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1.

Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA.

Tervi, Anniina; Junna, Nella; Broberg, Martin; Jones, Samuel E; Strausz, Satu; Kreivi, Hanna-Riikka; Heckman, Caroline A; Ollila, Hanna M.

Hum Mol Genet ; 32(1): 161-171, 2023 01 01.

Article in English | MEDLINE | ID: mdl-36018815

2.

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.

Kuusanmäki, Heikki; Dufva, Olli; Vähä-Koskela, Markus; Leppä, Aino-Maija; Huuhtanen, Jani; Vänttinen, Ida; Nygren, Petra; Klievink, Jay; Bouhlal, Jonas; Pölönen, Petri; Zhang, Qi; Adnan-Awad, Shady; Mancebo-Pérez, Cristina; Saad, Joseph; Miettinen, Juho; Javarappa, Komal K; Aakko, Sofia; Ruokoranta, Tanja; Eldfors, Samuli; Heinäniemi, Merja; Theilgaard-Mönch, Kim; Wartiovaara-Kautto, Ulla; Keränen, Mikko; Porkka, Kimmo; Konopleva, Marina; Wennerberg, Krister; Kontro, Mika; Heckman, Caroline A; Mustjoki, Satu.

Blood ; 141(13): 1610-1625, 2023 03 30.

Article in English | MEDLINE | ID: mdl-36508699

3.

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.

Laukkanen, Saara; Veloso, Alexandra; Yan, Chuan; Oksa, Laura; Alpert, Eric J; Do, Daniel; Hyvärinen, Noora; McCarthy, Karin; Adhikari, Abhinav; Yang, Qiqi; Iyer, Sowmya; Garcia, Sara P; Pello, Annukka; Ruokoranta, Tanja; Moisio, Sanni; Adhikari, Sadiksha; Yoder, Jeffrey A; Gallagher, Kayleigh; Whelton, Lauren; Allen, James R; Jin, Alex H; Loontiens, Siebe; Heinäniemi, Merja; Kelliher, Michelle; Heckman, Caroline A; Lohi, Olli; Langenau, David M.

Blood ; 140(17): 1891-1906, 2022 10 27.

Article in English | MEDLINE | ID: mdl-35544598

4.

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia.

Kuusanmäki, Heikki; Kytölä, Sari; Vänttinen, Ida; Ruokoranta, Tanja; Ranta, Amanda; Huuhtanen, Jani; Suvela, Minna; Parsons, Alun; Holopainen, Annasofia; Partanen, Anu; Kuusisto, Milla E L; Koskela, Sirpa; Räty, Riikka; Itälä-Remes, Maija; Västrik, Imre; Dufva, Olli; Siitonen, Sanna; Porkka, Kimmo; Wennerberg, Krister; Heckman, Caroline A; Ettala, Pia; Pyörälä, Marja; Rimpiläinen, Johanna; Siitonen, Timo; Kontro, Mika.

Haematologica ; 108(7): 1768-1781, 2023 Jul 01.

Article in English | MEDLINE | ID: mdl-36519325

5.

Using Proteomics Data to Identify Personalized Treatments in Multiple Myeloma: A Machine Learning Approach.

Katsenou, Angeliki; O'Farrell, Roisin; Dowling, Paul; Heckman, Caroline A; O'Gorman, Peter; Bazou, Despina.

Int J Mol Sci ; 24(21)2023 Oct 25.

Article in English | MEDLINE | ID: mdl-37958554

6.

Fusion gene detection by RNA-sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements.

Kerbs, Paul; Vosberg, Sebastian; Krebs, Stefan; Graf, Alexander; Blum, Helmut; Swoboda, Anja; Batcha, Aarif M N; Mansmann, Ulrich; Metzler, Dirk; Heckman, Caroline A; Herold, Tobias; Greif, Philipp A.

Haematologica ; 107(1): 100-111, 2022 01 01.

Article in English | MEDLINE | ID: mdl-34134471

7.

Prognostic significance of esterase gene expression in multiple myeloma.

Kumari, Romika; Majumder, Muntasir Mamun; Lievonen, Juha; Silvennoinen, Raija; Anttila, Pekka; Nupponen, Nina N; Lehmann, Fredrik; Heckman, Caroline A.

Br J Cancer ; 124(8): 1428-1436, 2021 04.

Article in English | MEDLINE | ID: mdl-33531688

8.

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types.

Majumder, Muntasir M; Leppä, Aino-Maija; Hellesøy, Monica; Dowling, Paul; Malyutina, Alina; Kopperud, Reidun; Bazou, Despina; Andersson, Emma; Parsons, Alun; Tang, Jing; Kallioniemi, Olli; Mustjoki, Satu; O'Gorman, Peter; Wennerberg, Krister; Porkka, Kimmo; Gjertsen, Bjørn T; Heckman, Caroline A.

Haematologica ; 105(6): 1527-1538, 2020 06.

Article in English | MEDLINE | ID: mdl-31439679

9.

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer.

Malyutina, Alina; Majumder, Muntasir Mamun; Wang, Wenyu; Pessia, Alberto; Heckman, Caroline A; Tang, Jing.

PLoS Comput Biol ; 15(5): e1006752, 2019 05.

Article in English | MEDLINE | ID: mdl-31107860

10.

