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1.
Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
Bioorg Med Chem Lett
; 28(20): 3356-3362, 2018 11 01.
Article
in English
| MEDLINE | ID: mdl-30227946
2.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Proc Natl Acad Sci U S A
; 111(6): 2349-54, 2014 Feb 11.
Article
in English
| MEDLINE | ID: mdl-24469833
3.
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature
; 463(7277): 88-92, 2010 Jan 07.
Article
in English
| MEDLINE | ID: mdl-20054396
4.
Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.
Antimicrob Agents Chemother
; 59(2): 1070-9, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25451058
5.
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.
Blood
; 122(6): 958-68, 2013 Aug 08.
Article
in English
| MEDLINE | ID: mdl-23814019
6.
RUC-4: a novel αIIbß3 antagonist for prehospital therapy of myocardial infarction.
Arterioscler Thromb Vasc Biol
; 34(10): 2321-9, 2014 Oct.
Article
in English
| MEDLINE | ID: mdl-25147334
7.
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
Proc Natl Acad Sci U S A
; 109(41): E2794-802, 2012 Oct 09.
Article
in English
| MEDLINE | ID: mdl-23011795
8.
Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.
Mol Vis
; 20: 285-300, 2014.
Article
in English
| MEDLINE | ID: mdl-24644403
9.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Article
in English
| MEDLINE | ID: mdl-22922757
10.
A novel class of ion displacement ligands as antagonists of the αIIbß3 receptor that limit conformational reorganization of the receptor.
Bioorg Med Chem Lett
; 24(4): 1148-53, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24461295
11.
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Blood
; 117(6): 1938-46, 2011 Feb 10.
Article
in English
| MEDLINE | ID: mdl-21106989
12.
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.
Proc Natl Acad Sci U S A
; 107(41): 17791-6, 2010 Oct 12.
Article
in English
| MEDLINE | ID: mdl-20876097
13.
Selective targeting of ITK blocks multiple steps of HIV replication.
Proc Natl Acad Sci U S A
; 105(18): 6684-9, 2008 May 06.
Article
in English
| MEDLINE | ID: mdl-18443296
14.
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorg Med Chem Lett
; 20(11): 3387-93, 2010 Jun 01.
Article
in English
| MEDLINE | ID: mdl-20451379
15.
Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.
J Clin Invest
; 130(4): 2017-2023, 2020 04 01.
Article
in English
| MEDLINE | ID: mdl-32149729
16.
Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).
Front Pharmacol
; 10: 234, 2019.
Article
in English
| MEDLINE | ID: mdl-31068801
17.
Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.
Mol Cancer Ther
; 18(11): 2097-2110, 2019 11.
Article
in English
| MEDLINE | ID: mdl-31395684
18.
Overcoming adaptive therapy resistance in AML by targeting immune response pathways.
Sci Transl Med
; 11(508)2019 09 04.
Article
in English
| MEDLINE | ID: mdl-31484791
19.
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.
Endocrinology
; 149(12): 5945-50, 2008 Dec.
Article
in English
| MEDLINE | ID: mdl-18669595
20.
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
J Med Chem
; 49(13): 3888-96, 2006 Jun 29.
Article
in English
| MEDLINE | ID: mdl-16789744