes (ΔCFHR3-CFHR1). Here we searched for correlations between clinical progression and levels of factor H (FH) and FH-related protein 1 (FHR-1) using well-characterized patient cohorts consisting of 112 patients with IgAN, 46 with non-complement-related autosomal dominant polycystic kidney disease (ADPKD), and 76 control individuals. Patients with either IgAN or ADPKD presented normal FH but abnormally elevated FHR-1 levels and FHR-1/FH ratios compared to control individuals. Highest FHR-1 levels and FHR-1/FH ratios are found in patients with IgAN with disease progression and in patients with ADPKD who have reached chronic kidney disease, suggesting that renal function impairment elevates the FHR-1/FH ratio, which may increase FHR-1/FH competition for activated C3 fragments. Interestingly, ΔCFHR3-CFHR1 homozygotes are protected from IgAN, but not from ADPKD, and we found five IgAN patients with low FH carrying CFH or CFI pathogenic variants. These data support a decreased FH activity in IgAN due to increased FHR-1/FH competition or pathogenic CFH variants. They also suggest that alternative pathway complement activation in patients with IgAN, initially triggered by galactose-deficient IgA1-containing immune complexes, may exacerbate in a vicious circle as renal function deterioration increase FHR-1 levels. Thus, a role of FHR-1 in IgAN pathogenesis is to compete with complement regulation by FH.
Subject(s)
Complement C3b Inactivator Proteins/analysis , Complement Pathway, Alternative/genetics , Glomerulonephritis, IGA/blood , Polycystic Kidney, Autosomal Dominant/blood , Renal Insufficiency, Chronic/blood , Adult , Blood Proteins/genetics , Cohort Studies , Complement C3b Inactivator Proteins/genetics , Complement Factor H/analysis , Complement Factor H/genetics , Disease Progression , Female , Glomerular Filtration Rate , Glomerulonephritis, IGA/genetics , Humans , Male , Middle Aged , Polycystic Kidney, Autosomal Dominant/genetics , Renal Insufficiency, Chronic/genetics , Young AdultABSTRACT
Oral hygiene is an important step in the control of the biofilm, a factor related to diseases such as gingivitis and tooth decay. The systematization of oral hygiene in children is a set of measures that seeks to achieve sequential learning, thus guaranteeing a better elimination of the biofilm. Objetive: To show a sequence of systematized steps in oral hygiene in a pediatric patient with a definitely positive behavior. Case Report: Six year old female patient, without relevant medical history. On clinical intraoral examination presented biofilm accumulation and swollen gums. The presumptive diagnosis was marginal gingivitis associated with biofilm, the treatment included a preventive phase with motivation and education. The control of the disease evolution was carried out with a card of Systematization Technique of Oral Hygiene, the methodology included the recording of the educational sessions using videos and photographs. Results: the adequate use of the amount of toothpaste was achieved, the integrity was improved to 100%, the brushing time increased from 24 to 120 seconds and it was possible to add tongue brushing and not rinsing after brushing within the oral hygiene routine. Conclusion: The patient was able to clean all dental surfaces, using homogeneous times for each surface, following an orderly sequence in toothbrushing, as well as to acquire knowledge regarding the amount of toothpaste to use, tongue brushing and not rinsing after toothbrushing. The systematization of oral hygiene allowed us to achieve these achievements in six sessions.
La higiene oral es un paso importante para el control de la biopelícula, la cual es un factor relacionado con enfermedades como gingivitis y caries dental. La sistematización de la higiene oral en niños es un conjunto de medidas que buscan lograr un aprendizaje secuencial, garantizando así una mejor eliminación del biofilm. Objetivo: Mostrar una secuencia de pasos sistematizados en la higiene oral en un paciente pediátrico con comportamiento definitivamente positivo. Reporte de un Caso: Paciente femenino de 6 años, sin antecedentes médicos relevantes. Al examen clínico intraoral presentó acumulación de biofilm y encías inflamadas. El diagnóstico presuntivo fue gingivitis marginal asociada a biofilm, el tratamiento incluyó una fase preventiva con motivación y educación. El control de la evolución se realizó con una ficha sobre la Técnica de Sistematización de Higiene oral, la metodología incluye el registro de las sesiones educativas usando vídeos y fotografías. Resultados: se logró el uso adecuado de la cantidad de dentífrico, se mejoró la integridad al 100%, el tiempo de cepillado pasó de 24 a 120 segundos y se consiguió integrar el cepillado de la lengua y el no enjuague post cepillado dentro de su higiene oral. Conclusión: La paciente consiguió realizar la limpieza de todas las superficies dentales, tiempos homogéneos para cada superficie, una secuencia ordenada en su cepillado dental, así como adquirir conocimientos en la cantidad de dentífrico utilizado, el cepillado de la lengua y el no enjuagarse después del cepillado dental. La sistematización de la higiene oral permitió conseguir estos logros en 6 sesiones.
Subject(s)
Humans , Female , Child , Oral Hygiene/education , Toothbrushing/methods , Pediatric Dentistry/education , Periodontal Diseases , Toothpastes/therapeutic use , Dental PlaqueABSTRACT
Objetivo: Reportar el uso crema dental en niños peruanos menores de 12 años, durante el periodo del 2016 - 2018. Materiales y métodos: El estudio fue descriptivo, longitudinal y retrospectivo, utilizándose los registros de la base de datos ENDES, Perú, durante 2016-2018. La muestra fue multietápico, probabilística y estratificada, formada por 118 716 registros de niños menores de 12 años de edad. Las variables fueron: uso de crema dental, concentración de flúor, departamento, ámbito geográfico y región natural. Se realizó un análisis descriptivo de las frecuencias absolutas y relativas. Resultados: De los participantes, se cepillaban los dientes, el 88%; se cepillan los dientes 2 veces al día, el 40%; utilizaban crema dental, el 98%; usaban crema dental con una concentración de flúor de 1000ppm o más, el 44,6% (n=15 376), 43,2% (n=14 545) y 44% (n=16 227), para los años 2016, 2017 y 2018, respectivamente. En los departamentos de Piura, Loreto, San Martin y Ucayali usan crema dental ≥1000ppm de flúor, en mayor porcentaje, en un 55% a 74,9%. Las cremas dentales con ≥1000ppm de flúor fueron más utilizadas en la región de la selva y zonas urbanas. Conclusión: Se encontró que la población se cepilla los dientes, con una frecuencia de 2 veces al día y utilizan crema dental; sin embargo, menos de la mitad de peruanos menores de 12 años de edad, utiliza crema dental fluorada con 1000 ppm o más. Estos resultados se podrían relacionarse con las políticas preventivas actuales contra la caries dental.