Reading the mind in the eyes of Black and White people: Interracial contact and perceived race affects brain activity when inferring mental states.

Inferring others' mental states, or mentalizing, is a critical social cognitive ability that underlies humans' remarkable capacity for complex social interactions. Recent work suggests that interracial contact shapes the recruitment of brain regions involved in mentalizing during impression formation. However, it remains unclear how a target's perceived racial group and a perceiver's previous contact with that racial group shapes mental state inferences. In this study, we examined brain activity in regions of interest associated with mentalizing and race perception among self-identified White perceivers who varied in lifetime contact while they inferred secondary emotions from perceived White eyes and perceived Black eyes (i.e., the Reading the Mind in the Eyes test). The interaction between lifetime contact and perceived target race predicted activity in the superior temporal sulcus (STS), a region consistently implicated in mental state inferences from perceptual cues, tracking eye gaze, and biological motion. Low and average contact White perceivers showed more left STS activity when inferring mental states from perceived White eyes than perceived Black eyes, whereas high contact White perceivers showed similar left STS activity regardless of perceived target race. These results indicate that interracial contact decreases racial biases in the recruitment of regions involved in mentalizing when inferring mental states from perceptual cues.

Perceiving social injustice during arrests of Black and White civilians by White police officers: An fMRI investigation.

From social media to courts of law, recordings of interracial police officer-civilian interactions are now widespread and publicly available. People may be motivated to preferentially understand the dynamics of these interactions when they perceive injustice towards those whose communities experience disproportionate policing relative to others (e.g., non-White racial/ethnic groups). To explore these questions, two studies were conducted (study 1 neuroimaging n = 69 and study 2 behavioral n = 58). The fMRI study examined White participants' neural activity when viewing real-world videos with varying degrees of aggression or conflict of White officers arresting a Black or White civilian. Activity in brain regions supporting social cognition was greater when viewing Black (vs. White) civilians involved in more aggressive police encounters. Additionally, although an independent sample of perceivers rated videos featuring Black and White civilians as similar in overall levels of aggression when civilian race was obscured, participants in the fMRI study (where race was not obscured) rated officers as more aggressive and their use of force as less legitimate when the civilian was Black. In study 2, participants who had not viewed the videos also reported that they believe police are generally more unjustly aggressive towards Black compared with White civilians. These findings inform our understanding of how perceptions of conflict with the potential for injustice shape social cognitive engagement when viewing arrests of Black and White individuals by White police officers.

Social justice neuroscience, a valuable and complex endeavor: Authors' reply to commentaries on "Perceiving social injustice during arrests of Black and White civilians by White police officers: An fMRI investigation".

In commentaries about our article, "Perceiving social injustice during arrests of Black and White civilians by White police officers: An fMRI investigation" (Dang et al., 2022), Harris (2022), Niv and Kardosh (2022), and Purdie-Greenway and Spagna (2022) made suggestions to increase the generalizability of future research on this topic and cautioned about misinterpretation of the obtained findings. We agree with their assessments, noting that this emerging program of research should be extended to different populations and stimuli. We conclude with a general discussion of the benefits and challenges associated with multidisciplinary research and share our thoughts about engaging in social justice neuroscience.

ß-Glucans Are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia.

ß-glucans, which can activate innate immune responses, are a major component in the cell wall of the cyst form of Pneumocystis In the current study, we examined whether ß-1,3-glucans are masked by surface proteins in Pneumocystis and what role ß-glucans play in Pneumocystis-associated inflammation. For 3 species, including Pneumocystis jirovecii, which causes Pneumocystis pneumonia in humans, Pneumocystis carinii, and Pneumocystis murina, ß-1,3-glucans were masked in most organisms, as demonstrated by increased exposure following trypsin treatment. Using quantitative polymerase chain reaction and microarray techniques, we demonstrated in a mouse model of Pneumocystis pneumonia that treatment with caspofungin, an inhibitor of ß-1,3-glucan synthesis, for 21 days decreased expression of a broad panel of inflammatory markers, including interferon γ, tumor necrosis factor α, interleukin 1ß, interleukin 6, and multiple chemokines/chemokine ligands. Thus, ß-glucans in Pneumocystis cysts are largely masked, which likely decreases innate immune activation; this mechanism presumably was developed for interactions with immunocompetent hosts, in whom organism loads are substantially lower. In immunosuppressed hosts with a high organism burden, organism death and release of glucans appears to be an important contributor to deleterious host inflammatory responses.

