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1.

Reverse Engineering Human Pathophysiology with Organs-on-Chips.

Ingber, Donald E.

Cell ; 164(6): 1105-1109, 2016 Mar 10.

Article in English | MEDLINE | ID: mdl-26967278

2.

Human organs-on-chips for disease modelling, drug development and personalized medicine.

Ingber, Donald E.

Nat Rev Genet ; 23(8): 467-491, 2022 08.

Article in English | MEDLINE | ID: mdl-35338360

3.

Mechanobiology and developmental control.

Mammoto, Tadanori; Mammoto, Akiko; Ingber, Donald E.

Annu Rev Cell Dev Biol ; 29: 27-61, 2013.

Article in English | MEDLINE | ID: mdl-24099083

4.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

Sperry, Megan M; Oskotsky, Tomiko T; Maric, Ivana; Kaushal, Shruti; Takeda, Takako; Horvath, Viktor; Powers, Rani K; Rodas, Melissa; Furlong, Brooke; Soong, Mercy; Prabhala, Pranav; Goyal, Girija; Carlson, Kenneth E; Wong, Ronald J; Kosti, Idit; Le, Brian L; Logue, James; Hammond, Holly; Frieman, Matthew; Stevenson, David K; Ingber, Donald E; Sirota, Marina; Novak, Richard.

PLoS Comput Biol ; 19(5): e1011050, 2023 05.

Article in English | MEDLINE | ID: mdl-37146076

5.

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics.

Ingber, Donald E.

Biochem J ; 480(4): 243-257, 2023 02 27.

Article in English | MEDLINE | ID: mdl-36821520

6.

Transferrin receptor targeting by de novo sheet extension.

Sahtoe, Danny D; Coscia, Adrian; Mustafaoglu, Nur; Miller, Lauren M; Olal, Daniel; Vulovic, Ivan; Yu, Ta-Yi; Goreshnik, Inna; Lin, Yu-Ru; Clark, Lars; Busch, Florian; Stewart, Lance; Wysocki, Vicki H; Ingber, Donald E; Abraham, Jonathan; Baker, David.

Proc Natl Acad Sci U S A ; 118(17)2021 04 27.

Article in English | MEDLINE | ID: mdl-33879614

7.

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.

Jordan, Robert; Ford-Scheimer, Stephanie L; Alarcon, Rodolfo M; Atala, Anthony; Borenstein, Jeffrey T; Brimacombe, Kyle R; Cherry, Sara; Clevers, Hans; Davis, Mindy I; Funnell, Simon G P; Gehrke, Lee; Griffith, Linda G; Grossman, Abigail C; Hartung, Thomas; Ingber, Donald E; Kleinstreuer, Nicole C; Kuo, Calvin J; Lee, Emily M; Mummery, Christine L; Pickett, Thames E; Ramani, Sasirekha; Rosado-Olivieri, Edwin A; Struble, Evi B; Wan, Zhengpeng; Williams, Mark S; Hall, Matthew D; Ferrer, Marc; Markossian, Sarine.

J Infect Dis ; 228(Suppl 5): S337-S354, 2023 10 03.

Article in English | MEDLINE | ID: mdl-37669225

8.

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?

Bai, Haiqing; Ingber, Donald E.

Physiology (Bethesda) ; 37(5): 0, 2022 09 01.

Article in English | MEDLINE | ID: mdl-35658627

9.

Molecular mapping of transmembrane mechanotransduction through the ß1 integrin-CD98hc-TRPV4 axis.

Potla, Ratnakar; Hirano-Kobayashi, Mariko; Wu, Hao; Chen, Hong; Mammoto, Akiko; Matthews, Benjamin D; Ingber, Donald E.

J Cell Sci ; 133(20)2020 11 02.

Article in English | MEDLINE | ID: mdl-32989042

10.

Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples.

Timilsina, Sanjay S; Jolly, Pawan; Durr, Nolan; Yafia, Mohamed; Ingber, Donald E.

Acc Chem Res ; 54(18): 3529-3539, 2021 09 21.

Article in English | MEDLINE | ID: mdl-34478255

11.

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips.

Prantil-Baun, Rachelle; Novak, Richard; Das, Debarun; Somayaji, Mahadevabharath R; Przekwas, Andrzej; Ingber, Donald E.

