Search details
1.
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery.
Nature
; 589(7843): 542-547, 2021 01.
Article
in English
| MEDLINE | ID: mdl-33238289
2.
Preclinical evaluation of [11 C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.
J Labelled Comp Radiopharm
; 64(4): 159-167, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33226657
3.
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin GeneâRelated Peptide Receptor.
J Pharmacol Exp Ther
; 2020 Jan 28.
Article
in English
| MEDLINE | ID: mdl-31992609
4.
MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
J Pharmacol Exp Ther
; 374(2): 252-263, 2020 08.
Article
in English
| MEDLINE | ID: mdl-32493725
5.
fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation.
Neuroimage
; 149: 348-360, 2017 04 01.
Article
in English
| MEDLINE | ID: mdl-28163142
6.
cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles.
J Labelled Comp Radiopharm
; 60(5): 263-269, 2017 05 15.
Article
in English
| MEDLINE | ID: mdl-28185305
7.
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 26(1): 126-32, 2016 Jan 01.
Article
in English
| MEDLINE | ID: mdl-26602277
8.
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 25(21): 4893-4898, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-26077491
9.
Evaluation of [¹8F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.
Neuroimage
; 68: 1-10, 2013 Mar.
Article
in English
| MEDLINE | ID: mdl-23238431
10.
In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.
J Pharmacol Exp Ther
; 347(2): 478-86, 2013 Nov.
Article
in English
| MEDLINE | ID: mdl-23975906
11.
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
ACS Med Chem Lett
; 14(7): 986-992, 2023 Jul 13.
Article
in English
| MEDLINE | ID: mdl-37465306
12.
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Sci Transl Med
; 14(627): eabg3684, 2022 01 12.
Article
in English
| MEDLINE | ID: mdl-35020407
13.
Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor.
Neuroimage
; 54(4): 2635-42, 2011 Feb 14.
Article
in English
| MEDLINE | ID: mdl-21078401
14.
Synthesis, characterization, and monkey PET studies of [¹8F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435.
Synapse
; 65(2): 125-35, 2011 Feb.
Article
in English
| MEDLINE | ID: mdl-20524178
15.
A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240.
EJNMMI Res
; 11(1): 49, 2021 May 27.
Article
in English
| MEDLINE | ID: mdl-34046730
16.
PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys.
Mol Imaging Biol
; 23(2): 250-259, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33104972
17.
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.
Mol Imaging Biol
; 23(2): 241-249, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33098025
18.
Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.
Mol Imaging Biol
; 22(1): 173-180, 2020 02.
Article
in English
| MEDLINE | ID: mdl-31111397
19.
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
J Med Chem
; 63(5): 2411-2425, 2020 03 12.
Article
in English
| MEDLINE | ID: mdl-32101422
20.
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
J Pharmacol Exp Ther
; 331(2): 470-84, 2009 Nov.
Article
in English
| MEDLINE | ID: mdl-19704033