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

Karjalainen, Riikka; Pemovska, Tea; Popa, Mihaela; Liu, Minxia; Javarappa, Komal K; Majumder, Muntasir M; Yadav, Bhagwan; Tamborero, David; Tang, Jing; Bychkov, Dmitrii; Kontro, Mika; Parsons, Alun; Suvela, Minna; Mayoral Safont, Mireia; Porkka, Kimmo; Aittokallio, Tero; Kallioniemi, Olli; McCormack, Emmet; Gjertsen, Bjørn T; Wennerberg, Krister; Knowles, Jonathan; Heckman, Caroline A.

Blood ; 130(6): 789-802, 2017 08 10.

Article in English | MEDLINE | ID: mdl-28619982

11.

The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia.

Kumar, Ashwini; Kankainen, Matti; Parsons, Alun; Kallioniemi, Olli; Mattila, Pirkko; Heckman, Caroline A.

BMC Genomics ; 18(1): 629, 2017 Aug 17.

Article in English | MEDLINE | ID: mdl-28818039

12.

A candid view of CANDOR.

Silvennoinen, Raija; Heckman, Caroline A.

Lancet ; 396(10245): 147-148, 2020 07 18.

Article in English | MEDLINE | ID: mdl-32682464

13.

Somatic STAT3 mutations in large granular lymphocytic leukemia.

Koskela, Hanna L M; Eldfors, Samuli; Ellonen, Pekka; van Adrichem, Arjan J; Kuusanmäki, Heikki; Andersson, Emma I; Lagström, Sonja; Clemente, Michael J; Olson, Thomas; Jalkanen, Sari E; Majumder, Muntasir Mamun; Almusa, Henrikki; Edgren, Henrik; Lepistö, Maija; Mattila, Pirkko; Guinta, Kathryn; Koistinen, Pirjo; Kuittinen, Taru; Penttinen, Kati; Parsons, Alun; Knowles, Jonathan; Saarela, Janna; Wennerberg, Krister; Kallioniemi, Olli; Porkka, Kimmo; Loughran, Thomas P; Heckman, Caroline A; Maciejewski, Jaroslaw P; Mustjoki, Satu.

N Engl J Med ; 366(20): 1905-13, 2012 May 17.

Article in English | MEDLINE | ID: mdl-22591296

14.

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia.

Kuusanmäki, Heikki; Leppä, Aino-Maija; Pölönen, Petri; Kontro, Mika; Dufva, Olli; Deb, Debashish; Yadav, Bhagwan; Brück, Oscar; Kumar, Ashwini; Everaus, Hele; Gjertsen, Bjørn T; Heinäniemi, Merja; Porkka, Kimmo; Mustjoki, Satu; Heckman, Caroline A.

Haematologica ; 105(3): 708-720, 2020 03.

Article in English | MEDLINE | ID: mdl-31296572

15.

Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia.

Elo, Laura L; Karjalainen, Riikka; Ohman, Tiina; Hintsanen, Petteri; Nyman, Tuula A; Heckman, Caroline A; Aittokallio, Tero.

Proteomics ; 14(21-22): 2443-53, 2014 Nov.

Article in English | MEDLINE | ID: mdl-25211154

16.

Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia.

Eldfors, Samuli; Saad, Joseph; Ikonen, Nemo; Malani, Disha; Vähä-Koskela, Markus; Gjertsen, Bjørn T; Kontro, Mika; Porkka, Kimmo; Heckman, Caroline A.

Blood Adv ; 8(7): 1621-1633, 2024 Apr 09.

Article in English | MEDLINE | ID: mdl-38197948

17.

Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling.

Mirzaie, Mehdi; Gholizadeh, Elham; Miettinen, Juho J; Ianevski, Filipp; Ruokoranta, Tanja; Saarela, Jani; Manninen, Mikko; Miettinen, Susanna; Heckman, Caroline A; Jafari, Mohieddin.

Oncogenesis ; 13(1): 11, 2024 Mar 01.

Article in English | MEDLINE | ID: mdl-38429288

18.

Robust scoring of selective drug responses for patient-tailored therapy selection.

Chen, Yingjia; He, Liye; Ianevski, Aleksandr; Ayuda-Durán, Pilar; Potdar, Swapnil; Saarela, Jani; Miettinen, Juho J; Kytölä, Sari; Miettinen, Susanna; Manninen, Mikko; Heckman, Caroline A; Enserink, Jorrit M; Wennerberg, Krister; Aittokallio, Tero.

Nat Protoc ; 19(1): 60-82, 2024 Jan.

Article in English | MEDLINE | ID: mdl-37996540

19.

Targeting CD33+ acute myeloid leukemia with GLK-33, a lintuzumab-auristatin conjugate with a wide therapeutic window.

Satomaa, Tero; Pynnönen, Henna; Aitio, Olli; Hiltunen, Jukka O; Pitkänen, Virve; Lähteenmäki, Tuula; Kotiranta, Titta; Heiskanen, Annamari; Hänninen, Anna-Liisa; Niemelä, Ritva; Helin, Jari; Kuusanmaki, Heikki; Vänttinen, Ida; Rathod, Ramji; Nieminen, Anni I; Yatkin, Emrah; Heckman, Caroline A; Kontro, Mika; Saarinen, Juhani.

Mol Cancer Ther ; 2024 Apr 02.

Article in English | MEDLINE | ID: mdl-38561023

20.

An ischemic myelopathy case series: Flaccid paraplegia following a spike ball save and numbness while walking normally.

Heckman, Caroline A; Miller, Derryl J; Kremer, Kelly M; Martinez, Mesha L; Jea, Andrew H.

Brain Circ ; 9(2): 107-111, 2023.

Article in English | MEDLINE | ID: mdl-37576578

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