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1.

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness.

Koutsogiannis, Zisis; Mina, John G; Albus, Christin A; Kol, Matthijs A; Holthuis, Joost C M; Pohl, Ehmke; Denny, Paul W.

FASEB J ; 37(11): e23229, 2023 11.

Article in English | MEDLINE | ID: mdl-37795915

2.

Membrane damage and repair: a thin line between life and death.

Barisch, Caroline; Holthuis, Joost C M; Cosentino, Katia.

Biol Chem ; 404(5): 467-490, 2023 04 25.

Article in English | MEDLINE | ID: mdl-36810295

3.

Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets.

Philippi, Michael; Richter, Christian P; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer; Holthuis, Joost C M; Garcia, K Christopher; Plückthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang.

Small ; 18(50): e2203723, 2022 12.

Article in English | MEDLINE | ID: mdl-36266931

4.

Lipid landscapes and pipelines in membrane homeostasis.

Holthuis, Joost C M; Menon, Anant K.

Nature ; 510(7503): 48-57, 2014 Jun 05.

Article in English | MEDLINE | ID: mdl-24899304

5.

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis.

Jain, Amrita; Beutel, Oliver; Ebell, Katharina; Korneev, Sergey; Holthuis, Joost C M.

J Cell Sci ; 130(2): 360-371, 2017 01 15.

Article in English | MEDLINE | ID: mdl-27888218

6.

Membrane contact sites, ancient and central hubs of cellular lipid logistics.

Jain, Amrita; Holthuis, Joost C M.

Biochim Biophys Acta Mol Cell Res ; 1864(9): 1450-1458, 2017 Sep.

Article in English | MEDLINE | ID: mdl-28554771

7.

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.

Bockelmann, Svenja; Mina, John G M; Korneev, Sergei; Hassan, Dina G; Müller, Dagmar; Hilderink, Angelika; Vlieg, Hedwich C; Raijmakers, Reinout; Heck, Albert J R; Haberkant, Per; Holthuis, Joost C M.

J Lipid Res ; 59(3): 515-530, 2018 03.

Article in English | MEDLINE | ID: mdl-29343537

8.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases.

Kol, Matthijs; Panatala, Radhakrishnan; Nordmann, Mirjana; Swart, Leoni; van Suijlekom, Leonie; Cabukusta, Birol; Hilderink, Angelika; Grabietz, Tanja; Mina, John G M; Somerharju, Pentti; Korneev, Sergei; Tafesse, Fikadu G; Holthuis, Joost C M.

J Lipid Res ; 58(5): 962-973, 2017 05.

Article in English | MEDLINE | ID: mdl-28336574

9.

Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching.

Cabukusta, Birol; Köhlen, Jan A; Richter, Christian P; You, Changjiang; Holthuis, Joost C M.

J Biol Chem ; 291(47): 24735-24746, 2016 Nov 18.

Article in English | MEDLINE | ID: mdl-27729449

10.

Inner workings and biological impact of phospholipid flippases.

Panatala, Radhakrishnan; Hennrich, Hanka; Holthuis, Joost C M.

J Cell Sci ; 128(11): 2021-32, 2015 Jun 01.

Article in English | MEDLINE | ID: mdl-25918123

11.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.

Kol, Matthijs; Panatala, Radhakrishnan; Nordmann, Mirjana; Swart, Leoni; van Suijlekom, Leonie; Cabukusta, Birol; Hilderink, Angelika; Grabietz, Tanja; Mina, John G M; Somerharju, Pentti; Korneev, Sergei; Tafesse, Fikadu G; Holthuis, Joost C M.

J Lipid Res ; 57(7): 1273-85, 2016 07.

Article in English | MEDLINE | ID: mdl-27165857

12.

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.

Tafesse, Fikadu G; Vacaru, Ana M; Bosma, Elleke F; Hermansson, Martin; Jain, Amrita; Hilderink, Angelika; Somerharju, Pentti; Holthuis, Joost C M.

J Cell Sci ; 127(Pt 2): 445-54, 2014 Jan 15.

Article in English | MEDLINE | ID: mdl-24259670

13.

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.

Bickert, Andreas; Ginkel, Christina; Kol, Matthijs; vom Dorp, Katharina; Jastrow, Holger; Degen, Joachim; Jacobs, René L; Vance, Dennis E; Winterhager, Elke; Jiang, Xian-Cheng; Dörmann, Peter; Somerharju, Pentti; Holthuis, Joost C M; Willecke, Klaus.

J Lipid Res ; 56(4): 821-35, 2015 Apr.

Article in English | MEDLINE | ID: mdl-25667419

14.

Fat & fabulous: bifunctional lipids in the spotlight.

Haberkant, Per; Holthuis, Joost C M.

Biochim Biophys Acta ; 1841(8): 1022-30, 2014 Aug.

Article in English | MEDLINE | ID: mdl-24440797

15.

Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen.

Vacaru, Ana M; van den Dikkenberg, Joep; Ternes, Philipp; Holthuis, Joost C M.

J Biol Chem ; 288(16): 11520-30, 2013 Apr 19.

Article in English | MEDLINE | ID: mdl-23449981

16.

Mapping functional interactions in a heterodimeric phospholipid pump.

Puts, Catheleyne F; Panatala, Radhakrishnan; Hennrich, Hanka; Tsareva, Alina; Williamson, Patrick; Holthuis, Joost C M.

J Biol Chem ; 287(36): 30529-40, 2012 Aug 31.

Article in English | MEDLINE | ID: mdl-22791719

17.

Cellular microcompartments constitute general suborganellar functional units in cells.

Holthuis, Joost C M; Ungermann, Christian.

Biol Chem ; 394(2): 151-61, 2013 Feb.

Article in English | MEDLINE | ID: mdl-23087101

18.

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase.

Jahn, Helene; Bartos, Ladislav; Dearden, Grace I; Dittman, Jeremy S; Holthuis, Joost C M; Vácha, Robert; Menon, Anant K.

Nat Commun ; 14(1): 8115, 2023 Dec 08.

Article in English | MEDLINE | ID: mdl-38065946

19.

Systematic analysis of the sphingomyelin synthase family in C. elegans.

Guzman, Gaelen G; Farley, Scotland; Kyle, Jennifer E; Bramer, Lisa M; Hoeltzl, Sandra; van den Dikkenberg, Joep; Holthuis, Joost C M; Tafesse, Fikadu G.

bioRxiv ; 2023 Jul 25.

Article in English | MEDLINE | ID: mdl-37546869

20.

An alliance between lipid transfer proteins and scramblases for membrane expansion.

Holthuis, Joost C M; Jahn, Helene; Menon, Anant K; Mizushima, Noboru.

Fac Rev ; 11: 22, 2022.

Article in English | MEDLINE | ID: mdl-36081427

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