Interracial contact differentially shapes brain networks involved in social and non-social judgments from faces: a combination of univariate and multivariate approaches.

The present work explores the relationship between interracial contact and the neural substrates of explicit social and non-social judgments about both racial ingroup and outgroup targets. Convergent evidence from univariate and multivariate partial least squares (PLS) analyses reveals that contact shapes the recruitment of brain regions involved in social cognition similarly for both ingroup and outgroup targets. Results support the hypothesis that increased contact is associated with generalized changes in social cognition toward both ingroup and outgroup faces. Specifically, regardless of target race, low- and average-contact perceivers showed the typically observed increased recruitment of temporoparietal junction and dorsomedial prefrontal cortex during social compared to perceptual judgments. However, high-contact perceivers did not show selective recruitment of these brain regions for social judgments. Complimenting univariate results, multivariate PLS analyses reveal that greater perceiver contact leads to reduced co-activation in networks of brain regions associated with face processing (e.g. fusiform gyrus) and salience detection (e.g. anterior cingulate cortex and insula). Across univariate and multivariate analyses, we found no evidence that contact differentially impacted cross-race face perception. Instead, when performing either a social or a novel perceptual task, interracial contact appears to broadly shape how perceivers engage with all faces.

Impact of interracial contact on inferring mental states from facial expressions.

Although decades of research have shown that intergroup contact critically impacts person perception and evaluation, little is known about how contact shapes the ability to infer others' mental states from facial cues (commonly referred to as mentalizing). In a pair of studies, we demonstrated that interracial contact and motivation to attend to faces jointly influence White perceivers' ability to infer mental states based on facial expressions displaying secondary emotions from both White targets alone (study 1) and White and Black targets (study 2; pre-registered). Consistent with previous work on the effect of motivation and interracial contact on other-race face memory, we found that motivation and interracial contact interacted to shape perceivers' accuracy at inferring mental states from secondary emotions. When motivated to attend to the task, high-contact White perceivers were more accurate at inferring both Black and White targets' mental states; unexpectedly, the opposite was true for low-contact perceivers. Importantly, the target race did not interact with interracial contact, suggesting that contact is associated with general changes in mentalizing irrespective of target race. These findings expand the theoretical understanding and implications of contact for fundamental social cognition.

Black "Reading the Mind in the Eyes" task: The development of a task assessing mentalizing from black faces.

Researchers investigating various facets of theory of mind, sometimes referred to as mentalizing, are increasingly exploring how social group membership influences this process. To facilitate this research, we introduce the Black Reading the Mind in The Eyes task, a freely available 36-item Black RME task with an array of norming data about these stimuli. Stimuli have been created and equated to match the original Reading the Mind in the Eyes (RME) task which included only White faces. Norming data were collected in three waves that characterized the physical properties of the stimuli and also participants' subjective ratings of the stimuli. Between each round of ratings, stimuli that did not equate with the original RME task or were not distinctly recognized as Black were removed and new stimuli were incorporated in the next round until we obtained 36 distinctive Black RME targets that matched the 36 mental states used in the original RME stimulus set. Both stimulus sets were similarly difficult and subsequent testing showed that neither Black nor White participants' mentalizing accuracy varied as a function of target race. We provide instructions for obtaining the database and stimulus ratings.

Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.

Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses.