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1.

Inefficient CAR-proximal signaling blunts antigen sensitivity.

Gudipati, Venugopal; Rydzek, Julian; Doel-Perez, Iago; Gonçalves, Vasco Dos Reis; Scharf, Lydia; Königsberger, Sebastian; Lobner, Elisabeth; Kunert, Renate; Einsele, Hermann; Stockinger, Hannes; Hudecek, Michael; Huppa, Johannes B.

Nat Immunol ; 21(8): 848-856, 2020 08.

Article in English | MEDLINE | ID: mdl-32632291

2.

BATF3 programs CD8⁺ T cell memory.

Ataide, Marco A; Komander, Karl; Knöpper, Konrad; Peters, Annika E; Wu, Hao; Eickhoff, Sarah; Gogishvili, Tea; Weber, Justus; Grafen, Anika; Kallies, Axel; Garbi, Natalio; Einsele, Hermann; Hudecek, Michael; Gasteiger, Georg; Hölzel, Michael; Vaeth, Martin; Kastenmüller, Wolfgang.

Nat Immunol ; 21(11): 1397-1407, 2020 11.

Article in English | MEDLINE | ID: mdl-32989328

3.

CAR T-cell therapy in multiple myeloma: mission accomplished?

Rasche, Leo; Hudecek, Michael; Einsele, Hermann.

Blood ; 143(4): 305-310, 2024 Jan 25.

Article in English | MEDLINE | ID: mdl-38033289

4.

Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors.

Bexte, Tobias; Botezatu, Lacramioara; Miskey, Csaba; Gierschek, Fenja; Moter, Alina; Wendel, Philipp; Reindl, Lisa Marie; Campe, Julia; Villena-Ossa, Jose Francisco; Gebel, Veronika; Stein, Katja; Cathomen, Toni; Cremer, Anjali; Wels, Winfried S; Hudecek, Michael; Ivics, Zoltán; Ullrich, Evelyn.

Mol Ther ; 2024 May 14.

Article in English | MEDLINE | ID: mdl-38751112

5.

Cytotoxicity of CD19-CAR-NK92 cells is primarily mediated via perforin/granzyme pathway.

Althaus, Jonas; Nilius-Eliliwi, Verena; Maghnouj, Abdelouahid; Döring, Sascha; Schroers, Roland; Hudecek, Michael; Hahn, Stephan A; Mika, Thomas.

Cancer Immunol Immunother ; 72(8): 2573-2583, 2023 Aug.

Article in English | MEDLINE | ID: mdl-37052701

6.

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia.

Jetani, Hardikkumar; Navarro-Bailón, Almudena; Maucher, Marius; Frenz, Silke; Verbruggen, Christina; Yeguas, Ana; Vidriales, María Belén; González, Marcos; Rial Saborido, Judit; Kraus, Sabrina; Mestermann, Katrin; Thomas, Simone; Bonig, Halvard; Luu, Maik; Monjezi, Razieh; Mougiakakos, Dimitrios; Sauer, Markus; Einsele, Hermann; Hudecek, Michael.

Blood ; 138(19): 1830-1842, 2021 11 11.

Article in English | MEDLINE | ID: mdl-34289026

7.

All-trans retinoic acid works synergistically with the Î³-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells.

García-Guerrero, Estefanía; Rodríguez-Lobato, Luis G; Sierro-Martínez, Belén; Danhof, Sophia; Bates, Stephan; Frenz, Silke; Haertle, Larissa; Götz, Ralph; Sauer, Markus; Rasche, Leo; Kortüm, K Martin; Pérez-Simón, Jose A; Einsele, Hermann; Hudecek, Michael; Prommersberger, Sabrina R.

Haematologica ; 108(2): 568-580, 2023 02 01.

Article in English | MEDLINE | ID: mdl-36722406

8.

What is the future of immunotherapy in multiple myeloma?

Rasche, Leo; Hudecek, Michael; Einsele, Hermann.

Blood ; 136(22): 2491-2497, 2020 11 26.

Article in English | MEDLINE | ID: mdl-32735639

9.

Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival.

Julamanee, Jakrawadee; Terakura, Seitaro; Umemura, Koji; Adachi, Yoshitaka; Miyao, Kotaro; Okuno, Shingo; Takagi, Erina; Sakai, Toshiyasu; Koyama, Daisuke; Goto, Tatsunori; Hanajiri, Ryo; Hudecek, Michael; Steinberger, Peter; Leitner, Judith; Nishida, Tetsuya; Murata, Makoto; Kiyoi, Hitoshi.

Mol Ther ; 29(9): 2677-2690, 2021 09 01.

Article in English | MEDLINE | ID: mdl-33940156

10.

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Prommersberger, Sabrina; Reiser, Michael; Beckmann, Julia; Danhof, Sophia; Amberger, Maximilian; Quade-Lyssy, Patricia; Einsele, Hermann; Hudecek, Michael; Bonig, Halvard; Ivics, Zoltán.

Gene Ther ; 28(9): 560-571, 2021 09.

Article in English | MEDLINE | ID: mdl-33846552

11.

Î³-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma.