Annu Rev Pharmacol Toxicol ; 58: 37-64, 2018 01 06.

Article in English | MEDLINE | ID: mdl-29309256

12.

Developmentally inspired human 'organs on chips'.

Ingber, Donald E.

Development ; 145(16)2018 05 18.

Article in English | MEDLINE | ID: mdl-29776965

13.

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus.

Wang, Ning; Tytell, Jessica D; Ingber, Donald E.

Nat Rev Mol Cell Biol ; 10(1): 75-82, 2009 Jan.

Article in English | MEDLINE | ID: mdl-19197334

14.

PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

De Ceunynck, Karen; Peters, Christian G; Jain, Abhishek; Higgins, Sarah J; Aisiku, Omozuanvbo; Fitch-Tewfik, Jennifer L; Chaudhry, Sharjeel A; Dockendorff, Chris; Parikh, Samir M; Ingber, Donald E; Flaumenhaft, Robert.

Proc Natl Acad Sci U S A ; 115(5): E982-E991, 2018 01 30.

Article in English | MEDLINE | ID: mdl-29343648

15.

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.

Feng, Di; Kumar, Mukesh; Muntel, Jan; Gurley, Susan B; Birrane, Gabriel; Stillman, Isaac E; Ding, Lai; Wang, Minxian; Ahmed, Saima; Schlondorff, Johannes; Alper, Seth L; Ferrante, Tom; Marquez, Susan L; Ng, Carlos F; Novak, Richard; Ingber, Donald E; Steen, Hanno; Pollak, Martin R.

J Am Soc Nephrol ; 31(7): 1479-1495, 2020 07.

Article in English | MEDLINE | ID: mdl-32540856

16.

Cellular nanoscale stiffness patterns governed by intracellular forces.

Mandriota, Nicola; Friedsam, Claudia; Jones-Molina, John A; Tatem, Kathleen V; Ingber, Donald E; Sahin, Ozgur.

Nat Mater ; 18(10): 1071-1077, 2019 10.

Article in English | MEDLINE | ID: mdl-31209386

17.

Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure.

Zhang, Weixia; Qu, Liangliang; Pei, Hao; Qin, Zhao; Didier, Jonathan; Wu, Zhengwei; Bobe, Frank; Ingber, Donald E; Weitz, David A.

Small ; 15(42): e1903087, 2019 10.

Article in English | MEDLINE | ID: mdl-31448553

18.

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.

Benam, Kambez H; Villenave, Remi; Lucchesi, Carolina; Varone, Antonio; Hubeau, Cedric; Lee, Hyun-Hee; Alves, Stephen E; Salmon, Michael; Ferrante, Thomas C; Weaver, James C; Bahinski, Anthony; Hamilton, Geraldine A; Ingber, Donald E.

Nat Methods ; 13(2): 151-7, 2016 Feb.

Article in English | MEDLINE | ID: mdl-26689262

19.

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.

Kim, Hyun Jung; Li, Hu; Collins, James J; Ingber, Donald E.

Proc Natl Acad Sci U S A ; 113(1): E7-15, 2016 Jan 05.

Article in English | MEDLINE | ID: mdl-26668389

20.

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape.

Bastings, Maartje M C; Anastassacos, Frances M; Ponnuswamy, Nandhini; Leifer, Franziska G; Cuneo, Garry; Lin, Chenxiang; Ingber, Donald E; Ryu, Ju Hee; Shih, William M.

Nano Lett ; 18(6): 3557-3564, 2018 06 13.

Article in English | MEDLINE | ID: mdl-29756442

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Reverse Engineering Human Pathophysiology with Organs-on-Chips.

Human organs-on-chips for disease modelling, drug development and personalized medicine.

Mechanobiology and developmental control.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics.

Transferrin receptor targeting by de novo sheet extension.

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?

Molecular mapping of transmembrane mechanotransduction through the ß1 integrin-CD98hc-TRPV4 axis.

Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples.

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips.

Developmentally inspired human 'organs on chips'.

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus.

PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.

Cellular nanoscale stiffness patterns governed by intracellular forces.

Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure.

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro.

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape.