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1.

Rational design of proteasome inhibitors based on the structure of the endogenous inhibitor PI31/Fub1.

Velez, Benjamin; Razi, Aida; Hubbard, Robert D; Walsh, Richard; Rawson, Shaun; Tian, Geng; Finley, Daniel; Hanna, John.

Proc Natl Acad Sci U S A ; 120(51): e2308417120, 2023 Dec 19.

Article in English | MEDLINE | ID: mdl-38091293

2.

A robust in vivo positive-readout system for monitoring siRNA delivery to xenograft tumors.

Lin, Xiaoyu; Li, Leiming; Wang, Rongqi; Wilcox, Denise; Zhao, Xiaobin; Song, Jingfeng; Huang, Xiaoli; Hansen, T Matthew; Dande, Prasad; Wada, Carol; Hubbard, Robert D; Kohlbrenner, William M; Fesik, Stephen W; Shen, Yu.

RNA ; 17(4): 603-12, 2011 Apr.

Article in English | MEDLINE | ID: mdl-21321186

3.

Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.

Wang, Gary T; Mantei, Robert A; Hubbard, Robert D; Wilsbacher, Julie L; Zhang, Qian; Tucker, Lora; Hu, Xiaoming; Kovar, Peter; Johnson, Eric F; Osterling, Donald J; Bouska, Jennifer; Wang, Jieyi; Davidsen, Steven K; Bell, Randy L; Sheppard, George S.

Bioorg Med Chem Lett ; 20(20): 6067-71, 2010 Oct 15.

Article in English | MEDLINE | ID: mdl-20817523

4.

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Fidanze, Steve D; Erickson, Scott A; Wang, Gary T; Mantei, Robert; Clark, Richard F; Sorensen, Bryan K; Bamaung, Nwe Y; Kovar, Peter; Johnson, Eric F; Swinger, Kerren K; Stewart, Kent D; Zhang, Qian; Tucker, Lora A; Pappano, William N; Wilsbacher, Julie L; Wang, Jieyi; Sheppard, George S; Bell, Randy L; Davidsen, Steven K; Hubbard, Robert D.

Bioorg Med Chem Lett ; 20(8): 2452-5, 2010 Apr 15.

Article in English | MEDLINE | ID: mdl-20346655

5.

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.

Pappano, William N; Jung, Paul M; Meulbroek, Jonathan A; Wang, Yi-Chun; Hubbard, Robert D; Zhang, Qian; Grudzien, Meagan M; Soni, Niru B; Johnson, Eric F; Sheppard, George S; Donawho, Cherrie; Buchanan, Fritz G; Davidsen, Steven K; Bell, Randy L; Wang, Jieyi.

BMC Cancer ; 9: 314, 2009 Sep 04.

Article in English | MEDLINE | ID: mdl-19732452

6.

Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.

Hubbard, Robert D; Bamaung, Nwe Y; Fidanze, Steve D; Erickson, Scott A; Palazzo, Fabio; Wilsbacher, Julie L; Zhang, Qian; Tucker, Lora A; Hu, Xiaoming; Kovar, Peter; Osterling, Donald J; Johnson, Eric F; Bouska, Jennifer; Wang, Jieyi; Davidsen, Steven K; Bell, Randy L; Sheppard, George S.

Bioorg Med Chem Lett ; 19(6): 1718-21, 2009 Mar 15.

Article in English | MEDLINE | ID: mdl-19217287

7.

Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.

Waterson, Alex G; Petrov, Kimberly G; Hornberger, Keith R; Hubbard, Robert D; Sammond, Douglas M; Smith, Stephon C; Dickson, Hamilton D; Caferro, Thomas R; Hinkle, Kevin W; Stevens, Kirk L; Dickerson, Scott H; Rusnak, David W; Spehar, Glenn M; Wood, Edgar R; Griffin, Robert J; Uehling, David E.

Bioorg Med Chem Lett ; 19(5): 1332-6, 2009 Mar 01.

Article in English | MEDLINE | ID: mdl-19208477

8.

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.

Stevens, Kirk L; Alligood, Krystal J; Alberti, Jennifer G Badiang; Caferro, Thomas R; Chamberlain, Stanley D; Dickerson, Scott H; Dickson, Hamilton D; Emerson, Holly K; Griffin, Robert J; Hubbard, Robert D; Keith, Barry R; Mullin, Robert J; Petrov, Kimberly G; Gerding, Roseanne M; Reno, Michael J; Rheault, Tara R; Rusnak, David W; Sammond, Douglas M; Smith, Stephon C; Uehling, David E; Waterson, Alex G; Wood, Edgar R.

Bioorg Med Chem Lett ; 19(1): 21-6, 2009 Jan 01.

Article in English | MEDLINE | ID: mdl-19028424

9.

Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines.

Hubbard, Robert D; Dickerson, Scott H; Emerson, Holly K; Griffin, Robert J; Reno, Michael J; Hornberger, Keith R; Rusnak, David W; Wood, Edgar R; Uehling, David E; Waterson, Alex G.

Bioorg Med Chem Lett ; 18(21): 5738-40, 2008 Nov 01.

Article in English | MEDLINE | ID: mdl-18842405

10.

Synthesis and biological evaluation of (-)-laulimalide analogues.

Wender, Paul A; Hegde, Sayee G; Hubbard, Robert D; Zhang, Lei; Mooberry, Susan L.

Org Lett ; 5(19): 3507-9, 2003 Sep 18.

Article in English | MEDLINE | ID: mdl-12967311

11.

Developing lipid nanoparticle-based siRNA therapeutics for hepatocellular carcinoma using an integrated approach.

Li, Leiming; Wang, Rongqi; Wilcox, Denise; Sarthy, Aparna; Lin, Xiaoyu; Huang, Xiaoli; Tian, Lu; Dande, Prasad; Hubbard, Robert D; Hansen, Todd M; Wada, Carol; Zhao, Xiaobin; Kohlbrenner, William M; Fesik, Stephen W; Shen, Yu.

Mol Cancer Ther ; 12(11): 2308-18, 2013 Nov.

Article in English | MEDLINE | ID: mdl-23943805

12.

Cationic lipids percentage and processing temperature are critical in designing siRNA lipid nanoparticles.

Zhao, Xiaobin; Liu, Yemin; Song, Jingfeng; Yong, Hong; Li, Leiming; Shen, Yu; Hubbard, Robert D; Kohlbrenner, William E; Zhou, Ji; Cluff, Kevin D; Skoug, John W.

J Drug Target ; 20(3): 281-9, 2012 Apr.

Article in English | MEDLINE | ID: mdl-22214439

13.

Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.

Wilsbacher, Julie L; Zhang, Qian; Tucker, Lora A; Hubbard, Robert D; Sheppard, George S; Bamaung, Nwe Y; Fidanze, Steve D; Wang, Gary T; Hu, Xiaoming; Davidsen, Steven K; Bell, Randy L; Wang, Jieyi.

J Biol Chem ; 283(35): 23721-30, 2008 Aug 29.

Article in English | MEDLINE | ID: mdl-18559346

14.

Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).

Hubbard, Robert D; Bamaung, Nwe Y; Palazzo, Fabio; Zhang, Qian; Kovar, Peter; Osterling, Donald J; Hu, Xiaoming; Wilsbacher, Julie L; Johnson, Eric F; Bouska, Jennifer; Wang, Jieyi; Bell, Randy L; Davidsen, Steven K; Sheppard, George S.

Bioorg Med Chem Lett ; 17(19): 5406-9, 2007 Oct 01.

Article in English | MEDLINE | ID: mdl-17689078

15.

Multicomponent cycloadditions: the four-component [5+1+2+1] cycloaddition of vinylcyclopropanes, alkynes, and CO.

Wender, Paul A; Gamber, Gabriel G; Hubbard, Robert D; Pham, Son M; Zhang, Lei.

J Am Chem Soc ; 127(9): 2836-7, 2005 Mar 09.

Article in English | MEDLINE | ID: mdl-15740103

16.

Three-component cycloadditions: the first transition metal-catalyzed [5+2+1] cycloaddition reactions.

Wender, Paul A; Gamber, Gabriel G; Hubbard, Robert D; Zhang, Lei.

J Am Chem Soc ; 124(12): 2876-7, 2002 Mar 27.

Article in English | MEDLINE | ID: mdl-11902870

17.

Total synthesis of (-)-laulimalide.

Wender, Paul A; Hegde, Sayee G; Hubbard, Robert D; Zhang, Lei.

J Am Chem Soc ; 124(18): 4956-7, 2002 May 08.

Article in English | MEDLINE | ID: mdl-11982349

18.

Microtubule-stabilizing agents based on designed laulimalide analogues.

Mooberry, Susan L; Randall-Hlubek, Deborah A; Leal, Rachel M; Hegde, Sayee G; Hubbard, Robert D; Zhang, Lei; Wender, Paul A.

Proc Natl Acad Sci U S A ; 101(23): 8803-8, 2004 Jun 08.

Article in English | MEDLINE | ID: mdl-15161976

19.

Advances towards the development of ATP-competitive small-molecule inhibitors of the insulin-like growth factor receptor (IGF-IR).

Hubbard, Robert D; Wilsbacher, Julie L.

ChemMedChem ; 2(1): 41-6, 2007 Jan.

Article in English | MEDLINE | ID: mdl-17089440

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