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1.

C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.

Manion, John; Musser, Melissa A; Kuziel, Gavin A; Liu, Min; Shepherd, Amy; Wang, Siyu; Lee, Pyung-Gang; Zhao, Leo; Zhang, Jie; Marreddy, Ravi K R; Goldsmith, Jeffrey D; Yuan, Ke; Hurdle, Julian G; Gerhard, Ralf; Jin, Rongsheng; Rakoff-Nahoum, Seth; Rao, Meenakshi; Dong, Min.

Nature ; 622(7983): 611-618, 2023 Oct.

Article in English | MEDLINE | ID: mdl-37699522

2.

Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response.

Eubank, Taryn A; Dureja, Chetna; Garey, Kevin W; Hurdle, Julian G; Gonzales-Luna, Anne J.

Clin Infect Dis ; 2024 Feb 21.

Article in English | MEDLINE | ID: mdl-38382090

3.

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.

Dureja, Chetna; Rutherford, Jacob T; Pavel, Fahad B A; Norseeda, Krissada; Prah, Isaac; Sun, Dianqing; Hevener, Kirk E; Hurdle, Julian G.

Antimicrob Agents Chemother ; 68(3): e0122223, 2024 Mar 06.

Article in English | MEDLINE | ID: mdl-38265216

4.

Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents.

Norseeda, Krissada; Bin Aziz Pavel, Fahad; Rutherford, Jacob T; Meer, Humna N; Dureja, Chetna; Hurdle, Julian G; Hevener, Kirk E; Sun, Dianqing.

Bioorg Med Chem ; 88-89: 117330, 2023 06 06.

Article in English | MEDLINE | ID: mdl-37224699

5.

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao, Liang; Zhang, Jie; Meraner, Paul; Tovaglieri, Alessio; Wu, Xiaoqian; Gerhard, Ralf; Zhang, Xinjun; Stallcup, William B; Miao, Ji; He, Xi; Hurdle, Julian G; Breault, David T; Brass, Abraham L; Dong, Min.

Nature ; 538(7625): 350-355, 2016 Oct 20.

Article in English | MEDLINE | ID: mdl-27680706

6.

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests.

Wu, Xiaoqian; Shen, Wan-Jou; Deshpande, Aditi; Olaitan, Abiola O; Palmer, Kelli L; Garey, Kevin W; Hurdle, Julian G.

J Clin Microbiol ; 59(9): e0058521, 2021 08 18.

Article in English | MEDLINE | ID: mdl-34132582

7.

Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation.

Gonzales-Luna, Anne J; Spinler, Jennifer K; Oezguen, Numan; Khan, Md Abdul Wadud; Danhof, Heather A; Endres, Bradley T; Alam, M Jahangir; Begum, Khurshida; Lancaster, Chris; Costa, Gabriela Pd; Savidge, Tor C; Hurdle, Julian G; Britton, Robert; Garey, Kevin W.

Anaerobe ; 70: 102387, 2021 Aug.

Article in English | MEDLINE | ID: mdl-34044101

8.

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.

Deshpande, Aditi; Wu, Xiaoqian; Huo, Wenwen; Palmer, Kelli L; Hurdle, Julian G.

Antimicrob Agents Chemother ; 64(8)2020 07 22.

Article in English | MEDLINE | ID: mdl-32457109

9.

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates.

Shen, Wan-Jou; Deshpande, Aditi; Hevener, Kirk E; Endres, Bradley T; Garey, Kevin W; Palmer, Kelli L; Hurdle, Julian G.

J Antimicrob Chemother ; 75(4): 859-867, 2020 04 01.

Article in English | MEDLINE | ID: mdl-31873741

10.

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Sapkota, Madhab; Marreddy, Ravi K R; Wu, Xiaoqian; Kumar, Manish; Hurdle, Julian G.

Anaerobe ; 61: 102129, 2020 Feb.

Article in English | MEDLINE | ID: mdl-31760080

11.

Bacterial persister cells tackled.

Hurdle, Julian G; Deshpande, Aditi.

Nature ; 556(7699): 40-41, 2018 04 05.

Article in English | MEDLINE | ID: mdl-29620744

12.

Surveillance of Clostridioides difficile Antimicrobial Resistance in the United States.

Gonzales-Luna, Anne J; Dureja, Chetna; Eubank, Taryn A; Garey, Kevin W; Hurdle, Julian G.

Clin Infect Dis ; 76(11): 2038-2039, 2023 06 08.

Article in English | MEDLINE | ID: mdl-36883582

13.

New ß-lactam - Tetramic acid hybrids show promising antibacterial activities.

Cherian, Philip T; Cheramie, Martin N; Marreddy, Ravi K R; Fernando, Dinesh M; Hurdle, Julian G; Lee, Richard E.

Bioorg Med Chem Lett ; 28(18): 3105-3112, 2018 10 01.

Article in English | MEDLINE | ID: mdl-30097368

14.

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

Dang, Uyen T; Zamora, Idalia; Hevener, Kirk E; Adhikari, Sudip; Wu, Xiaoqian; Hurdle, Julian G.

Antimicrob Agents Chemother ; 60(9): 5604-7, 2016 09.

Article in English | MEDLINE | ID: mdl-27381389

15.

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile.

Alam, Mohammed Zahidul; Wu, Xiaoqian; Mascio, Carmela; Chesnel, Laurent; Hurdle, Julian G.

Antimicrob Agents Chemother ; 59(9): 5165-70, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26055381

16.

Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection.

Cherian, Philip T; Wu, Xiaoqian; Yang, Lei; Scarborough, Jerrod S; Singh, Aman P; Alam, Zahidul A; Lee, Richard E; Hurdle, Julian G.

J Antimicrob Chemother ; 70(11): 3061-9, 2015 Nov.

Article in English | MEDLINE | ID: mdl-26286574

17.

The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection.

Wu, Xiaoqian; Hurdle, Julian G.

Can J Microbiol ; 60(4): 251-4, 2014 Apr.

Article in English | MEDLINE | ID: mdl-24693984

18.

Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target.

Rutherford, Jacob T; Avad, Kristiana; Dureja, Chetna; Norseeda, Krissada; Gc, Bibek; Wu, Chenggang; Sun, Dianqing; Hevener, Kirk E; Hurdle, Julian G.

ACS Infect Dis ; 10(5): 1612-1623, 2024 05 10.

Article in English | MEDLINE | ID: mdl-38597503

19.

The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Wu, Xiaoqian; Cherian, Philip T; Lee, Richard E; Hurdle, Julian G.

J Antimicrob Chemother ; 68(4): 806-15, 2013 Apr.

Article in English | MEDLINE | ID: mdl-23264511

20.

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.