Pont, Margot J; Hill, Tyler; Cole, Gabriel O; Abbott, Joe J; Kelliher, Jessica; Salter, Alexander I; Hudecek, Michael; Comstock, Melissa L; Rajan, Anusha; Patel, Bharvin K R; Voutsinas, Jenna M; Wu, Qian; Liu, Lingfeng; Cowan, Andrew J; Wood, Brent L; Green, Damian J; Riddell, Stanley R.

Blood ; 134(19): 1585-1597, 2019 11 07.

Article in English | MEDLINE | ID: mdl-31558469

12.

Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns.

Danhof, Sophia; Rasche, Leo; Mottok, Anja; Steinmüller, Tabea; Zhou, Xiang; Schreder, Martin; Kilian, Teresa; Strifler, Susanne; Rosenwald, Andreas; Hudecek, Michael; Einsele, Hermann; Gerhard-Hartmann, Elena.

Ann Hematol ; 100(6): 1537-1546, 2021 Jun.

Article in English | MEDLINE | ID: mdl-33575947

13.

New targets and technologies for CAR-T cells.

Freitag, Fabian; Maucher, Marius; Riester, Zeno; Hudecek, Michael.

Curr Opin Oncol ; 32(5): 510-517, 2020 09.

Article in English | MEDLINE | ID: mdl-32657796

14.

Overcoming key challenges in cancer immunotherapy with engineered T cells.

Arcangeli, Silvia; Mestermann, Katrin; Weber, Justus; Bonini, Chiara; Casucci, Monica; Hudecek, Michael.

Curr Opin Oncol ; 32(5): 398-407, 2020 09.

Article in English | MEDLINE | ID: mdl-32796230

15.

Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE).

Yakoub-Agha, Ibrahim; Chabannon, Christian; Bader, Peter; Basak, Grzegorz W; Bonig, Halvard; Ciceri, Fabio; Corbacioglu, Selim; Duarte, Rafael F; Einsele, Hermann; Hudecek, Michael; Kersten, Marie José; Köhl, Ulrike; Kuball, Jürgen; Mielke, Stephan; Mohty, Mohamad; Murray, John; Nagler, Arnon; Robinson, Stephen; Saccardi, Riccardo; Sanchez-Guijo, Fermin; Snowden, John A; Srour, Micha; Styczynski, Jan; Urbano-Ispizua, Alvaro; Hayden, Patrick J; Kröger, Nicolaus.

Haematologica ; 105(2): 297-316, 2020.

Article in English | MEDLINE | ID: mdl-31753925

16.

Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform.

Rydzek, Julian; Nerreter, Thomas; Peng, Haiyong; Jutz, Sabrina; Leitner, Judith; Steinberger, Peter; Einsele, Hermann; Rader, Christoph; Hudecek, Michael.

Mol Ther ; 27(2): 287-299, 2019 02 06.

Article in English | MEDLINE | ID: mdl-30573301

17.

Chemically Programmable and Switchable CAR-T Therapy.

Qi, Junpeng; Tsuji, Kohei; Hymel, David; Burke, Terrence R; Hudecek, Michael; Rader, Christoph; Peng, Haiyong.

Angew Chem Int Ed Engl ; 59(29): 12178-12185, 2020 07 13.

Article in English | MEDLINE | ID: mdl-32329959

18.

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.

Hudecek, Michael; Izsvák, Zsuzsanna; Johnen, Sandra; Renner, Matthias; Thumann, Gabriele; Ivics, Zoltán.

Crit Rev Biochem Mol Biol ; 52(4): 355-380, 2017 08.

Article in English | MEDLINE | ID: mdl-28402189

19.

Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the American Society for Blood and Marrow Transplantation.

Kansagra, Ankit J; Frey, Noelle V; Bar, Merav; Laetsch, Theodore W; Carpenter, Paul A; Savani, Bipin N; Heslop, Helen E; Bollard, Catherine M; Komanduri, Krishna V; Gastineau, Dennis A; Chabannon, Christian; Perales, Miguel A; Hudecek, Michael; Aljurf, Mahmoud; Andritsos, Leslie; Barrett, John A; Bachanova, Veronika; Bonini, Chiara; Ghobadi, Armin; Gill, Saar I; Hill, Joshua; Kenderian, Saad; Kebriaei, Partow; Nagler, Arnon; Maloney, David; Liu, Hien D; Shah, Nirali N; Kharfan-Dabaja, Mohamed A; Shpall, Elizabeth J; Mufti, Ghulam J; Johnston, Laura; Jacoby, Elad; Bazarbachi, Ali; DiPersio, John F; Pavletic, Steven Z; Porter, David L; Grupp, Stephan A; Sadelain, Michel; Litzow, Mark R; Mohty, Mohamad; Hashmi, Shahrukh K.

Biol Blood Marrow Transplant ; 25(3): e76-e85, 2019 03.

Article in English | MEDLINE | ID: mdl-30576834

20.

Highjacking myeloma's niche with beefed-up CAR-Ts.

Hudecek, Michael; Einsele, Hermann.

Blood ; 139(26): 3671-3672, 2022 06 30.

Article in English | MEDLINE | ID: mdl-35771562

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