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1.

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease.

Munir, Talha; Cairns, David A; Bloor, Adrian; Allsup, David; Cwynarski, Kate; Pettitt, Andrew; Paneesha, Shankara; Fox, Christopher P; Eyre, Toby A; Forconi, Francesco; Elmusharaf, Nagah; Kennedy, Ben; Gribben, John; Pemberton, Nicholas; Sheehy, Oonagh; Preston, Gavin; Schuh, Anna; Walewska, Renata; Duley, Lelia; Howard, Dena; Hockaday, Anna; Jackson, Sharon; Greatorex, Natasha; Girvan, Sean; Bell, Sue; Brown, Julia M; Webster, Nichola; Dalal, Surita; de Tute, Ruth; Rawstron, Andrew; Patten, Piers E M; Hillmen, Peter.

N Engl J Med ; 390(4): 326-337, 2024 Jan 25.

Article in English | MEDLINE | ID: mdl-38078508

2.

Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia.

Brown, Jennifer R; Eichhorst, Barbara; Hillmen, Peter; Jurczak, Wojciech; Kazmierczak, Maciej; Lamanna, Nicole; O'Brien, Susan M; Tam, Constantine S; Qiu, Lugui; Zhou, Keshu; Simkovic, Martin; Mayer, Jiri; Gillespie-Twardy, Amanda; Ferrajoli, Alessandra; Ganly, Peter S; Weinkove, Robert; Grosicki, Sebastian; Mital, Andrzej; Robak, Tadeusz; Osterborg, Anders; Yimer, Habte A; Salmi, Tommi; Wang, Megan-Der-Yu; Fu, Lina; Li, Jessica; Wu, Kenneth; Cohen, Aileen; Shadman, Mazyar.

N Engl J Med ; 388(4): 319-332, 2023 01 26.

Article in English | MEDLINE | ID: mdl-36511784

3.

Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline.

Kulasekararaj, Austin; Cavenagh, Jamie; Dokal, Inderjeet; Foukaneli, Theodora; Gandhi, Shreyans; Garg, Mamta; Griffin, Morag; Hillmen, Peter; Ireland, Robin; Killick, Sally; Mansour, Sahar; Mufti, Ghulam; Potter, Victoria; Snowden, John; Stanworth, Simon; Zuha, Roslin; Marsh, Judith.

Br J Haematol ; 204(3): 784-804, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38247114

4.

Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.

Hillmen, Peter; Szer, Jeff; Weitz, Ilene; Röth, Alexander; Höchsmann, Britta; Panse, Jens; Usuki, Kensuke; Griffin, Morag; Kiladjian, Jean-Jacques; de Castro, Carlos; Nishimori, Hisakazu; Tan, Lisa; Hamdani, Mohamed; Deschatelets, Pascal; Francois, Cedric; Grossi, Federico; Ajayi, Temitayo; Risitano, Antonio; Peffault de la Tour, Régis.

N Engl J Med ; 384(11): 1028-1037, 2021 03 18.

Article in English | MEDLINE | ID: mdl-33730455

5.

Plain language summary of zanubrutinib or ibrutinib in chronic lymphocytic leukemia that is resistant to treatment or has come back after treatment.

Brown, Jennifer R; Eichhorst, Barbara; Hillmen, Peter; Jurczak, Wojciech; Kazmierczak, Maciej; Lamanna, Nicole; O'Brien, Susan M; Tam, Constantine S; Qiu, Lugui; Zhou, Keshu; Simkovic, Martin; Mayer, Jiri; Gillespie-Twardy, Amanda; Ferrajoli, Alessandra; Ganly, Peter S; Weinkove, Robert; Grosicki, Sebastian; Mital, Andrzej; Robak, Tadeusz; Osterborg, Anders; Yimer, Habte A; Salmi, Tommi; Wang, Megan-Der-Yu; Fu, Lina; Li, Jessica; Wu, Kenneth; Cohen, Aileen; Shadman, Mazyar.

Future Oncol ; 20(12): 717-726, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38088119

6.

Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomised, phase 3 trial.

Hillmen, Peter; Pitchford, Alexandra; Bloor, Adrian; Broom, Angus; Young, Moya; Kennedy, Ben; Walewska, Renata; Furtado, Michelle; Preston, Gavin; Neilson, Jeffrey R; Pemberton, Nicholas; Sidra, Gamal; Morley, Nicholas; Cwynarski, Kate; Schuh, Anna; Forconi, Francesco; Elmusharaf, Nagah; Paneesha, Shankara; Fox, Christopher P; Howard, Dena R; Hockaday, Anna; Brown, Julia M; Cairns, David A; Jackson, Sharon; Greatorex, Natasha; Webster, Nichola; Shingles, Jane; Dalal, Surita; Patten, Piers E M; Allsup, David; Rawstron, Andrew; Munir, Talha.

