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1.

An affinity tool for the isolation of endogenous active mTORC1 from various cellular sources.

Ibrahim, Yasir H; Pantelios, Spyridon; Mutvei, Anders P.

J Biol Chem ; 299(5): 104644, 2023 05.

Article in English | MEDLINE | ID: mdl-36965617

2.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada, Shogo; Neinast, Michael; Jang, Cholsoon; Ibrahim, Yasir H; Lee, Gina; Babu, Apoorva; Li, Jian; Hoshino, Atsushi; Rowe, Glenn C; Rhee, James; Martina, José A; Puertollano, Rosa; Blenis, John; Morley, Michael; Baur, Joseph A; Seale, Patrick; Arany, Zoltan.

Genes Dev ; 30(22): 2551-2564, 2016 11 15.

Article in English | MEDLINE | ID: mdl-27913603

3.

PI3K activation promotes resistance to eribulin in HER2-negative breast cancer.

Gris-Oliver, Albert; Ibrahim, Yasir H; Rivas, Martín A; García-García, Celina; Sánchez-Guixé, Mònica; Ruiz-Pace, Fiorella; Viaplana, Cristina; Pérez-García, José M; Llombart-Cussac, Antonio; Grueso, Judit; Parés, Mireia; Guzmán, Marta; Rodríguez, Olga; Anton, Pilar; Cozar, Patricia; Calvo, Maria Teresa; Bruna, Alejandra; Arribas, Joaquín; Caldas, Carlos; Dienstmann, Rodrigo; Nuciforo, Paolo; Oliveira, Mafalda; Cortés, Javier; Serra, Violeta.

Br J Cancer ; 124(9): 1581-1591, 2021 04.

Article in English | MEDLINE | ID: mdl-33723394

4.

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients.

Scaltriti, Maurizio; Eichhorn, Pieter J; Cortés, Javier; Prudkin, Ludmila; Aura, Claudia; Jiménez, José; Chandarlapaty, Sarat; Serra, Violeta; Prat, Aleix; Ibrahim, Yasir H; Guzmán, Marta; Gili, Magui; Rodríguez, Olga; Rodríguez, Sonia; Pérez, José; Green, Simon R; Mai, Sabine; Rosen, Neal; Hudis, Clifford; Baselga, José.

Proc Natl Acad Sci U S A ; 108(9): 3761-6, 2011 Mar 01.

Article in English | MEDLINE | ID: mdl-21321214

5.

Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.

Gris-Oliver, Albert; Palafox, Marta; Monserrat, Laia; Brasó-Maristany, Fara; Òdena, Andreu; Sánchez-Guixé, Mònica; Ibrahim, Yasir H; Villacampa, Guillermo; Grueso, Judit; Parés, Mireia; Guzmán, Marta; Rodríguez, Olga; Bruna, Alejandra; Hirst, Caroline S; Barnicle, Alan; de Bruin, Elza C; Reddy, Avinash; Schiavon, Gaia; Arribas, Joaquín; Mills, Gordon B; Caldas, Carlos; Dienstmann, Rodrigo; Prat, Aleix; Nuciforo, Paolo; Razavi, Pedram; Scaltriti, Maurizio; Turner, Nicholas C; Saura, Cristina; Davies, Barry R; Oliveira, Mafalda; Serra, Violeta.

Clin Cancer Res ; 26(14): 3720-3731, 2020 07 15.

Article in English | MEDLINE | ID: mdl-32220884

6.

Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.

Ibrahim, Yasir H; Byron, Sara A; Cui, Xiaojiang; Lee, Adrian V; Yee, Douglas.

Mol Cancer Res ; 6(9): 1491-8, 2008 Sep.

Article in English | MEDLINE | ID: mdl-18819936

7.

Insulin-like growth factor-I and breast cancer therapy.

Ibrahim, Yasir H; Yee, Douglas.

Clin Cancer Res ; 11(2 Pt 2): 944s-50s, 2005 Jan 15.

Article in English | MEDLINE | ID: mdl-15701891

8.

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

Becker, Marc A; Ibrahim, Yasir H; Oh, Annabell S; Fagan, Dedra H; Byron, Sara A; Sarver, Aaron L; Lee, Adrian V; Shaw, Leslie M; Fan, Cheng; Perou, Charles M; Yee, Douglas.

PLoS One ; 11(3): e0150564, 2016.

Article in English | MEDLINE | ID: mdl-26991655

9.

Stratification and therapeutic potential of PML in metastatic breast cancer.

Martín-Martín, Natalia; Piva, Marco; Urosevic, Jelena; Aldaz, Paula; Sutherland, James D; Fernández-Ruiz, Sonia; Arreal, Leire; Torrano, Verónica; Cortazar, Ana R; Planet, Evarist; Guiu, Marc; Radosevic-Robin, Nina; Garcia, Stephane; Macías, Iratxe; Salvador, Fernando; Domenici, Giacomo; Rueda, Oscar M; Zabala-Letona, Amaia; Arruabarrena-Aristorena, Amaia; Zúñiga-García, Patricia; Caro-Maldonado, Alfredo; Valcárcel-Jiménez, Lorea; Sánchez-Mosquera, Pilar; Varela-Rey, Marta; Martínez-Chantar, Maria Luz; Anguita, Juan; Ibrahim, Yasir H; Scaltriti, Maurizio; Lawrie, Charles H; Aransay, Ana M; Iovanna, Juan L; Baselga, Jose; Caldas, Carlos; Barrio, Rosa; Serra, Violeta; Vivanco, Maria dM; Matheu, Ander; Gomis, Roger R; Carracedo, Arkaitz.

