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1.

Pharmacokinetic and pharmacodynamic properties of once-weekly insulin icodec in individuals with type 1 diabetes.

Hövelmann, Ulrike; Engberg, Susanne; Heise, Tim; Kristensen, Niels Rode; Nørgreen, Lea; Zijlstra, Eric; Ribel-Madsen, Rasmus.

Diabetes Obes Metab ; 26(5): 1941-1949, 2024 May.

Article in English | MEDLINE | ID: mdl-38379002

2.

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

Ambery, Philip; Zajac, Grzegorz; Almquist, Joachim; Prothon, Susanne; Astbury, Carol; Brown, Mary N; Nemes, Szilard; Nsabimana, Joselyne; Edman, Karl; Öberg, Lisa; Lepistö, Matti; Edenro, Goran; Dillmann, Inken; Mitra, Suman; Belfield, Graham; Keen, Christina; Heise, Tim.

Br J Clin Pharmacol ; 2024 May 01.

Article in English | MEDLINE | ID: mdl-38690606

3.

Safety, tolerability, pharmacodynamics and pharmacokinetics following once-daily doses of BI 187004, an inhibitor of 11 beta-hydroxysteroid dehydrogenase-1, over 28 days in patients with type 2 diabetes mellitus and overweight or obesity.

Bianzano, Susanna; Nordaby, Matias; Plum-Mörschel, Leona; Peil, Barbara; Heise, Tim.

Diabetes Obes Metab ; 25(3): 832-843, 2023 03.

Article in English | MEDLINE | ID: mdl-36478142

4.

A co-formulation of pramlintide and insulin A21G (ADO09) improves postprandial glucose and short-term control of mean glucose, time in range, and body weight versus insulin aspart in adults with type 1 diabetes.

Andersen, Grit; Eloy, Rosy; Famulla, Susanne; Heise, Tim; Meiffren, Grégory; Seroussi, Cyril; Gaudier, Martin; Mégret, Claire; Chan, You-Ping; Soula, Olivier; Riddle, Matthew.

Diabetes Obes Metab ; 25(5): 1241-1248, 2023 05.

Article in English | MEDLINE | ID: mdl-36633505

5.

Pharmacokinetic and pharmacodynamic properties of the novel basal insulin Fc (insulin efsitora alfa), an insulin fusion protein in development for once-weekly dosing for the treatment of patients with diabetes.

Heise, Tim; Chien, Jenny; Beals, John M; Benson, Charles; Klein, Oliver; Moyers, Julie S; Haupt, Axel; Pratt, Edward John.

Diabetes Obes Metab ; 25(4): 1080-1090, 2023 04.

Article in English | MEDLINE | ID: mdl-36541037

6.

Pharmacokinetic and pharmacodynamic bioequivalence of Gan & Lee insulin analogues aspart (rapilin®), lispro (prandilin®) and glargine (basalin®) with EU- und US-sourced reference insulins.

Chen, Wei; Lu, Jia; Plum-Mörschel, Leona; Andersen, Grit; Zijlstra, Eric; He, Anshun; Xie, Tian; Li, Longling; Hao, Chunyue; Gan, Zhongru; Heise, Tim.

Diabetes Obes Metab ; 25(12): 3817-3825, 2023 12.

Article in English | MEDLINE | ID: mdl-37735841

7.

What is the value of faster acting prandial insulin? Focus on ultra rapid lispro.

Heise, Tim; Piras de Oliveira, Carolina; Juneja, Rattan; Ribeiro, Anderson; Chigutsa, Farai; Blevins, Thomas.

Diabetes Obes Metab ; 24(9): 1689-1701, 2022 09.

Article in English | MEDLINE | ID: mdl-35593434

8.

Novel Drugs for Diabetes Therapy.

Heise, Tim.

Handb Exp Pharmacol ; 274: 415-438, 2022.

Article in English | MEDLINE | ID: mdl-35112236

9.

ADO09, a co-formulation of the amylin analogue pramlintide and the insulin analogue A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes.

Andersen, Grit; Meiffren, Grégory; Famulla, Susanne; Heise, Tim; Ranson, Aymeric; Seroussi, Cyril; Eloy, Rosy; Gaudier, Martin; Charvet, Richard; Chan, You-Ping; Soula, Olivier; DeVries, J Hans.

Diabetes Obes Metab ; 23(4): 961-970, 2021 04.

Article in English | MEDLINE | ID: mdl-33336850

10.

The majority of people with type 1 diabetes and multiple daily insulin injections benefit from using continuous glucose monitoring: An analysis based on the GOLD randomized trial (GOLD-5).

Ólafsdóttir, Arndís F; Bolinder, Jan; Heise, Tim; Polonsky, William; Ekelund, Magnus; Wijkman, Magnus; Pivodic, Aldina; Ahlén, Elsa; Schwarcz, Erik; Nyström, Thomas; Hellman, Jarl; Hirsch, Irl B; Lind, Marcus.

Diabetes Obes Metab ; 23(2): 619-630, 2021 02.

Article in English | MEDLINE | ID: mdl-33200487

11.

Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA).

Moser, Othmar; Riddell, Michael C; Eckstein, Max L; Adolfsson, Peter; Rabasa-Lhoret, Rémi; van den Boom, Louisa; Gillard, Pieter; Nørgaard, Kirsten; Oliver, Nick S; Zaharieva, Dessi P; Battelino, Tadej; de Beaufort, Carine; Bergenstal, Richard M; Buckingham, Bruce; Cengiz, Eda; Deeb, Asma; Heise, Tim; Heller, Simon; Kowalski, Aaron J; Leelarathna, Lalantha; Mathieu, Chantal; Stettler, Christoph; Tauschmann, Martin; Thabit, Hood; Wilmot, Emma G; Sourij, Harald; Smart, Carmel E; Jacobs, Peter G; Bracken, Richard M; Mader, Julia K.

Diabetologia ; 63(12): 2501-2520, 2020 12.

Article in English | MEDLINE | ID: mdl-33047169

12.

Pharmacokinetic and pharmacodynamic bioequivalence of proposed biosimilar MYL-1501D with US and European insulin glargine formulations in patients with type 1 diabetes mellitus.

Heise, Tim; Donnelly, Charles; Barve, Abhijit; Aubonnet, Patrick.

Diabetes Obes Metab ; 22(4): 521-529, 2020 04.

Article in English | MEDLINE | ID: mdl-31724253

13.

Ultra rapid lispro lowers postprandial glucose and more closely matches normal physiological glucose response compared to other rapid insulin analogues: A phase 1 randomized, crossover study.

Heise, Tim; Linnebjerg, Helle; Coutant, David; LaBell, Elizabeth; Zijlstra, Eric; Kapitza, Christoph; Bue-Valleskey, Juliana; Zhang, Qianyi; Dellva, Mary Anne; Leohr, Jennifer.

Diabetes Obes Metab ; 22(10): 1789-1798, 2020 10.

Article in English | MEDLINE | ID: mdl-32436641

14.

Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA).

Moser, Othmar; Riddell, Michael C; Eckstein, Max L; Adolfsson, Peter; Rabasa-Lhoret, Rémi; van den Boom, Louisa; Gillard, Pieter; Nørgaard, Kirsten; Oliver, Nick S; Zaharieva, Dessi P; Battelino, Tadej; de Beaufort, Carine; Bergenstal, Richard M; Buckingham, Bruce; Cengiz, Eda; Deeb, Asma; Heise, Tim; Heller, Simon; Kowalski, Aaron J; Leelarathna, Lalantha; Mathieu, Chantal; Stettler, Christoph; Tauschmann, Martin; Thabit, Hood; Wilmot, Emma G; Sourij, Harald; Smart, Carmel E; Jacobs, Peter G; Bracken, Richard M; Mader, Julia K.

Pediatr Diabetes ; 21(8): 1375-1393, 2020 12.

Article in English | MEDLINE | ID: mdl-33047481

15.

Costs and its drivers for diabetes mellitus type 2 patients in France and Germany: a systematic review of economic studies.

Stegbauer, Constance; Falivena, Camilla; Moreno, Ariadna; Hentschel, Anna; Rosenmöller, Magda; Heise, Tim; Szecsenyi, Joachim; Schliess, Freimut.

BMC Health Serv Res ; 20(1): 1043, 2020 Nov 16.

Article in English | MEDLINE | ID: mdl-33198734

16.

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study.

Ambery, Philip; Parker, Victoria E; Stumvoll, Michael; Posch, Maximilian G; Heise, Tim; Plum-Moerschel, Leona; Tsai, Lan-Feng; Robertson, Darren; Jain, Meena; Petrone, Marcella; Rondinone, Cristina; Hirshberg, Boaz; Jermutus, Lutz.

Lancet ; 391(10140): 2607-2618, 2018 06 30.

Article in English | MEDLINE | ID: mdl-29945727

17.

Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus.

Hövelmann, Ulrike; Olsen, Minna Braendholt; Mouritzen, Ulrik; Lamers, Daniela; Kronshage, Birgit; Heise, Tim.

Diabetes Obes Metab ; 21(3): 601-610, 2019 03.

Article in English | MEDLINE | ID: mdl-30350477

18.

Better glycaemic control with BioChaperone glargine lispro co-formulation than with insulin lispro Mix25 or separate glargine and lispro administrations after a test meal in people with type 2 diabetes.

Meiffren, Grégory; Herbrand, Theresa; Anastassiadis, Ernestos; Klein, Oliver; DeVries, J Hans; Heise, Tim; Alluis, Bertrand; Mégret, Claire; Gaudier, Martin; Soula, Olivier; Plum-Mörschel, Leona.

Diabetes Obes Metab ; 21(7): 1570-1575, 2019 07.

Article in English | MEDLINE | ID: mdl-30828929

19.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

Al-Qaissi, Ahmed; Papageorgiou, Maria; Javed, Zeeshan; Heise, Tim; Rigby, Alan S; Garrett, Andrew T; Hepburn, David; Kilpatrick, Eric S; Atkin, Stephen L; Sathyapalan, Thozhukat.

Diabetes Obes Metab ; 21(3): 569-574, 2019 03.

Article in English | MEDLINE | ID: mdl-30311402

20.

BioChaperone Lispro versus faster aspart and insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: A randomized euglycemic clamp study.

Heise, Tim; Meiffren, Grégory; Alluis, Bertrand; Seroussi, Cyril; Ranson, Aymeric; Arrubla, Jorge; Correia, José; Gaudier, Martin; Soula, Olivier; Soula, Rémi; DeVries, J Hans; Klein, Oliver; Bode, Bruce.

Diabetes Obes Metab ; 21(4): 1066-1070, 2019 04.

Article in English | MEDLINE | ID: mdl-30565407

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