Lancet Oncol ; 24(5): 535-552, 2023 05.

Article in English | MEDLINE | ID: mdl-37142374

7.

Acalabrutinib in treatment-naive chronic lymphocytic leukemia.

Byrd, John C; Woyach, Jennifer A; Furman, Richard R; Martin, Peter; O'Brien, Susan; Brown, Jennifer R; Stephens, Deborah M; Barrientos, Jacqueline C; Devereux, Stephen; Hillmen, Peter; Pagel, John M; Hamdy, Ahmed; Izumi, Raquel; Patel, Priti; Wang, Min Hui; Jain, Nitin; Wierda, William G.

Blood ; 137(24): 3327-3338, 2021 06 17.

Article in English | MEDLINE | ID: mdl-33786588

8.

Many People With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Benefit From Ibrutinib Treatment Up To 8 Years: A Plain Language Summary.

Barr, Paul M; Owen, Carolyn; Robak, Tadeusz; Tedeschi, Alessandra; Bairey, Osnat; Burger, Jan A; Hillmen, Peter; Dearden, Claire; Grosicki, Sebastian; McCarthy, Helen; Li, Jian Yong; Offner, Fritz; Moreno, Carol; Jermain, Mandy; Zhou, Cathy; Hsu, Emily; Szoke, Anita; Kipps, Thomas J; Ghia, Paolo.

Future Oncol ; 2023 01 09.

Article in English | MEDLINE | ID: mdl-36617990

9.

Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.

Tam, Constantine S; Brown, Jennifer R; Kahl, Brad S; Ghia, Paolo; Giannopoulos, Krzysztof; Jurczak, Wojciech; Simkovic, Martin; Shadman, Mazyar; Österborg, Anders; Laurenti, Luca; Walker, Patricia; Opat, Stephen; Chan, Henry; Ciepluch, Hanna; Greil, Richard; Tani, Monica; Trnený, Marek; Brander, Danielle M; Flinn, Ian W; Grosicki, Sebastian; Verner, Emma; Tedeschi, Alessandra; Li, Jianyong; Tian, Tian; Zhou, Lei; Marimpietri, Carol; Paik, Jason C; Cohen, Aileen; Huang, Jane; Robak, Tadeusz; Hillmen, Peter.

Lancet Oncol ; 23(8): 1031-1043, 2022 08.

Article in English | MEDLINE | ID: mdl-35810754

10.

Obinutuzumab as consolidation after chemo-immunotherapy: Results of the UK National Cancer Research Institute phase II/III GALACTIC trial.

Munir, Talha; Emmerson, Jake; Hockaday, Anna; Oughton, Jamie B; Howard, Dena; Phillips, David; Neilson, Jeff; Pemberton, Nicholas; Paneesha, Shankara; Kennedy, Ben; Rawstron, Andy; Hillmen, Peter.

Br J Haematol ; 199(5): 707-719, 2022 12.

Article in English | MEDLINE | ID: mdl-36017875

11.

Oral Iptacopan in Paroxysmal Nocturnal Hemoglobinuria.

Hillmen, Peter.

N Engl J Med ; 390(21): 2032-2033, 2024 Jun 06.

Article in English | MEDLINE | ID: mdl-38838319

12.

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease. Reply.

Munir, Talha; Hillmen, Peter.

N Engl J Med ; 390(17): 1634-1635, 2024 May 02.

Article in English | MEDLINE | ID: mdl-38692304

13.

Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results.

Byrd, John C; Wierda, William G; Schuh, Anna; Devereux, Stephen; Chaves, Jorge M; Brown, Jennifer R; Hillmen, Peter; Martin, Peter; Awan, Farrukh T; Stephens, Deborah M; Ghia, Paolo; Barrientos, Jacqueline; Pagel, John M; Woyach, Jennifer A; Burke, Kathleen; Covey, Todd; Gulrajani, Michael; Hamdy, Ahmed; Izumi, Raquel; Frigault, Melanie M; Patel, Priti; Rothbaum, Wayne; Wang, Min Hui; O'Brien, Susan; Furman, Richard R.

Blood ; 135(15): 1204-1213, 2020 04 09.

Article in English | MEDLINE | ID: mdl-31876911

14.

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL.

