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1.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber, Stuart L; Kotz, Joanne D; Li, Min; Aubé, Jeffrey; Austin, Christopher P; Reed, John C; Rosen, Hugh; White, E Lucile; Sklar, Larry A; Lindsley, Craig W; Alexander, Benjamin R; Bittker, Joshua A; Clemons, Paul A; de Souza, Andrea; Foley, Michael A; Palmer, Michelle; Shamji, Alykhan F; Wawer, Mathias J; McManus, Owen; Wu, Meng; Zou, Beiyan; Yu, Haibo; Golden, Jennifer E; Schoenen, Frank J; Simeonov, Anton; Jadhav, Ajit; Jackson, Michael R; Pinkerton, Anthony B; Chung, Thomas D Y; Griffin, Patrick R; Cravatt, Benjamin F; Hodder, Peter S; Roush, William R; Roberts, Edward; Chung, Dong-Hoon; Jonsson, Colleen B; Noah, James W; Severson, William E; Ananthan, Subramaniam; Edwards, Bruce; Oprea, Tudor I; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Stauffer, Shaun R; Emmitte, Kyle A.

Cell ; 161(6): 1252-65, 2015 Jun 04.

Article in English | MEDLINE | ID: mdl-26046436

2.

Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1.

Finneran, Dylan; Li, Qingyou; Subbarayan, Meena S; Joly-Amado, Aurelie; Kamath, Siddharth; Dengler, Daniela G; Gordon, Marcia N; Jackson, Michael R; Morgan, Dave; Bickford, Paula C; Smith, Layton H; Nash, Kevin R.

Glia ; 71(2): 245-258, 2023 02.

Article in English | MEDLINE | ID: mdl-36106533

3.

An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.

Berneburg, Isabell; Peddibhotla, Satyamaheshwar; Heimsch, Kim C; Haeussler, Kristina; Maloney, Patrick; Gosalia, Palak; Preuss, Janina; Rahbari, Mahsa; Skorokhod, Oleksii; Valente, Elena; Ulliers, Daniela; Simula, Luigi Felice; Buchholz, Kathrin; Hedrick, Michael P; Hershberger, Paul; Chung, Thomas D Y; Jackson, Michael R; Schwarzer, Evelin; Rahlfs, Stefan; Bode, Lars; Becker, Katja; Pinkerton, Anthony B.

Antimicrob Agents Chemother ; 66(4): e0210921, 2022 04 19.

Article in English | MEDLINE | ID: mdl-35266827

4.

Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax.

Herzog, Lee-Or; Walters, Beth; Buono, Roberta; Lee, J Scott; Mallya, Sharmila; Fung, Amos; Chiu, Honyin; Nguyen, Nancy; Li, Boyang; Pinkerton, Anthony B; Jackson, Michael R; Schneider, Robert J; Ronai, Ze'ev A; Fruman, David A.

Br J Cancer ; 124(6): 1098-1109, 2021 03.

Article in English | MEDLINE | ID: mdl-33318657

5.

Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase.

Baugh, Simon D P; Jackson, Michael R; Rashad, Adel Ahmed; Reitz, Allen B; Lam, Patrick Y S; Jorns, Marilyn Schuman.

Bioorg Med Chem Lett ; 54: 128443, 2021 12 15.

Article in English | MEDLINE | ID: mdl-34763081

6.

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators.

Pinkerton, Anthony B; Sessions, E Hampton; Hershberger, Paul; Maloney, Patrick R; Peddibhotla, Satyamaheshwar; Hopf, Meghan; Sergienko, Eduard; Ma, Chen-Ting; Smith, Layton H; Jackson, Michael R; Tanaka, Jun; Tsuji, Takashi; Akiu, Mayuko; Cohen, Steven E; Nakamura, Tsuyoshi; Gardell, Stephen J.

Bioorg Med Chem Lett ; 41: 128007, 2021 06 01.

Article in English | MEDLINE | ID: mdl-33798699

7.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Pinkerton, Anthony B; Sergienko, Eduard; Bravo, Yalda; Dahl, Russell; Ma, Chen-Ting; Sun, Qing; Jackson, Michael R; Cosford, Nicholas D P; Millán, José Luis.

Bioorg Med Chem Lett ; 28(1): 31-34, 2018 01 01.

Article in English | MEDLINE | ID: mdl-29174347

8.

Use of Tissue Metabolite Analysis and Enzyme Kinetics To Discriminate between Alternate Pathways for Hydrogen Sulfide Metabolism.

Augustyn, Kristie D Cox; Jackson, Michael R; Jorns, Marilyn Schuman.

Biochemistry ; 56(7): 986-996, 2017 02 21.

Article in English | MEDLINE | ID: mdl-28107627

9.

Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog.

