Subject(s)
Bone Neoplasms/secondary , Dermatomyositis/diagnosis , Glucocorticoids/therapeutic use , Interferon-alpha/therapeutic use , Melanoma/pathology , Methylprednisolone/therapeutic use , Skin Neoplasms/pathology , Dermatomyositis/drug therapy , Dermatomyositis/pathology , Female , Humans , Interferon alpha-2 , Melanoma/drug therapy , Middle Aged , Prognosis , Recombinant Proteins/therapeutic use , Skin Neoplasms/drug therapy , Treatment OutcomeABSTRACT
Fourteen cases of anogenital warts in children are reported. Girls were more frequently affected than boys (9/5). Three children had been infected during birth; two had autoinfection from non-anogenital warts; two girls had apparently been sexually abused. In the remaining 7 cases the origin of the warts was unknown. The authors discuss the epidemiological, therapeutic and social implications of this little known but important paediatric pathology, pointing to the possibility of sexual transmission in cases of "apparently" unknown origin.
Subject(s)
Anus Neoplasms/epidemiology , Condylomata Acuminata/epidemiology , Genital Neoplasms, Female/epidemiology , Genital Neoplasms, Male/epidemiology , Anus Neoplasms/etiology , Anus Neoplasms/therapy , Child , Child Abuse, Sexual , Child, Preschool , Condylomata Acuminata/etiology , Condylomata Acuminata/therapy , Cryosurgery , Cultural Characteristics , Electrocoagulation , Female , Genital Neoplasms, Female/etiology , Genital Neoplasms, Female/therapy , Genital Neoplasms, Male/etiology , Genital Neoplasms, Male/therapy , Herpesviridae/genetics , Humans , Infant , Male , Natural Childbirth/adverse effects , Socioeconomic FactorsABSTRACT
We treated 105 patients with anogenital warts with cotton swabs soaked in liquid nitrogen. 90.1% of the patients were cured, but recurrences were observed in 19.5%. With this method we obtained better clinical results than those obtained with the cryoprobes system. Good results were obtained when the lesions were accessible for treatment, but neither the time of evolution nor the size influenced the cure.
Subject(s)
Condylomata Acuminata/drug therapy , Genital Neoplasms, Female/drug therapy , Genital Neoplasms, Male/drug therapy , Neoplasm Recurrence, Local , Nitrogen/therapeutic use , Female , Follow-Up Studies , Humans , MaleABSTRACT
In order to describe the observation of "premature aging", in a 20 year old woman, the clinical characteristics of other genodermatosis are reviewed, and the question of differential diagnosis and etiopathogenesis is raised concluding that these syndromes would have a continuous clinicopathological spectrum with various possibilities of manifestation.
Subject(s)
Progeria/classification , Adult , Female , Humans , Intellectual Disability/etiology , Phenotype , Progeria/complications , Progeria/pathologyABSTRACT
Sézary syndrome (SS) is a leukaemic variant of cutaneous T-cell lymphoma (CTCL). We report a patient with SS who developed granulomatous lesions. These lesions broke out during treatment with bexarotene when the disease had appeared to stabilize. After a partial clinical remission the disease showed rapid progression and finally led to the patient's death. This contradicts the initial assessment, which considered the granulomatous inflammation as a good prognostic factor in CTCL.
Subject(s)
Antineoplastic Agents/adverse effects , Drug Eruptions/etiology , Granuloma/chemically induced , Sezary Syndrome/drug therapy , Tetrahydronaphthalenes/adverse effects , Adult , Bexarotene , Drug Eruptions/pathology , Fatal Outcome , Female , Granuloma/pathology , HumansABSTRACT
BACKGROUND: Molluscum contagiosum (MC) is a common cutaneous infection, which has been reported in association with cutaneous pseudolymphoma in few cases. METHODS: A 72-year-old woman with a nodule arising on the external canthus was reviewed. The lesion was surgically removed, and the histopathological study demonstrated an epidermal invagination filled by molluscum bodies and a diffuse infiltrate comprising atypical lymphocytes. RESULTS: Immunohistochemical stains disclosed predominance of T cells with positive CD30 labeling. Polymerase chain reaction failed to demonstrate clonal rearrangement of the T-cell receptor. CONCLUSION: After ruling out systemic involvement, the patient was followed up for 2 years with no evidence of recurrence. We report this case to the best of our knowledge and discuss the literature about atypical clinical and histological presentations of MC.
Subject(s)
Molluscum Contagiosum/pathology , Pseudolymphoma/pathology , Skin Diseases/pathology , Aged , Female , Humans , Immunohistochemistry , Ki-1 Antigen/metabolism , Molluscum Contagiosum/complications , Molluscum Contagiosum/surgery , Pseudolymphoma/complications , Pseudolymphoma/surgery , Skin/pathology , Skin Diseases/complications , Skin Diseases/surgery , T-Lymphocytes/metabolism , T-Lymphocytes/pathology , Treatment OutcomeABSTRACT
We report two brothers, aged 5 and 2 years, with typical features of congenital erythropoietic porphyria. The elder did not receive medical attention until the age of 2 years, even though his urine had been red almost from birth, and despite severe scarring of the hands and face. The younger brother suffered haemolysis at birth. The uroporphyrinogen III cosynthase (URO IIIS) enzyme activity of red blood cells was 2% and 1.2% in the brothers, and genetic studies showed two different mutations of the URO IIIS gene, C73R and P248Q. The latter is a recently described mutation.
Subject(s)
Erythrocytes/enzymology , Hand Dermatoses/blood , Porphyria, Erythropoietic/blood , Uroporphyrinogen III Synthetase/blood , Child, Preschool , Hand Dermatoses/genetics , Hand Dermatoses/urine , Humans , Infant , Male , Mutation, Missense , Porphyria, Erythropoietic/genetics , Porphyria, Erythropoietic/urine , Uroporphyrinogen III Synthetase/geneticsSubject(s)
Lymphedema/diagnosis , Nail Diseases/diagnosis , Respiration Disorders/diagnosis , Aged , Female , Humans , Nail Diseases/pathologyABSTRACT
No disponible
No disponible
Subject(s)
Female , Aged , Humans , Nail Diseases/diagnosis , Nail Diseases/complications , Lymphedema/complications , Respiratory Tract Diseases/complications , Diagnosis, Differential , Vitamin E/therapeutic useABSTRACT
No disponible
No disponible
Subject(s)
Female , Adult , Humans , Syringoma/diagnosis , Sweat Gland Neoplasms/diagnosis , Diagnosis, DifferentialABSTRACT
No disponible
No disponible