Kwok, Marwan; Oldreive, Ceri; Rawstron, Andy C; Goel, Anshita; Papatzikas, Grigorios; Jones, Rhiannon E; Drennan, Samantha; Agathanggelou, Angelo; Sharma-Oates, Archana; Evans, Paul; Smith, Edward; Dalal, Surita; Mao, Jingwen; Hollows, Robert; Gordon, Naheema; Hamada, Mayumi; Davies, Nicholas J; Parry, Helen; Beggs, Andrew D; Munir, Talha; Moreton, Paul; Paneesha, Shankara; Pratt, Guy; Taylor, A Malcolm R; Forconi, Francesco; Baird, Duncan M; Cazier, Jean-Baptiste; Moss, Paul; Hillmen, Peter; Stankovic, Tatjana.

Blood ; 135(6): 411-428, 2020 02 06.

Article in English | MEDLINE | ID: mdl-31794600

15.

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients.

Brown, Jennifer R; Byrd, John C; Ghia, Paolo; Sharman, Jeff P; Hillmen, Peter; Stephens, Deborah M; Sun, Clare; Jurczak, Wojciech; Pagel, John M; Ferrajoli, Alessandra; Patel, Priti; Tao, Lin; Kuptsova-Clarkson, Nataliya; Moslehi, Javid; Furman, Richard R.

Haematologica ; 107(6): 1335-1346, 2022 06 01.

Article in English | MEDLINE | ID: mdl-34587719

16.

Effect of eculizumab treatment in patients with paroxysmal nocturnal hemoglobinuria with or without high disease activity: Real-world findings from the International Paroxysmal Nocturnal Hemoglobinuria Registry.

Höchsmann, Britta; de Fontbrune, Flore Sicre; Lee, Jong Wook; Kulagin, Alexander D; Hillmen, Peter; Wilson, Amanda; Marantz, Jing L; Schrezenmeier, Hubert.

Eur J Haematol ; 109(3): 197-204, 2022 Sep.

Article in English | MEDLINE | ID: mdl-35390189

17.

Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.

Seymour, John F; Kipps, Thomas J; Eichhorst, Barbara; Hillmen, Peter; D'Rozario, James; Assouline, Sarit; Owen, Carolyn; Gerecitano, John; Robak, Tadeusz; De la Serna, Javier; Jaeger, Ulrich; Cartron, Guillaume; Montillo, Marco; Humerickhouse, Rod; Punnoose, Elizabeth A; Li, Yan; Boyer, Michelle; Humphrey, Kathryn; Mobasher, Mehrdad; Kater, Arnon P.

N Engl J Med ; 378(12): 1107-1120, 2018 Mar 22.

Article in English | MEDLINE | ID: mdl-29562156

18.

Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab.

Byrd, John C; Hillmen, Peter; O'Brien, Susan; Barrientos, Jacqueline C; Reddy, Nishitha M; Coutre, Steven; Tam, Constantine S; Mulligan, Stephen P; Jaeger, Ulrich; Barr, Paul M; Furman, Richard R; Kipps, Thomas J; Thornton, Patrick; Moreno, Carol; Montillo, Marco; Pagel, John M; Burger, Jan A; Woyach, Jennifer A; Dai, Sandra; Vezan, Remus; James, Danelle F; Brown, Jennifer R.

Blood ; 133(19): 2031-2042, 2019 05 09.

Article in English | MEDLINE | ID: mdl-30842083

19.

Phase 1b study of venetoclax-obinutuzumab in previously untreated and relapsed/refractory chronic lymphocytic leukemia.

Flinn, Ian W; Gribben, John G; Dyer, Martin J S; Wierda, William; Maris, Michael B; Furman, Richard R; Hillmen, Peter; Rogers, Kerry A; Iyer, Swaminathan Padmanabhan; Quillet-Mary, Anne; Ysebaert, Loic; Walter, Harriet S; Verdugo, Maria; Klein, Christian; Huang, Huang; Jiang, Yanwen; Lozanski, Gerard; Pignataro, Daniela Soriano; Humphrey, Kathryn; Mobasher, Mehrdad; Kipps, Thomas J.

Blood ; 133(26): 2765-2775, 2019 06 27.

Article in English | MEDLINE | ID: mdl-30862645

20.

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria.

Brodsky, Robert A; Peffault de Latour, Régis; Rottinghaus, Scott T; Röth, Alexander; Risitano, Antonio M; Weitz, Ilene C; Hillmen, Peter; Maciejewski, Jaroslaw P; Szer, Jeff; Lee, Jong Wook; Kulasekararaj, Austin G; Volles, Lori; Damokosh, Andrew I; Ortiz, Stephan; Shafner, Lori; Liu, Peng; Hill, Anita; Schrezenmeier, Hubert.

Haematologica ; 106(1): 230-237, 2021 01 01.

Article in English | MEDLINE | ID: mdl-31949012

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