Nat Commun ; 7: 12595, 2016 08 24.

Article in English | MEDLINE | ID: mdl-27553708

10.

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

García-García, Celina; Rivas, Martín A; Ibrahim, Yasir H; Calvo, María Teresa; Gris-Oliver, Albert; Rodríguez, Olga; Grueso, Judit; Antón, Pilar; Guzmán, Marta; Aura, Claudia; Nuciforo, Paolo; Jessen, Katti; Argilés, Guillem; Dienstmann, Rodrigo; Bertotti, Andrea; Trusolino, Livio; Matito, Judit; Vivancos, Ana; Chicote, Irene; Palmer, Héctor G; Tabernero, Josep; Scaltriti, Maurizio; Baselga, José; Serra, Violeta.

Clin Cancer Res ; 21(24): 5499-5510, 2015 Dec 15.

Article in English | MEDLINE | ID: mdl-26272063

11.

Insulin-like growth factor-I and cancer risk.

Ibrahim, Yasir H; Yee, Douglas.

Growth Horm IGF Res ; 14(4): 261-9, 2004 Aug.

Article in English | MEDLINE | ID: mdl-15231294

12.

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.

Serra, Violeta; Eichhorn, Pieter J A; García-García, Celina; Ibrahim, Yasir H; Prudkin, Ludmila; Sánchez, Gertrudis; Rodríguez, Olga; Antón, Pilar; Parra, Josep-Lluís; Marlow, Sara; Scaltriti, Maurizio; Pérez-Garcia, José; Prat, Aleix; Arribas, Joaquín; Hahn, William C; Kim, So Young; Baselga, José.

J Clin Invest ; 123(6): 2551-63, 2013 Jun.

Article in English | MEDLINE | ID: mdl-23635776

13.

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.

Elkabets, Moshe; Vora, Sadhna; Juric, Dejan; Morse, Natasha; Mino-Kenudson, Mari; Muranen, Taru; Tao, Jessica; Campos, Ana Bosch; Rodon, Jordi; Ibrahim, Yasir H; Serra, Violeta; Rodrik-Outmezguine, Vanessa; Hazra, Saswati; Singh, Sharat; Kim, Phillip; Quadt, Cornelia; Liu, Manway; Huang, Alan; Rosen, Neal; Engelman, Jeffrey A; Scaltriti, Maurizio; Baselga, José.

Sci Transl Med ; 5(196): 196ra99, 2013 Jul 31.

Article in English | MEDLINE | ID: mdl-23903756

14.

Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy.

García-García, Celina; Ibrahim, Yasir H; Serra, Violeta; Calvo, Maria Teresa; Guzmán, Marta; Grueso, Judit; Aura, Claudia; Pérez, José; Jessen, Katti; Liu, Yi; Rommel, Christian; Tabernero, Josep; Baselga, José; Scaltriti, Maurizio.

Clin Cancer Res ; 18(9): 2603-12, 2012 May 01.

Article in English | MEDLINE | ID: mdl-22407832

15.

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.

Juvekar, Ashish; Burga, Laura N; Hu, Hai; Lunsford, Elaine P; Ibrahim, Yasir H; Balmañà, Judith; Rajendran, Anbazhagan; Papa, Antonella; Spencer, Katherine; Lyssiotis, Costas A; Nardella, Caterina; Pandolfi, Pier Paolo; Baselga, José; Scully, Ralph; Asara, John M; Cantley, Lewis C; Wulf, Gerburg M.

Cancer Discov ; 2(11): 1048-63, 2012 Nov.

Article in English | MEDLINE | ID: mdl-22915751

16.

PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition.

Ibrahim, Yasir H; García-García, Celina; Serra, Violeta; He, Lei; Torres-Lockhart, Kristine; Prat, Aleix; Anton, Pilar; Cozar, Patricia; Guzmán, Marta; Grueso, Judit; Rodríguez, Olga; Calvo, Maria Teresa; Aura, Claudia; Díez, Orland; Rubio, Isabel T; Pérez, José; Rodón, Jordi; Cortés, Javier; Ellisen, Leif W; Scaltriti, Maurizio; Baselga, José.

Cancer Discov ; 2(11): 1036-47, 2012 Nov.

Article in English | MEDLINE | ID: mdl-22915752

17.

The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells.

Becker, Marc A; Ibrahim, Yasir H; Cui, Xiaojiang; Lee, Adrian V; Yee, Douglas.

Mol Endocrinol ; 25(3): 516-28, 2011 Mar.

Article in English | MEDLINE | ID: mdl-21292829

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