Melideo, Scott L; Jackson, Michael R; Jorns, Marilyn Schuman.

Biochemistry ; 53(28): 4739-53, 2014 Jul 22.

Article in English | MEDLINE | ID: mdl-24981631

10.

ß-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents.

Gereau, Graydon B; Zhou, Diana; Van Voorhies, Kalynn; Tyler, Ryan E; Campbell, Jeffrey; Murray, Jackson G; Alvarez-Pamir, Ali; Wykoff, Luke A; Companion, Michel A; Jackson, Michael R; Olson, Steven H; Barak, Lawrence S; Slosky, Lauren M; Vetreno, Ryan P; Besheer, Joyce; McElligott, Zoe A.

bioRxiv ; 2024 Apr 13.

Article in English | MEDLINE | ID: mdl-38645173

11.

Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.

Jackson, Michael R; Melideo, Scott L; Jorns, Marilyn Schuman.

Biochemistry ; 51(34): 6804-15, 2012 Aug 28.

Article in English | MEDLINE | ID: mdl-22852582

12.

Crystallization, optimization and preliminary X-ray characterization of a metal-dependent PI-PLC from Streptomyces antibioticus.

Jackson, Michael R; Selby, Thomas L.

Acta Crystallogr Sect F Struct Biol Cryst Commun ; 68(Pt 11): 1378-86, 2012 Nov 01.

Article in English | MEDLINE | ID: mdl-23143254

13.

Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure.

Jackson, Michael R; Cox, Kristie D; Baugh, Simon D P; Wakeen, Luke; Rashad, Adel A; Lam, Patrick Y S; Polyak, Boris; Jorns, Marilyn Schuman.

Cardiovasc Res ; 118(7): 1771-1784, 2022 06 22.

Article in English | MEDLINE | ID: mdl-34132787

14.

Interesting findings, questionable interpretation: Comment on Thornewill et al. (2020).

Jackson, Michael R.

Am Psychol ; 76(7): 1196-1197, 2021 10.

Article in English | MEDLINE | ID: mdl-34990176

15.

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.

Stanford, Stephanie M; Diaz, Michael A; Ardecky, Robert J; Zou, Jiwen; Roosild, Tarmo; Holmes, Zachary J; Nguyen, Tiffany P; Hedrick, Michael P; Rodiles, Socorro; Guan, April; Grotegut, Stefan; Santelli, Eugenio; Chung, Thomas D Y; Jackson, Michael R; Bottini, Nunzio; Pinkerton, Anthony B.

J Med Chem ; 64(9): 5645-5653, 2021 05 13.

Article in English | MEDLINE | ID: mdl-33914534

16.

Interrogation: hard for psychologists to act as whistleblowers.

Jackson, Michael R.

Nature ; 459(7250): 1052, 2009 Jun 25.

Article in English | MEDLINE | ID: mdl-19553973

17.

X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation.

Jackson, Michael R; Loll, Patrick J; Jorns, Marilyn Schuman.

Structure ; 27(5): 794-805.e4, 2019 05 07.

Article in English | MEDLINE | ID: mdl-30905673

18.

Discovery of ß-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

Pinkerton, Anthony B; Peddibhotla, Satyamaheshwar; Yamamoto, Fusayo; Slosky, Lauren M; Bai, Yushi; Maloney, Patrick; Hershberger, Paul; Hedrick, Michael P; Falter, Bekhi; Ardecky, Robert J; Smith, Layton H; Chung, Thomas D Y; Jackson, Michael R; Caron, Marc G; Barak, Lawrence S.

J Med Chem ; 62(17): 8357-8363, 2019 09 12.

Article in English | MEDLINE | ID: mdl-31390201

19.

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng, Yongmei; Sessions, E Hampton; Zhang, Fan; Ban, Fuqiang; Placencio-Hickok, Veronica; Ma, Chen-Ting; Zeng, Fu-Yue; Pass, Ian; Terry, David B; Cadwell, Gregory; Bankston, Laurie A; Liddington, Robert C; Chung, Thomas D Y; Pinkerton, Anthony B; Sergienko, Eduard; Gleave, Martin; Bhowmick, Neil A; Jackson, Michael R; Cherkasov, Artem; Ronai, Ze'ev A.

Cancer Lett ; 449: 145-162, 2019 05 01.

Article in English | MEDLINE | ID: mdl-30771432

20.

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli.

Peterson, Karin S; Huang, Jing-Feng; Zhu, Jessica; D'Agati, Vivette; Liu, Xuejun; Miller, Nancy; Erlander, Mark G; Jackson, Michael R; Winchester, Robert J.

J Clin Invest ; 113(12): 1722-33, 2004 Jun.

Article in English | MEDLINE | ID: mdl-15199407

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