Recovery from COVID-19 in athletes and impact on sporting participation.

Insight regarding the impact of COVID-19 on return to sporting participation is a key issue for many athletes. We report time-loss following respiratory tract infection (RTI), over the pandemic, in UK athletes preparing for international competition. During the study, 566 athletes developed COVID-19 and 217 developed other causes of RTI. Time-loss from COVID-19 reduced from a median (interquartile range) of 27 days (13- 40) in April-June 2020 to 10 days (8-13) from October-December 2022 (P<0.001). There was no change in time-loss following RTi (P=0.13). The time-loss period following COVID-19 has shortened over the pandemic. Further work is needed to explore why some athletes still have prolonged sporting time-loss.

Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity.

The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a medicinal chemistry program which initially identified a 3-furanyl analogue (6) with improved antiemetic potency and a methyl sulfone (5) with enhanced metabolic stability and oral bioavailability. The improved pharmacokinetic profile of methyl sulfone (5) was associated with its low lipophilicity, and a therefore a number of heterocyclic analogues with reduced log D were synthesized. Out of this program emerged 19 (GR203040), a tetrazolyl-substituted analogue. Tetrazole 19 inhibits radiation-induced emesis in the ferret with high potency when administered both subcutaneously and orally, has a long duration of action, and has high oral bioavailability in the dog. Tetrazole 19 is currently undergoing evaluation as a novel approach for the control of emesis associated with, for example, cancer chemotherapy.

The role of attributions in the development of dating relationships.

In this study, we examine the role of attributions in the context of dating relationships. A large sample completed a questionnaire comprising structured ratings and a free-response relationship description. As expected, cognitive or attributional activity was more frequent within relationships when they were in the early stages, when important choice points or changes were occurring, and when the relationships were perceived as unstable. Also as predicted, subjects who reported higher relationship happiness, commitment, and love for their partners tended to describe the relationship in more interpersonal terms, to rate the causal inputs of the partners as equal, and to attribute lower external attributions for relationship maintenance. Finally, some evidence was obtained that attributions for relationship maintenance are causally related to relationship happiness over a 2-month period. The results are discussed in terms of the relationship between cognitive processing and the development of dating relationships.

Model for the cost analysis of shunted hydrocephalic children.

This paper describes a model for forecasting the treatment costs for hydrocephalic patients with ventriculoperitoneal shunts. Modeling with institution-specific or reported failure rates allows the prediction of shunt failure in real and/or theoretical populations. The addition of costing factors (derived from hospitalization, operative and drug costs) to the model allows the derivation of partial or total cost estimates. The effects of varying the failure rate, infection rate, number of new patients, number of lost patients and costing factors can be simulated and measured. Basing this model on data from our institution, decreasing the rate of failure during the first year following shunt insertion or revision has the potential for greater cost savings over time than either decreasing the shunt infection rates or the duration of hospital stay. By combining shunt performance and financial data, an estimate of the cost of the treatment of a population with hydrocephalus, over time, can be derived. These data can be critical for institutional and program budgeting and serve as an estimate of the economic effects of treatment changes proposed in clinical trials.

Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children.

OBJECTIVE: To define the clinical and virologic characteristics of primary human herpesvirus 7 (HHV-7) infection and to compare these characteristics with those of primary human herpesvirus 6 (HHV-6) infection. STUDY DESIGN: A prospective convenience sample study of 496 children < or =3 years old. HHV-7 and HHV-6 infections were identified by viral isolation. Polymerase chain reaction and serology for HHV-7 and HHV-6 were performed. Clinical and laboratory characteristics of patients were obtained from medical records and follow-up interviews. RESULTS: Children with primary HHV-7 infection (n = 8) were identified and compared with children with primary HHV-6 infection (n = 29) detected during the same time period. All children were febrile (mean temperature 39.8 degrees C) with no difference in the degree of fever, frequency of rash, or gastrointestinal complications between the groups. The median age of children with primary HHV-7 infection was 26 months, significantly older than that of children with primary HHV-6 infection (median, 9 months). Children with primary HHV-7 infection were also more likely than those with primary HHV-6 infection to have seizures associated with the illness (P = .004). CONCLUSION: Primary infection with HHV-7 can cause a highly febrile illness in childhood, complicated by seizures. The serologic diagnosis of primary HHV-6 and HHV-7 infections may be confounded by cross-reacting antibodies.