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1.

New insights into activation and function of the AMPK.

Steinberg, Gregory R; Hardie, D Grahame.

Nat Rev Mol Cell Biol ; 24(4): 255-272, 2023 04.

Article in English | MEDLINE | ID: mdl-36316383

2.

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia, Isabel C; Lagarrigue, Sylviane; Giralt, Albert; Martinez-Carreres, Laia; Zanou, Nadège; Denechaud, Pierre-Damien; Castillo-Armengol, Judit; Chavey, Carine; Orpinell, Meritxell; Delacuisine, Brigitte; Nasrallah, Anita; Collodet, Caterina; Zhang, Lianjun; Viollet, Benoît; Hardie, D Grahame; Fajas, Lluis.

Mol Cell ; 68(2): 336-349.e6, 2017 Oct 19.

Article in English | MEDLINE | ID: mdl-29053957

3.

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand.

Hawley, Simon A; Russell, Fiona M; Hardie, D Grahame.

Biochem J ; 481(8): 587-599, 2024 Apr 24.

Article in English | MEDLINE | ID: mdl-38592738

4.

AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Hardie, D Grahame; Ross, Fiona A; Hawley, Simon A.

Nat Rev Mol Cell Biol ; 13(4): 251-62, 2012 Mar 22.

Article in English | MEDLINE | ID: mdl-22436748

5.

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.

Ross, Fiona A; Hawley, Simon A; Russell, Fiona M; Goodman, Nicola; Hardie, D Grahame.

Biochem J ; 480(23): 1951-1968, 2023 12 13.

Article in English | MEDLINE | ID: mdl-37962491

6.

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.

Drake, Joshua C; Wilson, Rebecca J; Laker, Rhianna C; Guan, Yuntian; Spaulding, Hannah R; Nichenko, Anna S; Shen, Wenqing; Shang, Huayu; Dorn, Maya V; Huang, Kian; Zhang, Mei; Bandara, Aloka B; Brisendine, Matthew H; Kashatus, Jennifer A; Sharma, Poonam R; Young, Alexander; Gautam, Jitendra; Cao, Ruofan; Wallrabe, Horst; Chang, Paul A; Wong, Michael; Desjardins, Eric M; Hawley, Simon A; Christ, George J; Kashatus, David F; Miller, Clint L; Wolf, Matthew J; Periasamy, Ammasi; Steinberg, Gregory R; Hardie, D Grahame; Yan, Zhen.

Proc Natl Acad Sci U S A ; 118(37)2021 09 14.

Article in English | MEDLINE | ID: mdl-34493662

7.

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Zhang, Chen-Song; Hawley, Simon A; Zong, Yue; Li, Mengqi; Wang, Zhichao; Gray, Alexander; Ma, Teng; Cui, Jiwen; Feng, Jin-Wei; Zhu, Mingjiang; Wu, Yu-Qing; Li, Terytty Yang; Ye, Zhiyun; Lin, Shu-Yong; Yin, Huiyong; Piao, Hai-Long; Hardie, D Grahame; Lin, Sheng-Cai.

Nature ; 548(7665): 112-116, 2017 08 03.

Article in English | MEDLINE | ID: mdl-28723898

8.

AMP-activated protein kinase - a journey from 1 to 100 downstream targets.

Hardie, D Grahame.

Biochem J ; 479(22): 2327-2343, 2022 11 30.

Article in English | MEDLINE | ID: mdl-36383046

9.

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation.

Hawley, Simon A; Russell, Fiona M; Ross, Fiona A; Hardie, D Grahame.

Int J Mol Sci ; 25(1)2023 Dec 29.

Article in English | MEDLINE | ID: mdl-38203624

10.

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner.

Seabright, Alex P; Fine, Nicholas H F; Barlow, Jonathan P; Lord, Samuel O; Musa, Ibrahim; Gray, Alexander; Bryant, Jack A; Banzhaf, Manuel; Lavery, Gareth G; Hardie, D Grahame; Hodson, David J; Philp, Andrew; Lai, Yu-Chiang.

FASEB J ; 34(5): 6284-6301, 2020 05.

Article in English | MEDLINE | ID: mdl-32201986

11.

A new protein kinase cascade.

Hardie, D Grahame.

Nat Rev Mol Cell Biol ; 15(4): 223, 2014 Apr.

Article in English | MEDLINE | ID: mdl-24622616

12.

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

Evans, A Mark; Hardie, D Grahame.

Int J Mol Sci ; 21(10)2020 May 15.

Article in English | MEDLINE | ID: mdl-32429235

13.

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

Salt, Ian P; Hardie, D Grahame.

Circ Res ; 120(11): 1825-1841, 2017 May 26.

Article in English | MEDLINE | ID: mdl-28546359

14.

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Hardie, D Grahame.

Nat Rev Mol Cell Biol ; 8(10): 774-85, 2007 Oct.

Article in English | MEDLINE | ID: mdl-17712357

15.

Metabolism of inflammation limited by AMPK and pseudo-starvation.

O'Neill, Luke A J; Hardie, D Grahame.

Nature ; 493(7432): 346-55, 2013 Jan 17.

Article in English | MEDLINE | ID: mdl-23325217

16.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas, Elaine C; Hook, Sharon C; Gray, Alexander; Chadt, Alexandra; Carling, David; Al-Hasani, Hadi; Heesom, Kate J; Hardie, D Grahame; Tavaré, Jeremy M.

Biochem J ; 475(18): 2969-2983, 2018 09 25.

Article in English | MEDLINE | ID: mdl-30135087

17.

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.

Hardie, D Grahame.

Genes Dev ; 25(18): 1895-908, 2011 Sep 15.

Article in English | MEDLINE | ID: mdl-21937710

18.

The mechanisms of action of metformin.

Rena, Graham; Hardie, D Grahame; Pearson, Ewan R.

Diabetologia ; 60(9): 1577-1585, 2017 09.

Article in English | MEDLINE | ID: mdl-28776086

19.

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

Xu, Yanchun; Gray, A; Hardie, D Grahame; Uzun, Alper; Shaw, Sunil; Padbury, James; Phornphutkul, Chanika; Tseng, Yi-Tang.

Am J Physiol Heart Circ Physiol ; 313(2): H283-H292, 2017 Aug 01.

Article in English | MEDLINE | ID: mdl-28550180

20.

Differential regulation by AMP and ADP of AMPK complexes containing different Î³ subunit isoforms.

Ross, Fiona A; Jensen, Thomas E; Hardie, D Grahame.

Biochem J ; 473(2): 189-99, 2016 Jan 15.

Article in English | MEDLINE | ID: mdl-26542978

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New insights into activation and function of the AMPK.

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand.

AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

AMP-activated protein kinase - a journey from 1 to 100 downstream targets.

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation.

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner.

A new protein kinase cascade.

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Metabolism of inflammation limited by AMPK and pseudo-starvation.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.

The mechanisms of action of metformin.

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

Differential regulation by AMP and ADP of AMPK complexes containing different Î³ subunit isoforms.