1.
NPJ Precis Oncol
; 6(1): 63, 2022 Sep 06.
Article
in English
| MEDLINE
| ID: mdl-36068285
ABSTRACT
Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical management, yet tissue access is restricted due to the sensitive tumor location. We developed a targeted deep sequencing platform to detect tumor driver mutations, copy number variations, and heterogeneity in the liquid biome. Here, we present the sensitivity, specificity, and clinical relevance of our minimally invasive platform for tumor mutation profiling in children diagnosed with CNS cancer.